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Cited by 145Bipolar Disorder and TreatmentChild and Adolescent Psychosocial and Emotional DevelopmentNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.

Irritability in Pediatric Mania and Other Childhood Psychopathology

LEIBENLUFT, ELLEN, BLAIR, R JAMES R., CHARNEY, DENNIS S., PINE, DANIEL S.·2003·Annals of the New York Academy of Sciences
DOI 10.1196/annals.1301.022
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Abstract

Irritability is an important symptom in childhood psychopathology that has received relatively little research attention. Recent controversy concerning the diagnosis of mania in children has focused attention on how little is known about how to assess irritability in a systematic way, and about its diagnostic associations. For example, subtyping irritability according to course (chronic vs. episodic), precipitants, and family history may facilitate the identification of psychopathology and the study of pathophysiology. While normative and pathologic irritability can be differentiated reliably, the validity of the distinction is unclear. In addition, there is a need for scales designed to measure the severity of irritability in children with mood and anxiety disorders. In order to facilitate research, we propose a definition of irritability from the perspective of affective neuroscience. Because reactive aggression may be a helpful animal model for irritability, we review the neural circuitry mediating this behavior. Behavioral paradigms that evoke frustration, as well as those that assess the ability to inhibit a prepotent motor response, maintain attentional focus, execute response reversal, recognize angry faces, and regulate emotional responses, may be useful in the study of irritability. Examples of such paradigms are described, and the pharmacology of irritability is reviewed briefly.

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Citations

Cites

Research works printed but not linked: 7

  1. American Psychiatric Association. 2000. Diagnostic and Statistical Manual of Mental Disorders 4th ed. Text Revision (DSM‐IV‐TR). American Psychiatric Association Press. Washington DC.
  2. Geller B., 2001, Reliability of the Washington University in St, Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS) mania and rapid cycling sections. J. Am. Acad. Child Adolesc. Psychiatry, 40, 450
  3. Axelson D., A preliminary study of the KSADS mania rating scale for childen and adolescents, J. Child Adolesc. Psychopharm
  4. Ramamurthi B., 1988, Stereotactic operation in behaviour disorders, Amygdalotomy and hypothalamotomy. Acta Neurochir. Suppl. (Wien), 44, 152
  5. 10.1111/j.1467-8624.1996.tb01778.x · DOI
  6. 10.1111/1469-7610.00336 · DOI
  7. Klein R.G. 1991. Preliminary results: lithium effects in conduct disorders. In CMR Syllabus and Proceedings Summary Symposium 2. The 144th Annual Meeting of the American Psychiatric Association: 199–220. New Orleans LA.

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Metadata

Authors
LEIBENLUFT, E., BLAIR, R. J. R., CHARNEY, D. S., & PINE, D. S.
Affiliations
  • United States Department of Health and Human Services (US)
  • National Institutes of Health (US)
Corresponding author
LEIBENLUFT, ELLEN
ORCID
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2003-12
Volume
1008
Issue
1
Pages
201-218
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1196/annals.1301.022
OpenAlex
W2077483072
Cited by
145
References
106
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 8 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 13 · 2015: 9 · 2014: 8 · 2013: 4 · 2012: 7
FWCI
3.06
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 785 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
irritability, childhood psychopathology, reactive aggression, frustration, affective neuroscience, mood disorders, anxiety disorders, emotion regulation, anger recognition, response inhibition
MeSH terms
Adolescent, Aggression, Bipolar Disorder, Child, Child Behavior Disorders, Family, Humans, Nerve Net, Phenotype, Sensitivity and Specificity, Mood Disorders, Diagnostic and Statistical Manual of Mental Disorders

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