Cited by 863Immune cells in cancerPhagocytosis and Immune RegulationImmune Response and Inflammation

The DOI matches its Crossref record; 46 of the 47 references it cites were found in a registry or an index.

Biochemical and functional characterization of three activated macrophage populations

Open access

Edwards, Justin P, Zhang, Xia, Frauwirth, Kenneth A, Mosser, David M·2006·Journal of Leukocyte Biology

Open this paper in CoChat — free account

Abstract

We generated three populations of macrophages (Mφ) in vitro and characterized each. Classically activated Mφ (Ca-Mφ) were primed with IFN-γ and stimulated with LPS. Type II-activated Mφ (Mφ-II) were similarly primed but stimulated with LPS plus immune complexes. Alternatively activated Mφ (AA-Mφ) were primed overnight with IL-4. Here, we present a side-by-side comparison of the three cell types. We focus primarily on differences between Mφ-II and AA-Mφ, as both have been classified as M2 Mφ, distinct from Ca-Mφ. We show that Mφ-II more closely resemble Ca-Mφ than they are to AA-Mφ. Mφ-II and Ca-Mφ, but not AA-Mφ, produce high levels of NO and have low arginase activity. AA-Mφ express FIZZ1, whereas neither Mφ-II nor Ca-Mφ do. Mφ-II and Ca-Mφ express relatively high levels of CD86, whereas AA-Mφ are virtually devoid of this costimulatory molecule. Ca-Mφ and Mφ-II are efficient APC, whereas AA-Mφ fail to stimulate efficient T cell proliferation. The differences between Ca-Mφ and Mφ-II are more subtle. Ca-Mφ produce IL-12 and give rise to Th1 cells, whereas Mφ-II produce high levels of IL-10 and thus, give rise to Th2 cells secreting IL-4 and IL-10. Mφ-II express two markers that may be used to identify them in tissue. These are sphingosine kinase-1 and LIGHT (TNF superfamily 14). Thus, Ca-Mφ, Mφ-II, and AA-Mφ represent three populations of cells with different biological functions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1189/jlb.0406249

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Antisense Knockdown of Sphingosine Kinase 1 in Human Macrophages Inhibits C5a Receptor-Dependent Signal Transduction, Ca2+ Signals, Enzyme Release, Cytokine Production, and Chemotaxis
Melendez, A. J., & Ibrahim, F. B. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1596 · Cited by 90
Retracted
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 12,401
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
Interleukin 4 potently enhances murine macrophage mannose receptor activity: A marker of alternative immunologic macrophage activation
Stein, M., Keshav, S., Harris, N., & Gordon, S. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.1.287 · Cited by 1,960
Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells
Stuehr, D. J., & Nathan, C. F. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.5.1543 · Cited by 1,744
Induction by Antigen of Intrathymic Apoptosis of CD4 + CD8 + TCR lo Thymocytes in Vivo
MURPHY, K. M. M., Heimberger, A. B., & Loh, D. Y. (1990) · Science · doi:10.1126/science.2125367 · Cited by 1,714
Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens
Nathan, C., & Shiloh, M. U. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.8841 · Cited by 1,469
Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences
Stout, R. D., Jiang, C., Matta, B., Tietzel, I., Watkins, S. K., & Suttles, J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.342 · Cited by 968
Alarmins: chemotactic activators of immune responses
Oppenheim, J. J., & Yang, D. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.06.002 · Cited by 780

Show all 47 references

Research works printed but not linked: 1

Anderson, 2002, A novel phenotype for an activated macrophage: the type 2 activated macrophage, J. Leukoc. Biol., 72, 101, 10.1189/jlb.72.1.101 · DOI

