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Cited by 182Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGenetic and Kidney Cyst Diseases

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Weight Gain and Dyslipidemia in Early Adulthood Associate With Polycystic Ovary Syndrome: Prospective Cohort Study

Ollila, Meri-Maija E., Piltonen, Terhi, Puukka, Katri, Ruokonen, Aimo, Järvelin, Marjo-Riitta, Tapanainen, Juha S., Franks, Stephen, Morin-Papunen, Laure·2016·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2015-3543
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Abstract

CONTEXT: Obesity affects the majority of women with polycystic ovary syndrome (PCOS), but previous studies are inconsistent about the prevalence of obesity and the importance of weight gain in the development of the syndrome. OBJECTIVE: Our objective was to explore the association between weight, weight gain, hyperandrogenism, and PCOS from adolescence to late adulthood. DESIGN: The study includes a prospective Northern Finland Birth Cohort 1966 study including 5889 females born in 1966 and followed at the ages of 14, 31, and 46 years. SETTING: The setting was the general community. PARTICIPANTS: Women presenting both oligo/amenorrhea (OA) and hirsutism (H) at age 31 (N = 125) or with formally diagnosed PCOS by age 46 (N = 181) were compared with women without PCOS symptoms or diagnosis (n = 1577). INTERVENTIONS: None. MAIN OUTCOME MEASURES: Body mass index (BMI), weight change through life, waist circumference, Free Androgen Index, lipids, glucose, insulin, high-sensitivity C-reactive protein, homeostatic model assessment for insulin resistance, and PCOS. RESULTS: Women with OA+H at age 31 or diagnosis of PCOS by age 46 had the highest BMI at all ages compared with the controls. Increase of BMI between ages 14 and 31, but not between 31 and 46, was greater in women with isolated OA (P = .006), OA+H (P = .001), and diagnosis of PCOS (P = .001) compared with controls. In the multivariate analysis, PCOS was significantly associated with BMI at all ages (BMI at age 31: odds ratio [OR] = 1.05 [95% confidence interval (CI), 1.00-1.10], Free Androgen Index (OR = 1.08 [95% CI, 1.03-1.14]), serum levels of insulin (OR = 1.05 [95% CI, 1.00-1.09]), and triglycerides (OR = 1.48 [95% CI, 1.08-2.03]). CONCLUSIONS: Symptoms or diagnosis of PCOS are associated with dyslipidemia, hyperandrogenemia, and significantly increased weight gain, especially in early adulthood. This observation is important because it may identify a sensitive time period when weight gain plays a crucial role in the emergence of PCOS and when preventive actions against metabolic and cardiovascular diseases should be implemented.

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Metadata

Authors
Ollila, M.-M. E., Piltonen, T., Puukka, K., Ruokonen, A., Järvelin, M.-R., Tapanainen, J. S., Franks, S., & Morin-Papunen, L.
Affiliations
  • Oulu University Hospital (FI)
  • University of Helsinki (FI)
  • NordLab (FI)
Corresponding author
Morin-Papunen, Laure
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2016-02
Volume
101
Issue
2
Pages
739-747
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2015-3543
OpenAlex
W2195897493
Cited by
182
References
43
Citations by year
2026: 16 · 2025: 16 · 2024: 28 · 2023: 18 · 2022: 20 · 2021: 23 · 2020: 21 · 2019: 8 · 2018: 8 · 2017: 13 · 2016: 10
FWCI
11.79
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Spiral (Imperial College London) (submittedVersion)
Funders
  • Finska Läkaresällskapet
  • Medical Research Center Oulu
  • National Institute for Health and Care Research
  • Academy of Finland (24300796, 129269, 1114194, 104781, 120315, 129269, 1114194, 24300796, 120315, 104781)
  • Oulun Yliopisto (75617, 129269)
  • Suomalainen Lääkäriseura Duodecim
  • Medical Research Council (MR/M012638/1)
  • Pohjois-Pohjanmaan Rahasto
  • Biocenter, University of Oulu
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords
polycystic ovary syndrome, weight gain, dyslipidemia, obesity, hyperandrogenism, body mass index, insulin resistance, triglycerides, free androgen index, oligoamenorrhea, hirsutism, early adulthood, Northern Finland Birth Cohort 1966, life course, insulin, C-reactive protein, lipid profile, glucose
MeSH terms
Adolescent, Adult, Body Weight, Female, Humans, Insulin, Lipids, Middle Aged, Polycystic Ovary Syndrome, Prospective Studies, Triglycerides, Cohort Studies, Weight Gain, Body Mass Index, Hyperandrogenism, Age of Onset, Dyslipidemias, Waist Circumference, Young Adult

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