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Cited by 124Sleep and related disordersSleep and Work-Related FatigueSleep and Wakefulness Research

Acute sleep restriction reduces insulin sensitivity in adolescent boys

Open access
Klingenberg, Lars, Chaput, Jean-Philippe, Holmbäck, Ulf, Visby, Trine, Jennum, Poul, Nikolic, Miki, Astrup, Arne, Sjödin, Anders·2013·Sleep
DOI 10.5665/sleep.2816PMC PMC3669075
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Abstract

BACKGROUND: Short sleep duration has been linked to impaired glucose metabolism in many experimental studies. Moreover, studies have reported indications of an increased metabolic stress following sleep restriction. OBJECTIVE: We aimed to investigate the effects of partial sleep deprivation on markers of glucose metabolism. Additionally, we aimed to investigate if short sleep duration induces a state of endocrine stress. DESIGN: A randomized crossover design, with 2 experimental conditions: 3 consecutive nights of short sleep (SS, 4 h/night) and long sleep (LS, 9 h/night) duration. SUBJECTS AND MEASUREMENTS: In 21 healthy, normal-weight male adolescents (mean ± SD age: 16.8 ± 1.3 y) we measured pre- and post-prandial glucose, insulin, C-peptide, and glucagon concentrations. Furthermore, we measured fasting cortisol, 24-h catecholamines, and sympathovagal balance. RESULTS: Fasting insulin was 59% higher (P = 0.001) in the SS than the LS condition as was both fasting (24%, P < 0.001) and post-prandial (11%, P = 0.018) C-peptide. Pre- and post-prandial glucose and glucagon were unchanged between conditions. The homeostasis model assessment of insulin resistance (HOMA-IR) index was 65% higher (P = 0.002) and the Matsuda index was 28% lower (P = 0.007) in the SS condition compared to the LS condition. The awakening cortisol response and 24-h norepinephrine were not affected by sleep duration, whereas 24-h epinephrine was 24% lower (P = 0.013) in the SS condition. Neither daytime nor 24-h sympathovagal balance differed between sleep conditions. Short wave sleep was preserved in the SS condition. CONCLUSION: Short-term sleep restriction is associated with decreased insulin sensitivity in healthy normal-weight adolescent boys. There were no indications of endocrine stress beyond this. CITATION: 2013;36(7):1085-1090.

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Authors
Klingenberg, L., Chaput, J.-P., Holmbäck, U., Visby, T., Jennum, P., Nikolic, M., Astrup, A., & Sjödin, A.
Affiliations
  • University of Copenhagen (DK)
  • Children's Hospital of Eastern Ontario (CA)
  • Uppsala University (SE)
  • MRC Elsie Widdowson Laboratory (GB)
Corresponding author
Klingenberg, Lars
ORCID
Venue
Sleep
Publisher
Oxford University Press (OUP)
Published
2013-07-01
Volume
36
Issue
7
Pages
1085-1090
ISSN
  • 0161-8105 (ISSN-L)
  • 1550-9109
DOI
10.5665/sleep.2816
PMC
PMC3669075
OpenAlex
W2067949421
Semantic Scholar
8736fa4a94d4b02c9c9a94d5535acd90889b2f8f
Cited by
124
References
29
Citations by year
2026: 3 · 2025: 9 · 2024: 8 · 2023: 2 · 2022: 8 · 2021: 10 · 2020: 15 · 2019: 11 · 2018: 13 · 2017: 10 · 2016: 10 · 2015: 14 · 2014: 9 · 2013: 2
FWCI
15.77
Type
journal article
Language
en
Open access
Locations
  • SLEEP (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
sleep restriction, short sleep duration, insulin sensitivity, insulin resistance, glucose metabolism, adolescents, cortisol, catecholamines, sympathovagal balance, C-peptide, glucagon, sleep deprivation

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