Sorted by citations

Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Self-citation
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337
Self-citation
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
Macrophage activation and polarization
Martinez, F. O. (2008) · Frontiers in Bioscience · doi:10.2741/2692 · Cited by 3,160
Macrophage Polarization
Murray, P. J. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034339 · Cited by 2,981
IL-10: The Master Regulator of Immunity to Infection
Couper, K. N., Blount, D. G., & Riley, E. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.5771 · Cited by 2,288
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
Miron, V. E., Boyd, A., Zhao, J.-W., Yuen, T. J., Ruckh, J. M., Shadrach, J. L., van Wijngaarden, P., Wagers, A. J., Williams, A., Franklin, R. J. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3469 · Cited by 1,777
Neuroinflammation and M2 Microglia: The Good, the Bad, and the Inflamed
Cherry, J. D., Olschowka, J. A., & O’Banion, M. K. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-98 · Cited by 1,748
The Isolation and Characterization of Murine Macrophages
Zhang, X., Gonçalves, R., & Mosser, D. M. (2008) · Current Protocols in Immunology · doi:10.1002/0471142735.im1401s83 · Cited by 1,557
Self-citation
Macrophages: master regulators of inflammation and fibrosis
Wynn, T., & Barron, L. (2010) · Seminars in Liver Disease · doi:10.1055/s-0030-1255354 · Cited by 1,392
Alveolar macrophages: plasticity in a tissue-specific context
Hussell, T., & Bell, T. J. (2014) · Nature Reviews Immunology · doi:10.1038/nri3600 · Cited by 1,377
The JAK-STAT Signaling Pathway: Input and Output Integration
Murray, P. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.2623 · Cited by 1,179
Overview of General and Discriminating Markers of Differential Microglia Phenotypes
Jurga, A. M., Paleczna, M., & Kuter, K. Z. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00198 · Cited by 1,000
M2b macrophage polarization and its roles in diseases
Wang, L., Zhang, S.-X., Wu, H., Rong, X., & Guo, J. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ru1018-378rr · Cited by 919
Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain
Colton, C. A. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9164-4 · Cited by 916
CD4 + CD25 + Foxp3 + regulatory T cells induce alternative activation of human monocytes/macrophages
Tiemessen, M. M., Jagger, A. L., Evans, H. G., van Herwijnen, M. J. C., John, S., & Taams, L. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706832104 · Cited by 883
Macrophage activation and its role in repair and pathology after spinal cord injury
Gensel, J. C., & Zhang, B. (2015) · Brain Research · doi:10.1016/j.brainres.2014.12.045 · Cited by 792
Advances in peripheral nerve regeneration
Scheib, J. L., & Höke, A. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.227 · Cited by 769
Osteoimmunomodulation for the development of advanced bone biomaterials
Chen, Z., Klein, T. J., Murray, R. Z., Crawford, R., Chang, J., Wu, C., & Xiao, Y. (2015) · Materials Today · doi:10.1016/j.mattod.2015.11.004 · Cited by 752
Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials
Sheikh, Z., Brooks, P., Barzilay, O., Fine, N., & Glogauer, M. (2015) · Materials · doi:10.3390/ma8095269 · Cited by 701
Inflammation and its role in age-related macular degeneration
Kauppinen, A., Paterno, J. J., Błasiak, J., Salminen, A., & Kaarniranta, K. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2147-8 · Cited by 683
Macrophages and Tissue Injury: Agents of Defense or Destruction?
Laskin, D. L., Sunil, V. R., Gardner, C. R., & Laskin, J. D. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105812 · Cited by 625
Diverse macrophage populations mediate acute lung inflammation and resolution
Aggarwal, N. R., King, L. S., & D’Alessio, F. R. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00341.2013 · Cited by 595
Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences
Martínez, F. O., Helming, L., Milde, R., Varin, A., Melgert, B. N., Draijer, C., Thomas, B., Fabbri, M., Crawshaw, A., Ho, L., et al. (2013) · Blood · doi:10.1182/blood-2012-06-436212 · Cited by 527
Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status
Vogel, D. Y., Vereyken, E. J., Glim, J. E., Heijnen, P. D., Moeton, M., van der Valk, P., Amor, S., Teunissen, C. E., van Horssen, J., & Dijkstra, C. D. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-35 · Cited by 479
