A Longitudinal Assessment of Hormonal and Physical Alterations during Normal Puberty in Boys. V. Rising Leptin Levels May Signal the Onset of Puberty

The adolescent brain and age-related behavioral manifestations

Spear, L. P. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00014-2 · Cited by 5,433

Leptin and the regulation of body weight in mammals

Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.-M., et al. (1998) · Nature · doi:10.1038/32911 · Cited by 2,346

Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

Farooqi, I. S., Jebb, S. A., Langmack, G., Lawrence, E., Cheetham, C. H., Prentice, A. M., Hughes, I. A., McCamish, M. A., & O'Rahilly, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411204 · Cited by 1,998

The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review

Klok, M. D., Jakobsdottir, S., & Drent, M. L. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00270.x · Cited by 1,442

Leptin

Ahima, R. S., & Flier, J. S. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.413 · Cited by 1,428

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15693 · Cited by 1,374

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215693 · Cited by 1,105

The Insulin-Related Ovarian Regulatory System in Health and Disease

Poretsky, L., Cataldo, N. A., Rosenwaks, Z., & Giudice, L. C. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0374 · Cited by 852

Leptin Regulation of Neuroendocrine Systems

Ahima, R. S., Saper, C. B., Flier, J. S., & Elmquist, J. K. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2000.0197 · Cited by 767

Human Leptin Deficiency Caused by a Missense Mutation: Multiple Endocrine Defects, Decreased Sympathetic Tone, and Immune System Dysfunction Indicate New Targets for Leptin Action, Greater Central than Peripheral Resistance to the Effects of Leptin, and Spontaneous Correction of Leptin-Mediated Defects

Ozata, M., Ozdemir, I. C., & Licinio, J. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.5999 · Cited by 739

The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men

Chan, J. L., Heist, K., DePaoli, A. M., Veldhuis, J. D., & Mantzoros, C. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17490 · Cited by 697

Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function.

Ahima, R. S., Prabakaran, D., & Flier, J. S. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1176 · Cited by 643

Leptin in Human Physiology and Pathophysiology

Mantzoros, C. S., Magkos, F., Brinkoetter, M., Sienkiewicz, E., Dardeno, T. A., Kim, S.-Y., Hamnvik, O.-P. R., & Koniaris, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00315.2011 · Cited by 593

Leptin and reproduction: a review

Moschos, S., Chan, J. L., & Mantzoros, C. S. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)03010-2 · Cited by 557

Leptin's Actions on the Reproductive Axis: Perspectives and Mechanisms

Cunningham, M. J., Clifton, D. K., & Steiner, R. A. (1999) · Biology of Reproduction · doi:10.1095/biolreprod60.2.216 · Cited by 532

Serum Leptin Levels in Normal Children: Relationship to Age, Gender, Body Mass Index, Pituitary-Gonadal Hormones, and Pubertal Stage

García-Mayor, R. V., Andrade, M. A., Rios, M., Lage, M., Diéguez, C., & Casanueva, F. F. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.9.4235 · Cited by 517

From leptin to other adipokines in health and disease: Facts and expectations at the beginning of the 21st century

Blüher, M., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.10.016 · Cited by 415

Neuroendocrine Regulation and Actions of Leptin

Casanueva, F. F., & Diéguez, C. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0187 · Cited by 385

Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa.

Chan, J. L., & Mantzoros, C. S. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66830-4 · Cited by 382

Gonadotropin-Releasing Hormone Deficiency in the Human (Idiopathic Hypogonadotropic Hypogonadism and Kallmann's Syndrome): Pathophysiological and Genetic Considerations

Seminara, S. B., Hayes, F. J., & Crowley, W. F. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.5.0344 · Cited by 419

Drug Insight: the role of leptin in human physiology and pathophysiology—emerging clinical applications

Brennan, A. M., & Mantzoros, C. S. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0196 · Cited by 374

The Neuroendocrinology of Human Puberty Revisited

Grumbach, M. M. (2002) · Hormone Research in Paediatrics · doi:10.1159/000058094 · Cited by 362

Delayed Puberty: Analysis of a Large Case Series from an Academic Center

Sedlmeyer, I. L., & Palmert, M. R. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8395 · Cited by 373

