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The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake

Yang, Muhua, Liu, Weidong, Pellicane, Christina, Sahyoun, Christine, Joseph, Biny K., Gallo-Ebert, Christina, Donigan, Melissa, Pandya, Devanshi, Giordano, Caroline, Bata, Adam, Nickels, Joseph T.·2014·Journal of Lipid Research
DOI 10.1194/jlr.m041335
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Crossref · 10.1194/jlr.m041335

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  • miR-185 suppresses LDLR expression directly, but also indirectly by inhibiting SREBP-2-dependent gene expression.

    “Similarly, miR-185 suppresses LDLR expression directly, but also indirectly by inhibiting SREBP-2-dependent gene expression [49].”

    From The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms (2025) · cites this paper as [49]

    The Results (page unavailable) show that miR-185 overexpression lowers LDLR expression and abolishes stimulated LDLR expression; the authors attribute this to repression of SREBP-2-dependent gene expression. The paper demonstrates direct targeting of SREBP-2 mRNA, not direct targeting of LDLR, so the claim of direct LDLR suppression is unsupported. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • The truncated 3'UTR lacks binding sites for both miR128-1 and miR-148, while the miR-185 binding site is still present.

    “This truncated 3’UTR lacks binding sites for both miR128-1 and miR-14852,53,67, while the miR-185 binding site is still present54,67.”

    From Pathways and Molecular Mechanisms Governing LDL Receptor Regulation (2025) · cites this paper as [53]

    The Results (page unavailable) identify miR-185 binding sites in the SREBP-2 3′UTR and report that mutating them interfered with miR-185 targeting. The paper examines the wild-type 3′UTR and point-mutated binding sites, but does not establish that a miR-185 site remains in the truncated 3′UTR described by the citing sentence. The miR-128-1 and miR-148 clause is attached to other citations, not this one. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • miR-185 inhibits expression of SREBP2, decreasing LDLR.

    “miR-185 Inhibits expression of SREBP2 ↓ [49]”

    From The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms (2025) · cites this paper as [49]

  • miR-27a promotes expression of PCSK9, decreasing LDLR.

    “miR-27a Promotes expression of PCSK9 ↓ [43,45,49]”

    From The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms (2025) · cites this paper as [49]

  • Two separate studies identified miR-185 as an indirect and direct post-transcriptional regulator of LDLR mRNA.

    “Two separate studies identified miR-185 as an indirect53 and direct54 post-transcriptional regulator of LDLR mRNA.”

    From Pathways and Molecular Mechanisms Governing LDL Receptor Regulation (2025) · cites this paper as [53]

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Metadata

Authors
Yang, M., Liu, W., Pellicane, C., Sahyoun, C., Joseph, B. K., Gallo-Ebert, C., Donigan, M., Pandya, D., Giordano, C., Bata, A., & Nickels, J. T.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2014-02
Volume
55
Issue
2
Pages
226-238
ISSN
0022-2275
DOI
10.1194/jlr.m041335
Cited by
93
References
4
Language
en
Licence

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