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Cited by 420Ovarian function and disordersSexual Differentiation and DisordersAdrenal Hormones and Disorders

Relative Prevalence of Different Androgen Excess Disorders in 950 Women Referred because of Clinical Hyperandrogenism

Carmina, E., Rosato, F., Jannì, A., Rizzo, M., Longo, R. A.·2006·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2005-1457
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Abstract

CONTEXT: We undertook this study to estimate the prevalence of the various androgen excess disorders using the new criteria suggested for the diagnosis of polycystic ovary syndrome (PCOS). SETTING: The study was performed at two endocrine departments at the University of Palermo (Palermo, Italy). PATIENTS: The records of all patients referred between 1980 and 2004 for evaluation of clinical hyperandrogenism were reevaluated. All past diagnoses were reviewed using the actual diagnostic criteria. To be included in this study, the records of the patients had to present the following available data: clinical evaluation of hyperandrogenism, body weight and height, testosterone (T), free T, dehydroepiandrosterone sulfate, 17-hydroxyprogesterone, progesterone, and pelvic sonography. A total of 1226 consecutive patients were seen during the study period, but only the scores of 950 patients satisfied all criteria and were reassessed for the diagnosis. RESULTS: The prevalence of androgen excess disorders was: PCOS, 72.1% (classic anovulatory patients, 56.6%; mild ovulatory patients, 15.5%), idiopathic hyperandrogenism, 15.8%; idiopathic hirsutism, 7.6%; 21-hydroxylase-deficient nonclassic adrenal hyperplasia, 4.3%; and androgen-secreting tumors, 0.2%. Compared with other androgen excess disorders, patients with PCOS had increased body weight whereas nonclassic adrenal hyperplasia patients were younger and more hirsute and had higher serum levels of T, free T, and 17-hydroxyprogesterone. CONCLUSIONS: Classic PCOS is the most common androgen excess disorder. However, mild androgen excess disorders (ovulatory PCOS and idiopathic hyperandrogenism) are also common and, in an endocrine setting, include about 30% of patients with clinical hyperandrogenism.

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  • Hyperandrogenism can occur without cutaneous manifestations even though hirsutism is common among women with hyperandrogenism.

    “Even though hirsutism is common among women with hyperandrogenism, the latter can occur in the absence of cutaneous manifestations [2,3]”

    From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [3]

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Authors
Carmina, E., Rosato, F., Jannì, A., Rizzo, M., & Longo, R. A.
Affiliations
University of Palermo (IT)
Corresponding author
Carmina, E.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2006-01
Volume
91
Issue
1
Pages
2-6
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2005-1457
OpenAlex
W2157699773
Cited by
420
References
18
Citations by year
2026: 8 · 2025: 15 · 2024: 15 · 2023: 19 · 2022: 21 · 2021: 16 · 2020: 14 · 2019: 29 · 2018: 13 · 2017: 17 · 2016: 25 · 2015: 29 · 2014: 26 · 2013: 20 · 2012: 27
FWCI
27.91
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
polycystic ovary syndrome, idiopathic hirsutism, 21-hydroxylase deficiency, androgen-secreting tumor, prevalence, diagnostic criteria, testosterone, 17-hydroxyprogesterone, body weight
MeSH terms
Acne Vulgaris, Adolescent, Adult, Alopecia, Androgens, Anovulation, Body Height, Body Weight, Diagnosis, Differential, Female, Hirsutism, Humans, Neoplasms, Ovary, Pelvis, Polycystic Ovary Syndrome, Progesterone, Retrospective Studies, Testosterone, Ultrasonography, Body Mass Index, Hyperandrogenism, 17-alpha-Hydroxyprogesterone

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