Leptin in reproduction

Caprio, M., Fabbrini, E., Isidori, A. M., Aversa, A., & Fabbri, A. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00352-0 · Cited by 308

Leptin signaling

Ahima, R. S., & Osei, S. Y. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.02.014 · Cited by 332

Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women

Licinio, J., Negrão, A. B., Mantzoros, C., Kaklamani, V., Wong, M.-L., Bongiorno, P. B., Mulla, A., Cearnal, L., Veldhuis, J. D., Flier, J. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2541 · Cited by 287

Expression of Functional Leptin Receptors in Rodent Leydig Cells

Caprio, M., Isidori, A. M., Carta, A. R., Moretti, C., Dufau, M. L., & Fabbri, A. (1999) · Endocrinology · doi:10.1210/endo.140.11.7088 · Cited by 289

The role of leptin in regulating bone metabolism

Upadhyay, J., Farr, O. M., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.10.021 · Cited by 277

Adolescent Obesity and Puberty: The “Perfect Storm”

Jasik, C. B., & Lustig, R. H. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1429.009 · Cited by 270

Leptin: physiology and pathophysiology

Frühbeck, G., Jebb, S. A., & Prentice, A. M. (1998) · Clinical Physiology · doi:10.1046/j.1365-2281.1998.00129.x · Cited by 261

Physiological Perspectives on Leptin as a Regulator of Reproduction: Role in Timing Puberty1

Foster, D. L., & Nagatani, S. (1999) · Biology of Reproduction · doi:10.1095/biolreprod60.2.205 · Cited by 229

Gender Differences in Both Spontaneous and Stimulated Leptin Secretion by Human Omental Adipose Tissue in Vitro: Dexamethasone and Estradiol Stimulate Leptin Release in Women, But Not in Men

Casabiell, X. A., Piñeiro, V., Peino, R., Lage, M., Camiña, J. P., Gallego, R., Vallejo, L. G., Diéguez, C., & Casanueva, F. F. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4849 · Cited by 239

Early and late weight gain and the timing of puberty

Dunger, D. B., Ahmed, M. L., & Ong, K. K. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.04.003 · Cited by 225

Leptin—Much More Than a Satiety Signal

Harris, R. B. S. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.45 · Cited by 222

Leptin: in search of role(s) in human physiology and pathophysiology

Mantzoros, C. S., & Moschos, S. J. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00571.x · Cited by 198

Leptin Concentrations in the Polycystic Ovary Syndrome

Mantzoros, C. S., Dunaif, A. E., & Flier, J. S. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.4017 · Cited by 201

Body Mass Index and Timing of Pubertal Initiation in Boys

Lee, J. M., Kaciroti, N., Appugliese, D. P., CORWYN, R. F., Bradley, R. H., & Lumeng, J. C. (2010) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpediatrics.2009.258 · Cited by 194

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215693 · Cited by 183

Role of Leptin in Reproduction

Mantzoros, C. S. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06228.x · Cited by 177

Effect of Puberty on the Relationship between Circulating Leptin and Body Composition

Horlick, M. N. B., ROSENBAUM, M. S., Nicholson, M., Levine, L. S., Fedun, B., Wang, J., Pierson, R. N., & Leibel, R. L. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6689 · Cited by 182

Leptin is a growth factor in cancer

Somasundar, P. S., McFadden, D. W., Hileman, S. M., & Vona-Davis, L. C. (2004) · Journal of Surgical Research · doi:10.1016/j.jss.2003.09.004 · Cited by 167

Zinc May Regulate Serum Leptin Concentrations in Humans

Mantzoros, C. S., Prasad, A. S., Beck, F. W. J., Grabowski, S. M., Kaplan, J., Adair, C., & Brewer, G. J. (1998) · Journal of the American College of Nutrition · doi:10.1080/07315724.1998.10718758 · Cited by 169

Menstrual disorders in adolescence: investigation and management

Hickey, M. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg038 · Cited by 160

Relationship between Concentration of Serum Leptin and Fetal Growth

Harigaya, A., Nagashima, K., Nako, Y., & Morikawa, A. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4321 · Cited by 160

