The DOI matches its Crossref record; 359 of the 359 references it cites were found in a registry or an index.
Endocrine Regulation of Menstruation
Abstract
In women, endometrial morphology and function undergo characteristic changes every menstrual cycle. These changes are crucial for perpetuation of the species and are orchestrated to prepare the endometrium for implantation of a conceptus. In the absence of pregnancy, the human endometrium is sloughed off at menstruation over a period of a few days. Tissue repair, growth, angiogenesis, differentiation, and receptivity ensue to prepare the endometrium for implantation in the next cycle. Ovarian sex steroids through interaction with different cognate nuclear receptors regulate the expression of a cascade of local factors within the endometrium that act in an autocrine/paracrine and even intracrine manner. Such interactions initiate complex events within the endometrium that are crucial for implantation and, in the absence thereof, normal menstruation. A clearer understanding of regulation of normal endometrial function will provide an insight into causes of menstrual dysfunction such as menorrhagia (heavy menstrual bleeding) and dysmenorrhea (painful periods). The molecular pathways that precipitate these pathologies remain largely undefined. Future research efforts to provide greater insight into these pathways will lead to the development of novel drugs that would target identified aberrations in expression and/or of local uterine factors that are crucial for normal endometrial function.
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“The endometrium undergoes cyclical regeneration in response to the steroid hormones estradiol and progesterone (Jabbour et al., 2006).”
From Endometriosis and nuclear receptors (2019) · cites this paper as Jabbour et al., 2006
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“Throughout the menstrual cycle, the endometrium produces cytokines and growth factors in response to variations in ovarian steroids”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Jabbour et al., 2006
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Metadata
- Authors
- Jabbour, H. N., Kelly, R. W., Fraser, H. M., & Critchley, H. O. D.
- Affiliations
- The Queen's Medical Research Institute (GB)
- Medical Research Council (GB)
- Corresponding author
- Jabbour, Henry N.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2005-09-13
- Volume
- 27
- Issue
- 1
- Pages
- 17-46
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2109160378
- Cited by
- 588
- References
- 359
- Citations by year
- 2026: 21 · 2025: 27 · 2024: 25 · 2023: 33 · 2022: 40 · 2021: 40 · 2020: 30 · 2019: 23 · 2018: 26 · 2017: 24 · 2016: 30 · 2015: 21 · 2014: 21 · 2013: 39 · 2012: 25
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (044744)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Keywords
- menstruation, endometrium, endometrial receptivity, implantation, nuclear receptors, autocrine and paracrine signaling, intracrine signaling, menorrhagia, dysmenorrhea, menstrual disorders, endometrial angiogenesis, endometrial repair
- MeSH terms
- Adolescent, Adult, Endocrine System, Endometrium, Female, Humans, Menstruation, Menstruation Disturbances, Middle Aged, Progesterone, Paracrine Communication
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