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Cited by 284

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Adiponectin, Inflammation, and the Expression of the Metabolic Syndrome in Obese Individuals: The Impact of Rapid Weight Loss through Caloric Restriction

Xydakis, Antonios M., Case, Christopher C., Jones, Peter H., Hoogeveen, Ron C., Liu, Mine-Yine, Smith, E. O’Brian, Nelson, Kathleen W., Ballantyne, Christie M.·2004·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2003-031826
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Abstract

Severe obesity increases the prevalence of the metabolic syndrome, and moderate acute weight loss with a very low-calorie diet in obese subjects with the metabolic syndrome leads to significant metabolic benefits. Adiponectin has been implicated in both the pathogenesis of obesity-related insulin resistance and increased inflammation. We analyzed the relationship of the adipocyte-derived hormone adiponectin with indices of inflammation, adiposity, and insulin resistance in obese subjects with (MS+, n = 40) and without (MS-, n = 40) the metabolic syndrome and examined the acute effects of rapid weight loss. MS+ subjects had significantly lower adiponectin (7.6 +/- 0.6 vs. 10.4 +/- 0.6 microg/ml; P = 0.003) and significantly higher TNF-alpha (3.3 +/- 0.2 vs. 2.8 +/- 0.3 pg/ml; P = 0.004) levels compared with MS- subjects matched for age and body mass index. Plasma adiponectin and TNF-alpha levels were inversely related to the number of metabolic syndrome factors in a stepwise manner. After 4-6 wk of weight loss, there was marked improvement in glucose, insulin, leptin, and triglycerides, whereas adiponectin and TNF-alpha concentrations did not change. Thus, increases in plasma levels of adiponectin or reductions in TNF-alpha are not required for marked improvements in glucose/insulin and lipid metabolism with acute weight loss.

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Metadata

Authors
Xydakis, A. M., Case, C. C., Jones, P. H., Hoogeveen, R. C., Liu, M.-Y., Smith, E. O., Nelson, K. W., & Ballantyne, C. M.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2004-06
Volume
89
Issue
6
Pages
2697-2703
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2003-031826
OpenAlex
W1998434356
Cited by
284
References
11
FWCI
20.71
Type
journal article
Language
en
Open access
closed

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