The paradoxical role of IL-10 in immunity and cancer
Mannino, M. H., Zhu, Z., Xiao, H., Bai, Q., Wakefield, M. R., & Fang, Y. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.07.009 · Cited by 475
Notch Signaling Determines the M1 versus M2 Polarization of Macrophages in Antitumor Immune Responses
Wang, Y., He, F., Feng, F., Liu, X., Dong, G., Qin, H., Hu, X., Zheng, M., Liang, L., Feng, L., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0269 · Cited by 483
Anatomy of a Discovery: M1 and M2 Macrophages
Mills, C. D. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00212 · Cited by 449
Roles of microglia in brain development, tissue maintenance and repair
Michell‐Robinson, M. A., Touil, H., Healy, L. M., Owen, D. R., Durafourt, B. A., Bar‐Or, A., Antel, J. P., & Moore, C. S. (2015) · Brain · doi:10.1093/brain/awv066 · Cited by 435
Systematic validation of specific phenotypic markers for in vitro polarized human macrophages
Ambarus, C. A., Krausz, S., van Eijk, M., Hamann, J., Radstake, T. R. D. J., Reedquist, K. A., Tak, P. P., & Baeten, D. L. P. (2012) · Journal of Immunological Methods · doi:10.1016/j.jim.2011.10.013 · Cited by 411
Immune Cells in the BBB Disruption After Acute Ischemic Stroke: Targets for Immune Therapy?
Qiu, Y., Zhang, C., Chen, A., Wang, H.-L., Zhou, Y., Li, Y., & Hu, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.678744 · Cited by 414
Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice
Bedoret, D., Wallemacq, H., Marichal, T., Desmet, C., Quesada Calvo, F., Henry, E., Closset, R., Dewals, B., Thielen, C., Gustin, P., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39717 · Cited by 399
Inflammatory Response in the Hippocampus of PS1M146L/APP751SLMouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic
Jimenez, S., Baglietto-Vargas, D., Caballero, C., Moreno-Gonzalez, I., Torres, M., Sanchez-Varo, R., Ruano, D., Vizuete, M., Gutierrez, A., & Vitorica, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3024-08.2008 · Cited by 383
“We determined the expression of YM-1 and Arg-1 genes, considered markers of the alternative differentiation in peripheral macrophages (Edwards et al., 2006).”
BackgroundInfluential
Monocytes and macrophages in tissue repair: Implications for immunoregenerative biomaterial design
Ogle, M. E., Segar, C. E., Sridhar, S., & Botchwey, E. A. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216650293 · Cited by 378
Redox control of inflammation in macrophages
Brüne, B., Dehne, N., Grossmann, N., Jung, M., Namgaladze, D., Schmid, T., von Knethen, A., & Weigert, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4785 · Cited by 377
Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned
Gudi, V., Gingele, S., Skripuletz, T., & Stangel, M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00073 · Cited by 375
“In general, following stimulation with certain cytokines in vitro and in vivo, blood-derived monocytes can differentiate into two subsets of peripheral macrophages, the M1 and M2 phenotype, (Stein et al., 1992; Gordon, 2003; Edwards et al., 2006; Martinez et al., 2008; Cassetta et al., 2011).”
Background
Macrophage-Mediated Inflammation in Skin Wound Healing
Hassanshahi, A., Moradzad, M., Ghalamkari, S., Fadaei, M., Cowin, A. J., & Hassanshahi, M. (2022) · Cells · doi:10.3390/cells11192953 · Cited by 390
Regulation of Inflammation by Adenosine
Haskó, G., & Cronstein, B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00085 · Cited by 367
Identifying Functional MicroRNAs in Macrophages with Polarized Phenotypes
Graff, J. W., Dickson, A. M., Clay, G., McCaffrey, A. P., & Wilson, M. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.327031 · Cited by 367
Alternatively activated macrophages in helminth infections
Kreider, T., Anthony, R. M., Urban, J. F., & Gause, W. C. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.07.002 · Cited by 362
Microglia in ALS: The Good, The Bad, and The Resting
Henkel, J. S., Beers, D. R., Zhao, W., & Appel, S. H. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9171-5 · Cited by 353
CNS-Derived Interleukin-4 Is Essential for the Regulation of Autoimmune Inflammation and Induces a State of Alternative Activation in Microglial Cells