Effects of obesity on growth and puberty

Dunger, D. B., Ahmed, M. L., & Ong, K. K. (2005) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2005.04.005 · Cited by 158

Adrenarche and the evolution of human life history

Campbell, B. (2006) · American Journal of Human Biology · doi:10.1002/ajhb.20528 · Cited by 150

Androgens before and after Weight Loss in Obese Children

Reinehr, T., de Sousa, G., Roth, C. L., & Andler, W. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0438 · Cited by 149

The long-term effect of recombinant methionyl human leptin therapy on hyperandrogenism and menstrual function in female and pituitary function in male and female hypoleptinemic lipodystrophic patients

Musso, C., Cochran, E., Javor, E., Young, J., DePaoli, A. M., & Gorden, P. (2005) · Metabolism · doi:10.1016/j.metabol.2004.08.021 · Cited by 146

Age and sex differences in immune response following LPS treatment in mice

Cai, K. C., van Mil, S., Murray, E., Mallet, J., Matar, C., & Ismail, N. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.08.002 · Cited by 151

Hormonal and Body Composition Predictors of Soluble Leptin Receptor, Leptin, and Free Leptin Index in Adolescent Girls with Anorexia Nervosa and Controls and Relation to Insulin Sensitivity

Misra, M., Miller, K. K., Almazan, C., Ramaswamy, K., Aggarwal, A., Herzog, D. B., Neubauer, G., Breu, J., & Klibanski, A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032251 · Cited by 144

Leptin in reproduction.

Blüher, S., & Mantzoros, C. S. (2007) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e3282f1cfdc · Cited by 142

Influences on the onset and tempo of puberty in human beings and implications for adolescent psychological development

Lee, Y., & Styne, D. M. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.03.014 · Cited by 145

Chronic Administration of Leptin into the Lateral Ventricle Induces Sexual Maturation in Severely Food‐restricted Female Rats

Gruaz, N. M., Lalaoui, M., Pierroz, D. D., Englaro, P., Sizoneko, P. C., Blum, W. F., & Aubert, M. L. (1998) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1998.00247.x · Cited by 135

Biology of leptin in the pig

Barb, C. R., Hausman, G. J., & Houseknecht, K. L. (2001) · Domestic Animal Endocrinology · doi:10.1016/s0739-7240(01)00123-0 · Cited by 145

Central precocious puberty: clinical and laboratory features*

Chemaitilly, W., Trivin, C., Adan, L., et al. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01229.x · Cited by 137

Leptin in human pregnancy: The relationship with gestational hormones

Sivan, E., Whittaker, P. G., Sinha, D., Homko, C. J., Lin, M. T., Reece, E. A., & Boden, G. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70118-8 · Cited by 133

Leptin Promotes the Development of Mouse Preimplantation Embryos in Vitro

Kawamura, K., Sato, N., Fukuda, J., Kodama, H., Kumagai, J., Tanikawa, H., Nakamura, A., & Tanaka, T. (2002) · Endocrinology · doi:10.1210/endo.143.5.8818 · Cited by 141

Childhood Obesity, Adipose Tissue Distribution, and the Pediatric Practitioner

Slyper, A. H. (1998) · PEDIATRICS · doi:10.1542/peds.102.1.e4 · Cited by 133

Ten years of leptin replacement therapy

Paz-Filho, G., Wong, M., & Licinio, J. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00840.x · Cited by 130

Metabolic signals in human puberty: Effects of over and undernutrition

Martos‐Moreno, G. Á., Chowen, J. A., & Argente, J. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.12.017 · Cited by 132

Leptin attenuates follicular apoptosis and accelerates the onset of puberty in immature rats

Almog, B., Gold, R., Tajima, K., Dantes, A., Salim, K., Rubinstein, M., Barkan, D., Homburg, R., Lessing, J. B., Nevo, N., et al. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00543-3 · Cited by 126

Effect of Leptin Replacement on Pituitary Hormone Regulation in Patients with Severe Lipodystrophy

Oral, E. A., Ruiz, E., Andewelt, A., Sebring, N., Wagner, A. J., Depaoli, A. M., & Gorden, P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.7.8591 · Cited by 129

