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Effects of Dietary Weight Loss on Sympathetic Activity and Cardiac Risk Factors Associated with the Metabolic Syndrome
Abstract
CONTEXT: Weight reduction, the first line treatment for the metabolic syndrome, improves insulin sensitivity and associated metabolic and cardiovascular abnormalities, but there is a paucity of data regarding its effect on sympathetic nervous system (SNS) activity in this clinical setting. OBJECTIVES: The objectives of this study were to test the hypothesis that dietary weight loss attenuates both insulin resistance and SNS activity and to examine the relationships between SNS activity and metabolic syndrome (MetS) components. DESIGN: This was a single-sample, repeated measures design study. SETTING: This study was performed at a tertiary referral center. PARTICIPANTS: Twenty-three MetS subjects (age, 58 +/- 2 yr; body mass index, 33.3 +/- 0.8 kg/m2; mean +/- sem) were studied. INTERVENTION: A hypocaloric modified Dietary Approaches to Stop Hypertension diet (26% fat, 22% protein, and 51% carbohydrate; 100 mmol/d sodium) was consumed for 3 months. MAIN OUTCOME MEASURES: The main outcome measures were postganglionic muscle sympathetic nerve activity (microneurography at a peroneal nerve), whole-body plasma norepinephrine spillover rate, spontaneous cardiac baroreflex function, and insulin sensitivity. RESULTS: The hypocaloric diet significantly reduced body weight by 7% and improved all MetS components. Norepinephrine spillover decreased from 877 +/- 180 to 503 +/- 39 ng/min (P = 0.005), and muscle sympathetic nerve activity decreased from 40.6 +/- 2.1 to 34.6 +/- 2.4 bursts/min (P = 0.01), whereas cardiac baroreflex sensitivity increased by 23.0 +/- 8.0% (P = 0.02). The change in the norepinephrine spillover rate correlated positively and independently with the change in plasma leptin concentration (r = 0.49; P = 0.03). CONCLUSION: Weight loss by a hypocaloric diet with moderate sodium restriction diminishes SNS activity in MetS subjects. This may be due to the consequences of decreased leptin concentration, enhanced insulin sensitivity, or improvements in cardiac baroreflex function.
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“During diet-induced weight loss, the decreases in sympathetic activity are accompanied by reduction in all components of the metabolic syndrome70.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [70]
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Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873
A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
Appel, L. J., Moore, T. J., Obarzanek, E., Vollmer, W. M., Svetkey, L. P., Sacks, F. M., Bray, G. A., Vogt, T. M., Cutler, J. A., Windhauser, M. M., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361601 · Cited by 5,981
Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621
Malik, S., Wong, N. D., Franklin, S. S., Kamath, T. V., L'Italien, G. J., Pio, J. R., & Williams, G. R. (2004) · Circulation · doi:10.1161/01.cir.0000140677.20606.0e · Cited by 1,837
Prospective Analysis of The Insulin-Resistance Syndrome (Syndrome X)
Haffner, S. M., Valdez, R. A., Hazuda, H. P., Mitchell, B. D., Morales, P. A., & D, M. P. S. M. (1992) · Diabetes · doi:10.2337/diab.41.6.715 · Cited by 1,234
The metabolic syndrome: prevalence in worldwide populations
Cameron, A. J., Shaw, J. E., & Zimmet, P. (2004) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2004.03.005 · Cited by 1,031
