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The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Angptl4 Protects against Severe Proinflammatory Effects of Saturated Fat by Inhibiting Fatty Acid Uptake into Mesenteric Lymph Node Macrophages

Lichtenstein, Laeticia, Mattijssen, Frits, de Wit, Nicole J., Georgiadi, Anastasia, Hooiveld, Guido J., van der Meer, Roelof, He, Yin, Qi, Ling, Köster, Anja, Tamsma, Jouke T., Tan, Nguan Soon, Müller, Michael, Kersten, Sander·2010·Cell Metabolism
DOI 10.1016/j.cmet.2010.11.002PMC PMC3387545
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  • Peritoneal macrophages isolated from ANGPTL4-deficient mice exhibit significantly more lipid uptake and inflammatory cytokine release than those from normal mice when incubated with chyle.

    “Peritoneal macrophages isolated from ANGPTL4-deficient mice exhibit significantly more lipid uptake and inflammatory cytokine release than those from normal mice when incubated with chyle (chylomicron-containing lymphatic fluid) (59).”

    From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [59]

    In Results, under “Absence of Angptl4 stimulates foam cell formation and inflammation in MLN-resident macrophages” (page unavailable), the paper explicitly reports no clear difference in foam-cell formation between wild-type and Angptl4-deficient peritoneal macrophages loaded with chyle, contrary to the claimed greater lipid uptake. It reports chyle-induced inflammatory gene expression, but the cited passages do not establish greater cytokine release from deficient cells than from wild-type cells. (LLM, conf=0.88)

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  • When ANGPTL4 knockout mice are fed a high-fat diet, they gain significantly more weight and adiposity than wild-type littermates.

    “For example, when ANGPTL4 knockout mice are fed a high-fat diet, they gain significantly more weight and adiposity than wild-type littermates (59, 84).”

    From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [59]

  • ANGPTL4-deficient mice fed a diet high in saturated fat accumulate Touton giant cells in their mesenteric lymph nodes.

    “ANGPTL4-deficient mice fed a diet high in saturated fat accumulate Touton giant cells, cells that result from the fusion of lipid-laden macrophages, in their mesenteric lymph nodes (34, 59).”

    From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [59]

  • These mice eventually die, likely as a consequence of the inflammation that results from unfettered lipid uptake into lymphatic macrophages.

    “These mice eventually die, likely as a consequence of the inflammation that results from unfettered lipid uptake into lymphatic macrophages (59).”

    From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [59]

  • ANGPTL4 deficiency in mice results in lower plasma triglycerides.

    “ANGPTL4 deficiency in mice also results in lower plasma triglycerides (16, 17, 59)”

    From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [59]

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Research works printed but not linked: 39

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Metadata

Authors
Lichtenstein, L., Mattijssen, F., de Wit, N. J., Georgiadi, A., Hooiveld, G. J., van der Meer, R., He, Y., Qi, L., Köster, A., Tamsma, J. T., Tan, N. S., Müller, M., & Kersten, S.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2010-12
Volume
12
Issue
6
Pages
580-592
ISSN
1550-4131
DOI
10.1016/j.cmet.2010.11.002
PMC
PMC3387545
Cited by
251
References
4
Language
en
Licence
Funders
  • National Institutes of Health (R01DK082582)
  • American Diabetes Association (7-08-JF-47)
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (40-00812-98-08030)

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