Cited by 140Retinal Diseases and TreatmentsFatty Acid Research and HealthRetinal Development and Disorders

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Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1

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Bazan, Nicolas G., Calandria, Jorgelina M., Serhan, Charles N.·2010·Journal of Lipid Research

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Abstract

Retinal degenerative diseases result in retinal pigment epithelial (RPE) and photoreceptor cell loss. These cells are continuously exposed to the environment (light) and to potentially pro-oxidative conditions, as the retina's oxygen consumption is very high. There is also a high flux of docosahexaenoic acid (DHA), a PUFA that moves through the blood stream toward photoreceptors and between them and RPE cells. Photoreceptor outer segment shedding and phagocytosis intermittently renews photoreceptor membranes. DHA is converted through 15-lipoxygenase-1 into neuroprotectin D1 (NPD1), a potent mediator that evokes counteracting cell-protective, anti-inflammatory, pro-survival repair signaling, including the induction of anti-apoptotic proteins and inhibition of pro-apoptotic proteins. Thus, NPD1 triggers activation of signaling pathway/s that modulate/s pro-apoptotic signals, promoting cell survival. This review provides an overview of DHA in photoreceptors and describes the ability of RPE cells to synthesize NPD1 from DHA. It also describes the role of neurotrophins as agonists of NPD1 synthesis and how photoreceptor phagocytosis induces refractoriness to oxidative stress in RPE cells, with concomitant NPD1 synthesis.

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Authors: Bazan, N. G., Calandria, J. M., & Serhan, C. N.
Affiliations: Louisiana State University (US)
Louisiana State University Health Sciences Center New Orleans (US)
Brigham and Women's Hospital (US)
Corresponding author: Bazan, Nicolas G.
ORCID: Bazan, Nicolas G.
Calandria, Jorgelina M.
Serhan, Charles N.
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 2010-08
Volume: 51
Issue: 8
Pages: 2018-2031
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1194/jlr.r001131
PMC: PMC2903812
OpenAlex: W2114448829
Cited by: 140
References: 121
Citations by year: 2026: 3 · 2025: 3 · 2024: 16 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 8 · 2018: 9 · 2017: 14 · 2016: 2 · 2015: 13 · 2014: 14 · 2013: 7 · 2012: 12
FWCI: 2.42
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 3713 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health (4r37gm038765-19)
National Eye Institute (EY005121, R01EY005121)
National Institute of General Medical Sciences (GM 38765, R01GM038765, R37-GM038765)
National Center for Research Resources (P20RR016816)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Keywords: neuroprotectin D1, docosahexaenoic acid, retinal pigment epithelium, retinal degeneration, phagocytosis, 15-lipoxygenase-1, neurotrophins, oxidative stress, apoptosis, anti-inflammatory signaling, polyunsaturated fatty acids
MeSH terms: Animals, Cell Differentiation, Docosahexaenoic Acids, Humans, Nerve Growth Factors, Photoreceptor Cells, Oxidative Stress, Retinal Pigment Epithelium

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Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1

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