Ponomarev, E. D., Maresz, K., Tan, Y., & Dittel, B. N. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1922-07.2007 · Cited by 396
Microglia Phenotypes in Aging and Neurodegenerative Diseases
Wendimu, M. Y., & Hooks, S. B. (2022) · Cells · doi:10.3390/cells11132091 · Cited by 336
Macrophage Polarization in Health and Disease
Cassetta, L., Cassol, E., & Poli, G. (2011) · The Scientific World JOURNAL · doi:10.1100/2011/213962 · Cited by 347
Effect of modulating macrophage phenotype on peripheral nerve repair
Mokarram, N., Merchant, A., Mukhatyar, V., Patel, G., & Bellamkonda, R. V. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.08.050 · Cited by 334
Mechanisms and treatment of allergic disease in the big picture of regulatory T cells
Akdiş, C. A., & Akdiş, M. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.02.030 · Cited by 335
Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases
Armada‐Moreira, A., Gomes, J. I., Pina, C. C., Savchak, O. K., Gonçalves‐Ribeiro, J., Rei, N., Pinto, S., Morais, T. P., Martins, R. S., Ribeiro, F. F., et al. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00090 · Cited by 337
OsteoMacs: Key players around bone biomaterials
Miron, R. J., & Bosshardt, D. D. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.12.017 · Cited by 328
Tumor-Associated Macrophage Subsets: Shaping Polarization and Targeting
Zhang, Q., & Sioud, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087493 · Cited by 333
Macrophages in tuberculosis: friend or foe
Guirado, E., Schlesinger, L. S., & Kaplan, G. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0388-2 · Cited by 331
Intracerebral Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta Deposition and Rescues Memory Deficits in Alzheimer's Disease Mice by Modulation of Immune Responses
Lee, J. K., Jin, H. K., Endo, S., Schuchman, E. H., Carter, J., & Bae, J.-S. (2009) · Stem Cells · doi:10.1002/stem.277 · Cited by 308
Fats, inflammation and insulin resistance: insights to the role of macrophage and T-cell accumulation in adipose tissue
Harford, K. A., Reynolds, C. M., McGillicuddy, F. C., & Roche, H. M. (2011) · Proceedings of The Nutrition Society · doi:10.1017/s0029665111000565 · Cited by 309
Macrophage Related Chronic Inflammation in Non-Healing Wounds
Li, M., Hou, Q., Zhong, L., Zhao, Y., & Fu, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.681710 · Cited by 307
Macrophage reaction against biomaterials in the mouse model–phenotypes, functions and markers
Klopfleisch, R. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.07.003 · Cited by 298
When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma
Roesch, S., Rapp, C., Dettling, S., & Herold‐Mende, C. C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020436 · Cited by 305
Transcriptomic analyses of murine resolution-phase macrophages
Stables, M. J., Shah, S. H., Camon, E. B., Lovering, R. C., Newson, J., Byström, J., Farrow, S. N., & Gilroy, D. W. (2011) · Blood · doi:10.1182/blood-2011-04-345330 · Cited by 291
Macrophages and Inflammatory Mediators in Chemical Toxicity: A Battle of Forces
Laskin, D. L. (2009) · Chemical Research in Toxicology · doi:10.1021/tx900086v · Cited by 291
Microglial phenotypes in Parkinson’s disease and animal models of the disease
Joers, V., Tansey, M. G., Mulas, G., & Carta, A. R. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.006 · Cited by 285
Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation
Lee, H. J., Lee, J. K., Lee, H.-W., Carter, J., Chang, J. W., Oh, W., Yang, Y. S., Suh, J., Lee, B., Jin, H. K., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.03.024 · Cited by 291
The resolution of inflammation: Anti-inflammatory roles for NF-κB
Lawrence, T., & Fong, C. H.-Y. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.12.016 · Cited by 291
Regulation of Human Macrophage M1–M2 Polarization Balance by Hypoxia and the Triggering Receptor Expressed on Myeloid Cells-1
Raggi, F., Pelassa, S., Pierobon, D., Penco, F., Gattorno, M., Novelli, F., Eva, A., Varesio, L., Giovarelli, M., & Bosco, M. C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01097 · Cited by 294
Spatial confinement downsizes the inflammatory response of macrophages
Jain, N., & Vogel, V. (2018) · Nature Materials · doi:10.1038/s41563-018-0190-6 · Cited by 271
Early Macrophage Recruitment and Alternative Activation Are Critical for the Later Development of Hypoxia-Induced Pulmonary Hypertension
