Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review

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1. Effects of Recombinant Human Growth Hormone Therapy on Bone Mineral Density in Adults With Growth Hormone Deficiency: A Meta-Analysis
   Barake, Maya, Klibanski, Anne, Tritos, Nicholas A. · 2014 · The Journal of Clinical Endocrinology & Metabolism
2. Five Years of Growth Hormone Replacement Therapy in Adults: Age- and Gender-Related Changes in Isometric and Isokinetic Muscle Strength
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3. Interplay of IGF-I and 17β-estradiol at age-specific levels in human sebocytes and fibroblasts in vitro
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4. Growth Hormone-Releasing Hormone Combined with Arginine or Growth Hormone Secretagogues for the Diagnosis of Growth Hormone Deficiency in Adults
   Ezio Ghigo, Gianluca Aimaretti, Emanuela Arvat · 2001 · Endocrine
5. Does long-term GH replacement therapy in hypopituitary adults with GH deficiency normalise quality of life?
   Maria Kołtowska‐Häggström, Anders F. Mattsson, John P. Monson, Paul Kind, Xavier Costa Badia, Felipe F. Casanueva, Jan J.V. Busschbach, Hans P. F. Koppeschaar, Gudmundur Johannsson · 2006 · European Journal of Endocrinology
6. Intact Insulin and Insulin-Like Growth Factor-I Receptor Signaling Is Required for Growth Hormone Effects on Skeletal Muscle Growth and Functionin Vivo
   Hyunsook Kim, Elisabeth R. Barton, Naser Muja, Shoshana Yakar, Patricia Alejandra Pennisi, Derek LeRoith · 2004 · Endocrinology
7. Cognitive, emotional, physical and social effects of growth hormone treatment in adults with Prader–Willi syndrome
   Charlotte Höybye, Magnus Thoren, Birgitta Böhm · 2005 · Journal of Intellectual Disability Research
8. Isolated growth hormone (GH) deficiency in adult patients: baseline clinical characteristics and responses to GH replacement in comparison with hypopituitary patients. A sub-analysis of the KIMS database
   Abs, Roger, Mattsson, Anders F., Bengtsson, Bengt-Åke, Feldt-Rasmussen, Ulla, Góth, Miklós I., Koltowska-Häggström, Maria, Monson, John P., Verhelst, Johan, Wilton, Patrick · 2005 · Growth Hormone & IGF Research
9. Fatigue after TBI: Association with neuroendocrine abnormalities
   Tamara L. Bushnik, Jeffrey Englander, Laurence J. Katznelson · 2007 · Brain Injury
10. The Effects of Growth Hormone Replacement Therapy on Bone Metabolism in Adult-Onset Growth Hormone Deficiency: A 2-Year Open Randomized Controlled Multicenter Trial
    Marie Bex, Roger Abs, Dominique M. Maiter, Albert M. Beckers, G. Lamberigts, Roger Bouillon · 2002 · Journal of Bone and Mineral Research
11. Cytokines and Bone Loss in a 5-Year Longitudinal Study—Hormone Replacement Therapy Suppresses Serum Soluble Interleukin-6 Receptor and Increases Interleukin-1-Receptor Antagonist: The Danish Osteoporosis Prevention Study
    Bo Abrahamsen, Vagn Bonnevie‐Nielsen, E.N. Ebbesen, Jeppe Gram, Henning Beck‐Nielsen · 2000 · Journal of Bone and Mineral Research
12. Growth Hormone and Sex Steroid Effects on Bone Metabolism and Bone Mineral Density in Healthy Aged Women and Men
    Colleen Christmas, K. G. O'Connor, Sherman Mitchell Harman, J. D. Tobin, Thomas Münzer, Michele F. Bellantoni, Caryn St. Clair, K. M. Pabst, John David Sorkin, Marc R. Blackman · 2002 · The Journals of Gerontology Series A
13. Diagnosis and treatment of growth hormone deficiency in adults
    Atil Y. Kargi, George R. Merriam · 2013 · Nature Reviews Endocrinology
14. Distribution of growth hormone-responsive cells in the mouse brain
    Isadora C. Furigo, Martin Metzger, Pryscila D. S. Teixeira, Carlos Roberto Jorge Soares, José Donato · 2016 · Brain Structure and Function
15. The effect of long‐term untreated growth hormone deficiency (GHD) and 9 years of GH replacement on the quality of life (QoL) of GH‐deficient adults
