Characterization of overall ceramide species in human stratum corneum

Functions of Ceramide in Coordinating Cellular Responses to Stress

Hannun, Y. A. (1996) · Science · doi:10.1126/science.274.5294.1855 · Cited by 1,612

Biochemistry of Lipids, Lipoproteins and Membranes

(2021) · Elsevier eBooks · doi:10.1016/c2020-0-00089-7 · Cited by 1,402

Epidermal Lipids, Barrier Function, and Desquamation

Elias, P. M. (1983) · Journal of Investigative Dermatology · doi:10.1038/jid.1983.12 · Cited by 1,356

Decreased Level of Ceramides in Stratum Corneum of Atopic Dermatitis: An Etiologic Factor in Atopic Dry Skin?

Imokawa, G., Abe, A., Jin, K., Higaki, Y., Kawashima, M., & Hidano, A. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12470233 · Cited by 1,040

Ceramide in apoptosis: an overview and current perspectives

Pettus, B. J., Chalfant, C. E., & Hannun, Y. A. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00331-1 · Cited by 788

Skin Lipids: Their Biochemical Uniqueness: Unlike internal organs, the skin biosynthesizes and excretes unusual fat soluble substances.

Nicolaides, N. (1974) · Science · doi:10.1126/science.186.4158.19 · Cited by 609

Ceramides and other bioactive sphingolipid backbones in health and disease: Lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy

Zheng, W., Kollmeyer, J., Symolon, H., Momin, A. A., Munter, E., Wang, E. L., Kelly, S. L., Allegood, J. C., Liu, Y., Peng, Q., et al. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.08.009 · Cited by 561

Ceramide composition of the psoriatic scale

Motta, S., Monti, M., Sesana, S., Caputo, R., Carelli, S., & Ghidoni, R. (1993) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(93)90135-n · Cited by 435

Studies on Contact Sensitivity to Chromium in the Guinea Pig. The Role of Valence in the Formation of the Antigenic Determinant

Siegenthaler, U., Laine, A. M., & Polák, L. (1983) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12531034 · Cited by 352

Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patients

Drobnik, W., Liebisch, G., Audebert, F., Fröhlich, D., Glück, T., Vogel, P. M., Rothe, G., & Schmitz, G. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200401-jlr200 · Cited by 350

Stratum Corneum Modulation By Chemical Enhancers and Lipid nanostructures: Implications for Transdermal Drug Delivery

Kapoor, M. S., GuhaSarkar, S., & Banerjee, R. (2017) · Therapeutic Delivery · doi:10.4155/tde-2017-0045 · Cited by 45

Controlled penetration of ceramides into and across the stratum corneum using various types of microemulsions and formulation associated toxicity studies

Sahle, F. F., Wohlrab, J., & Neubert, R. H. H. (2013) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2013.07.011 · Cited by 44

Recent advances in skin ‘barrier’ research

Rawlings, A. V. (2010) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.62.06.0002 · Cited by 47

State of the Art in Stratum Corneum Research. Part II: Hypothetical Stratum Corneum Lipid Matrix Models

Schmitt, T., & Neubert, R. H. H. (2020) · Skin Pharmacology and Physiology · doi:10.1159/000509019 · Cited by 43

4,8-Sphingadienine and 4-hydroxy-8-sphingenine activate ceramide production in the skin

Shirakura, Y., Kikuchi, K., Matsumura, K., Mukai, K., Mitsutake, S., & Igarashi, Y. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-108 · Cited by 42

Ceramide synthase 4 is highly expressed in involved skin of patients with atopic dermatitis

Ito, S., Ishikawa, J., Naoe, A., Yoshida, H., Hachiya, A., Fujimura, T., Kitahara, T., & Takema, Y. (2016) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13777 · Cited by 42

Changes in IR band areas and band shifts during water adsorption to lecithin and ceramide

Kudo, S., & Nakashima, S. (2019) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2019.117779 · Cited by 41

Mechanistic insights of the enhancement effect of sorbitan monooleate on olanzapine transdermal patch both in release and percutaneous absorption processes

Li, N., Quan, P., Wan, X., Liu, C., Liu, X., & Fang, L. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.07.006 · Cited by 40

Mass spectrometric analysis of neutral sphingolipids: Methods, applications, and limitations

Farwanah, H., Kolter, T., & Sandhoff, K. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.05.011 · Cited by 39

Breaking the Itch–Scratch Cycle: Topical Options for the Management of Chronic Cutaneous Itch in Atopic Dermatitis

