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Cited by 220Hormonal and reproductive studiesDiabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 61 of the 62 references it cites were found in a registry or an index.

Acute Sex Steroid Withdrawal Reduces Insulin Sensitivity in Healthy Men with Idiopathic Hypogonadotropic Hypogonadism

Yialamas, Maria A., Dwyer, Andrew A., Hanley, Erin, Lee, Hang, Pitteloud, Nelly, Hayes, Frances J.·2007·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2007-0454
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Abstract

CONTEXT: Evidence suggests that testosterone (T) influences insulin sensitivity in men. The mechanism of this effect is unclear but is thought to involve changes in body composition. OBJECTIVE: The aim of this study was to determine whether acute sex steroid withdrawal decreases insulin sensitivity in young, healthy men with idiopathic hypogonadotropic hypogonadism (IHH). DESIGN: This was a 2-wk prospective study. SETTING: The study was conducted at a General Clinical Research Center. PATIENTS: Twelve men with IHH (age 40.8 +/- 2.8 yr) were studied: 1) on hormone replacement with normal T levels and 2) 2 wk after discontinuing therapy. MAIN OUTCOME MEASURES: Each evaluation comprised a 75-g oral glucose tolerance test with assessment of insulin sensitivity (fasting insulin levels, homeostatic model assessment for insulin resistance, and Matsuda insulin sensitivity index) and insulin secretion (corrected insulin response). Serum cortisol, leptin, adiponectin, free fatty acids, IL-6, C-reactive protein, and TNF-alpha levels were also measured. RESULTS: Body mass index was unchanged (27.1 +/- 1.1 to 27.2 +/- 1.1 kg/m(2)). Serum T levels decreased from 529 +/- 65 to 28 +/- 8 ng/dl (P < 0.00005). Fasting insulin levels increased from 4.9 +/- 0.7 to 6.2 +/- 0.6 microU/ml (P = 0.005), homeostatic model assessment of insulin resistance increased from 1.07 +/- 0.2 to 1.4 +/- 1.01 (P < 0.005), and insulin sensitivity index decreased from 11.0 +/- 2.3 to 7.5 +/- 0.7 (P < 0.05). There was a trend for fasting glucose levels to increase, 86.7 +/- 1.3 to 90.8 +/- 1.7 mg/dl (P = 0.09). IL-6 levels increased from 1.2 +/- 0.2 to 2.4 +/- 0.5 pg/ml (P < 0.01), whereas TNF-alpha levels decreased from 1.0 +/- 0.1 to 0.6 +/- 0.1 pg/ml (P < 0.05). No other significant changes were observed. CONCLUSIONS: 1) Acute sex steroid withdrawal reduces insulin sensitivity in young healthy IHH men. 2) The acuity of the hypogonadism and absence of changes in body mass index or leptin levels suggest that sex steroids modulate insulin sensitivity in the absence of apparent or detectable changes in body composition.

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Metadata

Authors
Yialamas, M. A., Dwyer, A. A., Hanley, E., Lee, H., Pitteloud, N., & Hayes, F. J.
Affiliations
Massachusetts General Hospital (US)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2007-11-01
Volume
92
Issue
11
Pages
4254-4259
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2007-0454
OpenAlex
W2068756512
Cited by
220
References
62
Citations by year
2026: 4 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 3 · 2020: 12 · 2019: 10 · 2018: 14 · 2017: 15 · 2016: 9 · 2015: 9 · 2014: 16 · 2013: 14 · 2012: 14
FWCI
15.87
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r03dk064276-02)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R03 DK064276 A 01)
  • National Center for Research Resources (M01RR001066)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
idiopathic hypogonadotropic hypogonadism, testosterone withdrawal, insulin sensitivity, insulin resistance, testosterone replacement therapy, insulin secretion, interleukin-6, TNF-α, C-reactive protein, adiponectin, leptin, cortisol, body composition, young men, oral glucose tolerance test, HOMA-IR
MeSH terms
Adult, Aged, Body Composition, Gonadotropins, Humans, Hypogonadism, Insulin Resistance, Male, Middle Aged, Gonadal Steroid Hormones, Substance Withdrawal Syndrome, Testosterone, Body Mass Index, Cytokines, Adipokines

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