Fat Accumulation in the Liver Is Associated with Defects in Insulin Suppression of Glucose Production and Serum Free Fatty Acids Independent of Obesity in Normal Men

Nonalcoholic Fatty Liver Disease: A Novel Cardiometabolic Risk Factor for Type 2 Diabetes and Its Complications

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High-Fat Diet Reduces the Formation of Butyrate, but Increases Succinate, Inflammation, Liver Fat and Cholesterol in Rats, while Dietary Fibre Counteracts These Effects

Jakobsdottir, G., Xu, J., Molin, G., Ahrné, S., & NYMAN, M. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080476 · Cited by 295

Ethnic-Specific Criteria for Classification of Body Mass Index: A Perspective for Asian Indians and American Diabetes Association Position Statement

Misra, A. (2015) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2015.0007 · Cited by 292

C-reactive protein and the development of the metabolic syndrome and diabetes in middle-aged men

Laaksonen, D. E., NISKANEN, L. K., Nyyss�nen, K., Punnonen, K. R. A., Tuomainen, T., Valkonen, V.-P., Salonen, R. M., & Salonen, J. T. (2004) · Diabetologia · doi:10.1007/s00125-004-1472-x · Cited by 290

Dietary carbohydrates and fats in nonalcoholic fatty liver disease

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Gastric Bypass Surgery Improves Metabolic and Hepatic Abnormalities Associated With Nonalcoholic Fatty Liver Disease

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Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis

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Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism

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The role of glucocorticoid action in the pathophysiology of the Metabolic Syndrome

Wang, M. (2005) · Nutrition & Metabolism · doi:10.1186/1743-7075-2-3 · Cited by 284

Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study

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High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease

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Effects of Identical Weight Loss on Body Composition and Features of Insulin Resistance in Obese Women With High and Low Liver Fat Content

Tiikkainen, M., Bergholm, R., Vehkavaara, S., Rissanen, A., Häkkinen, A.-M., Tamminen, M., Teramo, K., & Yki-Järvinen, H. (2003) · Diabetes · doi:10.2337/diabetes.52.3.701 · Cited by 271

Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance

Stanhope, K. L., & Havel, P. J. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282f2b24a · Cited by 274

Fat in the liver and insulin resistance

Yki‐Järvinen, H. (2005) · Annals of Medicine · doi:10.1080/07853890510037383 · Cited by 269

Hepatic Steatosis: A Mediator of the Metabolic Syndrome. Lessons From Animal Models

den Boer, M., Voshol, P. J., Kuipers, F., Havekes, L. M., & Romijn, J. A. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000116217.57583.6e · Cited by 260

Kupffer cell activation is a causal factor for hepatic insulin resistance

Lanthier, N., Molendi‐Coste, O., Horsmans, Y., van Rooijen, N., Cani, P. D., & Leclercq, I. A. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00391.2009 · Cited by 269

Non-invasive means of measuring hepatic fat content

Mehta, S. R., Thomas, E. L., Bell, J. D., Johnston, D. G., & Taylor-Robinson, S. D. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.3476 · Cited by 259

Polycystic Ovary Syndrome with Hyperandrogenism Is Characterized by an Increased Risk of Hepatic Steatosis Compared to Nonhyperandrogenic PCOS Phenotypes and Healthy Controls, Independent of Obesity and Insulin Resistance

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Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease

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Standardized assessment of whole body adipose tissue topography by MRI

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Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver

Kotronen, A., Seppänen‐Laakso, T., Westerbacka, J., Kiviluoto, T. A., Arola, J. T., Ruskeepää, A., Orešič, M., & Yki‐Järvinen, H. (2008) · Diabetes · doi:10.2337/db08-1074 · Cited by 253

Nonalcoholic Fatty Liver Disease Is a Risk Factor for Type 2 Diabetes in Middle-Aged Japanese Men

Shibata, M., Kihara, Y., Taguchi, M., Tashiro, M., & Otsuki, M. (2007) · Diabetes Care · doi:10.2337/dc07-0792 · Cited by 238

Dysfunctional fat cells, lipotoxicity and type 2 diabetes

Defronzo, R. A. (2004) · International Journal of Clinical Practice · doi:10.1111/j.1368-504x.2004.00389.x · Cited by 236

Fructose as a key player in the development of fatty liver disease

Basaranoglu, M. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i8.1166 · Cited by 235

The Spectrum of Achalasia: Lessons From Studies of Pathophysiology and High-Resolution Manometry

Kahrilas, P. J., & Boeckxstaens, G. E. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.038 · Cited by 236

Eating two larger meals a day (breakfast and lunch) is more effective than six smaller meals in a reduced-energy regimen for patients with type 2 diabetes: a randomised crossover study

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Metabolic syndrome and non-alcoholic fatty liver disease

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Intrahepatic Diacylglycerol Content Is Associated With Hepatic Insulin Resistance in Obese Subjects

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Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance

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Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver

Milanski, M., Arruda, A. P., Coope, A., Ignácio-Souza, L. M., Nuñez, C. E. C., Roman, E. A., Romanatto, T., Pascoal, L. B., Caricilli, A. M., Torsoni, M. A., et al. (2012) · Diabetes · doi:10.2337/db11-0390 · Cited by 233