    Francis J. Gilchrist, Robert Douglas Murray, Stephen Michael Shalet · 2002 · Clinical Endocrinology
16. Lack of Evidence of Premature Atherosclerosis in Untreated Severe Isolated Growth Hormone (GH) Deficiency due to a GH-Releasing Hormone Receptor Mutation
    Joselina Luzia Menezes Oliveira, Celi Marques-Santos, José Augusto Barreto‐Filho, Roberto Ximenes, Allan Valadão de Oliveira Britto, Anita H. O. Souza, Clarisse Miranda Prado, Carla R. P. Oliveira, Rossana M. C. Pereira, Tábita A. R. Vicente et al. · 2006 · The Journal of Clinical Endocrinology & Metabolism
17. Biochemical and Biophysical Markers of Endothelial Dysfunction in Adults with Hypopituitarism and Severe GH Deficiency
    Tarik Abdelkareim Elhadd, Tarig A. M. Abdu, J. Oxtoby, Gwen Kennedy, M. McLaren, Richard H. Neary, J. J. F. Belch, Richard N. Clayton · 2001 · The Journal of Clinical Endocrinology & Metabolism
18. High Dose Growth Hormone Exerts an Anabolic Effect at Rest and during Exercise in Endurance-Trained Athletes
    Marie Louise Healy, James Gibney, David L Russell-Jones, Claire Pentecost, P Croos, P H Sönksen, Anne Margot Umpleby · 2003 · The Journal of Clinical Endocrinology & Metabolism
19. Posttraumatic hypopituitarism is associated with an unfavorable body composition and lipid profile, and decreased quality of life 12 months after injury
    Klose, M., Watt, T., Brennum, J., Feldt-Rasmussen, U. · 2007 · The Journal of Clinical Endocrinology & Metabolism
20. Skin and brain age together: The role of hormones in the ageing process
    Evgenia Makrantonaki, Peter Schönknecht, Amir M. Hossini, Elmar Kaiser, Myrto-Maria Katsouli, James Adjaye, Johannes Schröder, Christos C. Zouboulis · 2010 · Experimental Gerontology
21. Genetics and skin aging
    Evgenia Makrantonaki, Vassiliki Bekou, Christos C. Zouboulis · 2012 · Dermato-Endocrinology
22. Bovine Growth Hormone Transgenic Mice Are Resistant to Diet-Induced Obesity but Develop Hyperphagia, Dyslipidemia, and Diabetes on a High-Fat Diet
    Bob Olsson, Mohammad Bohlooly‐Y, Sharyn M. Fitzgerald, Fredrik Frick, Anna Ljungberg, Bo Åhrén, Jan Törnell, Göran M.L. Bergström, Jan Oscarsson · 2004 · Endocrinology
23. Growth hormone deficiency and replacement in elderly hypopituitary adults
    John P. Monson, Roger Abs, Bengt‐Åke Bengtsson, Helge Bennmarker, Ulla Feldt‐Rasmussen, Elizabeth Hernberg‐Ståhl, Marja C Thorén, B Westberg, Patrick Wilton, Christian C. Wüster · 2000 · Clinical Endocrinology
24. Genetic Code Expansion: Inception, Development, Commercialization
    Miglena Manandhar, Eugene Chun, Floyd E. Romesberg · 2021 · Journal of the American Chemical Society
25. Radiation-Induced Growth Hormone Deficiency
    Ken H. Darzy, Stephen Michael Shalet · 2003 · Hormone Research in Paediatrics
26. Growth hormone deficiency and replacement in hypopituitary patients previously treated for acromegaly or Cushing's disease
    Ulla Feldt‐Rasmussen, R. Abs, B-Å Bengtsson, Helge Bennmarker, Margareta Bramnert, Elizabeth Hernberg‐Ståhl, JP Monson, B Westberg, Patrick Wilton, Christian C. Wüster · 2002 · European Journal of Endocrinology
27. Normal and Aberrant Growth
    David W. Cooke, Sara A. DiVall, Sally Radovick · 2011 · Elsevier eBooks
28. Tumour recurrence and enlargement in patients with craniopharyngioma with and without GH replacement therapy during more than 10 years of follow-up
    Daniel S Olsson, Michael Buchfelder, Kurt Wiendieck, Natalia Kremenevskaja, B-Å Bengtsson, K E Jakobsson, Marianne Jarfelt, Gudmundur Johannsson, A. G. Nilsson · 2012 · European Journal of Endocrinology
29. Gender-Specific Responses of Lean Body Composition and Non-Gender-Specific Cardiac Function Improvement after GH Replacement in GH-Deficient Adults