Harrison, I. P., & Spada, F. (2019) · Medicines · doi:10.3390/medicines6030076 · Cited by 40

Interaction of miltefosine with intercellular membranes of stratum corneum and biomimetic lipid vesicles

Alonso, L., Mendanha, S. A., Marquezin, C. A., Berardi, M., Ito, A. S., Acuña, A. U., & Alonso, A. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.06.006 · Cited by 38

Effect of sphingosine and phytosphingosine ceramide ratio on lipid arrangement and barrier function in skin lipid models

Nădăban, A., Rousel, J., Yachioui, D. E., Gooris, G. S., Beddoes, C. M., Dalgliesh, R. M., Malfois, M., Rißmann, R., & Bouwstra, J. A. (2023) · Journal of Lipid Research · doi:10.1016/j.jlr.2023.100400 · Cited by 37

The roughness of lip skin is related to the ceramide profile in the stratum corneum

Tamura, E., Ishikawa, J., Naoe, A., & Yamamoto, T. (2016) · International Journal of Cosmetic Science · doi:10.1111/ics.12335 · Cited by 37

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Ishikawa, J., Yoshida, H., Ito, S., Naoe, A., Fujimura, T., Kitahara, T., Takema, Y., Zerweck, C. R., & Grove, G. L. (2013) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12019 · Cited by 37

Omega- O -Acylceramides in Skin Lipid Membranes: Effects of Concentration, Sphingoid Base, and Model Complexity on Microstructure and Permeability

Opálka, L., Kováčik, A., Maixner, J., & Vávrová, K. (2016) · Langmuir · doi:10.1021/acs.langmuir.6b03082 · Cited by 37

Nature versus nurture: does human skin maintain its stratum corneum lipid properties in vitro?

Thakoersing, V. S., Danso, M. O., Mulder, A. A., Gooris, G. S., Ghalbzouri, A. E., & Bouwstra, J. A. (2012) · Experimental Dermatology · doi:10.1111/exd.12031 · Cited by 36

Decrease of ceramides with long‐chain fatty acids in psoriasis: Possible inhibitory effect of interferon gamma on chain elongation

Kim, B., Shon, J. C., Seo, H. S., Liu, K., Lee, J. W., Ahn, S. K., & Hong, S. P. (2021) · Experimental Dermatology · doi:10.1111/exd.14431 · Cited by 36

Investigation of the Molecular Structure of the Human Stratum Corneum Ceramides [NP] and [EOS] by Mass Spectrometry

Hinder, A., Schmelzer, C. E. H., Rawlings, A. V., & Neubert, R. H. H. (2011) · Skin Pharmacology and Physiology · doi:10.1159/000322303 · Cited by 36

Sphingosine-1-phosphate as signaling molecule in the skin

Japtok, L., Bäumer, W., & Kleuser, B. (2014) · Allergo Journal International · doi:10.1007/s40629-014-0008-2 · Cited by 36

Effects of glucocorticoids on stratum corneum lipids and function in human skin—A detailed lipidomic analysis

Røpke, M. A., Alonso, C., Jung, S., Norsgaard, H., Richter, C., Darvin, M. E., Litman, T., Vogt, A., Lademann, J. M., Blume‐Peytavi, U., et al. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.08.009 · Cited by 35

Lipidomics for translational skin research: A primer for the uninitiated

Kendall, A. C., Koszyczarek, M. M., Jones, E. A., Hart, P. J., Towers, M. W., Griffiths, C. E. M., Morris, M. R., & Nicolaou, A. (2018) · Experimental Dermatology · doi:10.1111/exd.13558 · Cited by 35

Eucalyptus increases ceramide levels in keratinocytes and improves stratum corneum function

Ishikawa, J., Shimotoyodome, Y., Chen, S., Ohkubo, K., Takagi, Y., Fujimura, T., Kitahara, T., & Takema, Y. (2011) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2011.00675.x · Cited by 35

The role of ceramides in skin barrier function and the importance of their correct formulation for skincare applications

Schild, J., Kalvodová, A., Zbytovská, J., Farwick, M., & Pyko, C. (2024) · International Journal of Cosmetic Science · doi:10.1111/ics.12972 · Cited by 47

Effects of sphingoid bases on the sphingolipidome in early keratinocyte differentiation

Sigrüener, A., Tarabin, V., Paragh, G., Liebisch, G., Koehler, T., Farwick, M., & Schmitz, G. (2013) · Experimental Dermatology · doi:10.1111/exd.12231 · Cited by 34

