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EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance
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Persistent MTORC1 inhibition can cause downregulation of negative feedback loops on IRS-MTORC2-AKT, resulting in reactivation of MTORC2 under conditions of ongoing starvation.
“Also, persistent MTORC1 inhibition can cause downregulation of negative feedback loops on IRS-MTORC2-AKT that results in the reactivation of MTORC2 under conditions of ongoing starvation [578, 774, 775].”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [775]
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BackgroundInfluentialAkt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation
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Metadata
- Authors
- Wei, Y., Zou, Z., Becker, N., Anderson, M., Sumpter, R., Xiao, G., Kinch, L., Koduru, P., Christudass, C. S., Veltri, R. W., Grishin, N. V., Peyton, M., Minna, J., Bhagat, G., & Levine, B.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 154
- Issue
- 6
- Pages
- 1269-1284
- ISSN
- 0092-8674
- PMC
- PMC3917713
- Cited by
- 505
- References
- 7
- Language
- en
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