The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index; 3 of the 17 sources its claims cite were checked for support.
Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans
Abstract
Insulin resistance plays an important role in the pathophysiology of diabetes and is associated with obesity and other cardiovascular risk factors. The "gold standard" glucose clamp and minimal model analysis are two established methods for determining insulin sensitivity in vivo, but neither is easily implemented in large studies. Thus, it is of interest to develop a simple, accurate method for assessing insulin sensitivity that is useful for clinical investigations. We performed both hyperinsulinemic isoglycemic glucose clamp and insulin-modified frequently sampled iv glucose tolerance tests on 28 nonobese, 13 obese, and 15 type 2 diabetic subjects. We obtained correlations between indexes of insulin sensitivity from glucose clamp studies (SI(Clamp)) and minimal model analysis (SI(MM)) that were comparable to previous reports (r = 0.57). We performed a sensitivity analysis on our data and discovered that physiological steady state values [i.e. fasting insulin (I(0)) and glucose (G(0))] contain critical information about insulin sensitivity. We defined a quantitative insulin sensitivity check index (QUICKI = 1/[log(I(0)) + log(G(0))]) that has substantially better correlation with SI(Clamp) (r = 0.78) than the correlation we observed between SI(MM) and SI(Clamp). Moreover, we observed a comparable overall correlation between QUICKI and SI(Clamp) in a totally independent group of 21 obese and 14 nonobese subjects from another institution. We conclude that QUICKI is an index of insulin sensitivity obtained from a fasting blood sample that may be useful for clinical research.
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The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“A well accepted alternative for estimating insulin sensitivity involves minimal model analysis of a frequently sampled iv glucose tolerance test (FSIVGTT) (9 -11).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > I NSULIN IS
What the sources say
- Supportedcites [9] Bergman, 1987, Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp., J Clin Invest source
The Introduction describes minimal-model analysis of a frequently sampled intravenous glucose tolerance test as an alternative to the glucose clamp. The Discussion reports that it yielded an equivalent measure of insulin sensitivity in the study, while noting that wider validation would be needed before recommending general use. (LLM, conf=0.90)
- Not checked — no full text of the sourcecites [10] 1989, Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach., Diabetes source
- Not checked — no full text of the sourcecites [11] Saad, 1997, Differences between the tolbutamide-boosted and the insulin-modified minimal model protocols., Diabetes source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Moreover, we observed a comparable overall correlation between QUICKI and SI Clamp in a totally independent group of 21 obese and 14 nonobese subjects from another institution.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Abstract
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Thus, as expected, the obese and diabetic subjects were significantly more insulin resistant than the nonobese subjects (P Ͻ 2 ϫ 10 Ϫ5 ).”
- Also stated in: § Glucose clamp and minimal model estimates of insulin sensitivity · plain
“As expected, when subjects were evaluated with the gold standard glucose clamp method, obese subjects were more insulin resistant, on the average, than nonobese subjects, and diabetics were the most insulin-resistant group.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Glucose clamp studies
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes- Also stated in: § Glucose clamp and minimal model estimates of insulin sensitivity · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We performed a sensitivity analysis on our data and discovered that physiological steady state values [i.e.fasting insulin (I 0 ) and glucose (G 0 )] contain critical information about insulin sensitivity.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Abstract
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In addition, the linear regression analysis of the subgroups corresponded more closely to the overall regression line when comparing QUICKI and SI Clamp .”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesThe paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“In addition, QUICKI derived from the average results of two fasting blood samples (over 10 min) was similar to QUICKI calculated from a single sample.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Interestingly, we found that the product of fasting insulin and glucose yielded an index of insulin sensitivity that was applicable to both dia-betic and nondiabetic subjects.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The basal glucose levels in the diabetic group were significantly elevated compared with those in the other groups (166 Ϯ 15 mg/dL; P Ͻ 4 ϫ 10 Ϫ5 ).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Insulin-modified FSIVGTT studies
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Note that in contrast to the minimal model-derived SI MM , we were able to calculate meaningful values of QUICKI for all diabetic subjects studied.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Correlations between indexes of insulin sensitivity
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“QUICKI was calculated for all study subjects (mean, 0.382 Ϯ 0.007, 0.331 Ϯ 0.010, and 0.304 Ϯ 0.007 for nonobese, obese, and diabetic subjects, respectively).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes
- Probably not a substantial claim. 6
- It may state two separate claims as one. 15
- The quote only partly states this claim. 2
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Alternatively, periodic oscillations in insulin secretion (both ultradian and 10-to 15-min periods) have been reported in healthy subjects and may also contribute to the weaker correlation in this subgroup (21,22).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
What the sources say
- Not checked — no full text of the sourcecites [21] Polonsky, 1998, Temporal profiles and clinical significance of pulsatile insulin secretion., Horm Res source
- Supportedcites [22] Polonsky, 1988, Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects., J Clin Invest source
The Discussion ('O Normal') describes rapid insulin pulsations in the 10–14-minute range and slower ultradian oscillations of 1–3 hours. It presents the slower oscillations in normal subjects as a finding of this study and reports the rapid pulsations from earlier studies, supporting the claim that both have been reported in healthy subjects. (LLM, conf=0.93)
Strength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Alternatively, periodic oscillations in insulin secretion (both ultradian and 10-to 15-min periods) have been reported in healthy subjects and may also contribute to the weaker correlation in this subgroup (21,22).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
What the sources say
- Not checked — no full text of the sourcecites [21] Polonsky, 1998, Temporal profiles and clinical significance of pulsatile insulin secretion., Horm Res source
- Partly supportedcites [22] Polonsky, 1988, Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects., J Clin Invest sourceExperimental — accuracy not yet measured
The discussion (section “O Normal”; page not provided) reports ultradian insulin-secretion oscillations in normal subjects and describes rapid 10–14-minute pulsations. It does not examine QUICKI, clamp-derived insulin sensitivity, or whether oscillations weaken the correlation between them in a nonobese subgroup. (LLM, conf=0.86)
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We obtained correlations between indexes of insulin sensitivity from glucose clamp studies (SI Clamp ) and minimal model analysis (SI MM ) that were com-parable to previous reports (r ϭ 0.57).”