    Shereen Ezzat, S. Fear, R.C. Gaillard, C. Gayle, Hal Landy, Sorana Marcovitz, Thomas A. Mattioni, Stephen Nussey, A. Rees, Elisabeth Svanberg · 2002 · The Journal of Clinical Endocrinology & Metabolism
30. Effects of Recombinant Human Growth Hormone Therapy in Obesity in Adults: A Metaanalysis
    Mekala, Kavya C., Tritos, Nicholas A. · 2009 · The Journal of Clinical Endocrinology & Metabolism
31. Blood-Brain Barrier for Human Growth Hormone and Insulin-like Growth Factor-I
    Mihail Coculescu · 1999 · Journal of Pediatric Endocrinology and Metabolism
32. Menopausal obesity - myth or fact?
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33. Metabolic Syndrome in Children and Adolescents With Acute Lymphoblastic Leukemia After the Completion of Chemotherapy
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34. Serum Insulin-Like Growth Factor-I Levels and Prostate Cancer Risk--Interpreting the Evidence
    Pinchas Cohen · 1998 · JNCI Journal of the National Cancer Institute
35. The cardiovascular system in growth hormone excess and growth hormone deficiency.
    2012 · PubMed
36. Long-Acting C-Terminal Peptide–Modified hGH (MOD-4023): Results of a Safety and Dose-Finding Study in GHD Children
    Nataliya Zelinska, Violeta Iotova, Julia Skorodok, O. A. Malievskiy, Valentina Aleksandrovna Peterkova, Lubov N. Samsonova, Ron G. Rosenfeld, Zvi Zadik, Michal Jaron‐Mendelson, Ronit Koren et al. · 2017 · The Journal of Clinical Endocrinology & Metabolism
37. Incidence of Diabetes Mellitus and Evolution of Glucose Parameters in Growth Hormone–Deficient Subjects During Growth Hormone Replacement Therapy
    Anton Luger, Anders F. Mattsson, Maria Kołtowska‐Häggström, Maria Thunander, Miklós Góth, Johan A. Verhelst, Roger Abs · 2011 · Diabetes Care
38. Abnormal Vascular Reactivity in Growth Hormone Deficiency
    Brunella Capaldo, Vincenzo Guardasole, Francesco Pardo, Margherita Matarazzo, Francesca Di Rella, Fabio Giuliano Numis, Bartolomeo Merola, Salvatore Longobardi, Luigi Saccà · 2001 · Circulation
39. Impaired Cardiac Performance in Elderly Patients with Growth Hormone Deficiency
    Annamaria Colao, Alberto Cuocolo, Carolina Di Somma, Gaetana Cerbone, Anna Maria Della Morte, Emanuele Nicolai, Rosa Lucci, Marco Salvatore, Gaetano Lombardi · 1999 · The Journal of Clinical Endocrinology & Metabolism
40. Osteoporosis in Childhood: Bone Density of Children in Health and Disease
    Inge Margriet van der Sluis, S M de Muinck Keizer-Schrama · 2001 · Journal of Pediatric Endocrinology and Metabolism
41. Nutritional status in the neuroendocrine control of growth hormone secretion: the model of anorexia nervosa
    Massimo Scacchi, Angela Ida Pincelli, Francesco Cavagnini · 2003 · Frontiers in Neuroendocrinology
42. Decreased Quality of Life in Adult Patients with Growth Hormone Deficiency Compared with General Populations Using the New, Validated, Self-Weighted Questionnaire, Questions on Life Satisfaction Hypopituitarism Module
    Werner Friedrich Blum, Elena P. Shavrikova, David J. Edwards, Myriam Rosilio, Mark L. Hartman, Fernando Marín, Domenico Valle, Aart Jan van der Lely, Andrea F. Attanasio, Christian Joseph Strasburger et al. · 2003 · The Journal of Clinical Endocrinology & Metabolism
43. Aetiology, diagnosis, and management of hypopituitarism in adult life
    Vkb Prabhakar, Stephen Michael Shalet · 2006 · Postgraduate Medical Journal
44. Adults with Partial Growth Hormone Deficiency Have an Adverse Body Composition
    Robert Douglas Murray, Judith E. Adams, Stephen Michael Shalet · 2004 · The Journal of Clinical Endocrinology & Metabolism
45. The influence of gender on the short and long-term effects of growth hormone replacement on bone metabolism and bone mineral density in hypopituitary adults: a 5-year study
