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Cited by 133Regulation of Appetite and ObesityEating Disorders and BehaviorsSleep and related disorders

Neuroendocrine profiles associated with energy intake, sleep, and stress in the night eating syndrome

Allison, Kelly C., Ahima, Rexford S., O’Reardon, John P., Dinges, David F., Sharma, Vibhavasu, Cummings, David E., Heo, Moonseong, Martino, Nicole S. +1 more·2005·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2005-1018
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Abstract

CONTEXT: Night eating syndrome (NES) is characterized by evening hyperphagia and frequent awakenings with ingestion of food. It is associated with obesity and depressed mood. Greater understanding of hormonal influences on NES is desirable. OBJECTIVE: Our objective was to evaluate 25-h profiles of hormones involved in energy balance, sleep, and stress in NES. DESIGN: Blood assays for glucose, insulin, ghrelin, leptin, melatonin, cortisol, TSH, and prolactin were sampled repeatedly among NES and control subjects. Food intake and depressive symptoms were assessed. SETTING AND PARTICIPANTS: Fifteen NES and 14 matched control participants stayed three nights in a General Clinical Research Center. MAIN OUTCOME MEASURES: We assessed differences between NES and control participants in the 25-h profiles of eight hormones. RESULTS: Nocturnal food intake was higher among NES participants, although their daily calorie intake was similar to that of controls. Reflecting their increased nocturnal intake, insulin (P < 0.001) and glucose levels (P = 0.07) among NES participants were higher than those of controls. Ghrelin levels were significantly lower in NES participants than in controls from 0100-0900 h (P = 0.003). Levels of plasma cortisol, melatonin, leptin, and prolactin did not differ between groups, but there was a trend for TSH levels (P = 0.07) to be higher during the 25 h in NES. NES participants had greater depressive symptoms than controls (P < 0.001). The differences in the levels of glucose, insulin, and ghrelin between NES and controls are closely associated with nocturnal food intake.

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  • The core criteria of night eating syndrome (evening hyperphagia, associated with nighttime awakening and ingestion) are associated with definite behavioral and hormonal phase delays.

    “The core criteria of evening hyperphagia, associated with nighttime awakening and ingestion are associated with definite behavioral and hormonal phase delays (Allison et al., 2005; Birketvedt et al., 1999; O'Reardon et al., 2004).”

    From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Allison et al., 2005

  • Compared to those who do not eat late at night, individuals with NES consume a larger portion of their total calories at night (≥50% after dinner) and have higher overall daily and evening caloric intake in some but not all cases.

    “Compared to those who do not eat late at night, individuals with NES consume a larger portion of their total calories at night (≥50% after dinner) and have higher overall daily and evening caloric intake in some [30,31], but not all cases [32,33,34].”

    From The Health Impact of Nighttime Eating: Old and New Perspectives (2015) · cites this paper as [32]

  • Not all studies report differences in daily caloric intake between night eaters and controls.

    “However, not all studies report differences in daily caloric intake between night eaters and controls [32,33,34]”

    From The Health Impact of Nighttime Eating: Old and New Perspectives (2015) · cites this paper as [32]

  • Those with NES consume double the amount of carbohydrate and protein and four times the fat in daily meals compared to those without NES.

    “In addition, those with NES consume double the amount of carbohydrate and protein and four times the fat [32] in daily meals compared to those without NES.”

    From The Health Impact of Nighttime Eating: Old and New Perspectives (2015) · cites this paper as [32]

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Authors
Allison, K. C., Ahima, R. S., O’Reardon, J. P., Dinges, D. F., Sharma, V., Cummings, D. E., Heo, M., Martino, N. S., & Stunkard, A. J.
Affiliations
  • Department of Psychiatry, Weight and Eating Disorders Program (K.C.A., J.P.O., N.S.M., A.J.S.), Philadelphia, Pennsylvania 19104;
  • University of Pennsylvania (US)
  • Division of Sleep and Chronobiology (D.F.D.); Philadelphia, Pennsylvania 19104;
  • University of Washington (US)
  • Cornell University (US)
Corresponding author
Allison, Kelly C.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2005-11-01
Volume
90
Issue
11
Pages
6214-6217
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2005-1018
OpenAlex
W2078506812
Cited by
133
References
19
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 7 · 2016: 11 · 2015: 6 · 2014: 1 · 2013: 10 · 2012: 14
FWCI
2.57
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Massachusetts Institute of Technology
  • University of Pennsylvania
  • University of Washington
  • National Institutes of Health (RR00040)
  • National Heart, Lung, and Blood Institute (HL70154, R01HL070154)
  • National Institute of Nursing Research (NR04281, R01NR004281)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P01-DK49250, R01-DK56735, R01DK056735)
  • National Center for Research Resources (M01-RR-00040, M01RR000040)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
night eating syndrome, energy balance, insulin, glucose, ghrelin, leptin, melatonin, cortisol, thyroid-stimulating hormone, prolactin, depressive symptoms, sleep, stress hormones
MeSH terms
Adult, Animals, Feeding and Eating Disorders, Blood Glucose, Energy Intake, Female, Humans, Insulin, Middle Aged, Sleep, Stress, Psychological, Thyrotropin, Leptin, Peptide Hormones, Ghrelin

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