- Also stated in: § Correlations between indexes of insulin sensitivity · plain
“The overall correlation coefficient (r) calculated from a linear least squares regression was 0.57 (P Ͻ 2 ϫ 10 Ϫ5 ).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Abstract
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Correlations between indexes of insulin sensitivity · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, linear regression analysis for the subgroups revealed that the regression line for the diabetic and obese subgroups had a very different slope than that for the nonobese group.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Correlations between indexes of insulin sensitivity
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesThe quote only partly states this claim.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“When correlations between QUICKI and SI Clamp were calculated for each group separately, we found that r ϭ 0.49 for nonobese subjects (P Ͻ 0.01), r ϭ 0.89 for obese subjects (P Ͻ 2 ϫ 10 Ϫ5 ), and r ϭ 0.7 for diabetic subjects (P Ͻ 4 ϫ 10 Ϫ3 ).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Correlations between indexes of insulin sensitivity
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Reassuringly, in these independent studies, we found that the overall correlation between QUICKI and SI Clamp was similar to that in our original analysis (r ϭ 0.77; P Ͻ 2 ϫ 10 Ϫ11 ).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Correlations between indexes of insulin sensitivity
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesThe quote only partly states this claim.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Both obese and diabetic subjects had significantly greater BMIs and fasting insulin levels than the nonobese subjects (P Ͻ 6 ϫ 10 Ϫ6 ), consistent with the presence of obesity and insulin resistance.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Study subjects
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This analysis yielded r ϭ 0.74 for obese subjects (n ϭ 21) and r ϭ 0.91 for nonobese subjects (n ϭ 14), with an overall correlation coefficient of r ϭ 0.90 (n ϭ 35).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Correlations between indexes of insulin sensitivity
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, the correlation coefficient for the nonobese subgroup was 0.49, and the greatest variability in the correlation between QUICKI and SI Clamp was observed among the most insulin-sensitive subjects.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As expected, the fasting glucose levels for both nonobese and obese groups were normal, whereas the diabetic group had elevated levels.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Study subjects
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Similar to our results from glucose clamp studies (and in contrast to minimal model results), insulin sensitivity as assessed by QUICKI was highest in the nonobese group, intermediate in the obese group, and lowest in the diabetic group.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Insulin resistance plays an important role in the pathophysiology of diabetes and is associated with obesity and other cardiovascular risk factors.”
- Also stated in: § I NSULIN IS · plain
“plays an important pathophysiological role in diabetes (1,2).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Abstract
What the sources say
- Not matchedcites [1] 1988, Lilly lecture 1987. The triumvirate: β-cell, muscle, liver. A collusion responsible for NIDDM., Diabetes
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites [2] DeFronzo, 1992, Pathogenesis of NIDDM. A balanced overview., Diabetes Care source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
- Also stated in: § I NSULIN IS · plain
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Steady state conditions were generally achieved about 2 h after the initiation of each study and were maintained for at least 60 min.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Glucose clamp studies
Load-bearingStrength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The overall correlation we obtained between SI Clamp and SI MM was comparable to previous reports whose study subjects included diabetics, suggesting that our studies were technically adequate.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Glucose clamp and minimal model estimates of insulin sensitivity
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Furthermore, QUICKI provides a reproducible and robust estimate of insulin sensitivity, because equally strong correlations with SI Clamp were obtained when fasting data from either the glucose clamp or FSIVGTT studies were used to calculate QUICKI.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, this effect is unlikely to be occurring in our studies, because fasting samples were obtained at the same time in the morning for each subject, and calculating QUICKI from the average of several blood samples (instead of a single sample) did not significantly affect our correlations.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
Strength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, in analyzing an independent dataset, we observed very similar correlations between QUICKI and SI Clamp , strongly suggesting that QUICKI is a robust index of insulin sensitivity.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Relative merits of QUICKI
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“The inability of the minimal model to identify meaningful values for SI MM in a large fraction of our diabetic subjects is consistent with the experience of others and is most likely related to well described difficulties in estimating SI MM under conditions of inadequate insulin secretion (12).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Glucose clamp and minimal model estimates of insulin sensitivity
What the sources say
- Not checked — no full text of the sourcecites [12] Saad, 1994, A comparison between the minimal model and the glucose clamp in the assessment of insulin sensitivity across the spectrum of glucose tolerance. Insulin Resistance Atherosclerosis Study., Diabetes source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
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In the paper
“Studies in the same subject were performed at least 1 week apart, and the order of the studies was randomized.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Subjects and Methods
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We conclude that QUICKI is an index of insulin sensitivity obtained from a fasting blood sample that may be useful for clinical research.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Abstract
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“QUICKI is a novel, simple, accurate, and reproducible method for determining insulin sensitivity in humans that may be a useful tool in large epidemiological investigations that study the role of insulin resistance in the pathophysiology of important public health problems such as obesity, cardiovascular diseases, and diabetes.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Relative merits of QUICKI
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Potential limitations to QUICKI include difficulty in applying it to subjects with type 1 diabetes who lack endogenous insulin secretion.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Relative merits of QUICKI
Strength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
The glucose clamp is the gold standard method for directly measuring insulin sensitivity in vivo.