Leptin Levels in Pregnant Women and Newborn Infants: Gender Differences and Reduction During the Neonatal Period

Helland, I. B., Reseland, J. E., Saugstad, O. D., & Drevon, C. A. (1998) · PEDIATRICS · doi:10.1542/peds.101.3.e12 · Cited by 121

Leptin regulation of reproductive function and fertility

Smith, G. D., Jackson, L. M., & Foster, D. L. (2002) · Theriogenology · doi:10.1016/s0093-691x(01)00658-6 · Cited by 122

A heliocentric view of leptin

Frühbeck, G. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200196 · Cited by 120

Serum Leptin, Gonadotropin, and Testosterone Concentrations in Male Patients with Anorexia Nervosa during Weight Gain

Wabitsch, M., Ballauff, A., Holl, R. W., Blum, W. F., Heinze, E., Remschmidt, H., & Hebebrand, J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.7.7685 · Cited by 115

High-fructose diet during periadolescent development increases depressive-like behavior and remodels the hypothalamic transcriptome in male rats

Harrell, C. S., Burgado, J., Kelly, S. D., Johnson, Z. P., & Neigh, G. N. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.08.025 · Cited by 107

20 YEARS OF LEPTIN: Role of leptin in human reproductive disorders

Chou, S. H.-H., & Mantzoros, C. S. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0245 · Cited by 110

Leptin: A Molecule Integrating Somatic Energy Stores, Energy Expenditure and Fertility

ROSENBAUM, M. S., & Leibel, R. L. (1998) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(98)00028-9 · Cited by 109

Implications of leptin in neuroendocrine regulation of male reproduction

Landry, D. A., Cloutier, F., & Martin, L. J. (2013) · Reproductive Biology · doi:10.1016/j.repbio.2012.12.001 · Cited by 111

Leptin: obesity, diabetes and other peripheral effects - a review

Moran, O., & Phillip, M. (2003) · Pediatric Diabetes · doi:10.1034/j.1399-5448.2003.00017.x · Cited by 110

Adipose tissue and reproductive health

Mathew, H., Castracane, V. D., & Mantzoros, C. S. (2017) · Metabolism · doi:10.1016/j.metabol.2017.11.006 · Cited by 109

Serum leptin concentrations in relation to pubertal development

Carlsson, B., Ankarberg‐Lindgren, C., Rosberg, S., Norjavaara, E., Albertsson-Wikland, K. G., & Carlsson, L. M. S. (1997) · Archives of Disease in Childhood · doi:10.1136/adc.77.5.396 · Cited by 100

Neurobiological Bases Underlying the Control of the Onset of Puberty in the Rhesus Monkey: A Representative Higher Primate

Plant, T. M. (2001) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0211 · Cited by 99

The soluble leptin receptor

Schaab, M., & Kratzsch, J. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2015.08.002 · Cited by 101

Leptin, Nutrition, and Reproduction: Timing Is Everything

Hileman, S. M., Pierroz, D. D., & Flier, J. S. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.2.6490 · Cited by 103

Effect of Leptin on CYP17 Enzymatic Activities in Human Adrenal Cells: New Insight in the Onset of Adrenarche 1

Biason-Lauber, A., Zachmann, M., & Schoenle, E. J. (2000) · Endocrinology · doi:10.1210/endo.141.4.7402 · Cited by 98

Leptin mRNA expression and serum leptin concentrations as influenced by age, weight, and estradiol in pigs

Qian, H., Barb, C. R., Compton, M. M., Hausman, G. J., Azain, M. J., Kraeling, R. R., & Baile, C. A. (1999) · Domestic Animal Endocrinology · doi:10.1016/s0739-7240(99)00004-1 · Cited by 101

Leptin and Hormones

Triantafyllou, G. A., Paschou, S. Α., & Mantzoros, C. S. (2016) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2016.04.012 · Cited by 101

Interpretation of reproductive hormones before, during and after the pubertal transition—Identifying health and disordered puberty

Howard, S. R. (2021) · Clinical Endocrinology · doi:10.1111/cen.14578 · Cited by 110

What controls the timing of puberty? An update on progress from genetic investigation