Sympathetic Neural Activation in Visceral Obesity
Alvarez, G. E., Beske, S. D., Ballard, T. P., & Davy, K. P. (2002) · Circulation · doi:10.1161/01.cir.0000041244.79165.25 · Cited by 557
Layman, D. K., Boileau, R. A., Erickson, D. J., Painter, J. E., Shiue, H., Sather, C., & Christou, D. D. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.2.411 · Cited by 541
Reaven, G. M. (2004) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2004.03.002 · Cited by 517
Masuo, K., Kawaguchi, H., Mikami, H., Ogihara, T., & Tuck, M. L. (2003) · Hypertension · doi:10.1161/01.hyp.0000091371.53502.d3 · Cited by 516
Self-citationRegional Sympathetic Nervous Activity and Oxygen Consumption in Obese Normotensive Human Subjects
Vaz, M., Jennings, G., Turner, A., Cox, H., Lambert, G., & Esler, M. (1997) · Circulation · doi:10.1161/01.cir.96.10.3423 · Cited by 404
Self-citationGrassi, G., Seravalle, G., Colombo, M., Bolla, G., Cattaneo, B. M., Cavagnini, F., & Mancia, G. (1998) · Circulation · doi:10.1161/01.cir.97.20.2037 · Cited by 364
Sympathetic and Cardiorenal Actions of Leptin
Haynes, W. G., Sivitz, W. I., Morgan, D. A., Walsh, S. A., & Mark, A. L. (1997) · Hypertension · doi:10.1161/01.hyp.30.3.619 · Cited by 351
Baskin, D. G., Figlewicz, D. P., Woods, S. C., Porte, D., & Dorsa, D. M. (1987) · Annual Review of Physiology · doi:10.1146/annurev.ph.49.030187.002003 · Cited by 344
Determination of norepinephrine apparent release rate and clearance in humans
Esler, M., Jackman, G. P., Bobik, A., Kelleher, D., Jennings, G., Leonard, P., Skews, H., & Korner, P. I. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90371-0 · Cited by 340
Self-citationBerne, C., Fagius, J., Pollare, T., & Hjemdahl, P. (1992) · Diabetologia · doi:10.1007/bf00399935 · Cited by 293
Interactions Between Leptin and the Human Sympathetic Nervous System
Eikelis, N., Schlaich, M., Aggarwal, A., Kaye, D., & Esler, M. (2003) · Hypertension · doi:10.1161/01.hyp.0000066289.17754.49 · Cited by 271
Self-citationClasey, J. L., Bouchard, C., Teates, C. D., Riblett, J. E., Thorner, M. O., Hartman, M. L., & WELTMAN, A. L. (1999) · Obesity Research · doi:10.1002/j.1550-8528.1999.tb00404.x · Cited by 223
Ferreira, I., Snijder, M. B., Twisk, J. W. R., van Mechelen, W., Kemper, H. C. G., Seidell, J. C., & Stehouwer, C. D. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031619 · Cited by 216
Huggett, R. J., Burns, J., Mackintosh, A. F., & Mary, D. A. S. G. (2004) · Hypertension · doi:10.1161/01.hyp.0000147893.08533.d8 · Cited by 211
Drew, B. G., Fidge, N., Beaumier-Gallon, G., Kemp, B. E., & Kingwell, B. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306266101 · Cited by 169
Diet and Exercise in the Treatment of Obesity: Effects of 3 Interventions on Insulin Resistance
Weinstock, R. S. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.22.2477 · Cited by 151
Reduced cardiovagal baroreflex gain in visceral obesity: implications for the metabolic syndrome
Beske, S. D., Alvarez, G. E., Ballard, T. P., & Davy, K. P. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00642.2001 · Cited by 143
Chronic Management of Blood Pressure After Stroke
Pedelty, L., & Gorelick, P. B. (2004) · Hypertension · doi:10.1161/01.hyp.0000129170.50448.5f · Cited by 122
Endurance training increases metabolic rate and norepinephrine appearance rate in older individuals
Poehlman, É. T., & Danforth, E. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.261.2.e233 · Cited by 118
Contribution of individual organs to total noradrenaline release in humans.