    Drake, W. M., Rodríguez‐Arnao, J., Weaver, J. U., James, I. T., Coyte, D., Spector, T. D., Besser, G. M., Monson, J. P. · 2001 · Clinical Endocrinology
46. Healthcare Consumption Decreases in Parallel with Improvements in Quality of Life during GH Replacement in Hypopituitary Adults with GH Deficiency
    Elizabeth Hernberg‐Ståhl, Anton Luger, Roger Abs, Bengt‐Åke Bengtsson, Ulla Feldt‐Rasmussen, Patrick Wilton, B Westberg, John P. Monson · 2001 · The Journal of Clinical Endocrinology & Metabolism
47. Long-Term Effects of Growth Hormone Therapy on Bone Mineral Density, Body Composition, and Serum Lipid Levels in Growth Hormone Deficient Children: A 6-Year Follow-Up Study
    Inge Margriet van der Sluis, Annemieke M. Boot, Wim C.J. Hop, Yolanda B. de Rijke, Eric P. Krenning, Sabine M.P.F. de Muinck Keizer‐Schrama · 2002 · Hormone Research in Paediatrics
48. Growth hormone treatment improves body composition in adults with Prader–Willi syndrome
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49. Acromegaly per se does not increase the risk for coronary artery disease
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50. Safety and convenience of once-weekly somapacitan in adult GH deficiency: a 26-week randomized, controlled trial
    Gudmundur Johannsson, Ulla Feldt‐Rasmussen, Ida Holme Håkonsson, Henrik Biering, Patrice Rodien, Shigeyuki Tahara, Andrew A. Toogood, Michael Højby Rasmussen, _ _, _ _ et al. · 2018 · European Journal of Endocrinology
51. The Experience of Fatigue in the First 2 Years After Moderate-to-Severe Traumatic Brain Injury
    Tamara L. Bushnik, Jeffrey Englander, Jerry Wright · 2008 · Journal of Head Trauma Rehabilitation
52. Growth hormone and physical performance
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53. Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence
    Yan Han, Matthew C. Mitschelen, Georgina V. Bixler, Robert M. Brucklacher, Julie A. Farley, Song Iy Han, Willard M. Freeman, William Edmund Sonntag · 2011 · Journal of Endocrinology
54. Baseline Characteristics and Response to 2 Years of Growth Hormone (GH) Replacement of Hypopituitary Patients with GH Deficiency due to Adult-Onset Craniopharyngioma in Comparison with Patients with Nonfunctioning Pituitary Adenoma: Data from KIMS (Pfizer International Metabolic Database)
    Johan A. Verhelst, Pat Kendall‐Taylor, Eva Marie Erfurth, David Anthony Price, Mitchell E. Geffner, Maria Kołtowska‐Häggström, Peter Jönsson, Patrick Wilton, Roger Abs · 2005 · The Journal of Clinical Endocrinology & Metabolism
55. Late effects of total body irradiation and hematopoietic stem cell transplant in children under 3 years of age
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56. How does obesity affect the endocrine system? A narrative review
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57. Use of Growth Hormone, IGF-I, and Insulin for Anabolic Purpose: Pharmacological Basis, Methods of Detection, and Adverse Effects
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58. Sustained reduction in circulating cholesterol in adult hypopituitary patients given low dose titrated growth hormone replacement therapy: a two year study
    Dimos Florakis, Victor Hung, Gregory Kaltsas, Donna Coyte, Paul J. Jenkins, Shern L. Chew, Ashley Barry Grossman, G. MICHAEL BESSER, John P. Monson · 2000 · Clinical Endocrinology
59. Low Bone Mass Is an Infrequent Feature of the Adult Growth Hormone Deficiency Syndrome in Middle-Age Adults and the Elderly
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60. GH deficiency as the most common pituitary defect after TBI: clinical implications
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61. The Neuroendocrine Effects of Traumatic Brain Injury
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62. Sex steroids and the GH axis: implications for the management of hypopituitarism
