Levels of plasma steroid glucuronides in intact and castrated men with prostatic cancer.

BÉLANGER, ALAIN; BROCHU, MICHÈLE; CLICHE, JACQUES

doi:10.1210/jcem-62-5-812

Cited by 108Prostate Cancer Treatment and ResearchHormonal and reproductive studiesAdrenal Hormones and Disorders

Levels of plasma steroid glucuronides in intact and castrated men with prostatic cancer.

BÉLANGER, ALAIN, BROCHU, MICHÈLE, CLICHE, JACQUES·1986·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-62-5-812

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Abstract

The levels of plasma dehydroepiandrosterone (DHEA), androst-5-ene-3 beta,17 beta-diol (delta 5-diol), testosterone (T), dihydrostestosterone (DHT), androstane-3 alpha,17 beta-diol (3 alpha-diol), androsterone (ADT), and the related glucuronide (G) derivatives were determined in intact and castrated men with prostatic cancer. The plasma concentrations of DHEA and DHEA-G were not significantly different in intact and castrated men while delta 5-diol as well as delta 5-diol-G were 50% lowered in castrated men. As expected, T and DHT concentrations were markedly lower in castrated men. These low plasma levels of T and DHT were accompanied by a decrease of 3 alpha-diol, ADT, T-G, 3 alpha-diol-G, and ADT-G levels. There was, in unoperated men, a positive correlation between the levels of DHEA and ADT-G as well as DHEA and DHEA-G, while T values were highly correlated with ADT-G and 3 alpha-diol-G levels. Furthermore, a significant relationship was found between DHEA and ADT-G as well as 3 alpha-diol-G in castrated men. Our data clearly demonstrate that ADT-G and 3 alpha-diol-G levels are more affected by castration than are the corresponding unconjugated steroids and suggest that these steroid glucuronides should be good markers of androgen metabolism. Moreover, the significant relationship between DHEA, ADT-G, and 3 alpha-diol-G in castrated men also suggests that approximately 30% of C-19 steroids from the adrenals are converted to T and DHT, which are further transformed into steroid glucuronides.

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Approximately 50% of total androgens in the prostate of adult men derive from DHEA and DHEA-S.
“approximately 50% of total androgens in the prostate of adult men derive from these adrenal precursor steroids (77, 87, 88).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [87]

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Authors: BÉLANGER, A., BROCHU, M., & CLICHE, J.
Affiliations: Université Laval (CA)
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1986-05
Volume: 62
Issue: 5
Pages: 812-815
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-62-5-812
OpenAlex: W2071199069
Cited by: 108
References: 20
Citations by year: 2023: 1 · 2019: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 2
FWCI: 9.54
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: steroid glucuronides, prostate cancer, castration, androgen metabolism, dehydroepiandrosterone, androstanediol glucuronide, androstanediol, testosterone, dihydrotestosterone, plasma steroid levels
MeSH terms: Aged, Androgens, Androsterone, Dehydroepiandrosterone, Glucuronates, Humans, Male, Middle Aged, Orchiectomy, Prostatic Neoplasms, Dihydrotestosterone, Testosterone, Androstane-3,17-diol, Androstenediol

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Levels of plasma steroid glucuronides in intact and castrated men with prostatic cancer.

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