Host genetics influence the rumen microbiota and heritable rumen microbial features associate with feed efficiency in cattle
Open accessAbstract
The symbiotic rumen microbiota is essential for the digestion of plant fibers and contributes to the variation of production and health traits in ruminants. However, to date, the heritability of rumen microbial features and host genetic components associated with the rumen microbiota, as well as whether such genetic components are animal performance relevant, are largely unknown. In the present study, we assessed rumen microbiota from a cohort of 709 beef cattle and showed that multiple factors including breed, sex, and diet drove the variation of rumen microbiota among animals. The diversity indices, the relative abundance of ~ 34% of microbial taxa (59 out of 174), and the copy number of total bacteria had a heritability estimate ( h 2 ) ≥ 0.15, suggesting that they are heritable elements affected by host additive genetics. These moderately heritable rumen microbial features were also found to be associated with host feed efficiency traits and rumen metabolic measures (volatile fatty acids). Moreover, 19 single nucleotide polymorphisms (SNPs) located on 12 bovine chromosomes were found to be associated with 14 (12 of them had h 2 ≥ 0.15) rumen microbial taxa, and five of these SNPs were known quantitative trait loci for feed efficiency in cattle. These findings suggest that some rumen microbial features are heritable and could be influenced by host genetics, highlighting a potential to manipulate and obtain a desirable and efficient rumen microbiota using genetic selection and breeding. It could be a useful strategy to further improve feed efficiency and optimize rumen fermentation through targeting both cattle and their rumen microbiota.
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Genetic manipulation of rumen microbiota is possible through different techniques as host genetics influences some heritable microbial traits.
“However, genetic manipulation of rumen microbiota is also possible through different techniques as host genetics influences some heritable microbial traits (81–83).”
From Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction (2020) · cites this paper as [81]
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- Authors
- Li, F., Li, C., Chen, Y., Liu, J., Zhang, C., Irving, B., Fitzsimmons, C., Plastow, G., & Guan, L. L.
- Affiliations
- University of Alberta (CA)
- Agriculture and Agri-Food Canada (CA)
- Corresponding author
- Guan, Le Luo
- Venue
- Microbiome
- Published
- 2019-06-13
- Volume
- 7
- Issue
- 1
- Pages
- 92-92
- ISSN
- 2049-2618 (ISSN-L)
- PMC
- PMC6567441
- OpenAlex
- W2953135971
- Cited by
- 530
- References
- 71
- Citations by year
- 2026: 44 · 2025: 77 · 2024: 94 · 2023: 65 · 2022: 62 · 2021: 120 · 2020: 58 · 2019: 10
- FWCI
- 93.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Microbiome (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Federal Open Science Repository of Canada / Le Dépôt fédéral de science ouverte du Canada (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Alberta Livestock and Meat Agency (2013R029R)
- Natural Sciences and Engineering Research Council of Canada (Discovery)
- Alberta Innovates - Technology Futures (Graduate student scholarship)
- Alberta Agriculture and Forestry (2018F095R)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Ruminant Nutrition and Digestive Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- rumen microbiota, host genetics, heritability, feed efficiency, beef cattle, single nucleotide polymorphisms, quantitative trait loci, volatile fatty acids, rumen fermentation, genetic selection
- MeSH terms
- Host Microbial Interactions, Animals, Animal Feed, Animal Nutritional Physiological Phenomena, Archaea, Bacteria, Breeding, Cattle, Female, Fermentation, Genotype, Male, Phylogeny, Rumen, Microbiota
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