Vergadi, E., Chang, M. S., Lee, C., Liang, O. D., Liu, X., Fernandez‐Gonzalez, A., Mitsialis, S. A., & Kourembanas, S. (2011) · Circulation · doi:10.1161/circulationaha.110.978627 · Cited by 269
Macrophage polarization in diabetic wound healing
Wu, X., He, W., Mu, X., Liu, Y., Deng, J., Liu, Y., & Nie, X. (2022) · Burns & Trauma · doi:10.1093/burnst/tkac051 · Cited by 272
Cross-Talk Between Alveolar Macrophages and Lung Epithelial Cells is Essential to Maintain Lung Homeostasis
Bissonnette, É. Y., Lauzon‐Joset, J., Debley, J. S., & Ziegler, S. F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.583042 · Cited by 265
Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages
Clark, K., MacKenzie, K. F., Petkevicius, K., Kristariyanto, Y. A., Zhang, J., Choi, H. G., Peggie, M. W., Plater, L., Pedrioli, P. G. A., McIver, E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215450109 · Cited by 260
Brain Renin-Angiotensin System and Microglial Polarization: Implications for Aging and Neurodegeneration
Labandeira-García, J. L., Rodriguez-Perez, A. I., Garrido‐Gil, P., Rodríguez‐Pallares, J., Lanciego, J. L., & Guerra, M. J. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00129 · Cited by 259
The Role of Macrophages and Dendritic Cells in the Initiation of Inflammation in IBD
Steinbach, E. C., & Plevy, S. E. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e3182a69dca · Cited by 269
PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A–SIK–CRTC3 Pathway
MacKenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y. A., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202462 · Cited by 252
Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy
Toledo, B., Chen, L. Z., Paniagua-Sancho, M., Marchal, J. A., Perán, M., & Giovannetti, E. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01559-0 · Cited by 255
A Helminth Immunomodulator Reduces Allergic and Inflammatory Responses by Induction of IL-10-Producing Macrophages
Schnoeller, C., Rausch, S., Pillai, S., Avagyan, A., Wittig, B. M., Loddenkemper, C., Hamann, A., Hamelmann, E. H., Lucius, R., & Hartmann, S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.6.4265 · Cited by 240
Proinflammatory Clearance of Apoptotic Neutrophils Induces an IL-12lowIL-10high Regulatory Phenotype in Macrophages
Filardy, A. A., Pires, D. R., Nunes, M. P., Takiya, C. M., Freire-de-Lima, C. G., Ribeiro-Gomes, F. L., & DosReis, G. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000017 · Cited by 237
Rosiglitazone rescues memory impairment in Alzheimer’s transgenic mice: Mechanisms involving a reduced amyloid and tau pathology
Escribano, L., Simón, A.-M., Gimeno, E., Cuadrado-Tejedor, M., López de Maturana, R., García-Osta, A., Ricobaraza, A., Pérez-Mediavilla, A., Del Río, J., & Frechilla, D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.32 · Cited by 235
Ageing and the immune system: focus on macrophages
Linehan, E., & Fitzgerald, D. (2015) · European Journal of Microbiology and Immunology · doi:10.1556/eujmi-d-14-00035 · Cited by 234
Helminth 2‐Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages
Donnelly, S., Stack, C. M., O’Neill, S. M., Sayed, A. A., Williams, D. L., & Dalton, J. P. (2008) · The FASEB Journal · doi:10.1096/fj.08-106278 · Cited by 227
TUDCA: An Agonist of the Bile Acid Receptor GPBAR1/TGR5 With Anti‐Inflammatory Effects in Microglial Cells
Yanguas‐Casás, N., Barreda‐Manso, M. A., Nieto‐Sampedro, M., & Romero‐Ramírez, L. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25742 · Cited by 223
Retnla (Relmα/Fizz1) Suppresses Helminth-Induced Th2-Type Immunity
Pesce, J. T., Ramalingam, T. R., Wilson, M. S., Mentink-Kane, M. M., Thompson, R. W., Cheever, A. W., Urban, J. F., & Wynn, T. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000393 · Cited by 213
Preconditioning of bone marrow-derived mesenchymal stem cells highly strengthens their potential to promote IL-6-dependent M2b polarization
Philipp, D., Suhr, L., Wahlers, T., Choi, Y.-H., & Paunel-Görgülü, A. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-1039-2 · Cited by 213
Activation of Murine Macrophages
Mosser, D. M., & Zhang, X. (2008) · Current Protocols in Immunology · doi:10.1002/0471142735.im1402s83 · Cited by 222
Self-citation
Bone Repair Biomaterials: A Perspective from Immunomodulation
