Estrogen therapy and cognition: a review of the cholinergic hypothesis
Open accessAbstract
The pros and cons of estrogen therapy for use in postmenopausal women continue to be a major topic of debate in women's health.Much of this debate focuses on the potential benefits vs. harm of estrogen therapy on the brain and the risks for cognitive impairment associated with aging and Alzheimer's disease.Many animal and human studies suggest that estrogens can have significant beneficial effects on brain aging and cognition and reduce the risk of Alzheimer's-related dementia; however, others disagree.Important discoveries have been made, and hypotheses have emerged that may explain some of the inconsistencies.This review focuses on the cholinergic hypothesis, specifically on evidence that beneficial effects of estrogens on brain aging and cognition are related to interactions with cholinergic projections emanating from the basal forebrain.These cholinergic projections play an important role in learning and attentional processes, and their function is known to decline with advanced age and in association with Alzheimer's disease.Evidence suggests that many of the effects of estrogens on neuronal plasticity and function and cognitive performance are related to or rely upon interactions with these cholinergic projections; however, studies also suggest that the effectiveness of estrogen therapy decreases with age and time after loss of ovarian function.We propose a model in which deficits in basal forebrain cholinergic function contribute to age-related changes in the response to estrogen therapy.Based on this model, we propose that cholinergic-enhancing drugs, used in combination with an appropriate estrogencontaining drug regimen, may be a viable therapeutic strategy for use in older postmenopausal women with early evidence of mild cognitive decline.(Endocrine Reviews 31: 224 -253, 2010) I. Introduction II.The Neurobiology of Cognition III.Estrogens and Cognition A. Animal studies B. Studies in humans IV.The Role of Basal Forebrain Cholinergic Neurons in Cognitive Performance A. Alzheimer's disease B. Cholinergic lesion studies C. Effects on visuospatial attention and stimulus processing V. Effects of Estrogen Therapy on Basal Forebrain Cholinergic Function VI.Evidence That Effects on Basal Forebrain Cholinergic Projections Are Relevant to Estrogen Effects on Cognitive Performance A. Relevance to navigational performance in humans VII.Estrogen Therapy for the Prevention and Treatment of Cognitive Decline Associated with Aging and AD A. The importance of timing VIII.The Cholinergic Basis of the Critical Period Hypothesis IX.Testing the Cholinergic Hypothesis X. Cellular Mechanisms Underlying Estrogen Effects on Cholinergic Function and Cognitive Performance A. Hippocampus B. The role of specific estrogen receptors C. Mood/affect and effects on monoamines XI.
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Estradiol effects on dopaminergic striatal circuits, by reducing dopamine receptors and increasing dopamine release, may mediate these effects, particularly in the prefrontal cortex.
“E2 effects on dopaminergic striatal circuits by reducing dopamine receptors and increasing dopamine release may therefore mediate these effects (Archer, 1999; Gibbs, 2010), particularly in the prefrontal cortex (Berman et al., 1997).”
From Reproductive steroids and ADHD symptoms across the menstrual cycle (2018) · cites this paper as Gibbs, 2010
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Cites
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889 · see citing works
Cloning of a novel receptor expressed in rat prostate and ovary.
Kuiper, G. G. J. M., Enmark, E., Pelto‐Huikko, M., Nilsson, S., & Gustafsson, J.-Α. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5925 · Cited by 4,792 · see citing works
Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain
Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627 · see citing works
SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE
DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565 · see citing works
Squire, L. R., Stark, C. E. L., & Clark, R. E. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144130 · Cited by 2,680 · see citing works
Common regions of the human frontal lobe recruited by diverse cognitive demands
Duncan, J., & Owen, A. M. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01633-7 · Cited by 2,498 · see citing works
A transmembrane intracellular estrogen receptor mediates rapid cell signaling
Revankar, C. M., Cimino, D. F., Sklar, L. A., Arterburn, J. B., & Prossnitz, E. R. (2005) · Science · doi:10.1126/science.1106943 · Cited by 2,302 · see citing works
THE AMYGDALA MODULATES THE CONSOLIDATION OF MEMORIES OF EMOTIONALLY AROUSING EXPERIENCES
McGaugh, J. L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144157 · Cited by 2,296 · see citing works
Memory systems of the brain: A brief history and current perspective
Squire, L. R. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.06.005 · Cited by 2,269 · see citing works
Shumaker, S. A., Legault, C., Rapp, S. R., Thal, L., Wallace, R. B., Ockene, J. K., Hendrix, S. L., Jones III, B. N., Assaf, A. R., Jackson, R. D., et al. (2003) · JAMA · doi:10.1001/jama.289.20.2651 · Cited by 2,178 · see citing works
The prefontral cortex and cognitive control
Miller, E. K. (2000) · Nature Reviews Neuroscience · doi:10.1038/35036228 · Cited by 2,016 · see citing works
Sex Differences in Cognitive Abilities
Halpern, D. F. (2000) · Psychology Press eBooks · doi:10.4324/9781410605290 · Cited by 1,983 · see citing works
Mesulam, M. ‐., Mufson, E. J., Levey, A. I., & Wainer, B. H. (1983) · Journal of Comparative Neurology · doi:10.1002/cne.902140206 · Cited by 1,962 · see citing works
Temporal dynamics of brain activation during a working memory task
Cohen, J. D., Perlstein, W. M., Braver, T. S., Nystrom, L. E., Noll, D. C., Jonides, J., & Smith, E. E. (1997) · Nature · doi:10.1038/386604a0 · Cited by 1,876 · see citing works
A neostriatal habit learning system in humans
Knowlton, B. J., Mangels, J. A., & Squire, L. R. (1996) · Science · doi:10.1126/science.273.5280.1399 · Cited by 1,777 · see citing works
Learning and Memory Functions of the Basal Ganglia
Packard, M. G., & Knowlton, B. J. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142937 · Cited by 1,717 · see citing works
A PET study of visuospatial attention
Corbetta, M., Miezin, F. M., Shulman, G. L., & Petersen, S. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-03-01202.1993 · Cited by 1,522 · see citing works
Identity of an Estrogen Membrane Receptor Coupled to a G Protein in Human Breast Cancer Cells
Thomas, P., Pang, Y., Filardo, E. J., & Dong, J. (2004) · Endocrinology · doi:10.1210/en.2004-1064 · Cited by 1,410 · see citing works
Human Memory and the Cholinergic System
Drachman, D. A. (1974) · Archives of Neurology · doi:10.1001/archneur.1974.00490320001001 · Cited by 1,398 · see citing works
Shumaker, S. A. (2004) · JAMA · doi:10.1001/jama.291.24.2947 · Cited by 1,360 · see citing works
CENTRAL CHOLINERGIC SYSTEMS AND COGNITION
Everitt, B. J., & Robbins, T. W. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.649 · Cited by 1,348 · see citing works
Cognitive Neuroscience and the Study of Memory
Milner, B. A., Squire, L. R., & Kandel, E. R. (1998) · Neuron · doi:10.1016/s0896-6273(00)80987-3 · Cited by 1,300 · see citing works
Asher, R. (1961) · The Lancet · doi:10.1016/s0140-6736(61)91217-x · Cited by 1,293 · see citing works
The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry
Robbins, T. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1154-7 · Cited by 1,282 · see citing works
Coull, J. T., & Nobre, A. C. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07426.1998 · Cited by 1,254 · see citing works
Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer’s Disease
Stokin, G. B., Lillo, C., Falzone, T. L., Brusch, R. G., Rockenstein, E., Mount, S. L., Raman, R., Davies, P., Masliah, E., Williams, D. S., et al. (2005) · Science · doi:10.1126/science.1105681 · Cited by 1,214 · see citing works
An information theoretical approach to prefrontal executive function
Koechlin, E., & Summerfield, C. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.04.005 · Cited by 1,183 · see citing works
NECROPSY EVIDENCE OF CENTRAL CHOLINERGIC DEFICITS IN SENILE DEMENTIA
Perry, E., Perry, R., Blessed, G., & Tomlinson, B. E. (1977) · The Lancet · doi:10.1016/s0140-6736(77)91780-9 · Cited by 1,070 · see citing works
Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease
Mulnard, R. A., Cotman, C. W., Kawas, C. H., van Dyck, C. H., Sano, M. C., Doody, R. S., Koss, E., Pfeiffer, E., Jin, S., Gamst, A., et al. (2000) · JAMA · doi:10.1001/jama.283.8.1007 · Cited by 984 · see citing works
Cholinergic systems in mammalian brain and spinal cord
WOOLF, N. (1991) · Progress in Neurobiology · doi:10.1016/0301-0082(91)90006-m · Cited by 948 · see citing works
Estrogen Actions Throughout the Brain
McEwen, B. (2002) · Recent Progress in Hormone Research · doi:10.1210/rp.57.1.357 · Cited by 915 · see citing works
Hormone Replacement Therapy and Incidence of Alzheimer Disease in Older Women The Cache County Study
Zandi, P. P. (2002) · JAMA · doi:10.1001/jama.288.17.2123 · Cited by 908 · see citing works
Petrides, M., Alivisatos, B., Meyer, E., & Evans, A. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.3.878 · Cited by 897 · see citing works
Bartus, R. T. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7397 · Cited by 829 · see citing works
Rocca, W. A., Bower, J. H., Maraganore, D. M., Ahlskog, J. E., Grossardt, B. R., de Andrade, M., & Melton, L. J. (2007) · Neurology · doi:10.1212/01.wnl.0000276984.19542.e6 · Cited by 827 · see citing works
Effects of estrogen on memory function in surgically menopausal women
Phillips, S. M. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90007-t · Cited by 746 · see citing works
Sherwin, B. B. (1988) · Psychoneuroendocrinology · doi:10.1016/0306-4530(88)90060-1 · Cited by 705 · see citing works
DeKosky, S. T., Ikonomovic, M. D., Styren, S. D., Beckett, L., Wisniewski, S., Bennett, D. A., Cochran, E. J., Kordower, J. H., & Mufson, E. J. (2002) · Annals of Neurology · doi:10.1002/ana.10069 · Cited by 686 · see citing works
Grön, G., Wunderlich, A. P., Spitzer, M., Tomczak, R. J., & Riepe, M. W. (2000) · Nature Neuroscience · doi:10.1038/73980 · Cited by 685 · see citing works
Sex influences on the neurobiology of learning and memoryPreprint
Andreano, J. M., & Cahill, L. F. (2009) · Learning & Memory · doi:10.1101/lm.918309 · Cited by 684 · see citing works
Auld, D. S., Kornecook, T. J., Bastianetto, S., & Quirion, R. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00079-5 · Cited by 669 · see citing works
Sarter, M., Hasselmo, M. E., Bruno, J. P., & Givens, B. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.08.006 · Cited by 667 · see citing works
Memory and cognitive function in man
Drachman, D. A. (1977) · Neurology · doi:10.1212/wnl.27.8.783 · Cited by 619 · see citing works
Menopausal Hormone Replacement Therapy and Risk of Ovarian Cancer
Lacey, J. V. (2002) · JAMA · doi:10.1001/jama.288.3.334 · Cited by 617 · see citing works
Estrogen Signaling through the Transmembrane G Protein–Coupled Receptor GPR30
Prossnitz, E. R., Arterburn, J. B., Smith, H. O., Oprea, T. I., Sklar, L. A., & Hathaway, H. J. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100518 · Cited by 590 · see citing works
Astur, R., Ortiz, M. L., & Sutherland, R. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00019-9 · Cited by 586 · see citing works
Estrogen for Alzheimer’s disease in women
Henderson, V. W., Paganini‐Hill, A., Miller, B. L., Elble, R. J., Reyes, P. F., Shoupe, D., McCleary, C. A., Klein, R., Hake, A. M., & Farlow, M. R. (2000) · Neurology · doi:10.1212/wnl.54.2.295 · Cited by 548 · see citing works
In vivo effects of a GPR30 antagonist
Dennis, M. K., Burai, R., Ramesh, C., Petrie, W. K., Alcon, S. N., Nayak, T. K., Bologa, C., Leitão, A., Brailoiu, E., Deliu, E., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.168 · Cited by 533 · see citing works
The significance of the cholinergic system in the brain during aging and in Alzheimer’s disease
Schliebs, R., & Arendt, T. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0579-2 · Cited by 531 · see citing works
Luine, V. N. (1985) · Experimental Neurology · doi:10.1016/0014-4886(85)90108-6 · Cited by 523 · see citing works
Males and females use different distal cues in a virtual environment navigation task
Sandstrom, N. J., Kaufman, J., & Huettel, S. A. (1998) · Cognitive Brain Research · doi:10.1016/s0926-6410(98)00002-0 · Cited by 510 · see citing works
Brailoiu, E., Dun, S. L., Brailoiu, G. C., Mizuo, K., Sklar, L. A., Oprea, T. I., Prossnitz, E. R., & Dun, N. J. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0017 · Cited by 501 · see citing works
Components of verbal working memory: Evidence from neuroimaging
Smith, E. E., Jonides, J. J., Marshuetz, C., & Koeppe, R. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.876 · Cited by 492 · see citing works
Cholinergic Markers in Elderly Patients With Early Signs of Alzheimer Disease
Davis, K. L. (1999) · JAMA · doi:10.1001/jama.281.15.1401 · Cited by 492 · see citing works
Diverse Actions of Ovarian Steroids in the Serotonin Neural System
Bethea, C. L., Lu, N. Z., Gundlah, C., & Streicher, J. M. (2002) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0225 · Cited by 487 · see citing works
Voytko, M. L., Olton, D. S., Richardson, R., Gorman, L. K., Tobin, J., & Price, D. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-01-00167.1994 · Cited by 482 · see citing works
Singh, M., Meyer, E. M., Millard, W. J., & Simpkins, J. W. (1994) · Brain Research · doi:10.1016/0006-8993(94)91694-2 · Cited by 477 · see citing works
Walf, A. A., & Frye, C. A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301067 · Cited by 461 · see citing works
Maggiolini, M., Vivacqua, A., Fasanella, G., Recchia, A. G., Sisci, D., Pezzi, V., Montanaro, D., Musti, A. M., Picard, D., & Andò, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403588200 · Cited by 448 · see citing works
Presynaptic Cholinergic Dysfunction in Patients with Dementia
Sims, N. R., Bowen, D. M., Allen, S. J., Smith, C., Neary, D., Thomas, D. J., & DAVISON, A. N. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb11311.x · Cited by 421 · see citing works
Uncovering the mechanisms of estrogen effects on hippocampal function
Spencer-Segal, J. L., Waters, E. M., Romeo, R. D., Wood, G. E., Milner, T. A., & McEwen, B. S. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.08.006 · Cited by 415 · see citing works
Acute Effects of Estrogen on Neuronal Physiology
Woolley, C. S. (2006) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105219 · Cited by 410 · see citing works
Estrogen improves psychological function in asymptomatic postmenopausal women.
Ditkoff, E. C., Crary, W. G., Cristo, M., & Lobo, R. A. (1991) · PubMed · Cited by 408 · see citing works
Gibbs, R. B. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00103-2 · Cited by 404 · see citing works
Self-citationAlbanito, L., Madeo, A., Lappano, R., Vivacqua, A., Rago, V., Carpino, A., Oprea, T. I., Prossnitz, E. R., Musti, A. M., Andò, S., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2909 · Cited by 399 · see citing works
Brain estrogen deficiency accelerates Aβ plaque formation in an Alzheimer's disease animal model
Yue, X., Lu, M. G. W., Lancaster, T., Cao, P., Honda, S., Staufenbiel, M., Harada, N., Zhong, Z., Shen, Y., & Li, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505203102 · Cited by 393 · see citing works
GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release
Filardo, E. J., & Thomas, P. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.08.005 · Cited by 388 · see citing works
Cholinergic modulation of the functional organization of the cat visual cortex
Sillito, A. M., & Kemp, J. A. (1983) · Brain Research · doi:10.1016/0006-8993(83)90015-x · Cited by 387 · see citing works
Österlund, M. K., Kuiper, G. G. J. M., Gustafsson, J.-Α., & Hurd, Y. L. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00351-3 · Cited by 378 · see citing works
Lewandowski, S. A., Kalita, K. B., & Kaczmarek, L. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03015-6 · Cited by 378 · see citing works
Estrogen Replacement Therapy and Cognitive Function in Older Women
Barrett-Connor, E. L. (1993) · JAMA · doi:10.1001/jama.1993.03500200051032 · Cited by 377 · see citing works
Rapid enhancement of visual and place memory by estrogens in rats.
Luine, V., Jacome, L. F., & MacLusky, N. (2003) · Endocrinology · doi:10.1210/en.2003-0004 · Cited by 375 · see citing works
Progesterone and Estrogen Regulate Alzheimer-Like Neuropathology in Female 3xTg-AD Mice
Carroll, J. C., Rosario, E. R., Chang, L., Stanczyk, F. Z., Oddo, S., LaFerla, F. M., & Pike, C. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2718-07.2007 · Cited by 369 · see citing works
Sex Steroids Modify Working Memory
Janowsky, J. S., Chavez, B., & ORWOLL, E. S. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/089892900562228 · Cited by 360 · see citing works
Estrogen Enhances Performance of Female Rats during Acquisition of a Radial Arm Maze
Daniel, J. M., Fader, A. J., Spencer, A. L., & Dohanich, G. P. (1997) · Hormones and Behavior · doi:10.1006/hbeh.1997.1433 · Cited by 359 · see citing works
Jope, R. S. (1979) · Brain Research Reviews · doi:10.1016/0165-0173(79)90009-2 · Cited by 359 · see citing works
Astur, R., Tropp, J., Sava, S., Constable, R. T., & Markus, E. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.08.024 · Cited by 357 · see citing works
Cyclic Estrogen Replacement Improves Cognitive Function in Aged Ovariectomized Rhesus Monkeys
Rapp, P. R., Morrison, J. H., & Roberts, J. A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05708.2003 · Cited by 352 · see citing works
G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane
Funakoshi, T., Yanai, A., Shinoda, K., Kawano, M. M., & Mizukami, Y. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.191 · Cited by 352 · see citing works
Cognitive functions of the basal forebrain
Baxter, M. G., & Chiba, A. A. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80024-5 · Cited by 351 · see citing works
Saucier, D. M., Green, S. M., Leason, J., MacFadden, A., Bell, S., & Elias, L. J. (2002) · Behavioral Neuroscience · doi:10.1037//0735-7044.116.3.403 · Cited by 349 · see citing works
Li, C., Brake, W. G., Romeo, R. D., Dunlop, J. C., Gordon, M., Buzescu, R., Magariños, A. M., Allen, P. B., Greengard, P., Luine, V. N., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307313101 · Cited by 345 · see citing works
Vivacqua, A., Bonofiglio, D., Recchia, A., Musti, A., Picard, D., Andò, S., & Maggiolini, M. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0280 · Cited by 345 · see citing works
Effect of gonadal steroids on activities of monoamine oxidase and choline acetylase in rat brain
Luine, V. N., Khylchevskaya, R. I., & McEwen, B. S. (1975) · Brain Research · doi:10.1016/0006-8993(75)90704-0 · Cited by 344 · see citing works
Fischer, W., Gage, F. H., & Björklund, A. (1989) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1989.tb00772.x · Cited by 334 · see citing works
Short-term memory in the rhesus monkey: Disruption from the anti-cholinergic scopolamine
Bartus, R. T., & Johnson, H. R. (1976) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(76)90286-0 · Cited by 334 · see citing works
Baxter, M. G., Bucci, D. J., Gorman, L. K., Wiley, R. G., & Gallagher, M. (2013) · Behavioral Neuroscience · doi:10.1037/a0033939 · Cited by 331 · see citing works
Thompson, R. F. (2004) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070239 · Cited by 314 · see citing works
Estradiol facilitates performance as working memory load increases.
Bimonte, H. A., & Denenberg, V. (1999) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00068-7 · Cited by 310 · see citing works
Cholinergic Enhancement and Increased Selectivity of Perceptual Processing During Working Memory
Furey, M. L., Pietrini, P., & Haxby, J. V. (2000) · Science · doi:10.1126/science.290.5500.2315 · Cited by 308 · see citing works
Memory retention is modulated by acute estradiol and progesterone replacement.
Sandstrom, N. J., & Williams, C. L. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.2.384 · Cited by 306 · see citing works
Fischer, W., Chen, K. S., Gage, F. H., & Björklund, A. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90003-g · Cited by 293 · see citing works
Cholinergic function and Alzheimer's disease
Giacobini, E. (2003) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.935 · Cited by 284 · see citing works
Effects of estrogen on cognition, mood, and cerebral blood flow in AD
Wang, P. N., Liao, S. Q., Liu, R. S., Liu, C. Y., Chao, H. T., Lu, S. ‐., Yu, H., Wang, S. J., & Liu, H. C. (2000) · Neurology · doi:10.1212/wnl.54.11.2061 · Cited by 283 · see citing works
Sherwin, B. B., & Henry, J. F. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.08.002 · Cited by 281 · see citing works
Attentional functions of cortical cholinergic inputs: What does it mean for learning and memory?
Sarter, M. F., Bruno, J. P., & Givens, B. S. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00070-4 · Cited by 278 · see citing works
Saucier, D. M., Green, S. M., Leason, J., et al. (2002) · Behavioral Neuroscience · doi:10.1037/0735-7044.116.3.403 · Cited by 273 · see citing works
Fernandez, S. M., Lewis, M. C., Pechenino, A. S., Harburger, L. L., Orr, P. T., Gresack, J. E., Schafe, G. E., & Frick, K. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1968-08.2008 · Cited by 273 · see citing works
High-dose estradiol improves cognition for women with AD
Asthana, S., Baker, L. D., Craft, S., Stanczyk, F. Z., Veith, R. C., Raskind, M. A., & Plymate, S. R. (2001) · Neurology · doi:10.1212/wnl.57.4.605 · Cited by 266 · see citing works
Gibbs, R. B. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01511-4 · Cited by 265 · see citing works
Self-citationPostmenopausal hormone therapy and Alzheimer's disease risk: interaction with age
Henderson, V. W. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.024927 · Cited by 265 · see citing works
Minireview: A Plethora of Estrogen Receptors in the Brain: Where Will It End?
Toran‐Allerand, C. D. (2003) · Endocrinology · doi:10.1210/en.2003-1462 · Cited by 264 · see citing works
Daniel, J. M., Hulst, J. L., & Berbling, J. L. (2005) · Endocrinology · doi:10.1210/en.2005-0998 · Cited by 263 · see citing works
Daniel, J. M., & Dohanich, G. P. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06949.2001 · Cited by 263 · see citing works
Distribution of Estrogen Receptor-β-Like Immunoreactivity in Rat Forebrain
Li, X., Schwartz, P. E., & Rissman, E. F. (2008) · Neuroendocrinology · doi:10.1159/000127221 · Cited by 257 · see citing works
Estrogen Alters Spine Number and Morphology in Prefrontal Cortex of Aged Female Rhesus Monkeys
Hao, J., Rapp, P. R., Leffler, A. E., Leffler, S. R., Janssen, W. G. M., Lou, W. Y. W., McKay, H. M., Roberts, J. A., Wearne, S. L., Hof, P. R., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3440-05.2006 · Cited by 257 · see citing works
Drug enhancement of memory consolidation: historical perspective and neurobiological implications
McGaugh, J. L., & Roozendaal, B. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1285-6 · Cited by 250 · see citing works
Effects of estrogen replacement therapy on response to tacrine in patients with Alzheimer's disease
Schneider, L. S., Farlow, M. R., Henderson, V. W., & Pogoda, J. M. (1996) · Neurology · doi:10.1212/wnl.46.6.1580 · Cited by 249 · see citing works
Frye, C. A., Duffy, C. K., & Walf, A. A. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.04.003 · Cited by 248 · see citing works
Baxter, M. G., Bucci, D. J., Gorman, L. K., Wiley, R. G., & Gallagher, M. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.714 · Cited by 248 · see citing works
Sherwin, B. B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.2.3771-3 · Cited by 247 · see citing works
Shifts in preferred learning strategy across the estrous cycle in female rats
Korol, D. L., Malin, E. L., Borden, K. A., Busby, R. A., & Couper-Leo, J. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.01.005 · Cited by 244 · see citing works
Smith, D. E., Roberts, J. A., Gage, F. H., & Tuszynski, M. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10893 · Cited by 244 · see citing works
Estrogen-induced changes in place and response learning in young adult female rats.
Korol, D. L., & Kolo, L. L. (2002) · Behavioral Neuroscience · doi:10.1037/0735-7044.116.3.411 · Cited by 243 · see citing works
Asthana, S., Craft, S., Baker, L. D., Raskind, M. A., Birnbaum, R. S., Lofgreen, C., Veith, R. C., & Plymate, S. R. (1999) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00020-7 · Cited by 240 · see citing works
Walf, A. A., Rhodes, M. E., & Frye, C. A. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.01.004 · Cited by 240 · see citing works
Estrogen therapy selectively enhances prefrontal cognitive processes
Joffe, H., Hall, J. E., Gruber, S. A., Sarmiento, I. A., Cohen, L. S., Yurgelun-Todd, D. A., & Martin, K. A. (2006) · Menopause The Journal of The North American Menopause Society · doi:10.1097/01.gme.0000189618.48774.7b · Cited by 239 · see citing works
Gibbs, R. B., Wu, D., Hersh, L. B., & Pfaff, D. W. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1148 · Cited by 233 · see citing works
Self-citationYankova, M. P., Hart, S. A., & Woolley, C. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051624598 · Cited by 232 · see citing works
Markowska, A. L., & Savonenko, A. V. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10985.2002 · Cited by 230 · see citing works
Sex differences in cognitive abilities, 2nd ed.
Halpern, D. F. (1992) · Cited by 230 · see citing works
Brain Acetylcholine Synthesis Declines with Senescence
Gibson, G. E., Peterson, C. M., & Jenden, D. J. (1981) · Science · doi:10.1126/science.7256270 · Cited by 230 · see citing works
Estrogen regulates functional inhibition of hippocampal CA1 pyramidal cells in the adult female rat
Rudick, C. N., & Woolley, C. S. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06532.2001 · Cited by 228 · see citing works
Fader, A. J., Johnson, P. E. M., & Dohanich, G. P. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00219-6 · Cited by 224 · see citing works
Steering estrogen signals from the plasma membrane to the nucleus: Two sides of the coin
Manavathi, B., & Kumar, R. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20551 · Cited by 222 · see citing works
Grady, D. G., Yaffe, K. S., Kristof, M., Lin, F., Richards, C., & Barrett-Connor, E. L. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01270-6 · Cited by 222 · see citing works
The effects of physostigmine and scopolamine on recognition memory in monkeys
Aigner, T. G., & Mishkin, M. (1986) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(86)80008-5 · Cited by 220 · see citing works
Shughrue, P. J., Scrimo, P. J., & Merchenthaler, I. J. (2000) · Neuroscience · doi:10.1016/s0306-4522(99)00520-5 · Cited by 215 · see citing works
Henderson, V. W. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.017 · Cited by 215 · see citing works
Nerve growth factor: a tale of two receptors.
Barbacid, M. (1993) · PubMed · Cited by 215 · see citing works
Hormone replacement therapy for cognitive function in postmenopausal women
Lethaby, A. E., Hogervorst, E., Richards, M., Yesufu-Udechuku, A., & Yaffe, K. S. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003122.pub2 · Cited by 214 · see citing works
92016229 Estrogen improves psychological function in asymptomatic postmenopausal women
Ditkoff, E. C., Crary, W. G., Cristo, M., & Lobo, R. A. (1992) · Maturitas · doi:10.1016/0378-5122(92)90090-q · Cited by 212 · see citing works
Amyloid-β causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons
Chiba, T., Yamada, M., Sasabe, J., Terashita, K., Shimoda, M., Matsuoka, M., & Aiso, S. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.105 · Cited by 210 · see citing works
Estrogen Receptor-Mediated Rapid Signaling
Moriarty, K., Kim, K. H., & Bender, J. R. (2006) · Endocrinology · doi:10.1210/en.2006-0729 · Cited by 205 · see citing works
Frick, K. M. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.08.015 · Cited by 205 · see citing works
Hao, J., Janssen, W., Tang, Y., Roberts, J. A., McKay, H. M., Lasley, B., Allen, P., Greengard, P., Rapp, P., Kordower, J., et al. (2003) · The Journal of comparative neurology · doi:10.1002/cne.10837 · Cited by 202 · see citing works
Postmenopausal Estrogen Replacement and Risk for Venous Thromboembolism
Miller, J., Chan, B. K. S., & Nelson, H. D. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-9-200205070-00011 · Cited by 199 · see citing works
Gibbs, R. B. (1999) · Hormones and Behavior · doi:10.1006/hbeh.1999.1541 · Cited by 199 · see citing works
Self-citationTang, Y. C. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg121 · Cited by 197 · see citing works
Zandi, P. P., Carlson, M. C., Plassman, B. L., Welsh-Bohmer, K. A., Mayer, L. S., Steffens, D. C., & Breitner, J. C. S. (2003) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000055761.75837.23 · Cited by 197 · see citing works
Dalley, J. W. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh052 · Cited by 191 · see citing works
Chesler, E. J., & Juraska, J. M. (2000) · Hormones and Behavior · doi:10.1006/hbeh.2000.1626 · Cited by 191 · see citing works
Sherwin, B. B. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.7.2545 · Cited by 189 · see citing works
Witte, E. A., Davidson, M. C., & Marrocco, R. T. (1997) · Psychopharmacology · doi:10.1007/s002130050352 · Cited by 187 · see citing works
Gibbs, R. B. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01432-1 · Cited by 187 · see citing works
Self-citationGeula, C. (1998) · Neurology · doi:10.1212/wnl.51.1_suppl_1.s18 · Cited by 184 · see citing works
Decrease of brain acetylcholine release in aging freely-moving rats detected by microdialysis
Wu, C. F., Bertorelli, R., Sacconi, M., Pepeu, G., & Consolo, S. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80081-2 · Cited by 183 · see citing works
Neurotransmitter deficits in behavioural and psychological symptoms of Alzheimer's disease
Lanari, A., Amenta, F., Silvestrelli, G., Tomassoni, D., & Parnetti, L. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.09.016 · Cited by 180 · see citing works
Kritzer, M., & Creutz, L. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2637-08.2008 · Cited by 180 · see citing works
Fader, A. J., Hendricson, A. W., & Dohanich, G. P. (1998) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1998.3820 · Cited by 180 · see citing works
Antidepressant effects of ERβ-selective estrogen receptor modulators in the forced swim test
Walf, A. A., Rhodes, M. E., & Frye, C. A. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.03.023 · Cited by 179 · see citing works
Hao, J., Rapp, P. R., Janssen, W. G. M., Lou, W. Y. W., Lasley, B. L., Hof, P. R., & Morrison, J. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704757104 · Cited by 176 · see citing works
McMillan, P., Singer, C., & Dorsa, D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-05-01860.1996 · Cited by 173 · see citing works
Effects of gonadal hormone replacement on measures of basal forebrain cholinergic function
Gibbs, R. B. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00433-4 · Cited by 172 · see citing works
Self-citationPosttraining Estrogen and Memory Modulation
Packard, M. G. (1998) · Hormones and Behavior · doi:10.1006/hbeh.1998.1464 · Cited by 170 · see citing works
Mechanisms of Neuroprotection by Estrogen
Suzuki, S., Brown, C. M., & Wise, P. M. (2006) · Endocrine · doi:10.1385/endo:29:2:209 · Cited by 167 · see citing works
Walf, A., & Frye, C. (2007) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2006.07.003 · Cited by 166 · see citing works
Early postmenopausal hormone therapy may prevent cognitive impairment later in life
Bagger, Y. Z., Tank, L. S. B., Alexandersen, P., Qin, G., & Christiansen, C. (2005) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-200512010-00005 · Cited by 165 · see citing works
Gibbs, R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-03-01049.1996 · Cited by 161 · see citing works
Self-citationHormone therapy and cognitive function: Is there a critical period for benefit?
Maki, P. M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.001 · Cited by 161 · see citing works
Estrogen and cognition: Applying preclinical findings to clinical perspectives
Gibbs, R. B., & Gabor, R. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10811 · Cited by 158 · see citing works
Self-citationEffects of Oestrogen on Cognition: What Have We Learned From Basic Research?
Daniel, J. M. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01471.x · Cited by 156 · see citing works
Araujo, D., Lapchak, P. A., Meaney, M., Collier, B., & Quirion, R. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-09-03069.1990 · Cited by 155 · see citing works
Bimonte‐Nelson, H. A., Francis, K. R., Umphlet, C. D., & Granholm, A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04867.x · Cited by 154 · see citing works
Post-training estrogen enhances spatial and object memory consolidation in female mice
Gresack, J. E., & Frick, K. M. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.04.013 · Cited by 151 · see citing works
Age-related deficits as working memory load increases: relationships with growth factors
Bimonte, H. A. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00015-5 · Cited by 150 · see citing works
Gibbs, R. B. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6789 · Cited by 149 · see citing works
Self-citationInteractive effects of fitness and hormone treatment on brain health in postmenopausal women
Erickson, K. I., Colcombe, S. J., Elavsky, S., McAuley, E., Korol, D. L., Scalf, P. E., & Kramer, A. F. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.11.016 · Cited by 148 · see citing works
Gibbs, R. B., & Pfaff, D. W. (1992) · Experimental Neurology · doi:10.1016/0014-4886(92)90173-n · Cited by 148 · see citing works
Self-citationWolf, O. T., Kudielka, B. M., Hellhammer, D. H., Törber, S., McEwen, B. S., & Kirschbaum, C. (1999) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00025-6 · Cited by 147 · see citing works
Sex Differences in Cholinergic Enzymes of Diagonal Band Nuclei in the Rat Preoptic Area
Luine, V. N., & McEwen, B. S. (2008) · Neuroendocrinology · doi:10.1159/000123501 · Cited by 146 · see citing works
Jasnow, A. M., Schulkin, J. A., & Pfaff, D. W. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.06.005 · Cited by 146 · see citing works
Markham, J. A., Pych, J. C., & Juraska, J. M. (2002) · Hormones and Behavior · doi:10.1006/hbeh.2002.1819 · Cited by 144 · see citing works
Chudasama, Y., Dalley, J. W., Nathwani, F., Bouger, P., & Robbins, T. W. (2004) · Learning & Memory · doi:10.1101/lm.70904 · Cited by 144 · see citing works
New roles for estrogen receptor β in behavior and neuroendocrinology☆
Bodo, C., & Rissman, E. F. (2006) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2006.02.004 · Cited by 141 · see citing works
Presynaptic cholinergic mechanisms in brain of aged rats with memory impairments
Sherman, K. A., Kuster, J. E., Dean, R. L., Bartus, R. T., & Friedman, E. (1981) · Neurobiology of Aging · doi:10.1016/0197-4580(81)90006-3 · Cited by 139 · see citing works
Talboom, J. S., Williams, B. J., Baxley, E. R., West, S. G., & Bimonte‐Nelson, H. A. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.04.002 · Cited by 139 · see citing works
O'Malley, C. A., Hautamaki, R. D., Kelley, M., & Meyer, E. M. (1987) · Brain Research · doi:10.1016/0006-8993(87)90082-5 · Cited by 138 · see citing works
Gibbs, R. G., Hashash, A., & Johnson, D. A. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01375-3 · Cited by 138 · see citing works
Self-citationWalf, A., Koonce, C. J., & Frye, C. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.01.008 · Cited by 137 · see citing works
Dornan, W. A., McCampbell, A., Tinkler, G. P., Hickman, L., Bannon, A. W., Decker, M. W., & Gunther, K. L. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(96)02264-4 · Cited by 136 · see citing works
Effects of hormone replacement therapy on cognitive performance in elderly women
Binder, E. F., Schechtman, K. B., Birge, S. J., Williams, D. B., & Kohrt, W. M. (2001) · Maturitas · doi:10.1016/s0378-5122(00)00214-0 · Cited by 135 · see citing works
Nulliparity and Late Menopause Are Associated With Decreased Cognitive Decline
McLay, R. N., Maki, P. M., & Lyketsos, C. G. (2003) · Journal of Neuropsychiatry · doi:10.1176/jnp.15.2.161 · Cited by 135 · see citing works
Effects of cholinergic depletion on neuron activities in the cat visual cortex
Sato, H., Hata, Y., Hagihara, K., & Tsumoto, T. (1987) · Journal of Neurophysiology · doi:10.1152/jn.1987.58.4.781 · Cited by 133 · see citing works
Cholinergic enhancement of direction selectivity in the visual cortex of the cat
Murphy, P. C., & Sillito, A. M. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90170-s · Cited by 130 · see citing works
Agnès Lacreuse, A., Wilson, M. E., & Herndon, J. G. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00002-7 · Cited by 130 · see citing works
Gonadal Steroids, Learning, and Memory
Dohanich, G. P. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50024-x · Cited by 130 · see citing works
Kritzer, M. F., & Kohama, S. G. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990705)409:3 · Cited by 125 · see citing works
How do animals actually solve the T maze?
Dudchenko, P. A. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.4.850 · Cited by 123 · see citing works
The Critical Period Hypothesis: Can It Explain Discrepancies in the Oestrogen‐Cognition Literature?
Sherwin, B. B. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01508.x · Cited by 122 · see citing works
Mesulam, M. M. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)62112-3 · Cited by 120 · see citing works
Gibbs, R. B., & Johnson, D. A. (2008) · Endocrinology · doi:10.1210/en.2007-1645 · Cited by 120 · see citing works
Self-citationHammond, R., Mauk, R., Ninaci, D., Nelson, D., & Gibbs, R. B. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.06.008 · Cited by 119 · see citing works
Self-citationSzegő, É. M., Barabás, K., Balog, J., Szilágyi, N., Korach, K. S., Juhász, G. D., & Ábrahám, I. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0222-06.2006 · Cited by 115 · see citing works
Differential effects of estrogen on hippocampal- and striatal-dependent learning
Davis, D. M., Jacobson, T. K., Aliakbari, S., & Mizumori, S. J. Y. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.06.004 · Cited by 113 · see citing works
Aging is associated with a diffuse impairment of forebrain cholinergic neurons
Altavista, M. C., Rossi, P., Bentivoglio, A. R., Crociani, P., & Albanese, A. (1990) · Brain Research · doi:10.1016/0006-8993(90)91116-x · Cited by 112 · see citing works
Rudick, C. N., Gibbs, R. B., & Woolley, C. S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-11-04479.2003 · Cited by 112 · see citing works
Self-citationThe women's health initiative estrogen replacement therapy is neurotrophic and neuroprotective
Brinton, R. D. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00109-3 · Cited by 109 · see citing works
Selective immunolesions of hippocampal cholinergic input fail to impair spatial working memory
McMahan, R. W., Sobel, T. J., & Baxter, M. G. (1997) · Hippocampus · doi:10.1002/(sici)1098-1063(1997)7:2 · Cited by 109 · see citing works
Selective Effects of Cholinergic Modulation on Task Performance during Selective Attention
Furey, M. L., Pietrini, P., Haxby, J. V., & Drevets, W. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301461 · Cited by 107 · see citing works
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Research works printed but not linked: 2
- Gibbs R 2006 Preclinical data relating to estrogen's effects on cognitive performance. In: Rasgon NL, ed. The effects of estrogen on brain function. Baltimore, MD: The Johns Hopkins University Press; 9 -45
- Rasgon NL, Zappert LN, Williams KE 2006 Clinical data on estrogen's effects on mood. In: Rasgon NL, ed. The effects of estrogen on brain function. Baltimore, MD: The Johns Hopkins University Press; 95-115 299.
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Santoro, N. F., Epperson, C. N., & Mathews, S. B. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2015.05.001 · Cited by 677 · see citing works
Estradiol and cognitive function: Past, present and future
Luine, V. N. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.08.011 · Cited by 457 · see citing works
Estrogen, Stress, and Depression: Cognitive and Biological Interactions
Albert, K. M., & NEWHOUSE, P. A. (2019) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050718-095557 · Cited by 355 · see citing works
Rocca, W. A., Grossardt, B. R., & Shuster, L. T. (2011) · Brain Research · doi:10.1016/j.brainres.2010.10.031 · Cited by 283 · see citing works
Snyder, H. M., Asthana, S., Bain, L., Brinton, R., Craft, S., Dubal, D. B., Espeland, M. A., Gatz, M., Mielke, M. M., Raber, J., et al. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.08.004 · Cited by 262 · see citing works
Gender, sex steroid hormones, and Alzheimer’s disease
Vest, R. S., & Pike, C. J. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.04.006 · Cited by 260 · see citing works
The Role of Estrogen in Brain and Cognitive Aging
Russell, J. K., Jones, C. K., & Newhouse, P. A. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00766-9 · Cited by 257 · see citing works
Rocca, W. A., Gazzuola-Rocca, L., Smith, C. Y., Grossardt, B. R., Faubion, S. S., Shuster, L. T., Kirkland, J. L., Stewart, E. A., & Miller, V. M. (2016) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.08.002 · Cited by 227 · see citing works
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Dumas, J. A., & NEWHOUSE, P. A. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.02.022 · Cited by 209 · see citing works
Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury
Engler-Chiurazzi, E. B., Brown, C. M., Povroznik, J. M., & Simpkins, J. W. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.12.008 · Cited by 205 · see citing works
Frick, K. M., Kim, J., Tuscher, J. J., & Fortress, A. M. (2015) · Learning & Memory · doi:10.1101/lm.037267.114 · Cited by 202 · see citing works
Duarte-Guterman, P., Yagi, S., Chow, C., & Galea, L. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.05.024 · Cited by 194 · see citing works
Molecular mechanisms underlying the memory-enhancing effects of estradiol
Frick, K. M. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.05.001 · Cited by 177 · see citing works
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Eid, A., Mhatre, I., & Richardson, J. R. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.03.005 · Cited by 164 · see citing works
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Estrogen neuroprotection and the critical period hypothesis
Scott, E. L., Zhang, Q.-G., Wang, R., Vadlamudi, R. K., & Brann, D. W. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.10.001 · Cited by 152 · see citing works
Reid, G. A., & Darvesh, S. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.04.039 · Cited by 145 · see citing works
Regulation of object recognition and object placement by ovarian sex steroid hormones
Tuscher, J. J., Fortress, A. M., Kim, J., & Frick, K. M. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.08.001 · Cited by 134 · see citing works
Estrogens, estrogen receptors, and female cognitive aging: The impact of timing
Daniel, J. M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.05.003 · Cited by 126 · see citing works
Female reproductive factors and the risk of dementia: a nationwide cohort study
Yoo, J. E., Shin, D. W., Han, K., Kim, D. J., Won, H., Lee, J., Kim, S.-Y., Nam, G. E., & Park, H. S. (2020) · European Journal of Neurology · doi:10.1111/ene.14315 · Cited by 124 · see citing works
Postmenopausal hormone therapy and Alzheimer disease
Imtiaz, B., Tuppurainen, M. T., Rikkonen, T., Kivipelto, M., Soininen, H. S., Kröger, H., & Tolppanen, A. (2017) · Neurology · doi:10.1212/wnl.0000000000003696 · Cited by 110 · see citing works
Hammond, R., Nelson, D. A., & Gibbs, R. B. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.07.007 · Cited by 107 · see citing works
Self-citationHammond, R., & Gibbs, R. B. (2010) · Brain Research · doi:10.1016/j.brainres.2010.11.098 · Cited by 104 · see citing works
Self-citationKim, M., & Won, C. W. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16091491 · Cited by 97 · see citing works
Wan, T., Wang, Z., Luo, Y., Zhang, Y., He, W., Mei, Y., Xue, J., Li, M., Pan, H., Li, W., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8239642 · Cited by 95 · see citing works
Hormone Replacement Therapy and Risk for Neurodegenerative Diseases
Dye, R. V., Miller, K. J., Singer, E. J., & Levine, A. J. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/258454 · Cited by 96 · see citing works
Estrogen–cholinergic interactions: Implications for cognitive aging
NEWHOUSE, P. A., & Dumas, J. A. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.022 · Cited by 91 · see citing works
Smith, C. C., Vedder, L. C., Nelson, A. R., Bredemann, T. M., & McMahon, L. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009307107 · Cited by 90 · see citing works
Role of Ovarian Hormones in the Modulation of Sleep in Females Across the Adult Lifespan
Brown, A., & Gervais, N. J. (2020) · Endocrinology · doi:10.1210/endocr/bqaa128 · Cited by 83 · see citing works
Kline, A. E., McAloon, R. L., Henderson, K. A., Bansal, U. K., Ganti, B. M., Ahmed, R. H., Gibbs, R. B., & Sozda, C. N. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2010.1535 · Cited by 80 · see citing works
Self-citationReproductive steroids and ADHD symptoms across the menstrual cycle
Roberts, B., Eisenlohr-Moul, T., & Martel, M. M. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.11.015 · Cited by 77 · see citing works
O’Brien, J. L., Jackson, J. W., Grodstein, F., Blacker, D., & Weuve, J. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxt008 · Cited by 78 · see citing works
Towards a molecular understanding of sex differences in memory formation.
Mizuno, K., & Giese, K. P. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.03.001 · Cited by 79 · see citing works
Guo, H., Liu, M., Zhang, L., Wang, L., Hou, W., Ma, Y., & Ma, Y. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200123165652 · Cited by 74 · see citing works
Neuroimaging the Menstrual Cycle and Premenstrual Dysphoric Disorder
Comasco, E., & Poromaa, I. S. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0619-4 · Cited by 71 · see citing works
Functional and molecular neuroimaging of menopause and hormone replacement therapy
Comasco, E., Frøkjær, V. G., & Poromaa, I. S. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00388 · Cited by 69 · see citing works
Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging
Rocca, W. A., Rocca, L. G., Smith, C. Y., Grossardt, B. R., Faubion, S. S., Shuster, L. T., Kirkland, J. L., LeBrasseur, N. K., Schafer, M. J., Mielke, M. M., et al. (2018) · Physiology · doi:10.1152/physiol.00024.2018 · Cited by 69 · see citing works
Estrogen receptors and ischemic neuroprotection: Who, what, where, and when?
Schreihofer, D. A., & Ma, Y. (2013) · Brain Research · doi:10.1016/j.brainres.2013.02.051 · Cited by 68 · see citing works
The Menstrual Cycle Influences Emotion but Has Limited Effect on Cognitive Function.
Sundström-Poromaa, I. (2018) · Vitamins and hormones · doi:10.1016/bs.vh.2018.01.016 · Cited by 62 · see citing works
Frick, K. M. (2012) · Behavioral Neuroscience · doi:10.1037/a0026660 · Cited by 66 · see citing works
Epigenetic regulation of estrogen-dependent memory
Fortress, A. M., & Frick, K. M. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.05.001 · Cited by 62 · see citing works
Alzheimer's Disease, Oestrogen and Mitochondria: an Ambiguous Relationship
Grimm, A., Lim, Y.-A., Mensah‐Nyagan, A. G., Götz, J., & Eckert, A. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8281-x · Cited by 62 · see citing works
Hammond, R., Nelson, D. A., Kline, E. G., & Gibbs, R. B. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.07.004 · Cited by 61 · see citing works
Self-citationMennenga, S. E., Gerson, J. E., Koebele, S. V., Kingston, M. L., Tsang, C. W. S., Engler-Chiurazzi, E. B., Baxter, L. C., & Bimonte‐Nelson, H. A. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.01.002 · Cited by 61 · see citing works
Kwakowsky, A., Potapov, K., Kim, S., Peppercorn, K., Tate, W. P., & Ábrahám, I. M. (2016) · Scientific Reports · doi:10.1038/srep21101 · Cited by 59 · see citing works
Alzheimer’s disease, apolipoprotein E and hormone replacement therapy
Depypere, H. T., Vierin, A., Weyers, S., & Sieben, A. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.09.009 · Cited by 57 · see citing works
Amato, M. P., Prestipino, E., Bellinvia, A., Niccolai, C., Razzolini, L., Pastò, L., Fratangelo, R., Tudisco, L., Fonderico, M., Mattiolo, P. L., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222929 · Cited by 56 · see citing works
Engler-Chiurazzi, E. B., Talboom, J. S., Braden, B. B., Tsang, C. W. S., Mennenga, S. E., Andrews, M. G., Demers, L. M., & Bimonte‐Nelson, H. A. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.04.004 · Cited by 54 · see citing works
Kirshner, Z. Z., & Gibbs, R. B. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.01.015 · Cited by 53 · see citing works
Self-citationMerriman, J. D., Sereika, S. M., Brufsky, A., McAuliffe, P. F., McGuire, K. P., Myers, J. S., Phillips, M. L., Ryan, C. M., Gentry, A., Jones, L. D., et al. (2015) · Psycho-Oncology · doi:10.1002/pon.4009 · Cited by 51 · see citing works
Luteinizing hormone: Evidence for direct action in the CNS
Blair, J. A., Bhatta, S., McGee, H., & Casadesús, G. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.020 · Cited by 52 · see citing works
Strategies for Preventing Cognitive Decline in Healthy Older Adults
Dumas, J. A. (2017) · The Canadian Journal of Psychiatry · doi:10.1177/0706743717720691 · Cited by 51 · see citing works
Khaksari, M., Soltani, Z., & Shahrokhi, N. (2017) · Translational Stroke Research · doi:10.1007/s12975-017-0588-5 · Cited by 50 · see citing works
Estradiol replacement extends the window of opportunity for hippocampal function
Vedder, L. C., Bredemann, T. M., & McMahon, L. L. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.04.004 · Cited by 49 · see citing works
Ibrahim, W. W., Abdelkader, N. F., Ismail, H. M., & Khattab, M. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-46558-1 · Cited by 49 · see citing works
Mansour, H. M., Fawzy, H. M., El-Khatib, A. S., & Khattab, M. M. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113697 · Cited by 49 · see citing works
Minireview: Estrogen Receptor-Initiated Mechanisms Causal to Mammalian Reproductive Behaviors
Pfaff, D. W., Waters, E. M., Khan, Q., Zhang, X., & Numan, M. (2011) · Endocrinology · doi:10.1210/en.2010-1007 · Cited by 48 · see citing works
Decreased voluntary activity and amygdala levels of serotonin and dopamine in ovariectomized rats
Izumo, N., Ishibashi, Y., Ohba, M., Morikawa, T., & Manabe, T. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.031 · Cited by 48 · see citing works
Bakoyiannis, I., Tsigka, E.-A., Perrea, D. N., & Pergialiotis, V. (2015) · Clinical Drug Investigation · doi:10.1007/s40261-015-0364-9 · Cited by 47 · see citing works
Tamoxifen Improves Cholinergically Modulated Cognitive Performance in Postmenopausal Women
NEWHOUSE, P. A., Albert, K. M., Astur, R. S., Johnson, J. V., Naylor, M. R., & Dumas, J. A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.172 · Cited by 46 · see citing works
Detection of estradiol in rat brain tissues: Contribution of local versus systemic production
Li, J., & Gibbs, R. B. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.11.037 · Cited by 46 · see citing works
Self-citationNeuroanatomical Changes Associated with Cognitive Aging
Juraska, J. M., & Lowry, N. C. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_137 · Cited by 45 · see citing works
Barha, C. K., & Galea, L. A. M. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.07.009 · Cited by 42 · see citing works
NEWHOUSE, P. A., Dumas, J. A., Wilkins, H., Coderre, E. L., Sites, C. K., Naylor, M. R., Benkelfat, C., & Young, S. N. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181e15df4 · Cited by 42 · see citing works
Sex Differences in Alzheimer’s Disease: Where Do We Stand?
Medeiros, A. D. M., & Silva, R. H. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180213 · Cited by 42 · see citing works
Bimonte-Nelson, H., Acosta, J. I., & Talboom, J. (2010) · Molecules · doi:10.3390/molecules15096050 · Cited by 46 · see citing works
Pratap, U. P., Patil, A., Sharma, H., Hima, L., Ramanathan, C., Hariharan, M. M., Shitoot, S., Priyanka, H. P., & ThyagaRajan, S. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.05.015 · Cited by 41 · see citing works
Optimizing treatments for nicotine dependence by increasing cognitive performance during withdrawal
Ashare, R. L., & Schmidt, H. D. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.908180 · Cited by 40 · see citing works
Prakapenka, A. V., Hiroi, R., Quihuis, A. M., Carson, C., Patel, S., Berns-Leone, C., Fox, C., Sirianni, R. W., & Bimonte‐Nelson, H. A. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.11.015 · Cited by 40 · see citing works
Dumas, J. A., Kutz, A. M., Naylor, M. R., Johnson, J. V., & NEWHOUSE, P. A. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.043 · Cited by 38 · see citing works
Epigenetics, Oestradiol and Hippocampal Memory Consolidation
Frick, K. M. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12106 · Cited by 36 · see citing works
Carreras, I., Aytan, N., Mellott, T. J., Choi, J., Lehar, M., Crabtree, L., Leite‐Morris, K. A., Jenkins, B. G., Blusztajn, J. K., & Dedeoglu, A. (2017) · Brain Research · doi:10.1016/j.brainres.2017.12.030 · Cited by 36 · see citing works
Effects of Tibolone on the Central Nervous System: Clinical and Experimental Approaches
Pinto‐Almazán, R., Segura-Uribe, J. J., Farfán‐García, E. D., & Guerra‐Araiza, C. (2017) · BioMed Research International · doi:10.1155/2017/8630764 · Cited by 35 · see citing works
Use of Hormone Replacement Therapy and Risk of Dementia
Sung, Y., Tsai, C., Kuo, C.-Y., Lee, J., Chou, C.-H., Chen, Y., Chou, Y., & Sun, C. (2022) · Neurology · doi:10.1212/wnl.0000000000200960 · Cited by 34 · see citing works
Garcia, A. N., Shah, M. A., Dixon, C. E., Wagner, A. K., & Kline, A. E. (2011) · PM&R · doi:10.1016/j.pmrj.2011.03.017 · Cited by 33 · see citing works
Galea, L. A. M., Roes, M., Dimech, C. J., Chow, C., Mahmoud, R., Lieblich, S. E., & Duarte‐Guterman, P. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.06.030 · Cited by 33 · see citing works
Neuroimmunomodulation by estrogen in health and disease
Priyanka, H. P., & Nair, R. S. (2020) · AIMS neuroscience · doi:10.3934/neuroscience.2020025 · Cited by 32 · see citing works
Li, Z., Wang, Y., Wang, Z., Kong, L., Liu, L., Li, L., & Tang, Y. (2022) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13530 · Cited by 32 · see citing works
Managing Aromatase Inhibitors in Breast Cancer Survivors: Not Just for Oncologists
Files, J. A., Ko, M. G., & Pruthi, S. (2010) · Mayo Clinic Proceedings · doi:10.4065/mcp.2010.0137 · Cited by 32 · see citing works
Luteinizing Hormone Involvement in Aging Female Cognition: Not All Is Estrogen Loss
Bhatta, S., Blair, J. A., & Casadesús, G. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00544 · Cited by 32 · see citing works
Cognitive performance in healthy women during induced hypogonadism and ovarian steroid addback
Schmidt, P. J., Keenan, P. A., Schenkel, L. A., Berlin, K., Gibson, C. J., & Rubinow, D. R. (2012) · Archives of Women s Mental Health · doi:10.1007/s00737-012-0316-9 · Cited by 31 · see citing works
Agnès Lacreuse, A., Mong, J. A., & Hara, Y. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.03.001 · Cited by 31 · see citing works
Role of GPR30 in mediating estradiol effects on acetylcholine release in the hippocampus
Gibbs, R. B., Nelson, D. A., & Hammond, R. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.06.002 · Cited by 30 · see citing works
Self-citationBlevins, J. K., Coxworth, J. E., Herndon, J. G., & Hawkes, K. (2013) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22300 · Cited by 27 · see citing works
Cloutier, C. J., Kavaliers, M., & Ossenkopp, K. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.08.006 · Cited by 26 · see citing works
Menopause, hormone therapy and cognition: maximizing translation from preclinical research
Bimonte‐Nelson, H. A., Bernaud, V. E., & Koebele, S. V. (2021) · Climacteric · doi:10.1080/13697137.2021.1917538 · Cited by 25 · see citing works
Galanthamine plus estradiol treatment enhances cognitive performance in aged ovariectomized rats
Gibbs, R. B., Chipman, A. M., Hammond, R., & Nelson, D. A. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.08.010 · Cited by 25 · see citing works
Self-citationMartins, D. B., Mazzanti, C. M. D. A., França, R. T., Pagnoncelli, M., Costa, M. M., de Souza, E. M., Gonçalves, J. F., Spanevello, R. M., Schmatz, R., da Costa, P., et al. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.12.006 · Cited by 25 · see citing works
Comparison of transitional vs surgical menopause on monoamine and amino acid levels in the rat brain
Long, T., Yao, J. K., Li, J., Kirshner, Z. Z., Nelson, D., Dougherty, G. G., & Gibbs, R. B. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.05.003 · Cited by 24 · see citing works
Self-citationSmith, E., Bailey, P. E., Crawford, J., Samaras, K., Baune, B. T., Campbell, L. V., Kochan, N. A., Menant, J. C., Sturnieks, D. L., Brodaty, H., et al. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13157 · Cited by 24 · see citing works
Danggui‐Shaoyao‐San Improves Learning and Memory in Female SAMP8 via Modulation of Estradiol
Huang, Y. Y., Hu, Z.-Y., Yuan, H., Shu, L., Liu, G., Shan-yi, Q., Sun, L., Zhou, W., & Zhang, Y. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/327294 · Cited by 24 · see citing works
Espinosa‐Raya, J., Neri-Gómez, T., Orozco-Suárez, S. A., Campos, M. G., & Guerra‐Araiza, C. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.10.005 · Cited by 24 · see citing works
Long, T., Yao, J. K., Li, J., Kirshner, Z. Z., Nelson, D., Dougherty, G. G., & Gibbs, R. B. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110533 · Cited by 23 · see citing works
Self-citationLi, J., Oberly, P. J., Poloyac, S. M., & Gibbs, R. B. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.04.013 · Cited by 22 · see citing works
Self-citationEffects of sex steroid hormones on memory
Pompili, A., Iorio, C., & Gasbarri, A. (2020) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2020-012 · Cited by 22 · see citing works
Dumas, J. A., McDonald, B. C., Saykin, A. J., McAllister, T. W., Hynes, M. L., West, J. D., & NEWHOUSE, P. A. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181e04db9 · Cited by 22 · see citing works
Kirshner, Z. Z., Yao, J. K., Li, J., Long, T., Nelson, D., & Gibbs, R. B. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117975 · Cited by 21 · see citing works
Self-citationGibbs, R. B., Chipman, A. M., & Nelson, D. A. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.01.011 · Cited by 21 · see citing works
Self-citationPollard, K. J., Wartman, H. D., & Daniel, J. M. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.05.002 · Cited by 20 · see citing works
The role of estrogen receptor β and nicotinic cholinergic receptors in postpartum depression
Fernandez, J. W., Grizzell, J. A., & Wecker, L. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.10.002 · Cited by 20 · see citing works
- Authors
- Gibbs, R. B.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Gibbs, Robert B.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2010-04-01
- Volume
- 31
- Issue
- 2
- Pages
- 224-253
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- PMC
- PMC2852210
- OpenAlex
- W2009343153
- Cited by
- 206
- References
- 313
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 10 · 2023: 6 · 2022: 5 · 2021: 13 · 2020: 11 · 2019: 12 · 2018: 16 · 2017: 8 · 2016: 15 · 2015: 15 · 2014: 14 · 2013: 14 · 2012: 19
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrine Reviews (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- University of Pittsburgh
- Duquesne University
- National Institutes of Health
- University of Pittsburgh School of Pharmacy
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- estrogen therapy, cholinergic hypothesis, postmenopausal women, cognitive decline, Alzheimer's disease, brain aging, estrogen receptor, hippocampus, critical period hypothesis, mild cognitive impairment, visuospatial attention, ovarian function, neuroprotection, neuroplasticity, mood and cognition
- MeSH terms
- Aging, Animals, Cognition, Estrogens, Female, Humans, Models, Neurological, Estrogen Replacement Therapy, Prosencephalon, Cholinergic Agents
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