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63. Improvement in insulin sensitivity without concomitant changes in body composition and cardiovascular risk markers following fixed administration of a very low growth hormone (GH) dose in adults with severe GH deficiency
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64. Insulin-like Growth Factor-I in Muscle Metabolism and Myotherapies
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65. Diagnostic reliability of a single IGF‐I measurement in 237 adults with total anterior hypopituitarism and severe GH deficiency
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66. Favorable long-term effects of growth hormone replacement therapy on quality of life, bone metabolism, body composition and lipid levels in patients with adult-onset growth hormone deficiency
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67. Growth Hormone Improves Lean Body Mass, Physical Performance, and Quality of Life in Subjects With HIV-Associated Weight Loss or Wasting on Highly Active Antiretroviral Therapy
    Graeme J Moyle, Eric S. Daar, Joseph M. Gertner, Donald P. Kotler, Jean‐Claude Melchior, Fanny O Brien, Elisabeth Svanberg · 2004 · JAIDS Journal of Acquired Immune Deficiency Syndromes
68. Improvement of Cardiac Performance and Cardiovascular Risk Factors in Children with GH Deficiency after Two Years of GH Replacement Therapy: An Observational, Open, Prospective, Case-Control Study
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69. The effects of GH replacement in adult GH‐deficient patients: changes in body composition without concomitant changes in the adipokines and insulin resistance
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70. Status of long-acting-growth hormone preparations — 2015
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71. A Densitometric and Morphometric Analysis of the Skeleton in Adults with Varying Degrees of Growth Hormone Deficiency
    Robert Douglas Murray, Judith E. Adams, Stephen Michael Shalet · 2006 · The Journal of Clinical Endocrinology & Metabolism
72. Effects of Growth Hormone (GH) Replacement Therapy on Very Low Density Lipoprotein Apolipoprotein B100 Kinetics in Patients with Adult GH Deficiency: A Stable Isotope Study1
    Emanuel Christ, M. H. Cummings, E Albany, Anne Margot Umpleby, Peter J. Lumb, Anthony S. Wierzbicki, Rossi P. Naoumova, Massoud A. Boroujerdi, P.H. Sönksen, D. L. Russell-Jones · 1999 · The Journal of Clinical Endocrinology & Metabolism
73. Comparison between insulin tolerance test, growth hormone (GH)-releasing hormone (GHRH), GHRH plus acipimox and GHRH plus GH-releasing peptide-6 for the diagnosis of adult GH deficiency in normal subjects, obese and hypopituitary patients
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74. Seeking the Optimal Target Range for Insulin-Like Growth Factor I during the Treatment of Adult Growth Hormone Disorders
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75. Anterior Pituitary Hormone Abnormalities following Traumatic Brain Injury
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76. Recombinant Growth Hormone (GH) Therapy in GH-Deficient Adults: A Long-Term Controlled Study on Daily Versus Thrice Weekly Injections
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77. Changing Patterns of the Adult Growth Hormone Deficiency Diagnosis Documented in a Decade-Long Global Surveillance Database
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78. Growth Hormone Research Society perspective on biomarkers of GH action in children and adults
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79. Primary "Empty Sella" in Adults: Endocrine Findings
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80. Left ventricular mass and function in children with GH deficiency before and during 12 months GH replacement therapy