Wang, Y., Zhang, H., Hu, Y., Jing, Y., Geng, Z., & Su, J. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202208639 · Cited by 218
Regulatory macrophages: Setting the Threshold for Therapy
Fleming, B. D., & Mosser, D. M. (2011) · European Journal of Immunology · doi:10.1002/eji.201141717 · Cited by 202
Self-citation
An M1-like Macrophage Polarization in Decidual Tissue during Spontaneous Preterm Labor That Is Attenuated by Rosiglitazone Treatment
Xu, Y., Romero, R. J., Miller, D., Kadam, L., Mial, T. N., Plazyo, O., Garcia‐Flores, V., Hassan, S. S., Xu, Z., Tarca, A. L., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502055 · Cited by 202
Secreted protein lipocalin‐2 promotes microglial M1 polarization
Jang, E., Lee, S., Kim, J., Kim, J., Seo, J., Lee, W., Mori, K., Nakao, K., & Suk, K. (2013) · The FASEB Journal · doi:10.1096/fj.12-222257 · Cited by 198
M1 and M2 immune activation in Parkinson’s Disease: Foe and ally?
Moehle, M. S., & West, A. B. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.11.018 · Cited by 209
Macrophages and CNS remyelination
Miron, V. E., & Franklin, R. J. M. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12705 · Cited by 206
Functional diversity of microglia – how heterogeneous are they to begin with?
Hanisch, U.-K. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00065 · Cited by 195
Diverse functional roles of lipocalin-2 in the central nervous system
Jha, M. K., Lee, S., Park, D. H., Kook, H., Park, K.-G., Lee, I.-K., & Suk, K. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.006 · Cited by 195
Neuroinflammatory phenotype in early Alzheimer's disease
Sudduth, T. L., Schmitt, F. A., Nelson, P. T., & Wilcock, D. M. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.09.012 · Cited by 201
Macrophage and dendritic cell phenotypic diversity in the context of biomaterials
Kou, P. M., & Babensee, J. E. (2011) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32971 · Cited by 190
Macrophages are necessary for epimorphic regeneration in African spiny mice
Simkin, J., Gawriluk, T. R., Gensel, J. C., & Seifert, A. W. (2017) · eLife · doi:10.7554/elife.24623 · Cited by 197
M2-Polarized tumor-associated macrophages are associated with poor prognoses resulting from accelerated lymphangiogenesis in lung adenocarcinoma
Zhang, B., Yao, G., Zhang, Y., Gao, J., Yang, B., 饶智国, & 高建飞 (2011) · Clinics · doi:10.1590/s1807-59322011001100006 · Cited by 188
Azithromycin alters macrophage phenotype
Murphy, B. S., Sundareshan, V., Cory, T. J., Hayes, D., Anstead, M., & Feola, D. J. (2008) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkn007 · Cited by 193
Immune cell subset differentiation and tissue inflammation
Fang, P., Li, X., Dai, J., Cole, L. E., Camacho, J. A., Zhang, Y., Ji, Y. H., Wang, J., Yang, X., & Wang, H. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0637-x · Cited by 189
Suppression of Ulcerative Colitis in Mice by Orally Available Inhibitors of Sphingosine Kinase
Maines, L. W., Fitzpatrick, L. R., French, K. J., Zhuang, Y., Xia, Z., Keller, S. N., Upson, J. J., & Smith, C. D. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-0133-6 · Cited by 184
Neuroinflammation in Alzheimer’s disease; A source of heterogeneity and target for personalized therapy
Latta, C. H., Brothers, H. M., & Wilcock, D. M. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.061 · Cited by 188
Innate Immune Responses to TREM-1 Activation: Overlap, Divergence, and Positive and Negative Cross-Talk with Bacterial Lipopolysaccharide
Dower, K., Ellis, D. K., Saraf, K. A., Jelinsky, S. A., & Lin, L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3520 · Cited by 181
Kupffer Cell Metabolism and Function.
Nguyen‐Lefebvre, A. T., & Horuzsko, A. (2015) · PubMed · Cited by 174
MicroRNA 21 Is a Homeostatic Regulator of Macrophage Polarization and Prevents Prostaglandin E2-Mediated M2 Generation
Wang, Z., Brandt, S., Medeiros, A., Wang, S., Wu, H., Dent, A., & Serezani, C. H. (2015) · PLOS ONE · doi:10.1371/journal.pone.0115855 · Cited by 169
Microglia and Astrocyte Function and Communication: What Do We Know in Humans?
Garland, E. F., Hartnell, I. J., & Boche, D. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.824888 · Cited by 165
Macrophages
Melgert, B. N., Oriss, T. B., Qi, Z., Dixon‐McCarthy, B., Geerlings, M., Hylkema, M. N., & Ray, A. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0016oc · Cited by 165

