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Cited by 229Cancer survivorship and carePalliative and Oncologic CarePalliative Care and End-of-Life Issues

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Longitudinal Study of Depressive Symptoms in Patients With Metastatic Gastrointestinal and Lung Cancer

Lo, Christopher, Zimmermann, Camilla, Rydall, Anne, Walsh, Andrew, Jones, Jennifer M., Moore, Malcolm J., Shepherd, Frances A., Gagliese, Lucia, Rodin, Gary·2010·Journal of Clinical Oncology
DOI 10.1200/jco.2009.26.9712
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Abstract

Purpose: Although early intervention is increasingly advocated to prevent and relieve distress in patients with metastatic cancer, the risk factors for such symptoms and their trajectory are not well established. We therefore conducted a longitudinal study to determine the course and predictors of depressive symptoms. Patients and Methods: Patients (N = 365) with metastatic gastrointestinal or lung cancer completed measures of physical distress, self-esteem, attachment security, spiritual well-being, social support, hopelessness, and depression at baseline; physical distress, social support, hopelessness, and depression were subsequently assessed at 2-month intervals. Results: Of the sample, 35% reported at least mild depressive symptoms, with 16% reporting moderate to severe depressive symptoms that persisted in at least one third of such individuals. Moderate to severe depressive symptoms were almost three times more common in the final 3 months of life than ≥ 1 year before death. Predictors of depressive symptoms included younger age, antidepressant use at baseline, lower self-esteem and spiritual well-being, and greater attachment anxiety, hopelessness, physical burden of illness, and proximity to death. The combination of greater physical suffering and psychosocial vulnerability put individuals at greatest risk for depression. Conclusion: Depressive symptoms in advanced cancer patients are relatively common and may arise as a final common pathway of distress in response to psychosocial vulnerabilities, physical suffering, and proximity to death. These findings support the need for an integrated approach to address emotional and physical distress in this population and to determine whether early intervention may prevent depression at the end of life.

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Crossref · 10.1200/jco.2009.26.9712

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Research works printed but not linked: 2

  1. Akechi T, 2008, Cochrane Database Syst Rev, 2, CD005537
  2. 10.3102/10769986023004323 · DOI · Paper page

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Metadata

Authors
Lo, C., Zimmermann, C., Rydall, A., Walsh, A., Jones, J. M., Moore, M. J., Shepherd, F. A., Gagliese, L., & Rodin, G.
Affiliations
University Health Network (CA)
ORCID
Venue
Journal of Clinical Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Published
2010-06-20
Volume
28
Issue
18
Pages
3084-3089
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
DOI
10.1200/jco.2009.26.9712
OpenAlex
W2127896588
Cited by
228
References
48
Citations by year
2026: 5 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 15 · 2021: 24 · 2020: 16 · 2019: 15 · 2018: 17 · 2017: 13 · 2016: 12 · 2015: 13 · 2014: 18 · 2013: 18 · 2012: 20
FWCI
9.47
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Oncology (publishedVersion)
  • PubMed (publishedVersion)
  • ResearchOnline at James Cook University (James Cook University) (submittedVersion)
Funders
Canadian Institutes of Health Research (/MOP-62861)
Topics
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
Keywords
depressive symptoms, metastatic cancer, gastrointestinal cancer, lung cancer, end-of-life care, physical distress, hopelessness, attachment security, self-esteem, spiritual well-being, social support, antidepressant use, proximity to death, psychosocial vulnerability, predictors of depression
MeSH terms
Adult, Aged, Aged, 80 and over, Attitude to Death, Attitude to Health, Cross-Sectional Studies, Depressive Disorder, Female, Gastrointestinal Neoplasms, Humans, Longitudinal Studies, Lung Neoplasms, Male, Middle Aged, Neoplasm Metastasis, Quality of Life, Risk Factors, Self Concept, Social Support, Survival Rate, Spirituality, Young Adult

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