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Cited by 55Sleep and Work-Related FatigueSleep and Wakefulness ResearchSleep and related disorders

Mild Sleep Restriction Acutely Reduces Plasma Glucagon Levels in Healthy Men

Schmid, Sebastian M., Jauch-Chara, Kamila, Hallschmid, Manfred, Schultes, Bernd·2009·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2009-0969
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Abstract

BACKGROUND: Sleep loss has repeatedly been suggested to affect glucose metabolism adversely, raising the question as to the impact of subtle forms of sleep loss. OBJECTIVE: The aim of the study was to assess the effects of a single night of sleep restriction to 4.5 h on endocrine parameters of glucose metabolism. DESIGN: We conducted crossover, balanced experiments including two conditions, i.e. one night of 4.5 h and one night of 7 h of sleep. SUBJECTS AND MEASUREMENTS: In 10 healthy men, circulating concentrations of insulin, C-peptide, epinephrine, norepinephrine, GH, ACTH, cortisol, and glucagon were measured after sleep and sleep restriction, respectively, during basal rest and a subsequent stepwise hypoglycemic clamp. RESULTS: Mild sleep restriction induced a robust reduction in basal plasma glucagon levels that persisted throughout the hypoglycemic clamp (P < 0.03). Basal glucose, insulin, and C-peptide levels were unaffected by sleep restriction. Also, basal and hypoglycemia-stimulated concentrations of epinephrine, norepinephrine, and GH were unchanged after sleep restriction. Concentrations of ACTH (P < 0.05) and cortisol (P < 0.001) were reduced after sleep loss during baseline and at the start of hypoglycemia, but reached roughly comparable levels in both conditions at the end of the clamp (ACTH, P > 0.06; cortisol, P > 0.93). CONCLUSION: Our data show that mild restriction of nocturnal sleep to 4.5 h has a reducing effect on circulating glucagon levels. This finding provides further evidence for the notion that glucose homeostasis is sensitive to subtle changes in sleep duration.

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  • Three studies found no alterations in measures of glucose metabolism.

    “Conversely, three studies [11, 145, 217] found no alterations in measures of glucose metabolism.”

    From Sleep and metabolic function (2012) · cites this paper as [145]

  • Counter-regulatory hormones including glucagon and catecholamines are impacted by sleep curtailment.

    “Other counter-regulatory hormones coordinate glucose homeostasis and are impacted by sleep curtailment, including glucagon [30] and catecholamines [31].”

    From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [30]

  • Two crossover studies of a single night of total sleep deprivation or partial sleep deprivation showed decreased basal glucagon levels, while catecholamine levels remained unchanged.

    “Two crossover studies of a single night of total sleep [32] or partial sleep [30] deprivation showed decreased basal glucagon levels, however catecholamines levels remained unchanged.”

    From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [30]

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Authors
Schmid, S. M., Jauch-Chara, K., Hallschmid, M., & Schultes, B.
Affiliations
  • University of Lübeck (DE)
  • Psychiatry and Psychotherapy (K.J.-C.), University of Luebeck, D-23538 Luebeck, Germany
  • Kantonsspital St. Gallen (CH)
Corresponding author
Schultes, Bernd
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2009-12-01
Volume
94
Issue
12
Pages
5169-5173
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2009-0969
OpenAlex
W2162354918
Cited by
55
References
17
Citations by year
2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2020: 5 · 2019: 5 · 2017: 2 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 7
FWCI
6.78
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
sleep restriction, glucagon, glucose metabolism, glucose homeostasis, hypoglycemic clamp, ACTH, cortisol, insulin, C-peptide, epinephrine, norepinephrine, growth hormone, sleep duration
MeSH terms
Adult, Blood Glucose, C-Peptide, Glucagon, Hormones, Humans, Insulin, Male, Sleep Deprivation, Cross-Over Studies, Young Adult

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