Gajdos, Z. K. Z., Hirschhorn, J. N., & Palmert, M. R. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328320253c · Cited by 95

Leptin: a possible link between food intake, energy expenditure, and reproductive function

Magni, P., Motta, M., & Martini, L. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00149-x · Cited by 95

The influence of puberty onset, Body Mass Index, and pressure to be thin on disordered eating behaviors in children and adolescents

Tremblay, L., & Larivière, M. A. S. (2008) · Eating Behaviors · doi:10.1016/j.eatbeh.2008.12.001 · Cited by 104

Adipose tissue and reproduction in women

BOHLER, H. C. L., Mokshagundam, S. L., & Winters, S. J. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.03.079 · Cited by 96

Pathogenesis of polycystic ovary syndrome: what is the role of obesity?

Salehi, M., Bravo-Vera, R., Sheikh, A., Gouller, A., & Poretsky, L. (2004) · Metabolism · doi:10.1016/j.metabol.2003.10.005 · Cited by 90

Puberty in Chronically Diseased Patients

Simon, D. (2002) · Hormone Research in Paediatrics · doi:10.1159/000058102 · Cited by 89

Current concepts concerning the role of leptin in reproductive function

Holness, M. J., Munns, M. J., & Sugden, M. C. (1999) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(99)00126-4 · Cited by 85

A Role for Leptin in Sexual Maturation and Puberty?

Kiess, W., Reich, A., Meyer, K., Glasow, A., Deutscher, J., Klammt, J., Yang, Y., Müller, G., & Kratzsch, J. (1999) · Hormone Research in Paediatrics · doi:10.1159/000053163 · Cited by 84

The Acute Effects of Leptin Require PI3K Signaling in the Hypothalamic Ventral Premammillary Nucleus

Williams, K. W., Sohn, J., Donato, J., Lee, C. E., Zhao, J. J., Elmquist, J. K., & Elias, C. F. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2602-11.2011 · Cited by 82

Genetic Variants in the LEPR , CRY1 , RNASEL , IL4 , and ARVCF Genes Are Prognostic Markers of Prostate Cancer-Specific Mortality

Lin, D. W., FitzGerald, L. M., Fu, R., Kwon, E. M., Zheng, S. L., Kolb, S., Wiklund, F. E., Stattin, P. E., Isaacs, W. B., Xu, J., et al. (2011) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-11-0236 · Cited by 81

Roles of Leptin in Reproduction, Pregnancy and Polycystic Ovary Syndrome: Consensus Knowledge and Recent Developments

Vazquez, M. J., Romero‐Ruíz, A., & Tena‐Sempere, M. (2014) · Metabolism · doi:10.1016/j.metabol.2014.10.013 · Cited by 82

Functional and Phenotypic Characteristics of Human Leptin Receptor Mutations

Nunziata, A., Funcke, J., Borck, G., von Schnurbein, J., Brandt, S., Lennerz, B. S., Moepps, B., Gierschik, P., Fischer‐Posovszky, P., & Wabitsch, M. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2018-00123 · Cited by 85

Leptin in relation to prostate cancer and benign prostatic hyperplasia

Λάγιου, Π., Signorello, L. B., Trichopoulos, D., Τζώνου, Α., Trichopoulou, A., & Mantzoros, C. S. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19980330)76:1 · Cited by 76

Phenotypic Effects of Leptin in an Ectotherm: A New Tool to Study the Evolution of Life Histories and Endothermy?

Niewiarowski, P. H., Balk, M. L., & Londraville, R. L. (2000) · Journal of Experimental Biology · doi:10.1242/jeb.203.2.295 · Cited by 78

Determinants of Early Life Leptin Levels and Later Life Degenerative Outcomes

Alexe, D. M., Syridou, G., & Petridou, E. T. (2006) · Clinical Medicine & Research · doi:10.3121/cmr.4.4.326 · Cited by 77

The Impact of Reversible Gonadal Sex Steroid Suppression on Serum Leptin Concentrations in Children with Central Precocious Puberty1

Palmert, M. R., Radovick, S., & Boepple, P. A. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.4.4700 · Cited by 77

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