Developmental alterations of physical properties and components of neonatal-infantile stratum corneum of upper thighs and diaper-covered buttocks during the 1st year of life

Minami‐Hori, M., Honma, M., Fujii, M., Nomura, W., Kanno, K., Hayashi, T., Nakamura, E., Nagaya, K., Miyauchi, Y., Fujimura, T., et al. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.08.015 · Cited by 35

Efficacy and safety of a topical moisturizer containing linoleic acid and ceramide for mild‐to‐moderate psoriasis vulgaris: A multicenter randomized controlled trial

Li, X., Yang, Q., Zheng, J., Gu, H., Chen, K., Jin, H., He, C., Xu, A., Xu, J. H., Zhang, J., et al. (2020) · Dermatologic Therapy · doi:10.1111/dth.14263 · Cited by 33

Investigation of a CER[NP]- and [AP]-Based Stratum Corneum Modeling Membrane System: Using Specifically Deuterated CER Together with a Neutron Diffraction Approach

Schmitt, T., Lange, S., Dobner, B., Sonnenberger, S., Hauß, T., & Neubert, R. H. H. (2017) · Langmuir · doi:10.1021/acs.langmuir.7b01848 · Cited by 33

MS-DIAL 4: accelerating lipidomics using an MS/MS, CCS, and retention time atlasPreprint

Tsugawa, H., Ikeda, K., Takahashi, M., Satoh, A., Mori, Y., Uchino, H., Okahashi, N., Yamada, Y., Tada, I., Bonini, P., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.11.944900 · Cited by 32

Scalable Synthesis of Human Ultralong Chain Ceramides

Opálka, L., Kováčik, A., Sochorová, M., Roh, J., Kuneš, J., Lenčo, J., & Vávrová, K. (2015) · Organic Letters · doi:10.1021/acs.orglett.5b02816 · Cited by 31

Fatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols

Lin, M., Hsu, F., Crumrine, D. A., Meyer, J. M., Elias, P. M., & Miner, J. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-49684-y · Cited by 32

Reevaluation of the non-lesional dry skin in atopic dermatitis by acute barrier disruption: an abnormal permeability barrier homeostasis with defective processing to generate ceramide

Sugiura, A., Nomura, T., Mizuno, A., & Imokawa, G. (2013) · Archives of Dermatological Research · doi:10.1007/s00403-013-1430-x · Cited by 32

Quantitative Structure-Activity Relationship of Enhancers of Licochalcone A and Glabridin Release and Permeation Enhancement from Carbomer Hydrogel

Wang, Z., Xue, Y., Zhu, Z., Hu, Y., Zeng, Q., Wu, Y., Wang, Y., Shen, C., Jiang, C., Liu, L., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020262 · Cited by 30

Synthesis and Structure-Activity Relationships of Skin Ceramides

Novotný, J., Hrabálek, A., & Vávrová, K. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710791331068 · Cited by 30

The Role of the Trans Double Bond in Skin Barrier Sphingolipids: Permeability and Infrared Spectroscopic Study of Model Ceramide and Dihydroceramide Membranes

Školová, B., Jandovská, K., Pullmannová, P., Tesař, O., Roh, J., Hrabálek, A., & Vávrová, K. (2014) · Langmuir · doi:10.1021/la500622f · Cited by 30

Structural and barrier properties of the skin ceramide lipid bilayer: a molecular dynamics simulation study

Badhe, Y. P., Gupta, R. K., & Rai, B. (2019) · Journal of Molecular Modeling · doi:10.1007/s00894-019-4008-5 · Cited by 30

N ‐Acyl ethanolamide and eicosanoid involvement in irritant dermatitis

Kendall, A. C., Pilkington, S. M., Sassano, G., Rhodes, L. E., & Nicolaou, A. (2016) · British Journal of Dermatology · doi:10.1111/bjd.14521 · Cited by 30

Bioconjugation Strategies for Revealing the Roles of Lipids in Living Cells

Knittel, C. H., & Devaraj, N. K. (2022) · Accounts of Chemical Research · doi:10.1021/acs.accounts.2c00511 · Cited by 28

Metabolic engineering of the non-conventional yeast Pichia ciferrii for production of rare sphingoid bases

Börgel, D., van den Berg, M. A., Hueller, T., Andrea, H., Liebisch, G., Boles, E., Schorsch, C., van der Pol, R., Arink, A. M., Boogers, I., et al. (2012) · Metabolic Engineering · doi:10.1016/j.ymben.2012.03.003 · Cited by 29

Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors

Murakami, I., Wakasa, Y., Yamashita, S., Kurihara, T., Zama, K., Kobayashi, N., Mizutani, Y., Mitsutake, S., Shigyo, T., & Igarashi, Y. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-150 · Cited by 29

Profile and quantification of human stratum corneum ceramides by normal-phase liquid chromatography coupled with dynamic multiple reaction monitoring of mass spectrometry: development of targeted lipidomic method and application to human stratum corneum of different age groups

Jia, Z., Zhang, J., Shen, C., & Ma, L. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-9775-6 · Cited by 29

Lipids in the Skin and pH

Wohlrab, J., Gebert, A., & Neubert, R. H. H. (2018) · Current problems in dermatology · doi:10.1159/000489519 · Cited by 29

Strawberry seed extract and its major component, tiliroside, promote ceramide synthesis in the stratum corneum of human epidermal equivalents

Takeda, S., Shimoda, H., Takarada, T., & Imokawa, G. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205061 · Cited by 29

Treatment with Synthetic Pseudoceramide Improves Atopic Skin, Switching the Ceramide Profile to a Healthy Skin Phenotype

Ishida, K., Takahashi, A., Bito, K., Draelos, Z. D., & Imokawa, G. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.01.014 · Cited by 29

A lipidomic platform establishment for structural identification of skin ceramides with non-hydroxyacyl chains

Shin, J.-H., Shon, J. C., Lee, K., Kim, S., Park, C. S., Choi, E. H., Lee, C. H., Lee, H. S., & Liu, K. (2014) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-013-7601-y · Cited by 28

The Chemistry and Biology of 6‐Hydroxyceramide, the Youngest Member of the Human Sphingolipid Family

Kováčik, A., Roh, J., & Vávrová, K. (2014) · ChemBioChem · doi:10.1002/cbic.201402153 · Cited by 28

The effects of transdermal permeation enhancers on thermotropic phase behaviour of a stratum corneum lipid model

Zbytovská, J., Vávrová, K., Kiselev, M. A., Lessieur, P., Wartewig, S., & Neubert, R. H. H. (2009) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2009.09.025 · Cited by 28

Transcription Factor Ctip2 Controls Epidermal Lipid Metabolism and Regulates Expression of Genes Involved in Sphingolipid Biosynthesis during Skin Development

Wang, Z., Kirkwood, J. S., Taylor, A. W., Stevens, J. F., Leid, M. E., Ganguli‐Indra, G., & Indra, A. K. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.358 · Cited by 28

Impact of the ceramide subspecies on the nanostructure of stratum corneum lipids using neutron scattering and molecular dynamics simulations. Part I: impact of CER[NS]

Schmitt, T., Gupta, R. K., Lange, S., Sonnenberger, S., Dobner, B., Hauß, T., Rai, B., & Neubert, R. H. H. (2018) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2018.05.006 · Cited by 28

Ceramides with a pentadecasphingosine chain and short acyls have strong permeabilization effects on skin and model lipid membranes

Školová, B., Janůšová, B., & Vávrová, K. (2015) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.11.019 · Cited by 27

Long and very long lamellar phases in model stratum corneum lipid membranes

Pullmannová, P., Ermakova, E. V., Kováčik, A., Opálka, L., Maixner, J., Zbytovská, J., Kučerka, N., & Vávrová, K. (2019) · Journal of Lipid Research · doi:10.1194/jlr.m090977 · Cited by 27

In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein

Martins, M., Azóia, N. G., Ribeiro, A., Shimanovich, U., Silva, C., & Cavaco-Paulo, A. M. (2013) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2013.02.032 · Cited by 27

Measurement of trihydroxy-linoleic acids in stratum corneum by tape-stripping: Possible biomarker of barrier function in atopic dermatitis

Chiba, T., Nakahara, T., Kohda, F., Ichiki, T., Manabe, M., & Furue, M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210013 · Cited by 27

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Boiten, W. A., Berkers, T., Absalah, S., van Smeden, J., Lavrijsen, A. P. M., & Bouwstra, J. A. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m079186 · Cited by 26

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Schmitt, T., Lange, S., Sonnenberger, S., Dobner, B., Demé, B., Langner, A., & Neubert, R. H. H. (2018) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2018.06.008 · Cited by 26

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Muñoz‐Garcia, A., Ro, J., Reichard, J. D., Kunz, T., & Williams, J. B. (2011) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2011.10.025 · Cited by 26

