Serum aldosterone concentration and cardiovascular risk in women with polycystic ovarian syndrome
Abstract
Context: Polycystic ovary syndrome (PCOS) is associated with early impairment of vascular structure and a low-grade chronic inflammation. Aldosterone is a well-recognized cardiovascular risk (CVR) factor and is related to inflammatory processes. Objective: Our objective was to investigate serum aldosterone levels in PCOS and correlate them to some CVR factors and early atherosclerotic markers. Design and Setting: A prospective baseline-controlled clinical study was conducted at the University “Federico II” of Naples School of Medicine (Naples, Italy). Patients: Fifty PCOS women age- and body mass index-matched with 50 healthy women were enrolled. Mean Outcome Measures: Anthropometric, hormonal, and metabolic patterns, including plasma aldosterone, renin, and C-reactive protein, were measured in each subject. Intima-media thickness was also evaluated in each patient and control. Results: Aldosterone levels were significantly increased (P < 0.001) in PCOS compared with healthy women (10.5 ± 3.2 vs. 5.7 ± 2.5 ng/dl). In PCOS, a significant (P < 0.001) direct correlation between plasma aldosterone and homeostasis model assessment, C-reactive protein, intima-media thickness, and mean blood pressure was found. On the other hand, high-density lipoprotein cholesterol and potassium were inversely (P < 0.001) related to serum aldosterone. Multiple linear regression analysis showed that the area under the curve for insulin and homeostasis model assessment was linearly related to aldosterone in PCOS. Conclusion: PCOS women show an insulin resistance related increase in serum aldosterone levels.
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Use of COCs stimulates synthesis of angiotensinogen and activates the renin-angiotensin-aldosterone system.
“It is known that aldosterone is the main proinflammatory hormone and, unfortunately, the use of COCs stimulates the synthesis of angiotensinogen and activates the renin–angiotensin–aldosterone system (RAAS) [13,14,68].”
From Controversies in the Pathogenesis, Diagnosis and Treatment of PCOS: Focus on Insulin Resistance, Inflammation, and Hyperandrogenism (2022) · cites this paper as [68]
Aldosterone is the main proinflammatory hormone.
“It is known that aldosterone is the main proinflammatory hormone and, unfortunately, the use of COCs stimulates the synthesis of angiotensinogen and activates the renin–angiotensin–aldosterone system (RAAS) [13,14,68].”
From Controversies in the Pathogenesis, Diagnosis and Treatment of PCOS: Focus on Insulin Resistance, Inflammation, and Hyperandrogenism (2022) · cites this paper as [68]
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- Authors
- Cascella, T., Palomba, S., Tauchmanovà, L., Manguso, F., Di Biase, S., Labella, D., Giallauria, F., Vigorito, C., Colao, A., Lombardi, G., & Orio, F.
- Affiliations
- University of Naples Federico II (IT)
- Magna Graecia University (IT)
- Department of Molecular and Clinical Endocrinology and Oncology (T.C., L.T., A.C., G.L., F.O.),” 80131 Naples, Italy
- MeriGen Laboratory of Molecular Biology (S.D.B., D.L.), 80131 Naples, Italy
- Federico II University Hospital (IT)
- Corresponding author
- Orio, Francesco
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2006-11-01
- Volume
- 91
- Issue
- 11
- Pages
- 4395-4400
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2090608637
- Cited by
- 120
- References
- 48
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 9 · 2020: 10 · 2019: 9 · 2018: 6 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 7
- FWCI
- 8.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- CINECA IRIS Institutial research information system (Parthenope University of Naples) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- polycystic ovary syndrome, serum aldosterone, cardiovascular risk, insulin resistance, intima-media thickness, C-reactive protein, renin, atherosclerosis, HOMA, blood pressure, HDL cholesterol, potassium, women
- MeSH terms
- Adult, Aldosterone, Cardiovascular Diseases, Female, Humans, Polycystic Ovary Syndrome, Prospective Studies, Risk Factors, Causality, Case-Control Studies, Atherosclerosis
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