Non-invasive measurement of small peptides in the common marmoset (Callithrix jacchus): A radiolabeled clearance study and endogenous excretion under varying social conditions
Abstract
A non-invasive assay for measurement of oxytocin (OT) and vasopressin (AVP) in primates would enable researchers to study the relationship between the endocrine system and behavior without disturbing potentially endangered animals in their natural habitats. In order to test whether or not OT specifically would be measurable in the urine of a primate, 10 microCi of tritium-labeled OT were injected into the peripheral blood supply of four adult male common marmosets (Callithrix jacchus), with continuous urinary collection over 48 h. When urine was processed by HPLC separation and beta counting for radioactive clearance, the label was present in all samples in the fraction where OT elutes. Large amounts of OT were also seen in a fraction other than that containing the OT standard, indicating that OT is measurable but that it also undergoes substantial metabolic breakdown. In a second experiment, we isolated six common marmosets for 48 h and then exposed them to social contact to evaluate the effect of changing social stimuli on endogenous urinary measurement of both OT and AVP. Both were measured after HPLC separation to isolate the intact molecule and also to control for cross-reactivity with metabolites in subsequent RIA. Cortisol was also measured to objectively evaluate the stress response. A priori assumptions were that urinary OT and AVP would be lower during a period of isolation and higher during periods of social contact. These assumptions were met, leading us to conclude that peripheral OT and AVP are measurable via urinary assay and that such an assay is a valid means of evaluating social condition in this species.
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Peripheral measures of oxytocin from plasma or urine correlate positively with psychological and behavioural patterns, indicating that peripheral oxytocin levels reflect central processing of oxytocin.
“Significantly, peripheral measures of oxytocin from plasma or urine correlate positively with psychological and behavioural patterns, such as aversion reduction in male mice [19], social contact in marmosets [40], lactation in rhesus macaques [41], rates of affiliative behaviours in pair-bonded tamarins [42] and grooming in closely bonded chimpanzees [15], indicating that peripheral oxytocin level”
From Food sharing is linked to urinary oxytocin levels and bonding in related and unrelated wild chimpanzees (2014) · cites this paper as [40]
Congruent patterns are observed when linking social behaviors to endogenous measures of oxytocin in plasma, urine or saliva in non-human primates and humans.
“Congruent patterns are observed when linking social behaviors to endogenous measures of oxytocin in plasma, urine or saliva in non-human primates (Seltzer and Ziegler, 2007; Maestripieri et al., 2009; Snowdon et al., 2010; Crockford et al., 2013) and humans (Christensson et al., 1989; Holt-Lunstad et al., 2008; Morhenn et al., 2008; Gordon et al., 2010).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Seltzer and Ziegler, 2007
For humans and the common marmoset, radiolabeled studies indicate a time course from circulation into the urine as 30-60 min for peak levels to appear, and this window appears consistent across the primate order.
“For humans and the common marmoset, radiolabeled studies have indicated a time course from circulation into the urine as 30–60 min for peak levels to appear (Amico et al., 1987; Seltzer and Ziegler, 2007). This indicates that when examining responses to an event, the desired collection time would be within this window and the window appears to be consistent across the primate order.”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Seltzer and Ziegler, 2007
Validations to test for this have been performed for several primate species (cotton-top tamarins, marmoset, humans, chimpanzees).
“Validations to test for this have been performed for several primate species (cotton-top tamarins: Snowdon et al., 2010; marmoset: Seltzer and Ziegler, 2007; humans: Seltzer et al., 2010; chimpanzees: Ziegler et al., unpublished data).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Seltzer and Ziegler, 2007
HPLC separation and validation with the assay antibody can assure that the assay is exclusively measuring the intact oxytocin and/or peptides that stem from oxytocin metabolism in the sample.
“HPLC separation and validation with the assay antibody can assure that the assay is exclusively measuring the intact oxytocin and/or peptides that stem from the oxytocin metabolism in the sample (Seltzer and Ziegler, 2007).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Seltzer and Ziegler, 2007
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Primate Personality and Behavioral Endocrinology
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Does mirror enrichment improve primate well-being?
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Plasma and Urinary Oxytocin Trajectories in Extremely Premature Infants During NICU Hospitalization
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Validation of a commercial enzyme immunoassay to assess urinary oxytocin in humans
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Physical Examination, Diagnosis, and Common Clinical Procedures
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RetractedSerres‐Corral, P., Almagro, V., Carbonell, L., Borragan, S., Martínez‐Nevado, E., Quevedo, M. Á., Fernández-Bellón, H., Carbajal, A., & López‐Béjar, M. (2025) · Animals · doi:10.3390/ani15162409 · Cited by 1 · see citing works
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Oxytocin and Romantic Relationships: A Functional Perspective
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Gnanadesikan, G. E., Hammock, E. A. D., Tecot, S. R., Lewis, R. J., Hart, R., Carter, C. S., & MacLean, E. L. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.03.482682
- Authors
- Seltzer, L. J., & Ziegler, T. E.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Seltzer, Leslie J.
- ORCID
- Ziegler, Toni E.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2007-03
- Volume
- 51
- Issue
- 3
- Pages
- 436-442
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W2025018957
- Semantic Scholar
- 1fa261864b504d6206ba09f72ed36eef1924586a
- Cited by
- 58
- References
- 56
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 10 · 2017: 1 · 2016: 5 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 4
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (P51OD011106)
- National Institute of Mental Health (R21MH070423)
- National Center for Research Resources (RR 000167, P51RR000167)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, vasopressin, Callithrix jacchus, social isolation, social contact, cortisol, stress response, primate endocrinology
- MeSH terms
- Animals, Callithrix, Creatinine, Hydrocortisone, Injections, Intravenous, Male, Metabolic Clearance Rate, Oxytocin, Social Environment, Tritium, Vasopressins, Behavioral Research
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