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Ramos, A. P., & Lafleur, M. (2015) · Langmuir · doi:10.1021/acs.langmuir.5b03271 · Cited by 26

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Eichner, A., Sonnenberger, S., Dobner, B., Hauß, T., Schroeter, A., & Neubert, R. H. H. (2016) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2016.09.002 · Cited by 24

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Fujiwara, A., Morifuji, M., Kitade, M., Kawahata, K., Fukasawa, T., Yamaji, T., Itoh, H., & Kawashima, M. (2018) · Archives of Dermatological Research · doi:10.1007/s00403-018-1859-z · Cited by 24

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Chen, Y., Liao, M., Ma, K., Wang, Z., Demé, B., Penfold, J., Lu, J. R., Webster, J. R. P., & Li, P. (2021) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2021.09.098 · Cited by 24

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Gooris, G. S., Kamran, M., Kros, A., Moore, D. J., & Bouwstra, J. A. (2018) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2018.02.024 · Cited by 24

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Nojiri, H., Ishida, K., Yao, X., Liu, W., & Imokawa, G. (2018) · Archives of Dermatological Research · doi:10.1007/s00403-018-1833-9 · Cited by 24

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Calvano, C. D., Glaciale, M., Palmisano, F., & Cataldi, T. R. I. (2018) · Electrophoresis · doi:10.1002/elps.201700475 · Cited by 23

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Uche, L. E., Gooris, G. S., Bouwstra, J. A., & Beddoes, C. M. (2020) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2020.183487 · Cited by 23

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McGurk, K. A., Williams, S. G., Guo, H., Watkins, H. C., Farrall, M., Cordell, H. J., Nicolaou, A., & Keavney, B. D. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab002 · Cited by 24

Omega‐3 carboxylic acids and fenofibrate differentially alter plasma lipid mediators in patients with non‐alcoholic fatty liver disease

Camacho‐Muñoz, D., Kiezel‐Tsugunova, M., Kiss, O., Uddin, M., Sundén, M., Ryaboshapkina, M., Lind, L., Oscarsson, J., & Nicolaou, A. (2021) · The FASEB Journal · doi:10.1096/fj.202100380rrr · Cited by 22

Relationship between cutaneous barrier function and ceramide species in human stratum corneum

Joo, K., Nam, G., Park, S. Y., Han, J. Y., Jeong, H., Lee, S., Kim, H. K., & Lim, K. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2010.07.016 · Cited by 22

Anaphylactoid and systemic reactions following saline enema administration. Six case reports.

Lozynsky, O. A., Dupuis, L. L., Shandling, B., Gilmour, R. F., & Zimmerman, B. (1986) · PubMed · Cited by 22

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Nădăban, A., Gooris, G. S., Beddoes, C. M., Dalgliesh, R. M., & Bouwstra, J. A. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100258 · Cited by 21

SC lipid model membranes designed for studying impact of ceramide species on drug diffusion and permeation, Part III: Influence of penetration enhancer on diffusion and permeation of model drugs

Ochalek, M., Podhaisky, H., Rüttinger, H. H., Neubert, R. H. H., & Wohlrab, J. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.06.044 · Cited by 21

Investigation of the enhancement effect of the natural transdermal permeation enhancers from Ledum palustre L. var. angustum N. Busch: Mechanistic insight based on interaction among drug, enhancers and skin

Nan, L., Liu, C., Li, Q., Wan, X., Guo, J., Quan, P., & Fang, L. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.08.025 · Cited by 21

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Badhe, Y. P., Schmitt, T., Gupta, R. K., Rai, B., & Neubert, R. H. H. (2022) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2022.184007 · Cited by 20

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Sho, Y., Sakai, T., Sato, T., Sonezaki, M., Taima, H., Taguchi, H., Kaizu, K., Nishizaka, T., Takagi, Y., & Hatano, Y. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.06.012 · Cited by 20

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Tanaka, K., Yamada, M., Tamiya‐Koizumi, K., Kannagi, R., Aoyama, T., Hara, A., & Kyogashima, M. (2011) · Glycoconjugate Journal · doi:10.1007/s10719-011-9325-6 · Cited by 20

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Brown, M. B., Williams, A., Chilcott, R. P., Brady, B., Lenn, J. D., Evans, C., Allen, L., McAuley, W. J., Beebeejaun, M., Haslinger, J., et al. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.123.000549 · Cited by 20

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