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81. Impact of Growth Hormone Status on Body Composition and the Skeleton
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82. Adult GH deficiency throughout lifetime
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83. Pituitary Physiology and Diagnostic Evaluation
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84. Growth Hormone Therapy and its Relationship to Insulin Resistance, Glucose Intolerance and Diabetes Mellitus
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85. Atypical depression in growth hormone deficient adults, and the beneficial effects of growth hormone treatment on depression and quality of life
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86. Effects of Growth Hormone on Body Composition and Bone Metabolism
    Aaron L. Carrel, David B. Allen · 2000 · Endocrine
87. Designing a Long-Acting Human Growth Hormone (hGH) by Fusing the Carboxyl-Terminal Peptide of Human Chorionic Gonadotropin β-Subunit to the Coding Sequence of hGH
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88. Characterization of the metabolic phenotypes of Cushing's syndrome and growth hormone deficiency: a study of body composition and energy metabolism
    Morton G. Burt, James Gibney, Ken K. Y. Ho · 2006 · Clinical Endocrinology
89. Anterior hypopituitarism following traumatic brain injury
    Randall J. Urban, P. Harris, Brent E. Masel · 2004 · Brain Injury
90. Assessment of quality of life in adult patients with GH deficiency: KIMS contribution to clinical practice and pharmacoeconomic evaluations
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91. Comparing progression of non-functioning pituitary adenomas in hypopituitarism patients with and without long-term GH replacement therapy
    Daniel S Olsson, Michael Buchfelder, Sven Martin Schlaffer, B-Å Bengtsson, K E Jakobsson, Gudmundur Johannsson, A. G. Nilsson · 2009 · European Journal of Endocrinology
92. Psychological effects of withdrawal of growth hormone therapy from adults with growth hormone deficiency
    Carolyn McMillan, Clare Bradley, James Gibney, Marie Louise Healy, David L Russell-Jones, Peter H. Sönksen · 2003 · Clinical Endocrinology
93. Childhood-onset growth hormone deficiency, cognitive function and brain N-acetylaspartate
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94. Growth hormone replacement in adults and bone mineral density: a systematic review and meta‐analysis
    Peter Davidson, Ruairidh Milne, Deborah L. Chase, Cyrus C. Cooper · 2003 · Clinical Endocrinology
95. Does GH replacement therapy in adult GH-deficient patients result in recurrence or increase in size of pituitary tumours?
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96. Serum Leptin Response to the Acute and Chronic Administration of Growth Hormone (GH) to Elderly Subjects with GH Deficiency
    Matthew S. Gill, Andrew A. Toogood, Jenny Jones, Peter Clayton, Stephen Michael Shalet · 1999 · The Journal of Clinical Endocrinology & Metabolism
97. Cardiovascular Risk Reduction in High-Risk Pediatric Patients*
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98. Growth Hormone (GH) Substitution in GH-Deficient Patients Inhibits 11β-Hydroxysteroid Dehydrogenase Type 1 Messenger Ribonucleic Acid Expression in Adipose Tissue
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99. Insufficient Growth Hormone Secretion is Associated With Metabolic Syndrome After Allogeneic Stem Cell Transplantation in Childhood
    Mervi H. Taskinen, Marita Lipsanen‐Nyman, Aila E. Tiitinen, Liisa Hovi, Ulla M. Saarinen‐Pihkala · 2007 · Journal of Pediatric Hematology/Oncology
100. Association between Insulin-Like Growth Factor-I
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