Esler, M., Jennings, G., Leonard, P., SACHARIAS, N., Burke, F., Johns, J., & Blombery, P. A. (1984) · PubMed · Cited by 114
Self-citationLee, Z. S. K., Critchley, J., Tomlinson, B., Young, R. P., Thomas, G. N., Cockram, C. S., Chan, T. Y. K., & Chan, J. C. N. (2001) · Metabolism · doi:10.1053/meta.2001.19502 · Cited by 113
Gender differences in muscle sympathetic nerve activity: effect of body fat distribution
Jones, P. P., Snitker, S., Skinner, J. S., & Ravussin, É. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.2.e363 · Cited by 110
Yamashita, T., Sasahara, T., Pomeroy, S., Collier, G., & Nestel, P. J. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90297-9 · Cited by 103
Self-citationWhat is the contribution of obesity to the metabolic syndrome?
Grundy, S. M. (2004) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2004.03.001 · Cited by 98
van de Borne, P., Montano, N., Zimmerman, B. M., Pagani, M., & Somers, V. K. (1997) · Circulation · doi:10.1161/01.cir.96.12.4326 · Cited by 81
Poehlman, É. T., Gardner, A. W., Goran, M. I., Arciero, P. J., Toth, M. J., Ades, P. A., & Calles-Escandón, J. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.78.3.802 · Cited by 70
Laaksonen, D. E., Laitinen, T. P., Schönberg, J., Rissanen, A., & NISKANEN, L. K. (2003) · Journal of Hypertension · doi:10.1097/00004872-200302000-00029 · Cited by 70
Sympathetic and cardiac baroreflex function in panic disorder
Lambert, É., Thompson, J. M., Schlaich, M. P., Laude, D., Elghozi, J., Esler, M., & Lambert, G. W. (2002) · Journal of Hypertension · doi:10.1097/00004872-200212000-00025 · Cited by 67
Self-citationRaising lipids acutely reduces baroreflex sensitivity
Gadegbeku, C. A., Dhandayuthapani, A., Sadler, Z. E., & Egan, B. M. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(02)02275-6 · Cited by 59
Insulin resistance in obesity: body-weight or energy balance?
Assali, A., Ganor, A., Beigel, Y., Shafer, Z., Hershcovici, T., & Fainaru, M. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1710293 · Cited by 55
Nestel, P. J., Yamashita, T., Sasahara, T., Chin-Dusting, J. P. F., Esler, M., Dart, A. M., & Jennings, G. (1998) · Clinical Science · doi:10.1042/cs0950203 · Cited by 31
Self-citationBenthem, L., Kuipers, F., Steffens, A. B., & SCHEURINK, A. J. W. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07804.x · Cited by 16
Nestel, P. J., YAMASHITA, T., Sasahara, T., et al. (1998) · Clinical Science · doi:10.1042/cs19970263 · Cited by 14
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Esler, M., Straznicky, N., Eikelis, N., Masuo, K., Lambert, G., & Lambert, E. (2006) · Hypertension · doi:10.1161/01.hyp.0000242642.42177.49 · Cited by 443
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Metadata
- Authors
- Straznicky, N. E., Lambert, E. A., Lambert, G. W., Masuo, K., Esler, M. D., & Nestel, P. J.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- Corresponding author
- Straznicky, Nora E.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2005-11
- Volume
- 90
- Issue
- 11
- Pages
- 5998-6005
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1976286624
- Cited by
- 227
- References
- 43
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 6 · 2021: 10 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 10 · 2016: 13 · 2015: 14 · 2014: 10 · 2013: 13 · 2012: 12
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Diabetes Australia Research Trust
- Diabetes Australia
- Heart Research Institute
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- metabolic syndrome, dietary weight loss, hypocaloric diet, sympathetic activity, muscle sympathetic nerve activity, norepinephrine spillover, cardiac baroreflex sensitivity, insulin sensitivity, leptin, sodium restriction, DASH diet
- MeSH terms
- Aged, Cardiovascular Diseases, Female, Humans, Insulin Resistance, Male, Middle Aged, Muscles, Norepinephrine, Risk Factors, Sympathetic Nervous System, Weight Loss, Baroreflex, Metabolic Syndrome
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