Cited by 145Bipolar Disorder and TreatmentChild and Adolescent Psychosocial and Emotional DevelopmentNeural and Behavioral Psychology Studies

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Irritability in Pediatric Mania and Other Childhood Psychopathology

LEIBENLUFT, ELLEN, BLAIR, R JAMES R., CHARNEY, DENNIS S., PINE, DANIEL S.·2003·Annals of the New York Academy of Sciences

DOI 10.1196/annals.1301.022

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Abstract

Irritability is an important symptom in childhood psychopathology that has received relatively little research attention. Recent controversy concerning the diagnosis of mania in children has focused attention on how little is known about how to assess irritability in a systematic way, and about its diagnostic associations. For example, subtyping irritability according to course (chronic vs. episodic), precipitants, and family history may facilitate the identification of psychopathology and the study of pathophysiology. While normative and pathologic irritability can be differentiated reliably, the validity of the distinction is unclear. In addition, there is a need for scales designed to measure the severity of irritability in children with mood and anxiety disorders. In order to facilitate research, we propose a definition of irritability from the perspective of affective neuroscience. Because reactive aggression may be a helpful animal model for irritability, we review the neural circuitry mediating this behavior. Behavioral paradigms that evoke frustration, as well as those that assess the ability to inhibit a prepotent motor response, maintain attentional focus, execute response reversal, recognize angry faces, and regulate emotional responses, may be useful in the study of irritability. Examples of such paradigms are described, and the pharmacology of irritability is reviewed briefly.

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Authors: LEIBENLUFT, E., BLAIR, R. J. R., CHARNEY, D. S., & PINE, D. S.
Affiliations: United States Department of Health and Human Services (US)
National Institutes of Health (US)
Corresponding author: LEIBENLUFT, ELLEN
ORCID: LEIBENLUFT, ELLEN
CHARNEY, DENNIS S.
PINE, DANIEL S.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2003-12
Volume: 1008
Issue: 1
Pages: 201-218
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1196/annals.1301.022
OpenAlex: W2077483072
Cited by: 145
References: 106
Citations by year: 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 8 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 13 · 2015: 9 · 2014: 8 · 2013: 4 · 2012: 7
FWCI: 3.06
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 785 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: irritability, childhood psychopathology, reactive aggression, frustration, affective neuroscience, mood disorders, anxiety disorders, emotion regulation, anger recognition, response inhibition
MeSH terms: Adolescent, Aggression, Bipolar Disorder, Child, Child Behavior Disorders, Family, Humans, Nerve Net, Phenotype, Sensitivity and Specificity, Mood Disorders, Diagnostic and Statistical Manual of Mental Disorders

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Irritability in Pediatric Mania and Other Childhood Psychopathology

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