Authors: Edwards, J. P., Zhang, X., Frauwirth, K. A., & Mosser, D. M.
Affiliations: University of Maryland, College Park (US)
Corresponding author: Mosser, David M
ORCID: Edwards, Justin P
Zhang, Xia
Mosser, David M
Venue: Journal of Leukocyte Biology
Publisher: Oxford University Press (OUP)
Published: 2006-08-11
Volume: 80
Issue: 6
Pages: 1298-1307
ISSN: 0741-5400 (ISSN-L)
1938-3673
DOI: 10.1189/jlb.0406249
PMC: PMC2642590
OpenAlex: W2168203604
Cited by: 863
References: 47
Citations by year: 2026: 14 · 2025: 21 · 2024: 34 · 2023: 25 · 2022: 45 · 2021: 51 · 2020: 49 · 2019: 44 · 2018: 45 · 2017: 43 · 2016: 48 · 2015: 78 · 2014: 62 · 2013: 61 · 2012: 47
FWCI: 10.22
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Journal of Leukocyte Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (AI49383)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: macrophage polarization, M1 macrophages, M2 macrophages, interferon-gamma, LPS, immune complexes, IL-4, nitric oxide, arginase, Fizz1, CD86, antigen presentation, T cell proliferation, IL-12, IL-10, Th1/Th2 differentiation, sphingosine kinase 1, light
MeSH terms: Sphingosine Kinase, Animals, Arginase, Cells, Cultured, Lipopolysaccharides, Macrophage Activation, Macrophages, Mice, Inbred BALB C, Nitric Oxide, Proteins, Cytokines, Phosphotransferases (Alcohol Group Acceptor), Th1 Cells, Th2 Cells, Coculture Techniques, Nerve Growth Factor, Intercellular Signaling Peptides and Proteins, Cell Proliferation, Mice, B7-2 Antigen, Tumor Necrosis Factor Ligand Superfamily Member 14

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Biochemical and functional characterization of three activated macrophage populations

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks