The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
The Nonskeletal Effects of Vitamin D: An Endocrine Society Scientific Statement
Open accessAbstract
Significant controversy has emerged over the last decade concerning the effects of vitamin D on skeletal and nonskeletal tissues. The demonstration that the vitamin D receptor is expressed in virtually all cells of the body and the growing body of observational data supporting a relationship of serum 25-hydroxyvitamin D to chronic metabolic, cardiovascular, and neoplastic diseases have led to widespread utilization of vitamin D supplementation for the prevention and treatment of numerous disorders. In this paper, we review both the basic and clinical aspects of vitamin D in relation to nonskeletal organ systems. We begin by focusing on the molecular aspects of vitamin D, primarily by examining the structure and function of the vitamin D receptor. This is followed by a systematic review according to tissue type of the inherent biological plausibility, the strength of the observational data, and the levels of evidence that support or refute an association between vitamin D levels or supplementation and maternal/child health as well as various disease states. Although observational studies support a strong case for an association between vitamin D and musculoskeletal, cardiovascular, neoplastic, and metabolic disorders, there remains a paucity of large-scale and long-term randomized clinical trials. Thus, at this time, more studies are needed to definitively conclude that vitamin D can offer preventive and therapeutic benefits across a wide range of physiological states and chronic nonskeletal disorders.
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Evidence based medicine: what it is and what it isn't
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Self-citationDecreased bioavailability of vitamin D in obesity
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Cited by
Vitamin D-effects on skeletal and extraskeletal health and the need for supplementation
Wacker, M., & Holick, M. (2013) · Nutrients · doi:10.3390/nu5010111 · Cited by 733
The roles of vitamin D in skeletal muscle: form, function, and metabolism
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Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery
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Self-citationVitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study
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Metadata
- Authors
- Rosen, C. J., Adams, J. S., Bikle, D. D., Black, D. M., Demay, M. B., Manson, J. E., Murad, M. H., & Kovacs, C. S.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2012-05-17
- Volume
- 33
- Issue
- 3
- Pages
- 456-492
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W1976472175
- Cited by
- 765
- References
- 19
- FWCI
- 44.68
- Type
- journal article
- Language
- en
- Open access
- green
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