Pathogenesis of nonalcoholic steatohepatitis

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Prevalence of non-alcoholic fatty liver disease in urban south Indians in relation to different grades of glucose intolerance and metabolic syndrome

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Central Role of Fatty Liver in the Pathogenesis of Insulin Resistance in Obese Adolescents

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Effect of 6‐Month Calorie Restriction and Exercise on Serum and Liver Lipids and Markers of Liver Function

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Enigmatic Ectopic Fat: Prevalence of Nonalcoholic Fatty Pancreas Disease and Its Associated Factors in a Chinese Population

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Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor

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Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver

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Exercise Reduces Liver Lipids and Visceral Adiposity in Patients With Nonalcoholic Steatohepatitis in a Randomized Controlled Trial

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Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism

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Effect of liver fat on insulin clearance

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Adipose tissue distribution is different in type 2 diabetes

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Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance

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A Choline-Deficient Diet Exacerbates Fatty Liver but Attenuates Insulin Resistance and Glucose Intolerance in Mice Fed a High-Fat Diet

Raubenheimer, P. J., Nyirenda, M., & Walker, B. R. (2006) · Diabetes · doi:10.2337/db06-0097 · Cited by 199

Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations

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Thematic review series: Patient-Oriented Research. Free fatty acid metabolism in human obesity

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Nonalcoholic fatty liver disease: Evolving paradigms

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Primacy of Hepatic Insulin Resistance in the Development of the Metabolic Syndrome Induced by an Isocaloric Moderate-Fat Diet in the Dog

Kim, S. P., Ellmerer, M., Citters, G. W. V., & Bergman, R. N. (2003) · Diabetes · doi:10.2337/diabetes.52.10.2453 · Cited by 195

Influence of Hepatic Steatosis (Fatty Liver) on Severity and Composition of Dyslipidemia in Type 2 Diabetes

Toledo, F. G. S., Sniderman, A. D., & Kelley, D. E. (2006) · Diabetes Care · doi:10.2337/dc06-0455 · Cited by 196

Pathogenesis and pathophysiology of the cardiometabolic syndrome

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Effect of fenofibrate and niacin on intrahepatic triglyceride content, very low-density lipoprotein kinetics, and insulin action in obese subjects with nonalcoholic fatty liver disease

Fabbrini, E., Mohammed, B. S., Korenblat, K. M., Magkos, F., McCrea, J., Patterson, B. W., & Klein, S. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2622 · Cited by 192

Quantification of Liver Fat Content: Comparison of Triple-Echo Chemical Shift Gradient-Echo Imaging and in Vivo Proton MR Spectroscopy

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Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms

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A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels

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Hypoadiponectinemia Predicts the Severity of Hepatic Fibrosis and Pancreatic Beta-Cell Dysfunction in Nondiabetic Nonobese Patients with Nonalcoholic Steatohepatitis

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Peroxisome Proliferator–Activated Receptor-α Agonist Treatment in a Transgenic Model of Type 2 Diabetes Reverses the Lipotoxic State and Improves Glucose Homeostasis

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Rosiglitazone in the Treatment of Haart-Associated Lipodystrophy – a Randomized Double-Blind Placebo-Controlled Study

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Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies

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Hepatic Steatosis as a Marker of Metabolic Dysfunction

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Increased Expression and Activity of the Transcription Factor FOXO1 in Nonalcoholic Steatohepatitis

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Modulation of sterol regulatory element binding proteins (SREBPs) as potential treatments for non-alcoholic fatty liver disease (NAFLD)

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Interleukin-10 is a protective factor against diet-induced insulin resistance in liver

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CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice

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Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B–null mice

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Abdominal Obesity and Fatty Liver

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Body Fat Distribution and Cortisol Metabolism in Healthy Men: Enhanced 5β-Reductase and Lower Cortisol/Cortisone Metabolite Ratios in Men with Fatty Liver

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The Emerging Functions of UCP2 in Health, Disease, and Therapeutics

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PEDIATRIC OBESITY AND INSULIN RESISTANCE: Chronic Disease Risk and Implications for Treatment and Prevention Beyond Body Weight Modification

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Nonalcoholic fatty liver disease and polycystic ovary syndrome

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Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes?

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Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids

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Concurrent exercise prevents high-fat-diet-induced macrovesicular hepatic steatosis

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The Association between Nonalcoholic Fatty Pancreas Disease and Diabetes

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Glucose dysregulation and hepatic steatosis in obese adolescents

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Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans

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Role of ChREBP in hepatic steatosis and insulin resistance

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Cohort Study of Non-alcoholic Fatty Liver Disease, NAFLD fibrosis score, and the Risk of Incident Diabetes in a Korean population

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Hepatic lipid accumulation in healthy subjects: A comparative study using spectral fat‐selective MRI and volume‐localized 1H‐MR spectroscopy

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Control of Adipocyte Differentiation in Different Fat Depots; Implications for Pathophysiology or Therapy

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Sterol Regulatory Element-binding Protein-1 (SREBP-1) Is Required to Regulate Glycogen Synthesis and Gluconeogenic Gene Expression in Mouse Liver

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