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Cited by 765

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

The Nonskeletal Effects of Vitamin D: An Endocrine Society Scientific Statement

Open access
Rosen, Clifford J., Adams, John S., Bikle, Daniel D., Black, Dennis M., Demay, Marie B., Manson, JoAnn E., Murad, M. Hassan, Kovacs, Christopher S.·2012·Endocrine Reviews
DOI 10.1210/er.2012-1000
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Abstract

Significant controversy has emerged over the last decade concerning the effects of vitamin D on skeletal and nonskeletal tissues. The demonstration that the vitamin D receptor is expressed in virtually all cells of the body and the growing body of observational data supporting a relationship of serum 25-hydroxyvitamin D to chronic metabolic, cardiovascular, and neoplastic diseases have led to widespread utilization of vitamin D supplementation for the prevention and treatment of numerous disorders. In this paper, we review both the basic and clinical aspects of vitamin D in relation to nonskeletal organ systems. We begin by focusing on the molecular aspects of vitamin D, primarily by examining the structure and function of the vitamin D receptor. This is followed by a systematic review according to tissue type of the inherent biological plausibility, the strength of the observational data, and the levels of evidence that support or refute an association between vitamin D levels or supplementation and maternal/child health as well as various disease states. Although observational studies support a strong case for an association between vitamin D and musculoskeletal, cardiovascular, neoplastic, and metabolic disorders, there remains a paucity of large-scale and long-term randomized clinical trials. Thus, at this time, more studies are needed to definitively conclude that vitamin D can offer preventive and therapeutic benefits across a wide range of physiological states and chronic nonskeletal disorders.

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Metadata

Authors
Rosen, C. J., Adams, J. S., Bikle, D. D., Black, D. M., Demay, M. B., Manson, J. E., Murad, M. H., & Kovacs, C. S.
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
2012-05-17
Volume
33
Issue
3
Pages
456-492
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/er.2012-1000
OpenAlex
W1976472175
Cited by
765
References
19
FWCI
44.68
Type
journal article
Language
en
Open access
green

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