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Cited by 55Treatment of Major DepressionChild and Adolescent Psychosocial and Emotional DevelopmentMental Health Treatment and Access

Treated depression in adolescents: predictors of outcome at 28 weeks

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Wilkinson, Paul, Dubicka, Bernadka, Kelvin, Raphael, Roberts, Chris, Goodyer, Ian·2009·British Journal of Psychiatry
DOI 10.1192/bjp.bp.108.052381
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Abstract

BACKGROUND: There is great heterogeneity of clinical presentation and outcome in paediatric depression. AIMS: To identify which clinical and environmental risk factors at baseline and during treatment predicted major depression at 28-week follow-up in a sample of adolescents with depression. METHOD: One hundred and ninety-two British adolescents with unipolar major depression were enrolled in a randomised controlled trial (the Adolescent Depression Antidepressants and Psychotherapy Trial, ADAPT). Participants were treated for 28 weeks with routine psychosocial care and selective serotonin reuptake inhibitors (SSRIs), with half also receiving cognitive-behavioural therapy (CBT). Full clinical and demographic assessment was carried out at baseline and 28 weeks. RESULTS: Depression at 28 weeks was predicted by the additive effects of severity, obsessive-compulsive disorder and suicidal ideation at entry together with presence of at least one disappointing life event over the follow-up period. CONCLUSIONS: Clinicians should assess for severity, suicidality and comorbid obsessive-compulsive disorder at presentation and should monitor closely for subsequent life events during treatment.

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  • The pilot effect size of 0.87 compares favorably with those reported in meta-analysis of clinical trials of standard CBT or antidepressant drugs.

    “This magnitude of change compares favorably with those reported in meta–analysis of clinical trials of standard cognitive-behavioral therapy (CBT) or antidepressant drugs (TADS; Kratochvil et al., 2006; ADAPT: Wilkinson et al., 2009), as well as reviews by Klein et al. (2007) and Weisz et al. (2006).”

    From A hope intervention for adolescents: a randomized controlled trial delivered by paraprofessionals (2025) · cites this paper as Wilkinson et al., 2009

    The Method identifies this study as ADAPT, a trial of antidepressant treatment with or without CBT, and the Results and Comparison of changes in clinical variables report improvement over 28 weeks. Our copy does not provide a treatment effect size that establishes whether the citing paper’s pilot effect size of 0.87 compares favorably with ADAPT; this paper is also not a meta-analysis. (LLM, conf=0.82)

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Authors
Wilkinson, P., Dubicka, B., Kelvin, R., Roberts, C., & Goodyer, I.
Affiliations
  • University of Cambridge (GB)
  • University of Manchester (GB)
Corresponding author
Wilkinson, Paul
ORCID
Venue
British Journal of Psychiatry
Publisher
Royal College of Psychiatrists
Published
2009-04
Volume
194
Issue
4
Pages
334-341
ISSN
  • 0007-1250 (ISSN-L)
  • 1472-1465
DOI
10.1192/bjp.bp.108.052381
OpenAlex
W2022389039
Cited by
55
References
30
Citations by year
2025: 3 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 3 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 5
FWCI
4.55
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified, 3198 d)
Locations
  • The British Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
Funders
Health Technology Assessment Programme
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords
adolescent depression, unipolar major depression, predictors of treatment outcome, depression severity, obsessive-compulsive disorder comorbidity, suicidal ideation, life events, cognitive behavioral therapy, selective serotonin reuptake inhibitors, psychosocial care, ADAPT trial
MeSH terms
Adolescent, Antidepressive Agents, Child, Combined Modality Therapy, Depressive Disorder, England, Female, Follow-Up Studies, Humans, Male, Psychiatric Status Rating Scales, Risk Factors, Cognitive Behavioral Therapy, Treatment Outcome, Selective Serotonin Reuptake Inhibitors

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