“Although the glucose clamp is considered to be the gold standard method for directly measuring insulin sensitivity in vivo, it can be implemented in a number of different ways.”
The paper relies on this without support.
The distribution of fasting insulin values is skewed.
“One rational for these transformations is the fact that the distribution of fasting insulin values is skewed.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A recent placebo-controlled trial of ursodiol in NASH found that a proportion of patients receiving placebo had decreases in steatosis, but that improvements in inflammation and cell injury were uncommon.30”
From A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis (2004) · cites this paper as [30]
In the citing paper
“ndirect estimates of insulin resistance, such as HOMA-IR 63 and QUICKI, 64 are derived from fasting S-insulin and glucose concentrations and have been widely used in both nondiabetic and type 2 diabetic subjects as surrogates of insulin sensitivity.65,66”
From Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. (2008) · cites this paper as [64]
Citations
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DeFronzo, R. A. (1988) · Diabetes · doi:10.2337/diab.37.6.667 · Cited by 2,456
Pathogenesis of NIDDM. A balanced overview.
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Toward Physiological Understanding of Glucose Tolerance: Minimal-Model Approach
Bergman, R. N. (1989) · Diabetes · doi:10.2337/diab.38.12.1512 · Cited by 1,001
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Glucose regulation is associated with cognitive performance in young nondiabetic adults
Messier, C., Awad, N., Gagnon, M., Desrochers, A., & Tsiakas, M. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.023 · Cited by 25
Aldawsari, H. M., Hanafy, A., Labib, G. S., & Badr, J. M. (2014) · Zeitschrift für Naturforschung C · doi:10.5560/znc.2014-0047 · Cited by 25
“The revised quantitative insulin sensitivity check index (RQUICKI = 1/[log fasting insulin (mU/ml) + log fasting glucose (mg/dl)]) was used to assess the insulin sensitivity (Katz et al., 2000).”
MethodElgendi, S. S., Bakeet, M. Y., El-Hamed, E. A., Ibrahim, F. K., & Ahmed, R. I. (2008) · Journal of Cardiology · doi:10.1016/j.jjcc.2008.08.001 · Cited by 25
Dalfrà, M. G., Pacini, G., Parretti, E., Ragazzi, E., Mello, G., & Lapolla, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00024.2011 · Cited by 25
“Both indices, which have previously been validated against the euglycemic clamp (20, 29, 30, 41), are widely used (1) also in pregnancy (26, 35).”
MethodAntuna-Puente, B. P., Disse, E., Faraj, M., Lavoie, M.-È., Laville, M., RABASA-LHORET, R. P. R., & Bastard, J. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0091 · Cited by 24
“Indeed the existing fasting indices, like HOMA-IR, QUICKI and revised QUICKI, have been validated in different studies in distinct populations with different glucose tolerance and various levels of insulin sensitivity though the performance of each index was different depending on the type of population considered [3,…”
BackgroundMethodResultInfluentialΤζιόμαλος, Κ., Katsikis, I., Papadakis, E. P., Kandaraki, E., Μacut, D., & Panidis, D. (2013) · Human Reproduction · doi:10.1093/humrep/des456 · Cited by 24
TNF-α IN THE DEVELOPMENT OF INSULIN RESISTANCE AND OTHER DISORDERS IN METABOLIC SYNDROME
Gwozdziewiczová, S., Lichnovská, R., Yahia, R. B., Chlup, R., & Hřebíček, J. (2005) · Biomedical Papers · doi:10.5507/bp.2005.013 · Cited by 25
“The homeostatic index of insulin sensitivity QUICKI (Quantitative Insulin Sensitivity Check Index) was calculated according to Katz et al.(6): QUICKI = 1 / log fasting insulin (μU/ml) + log fasting glucose (mg/100ml).”
MethodZitzmann, M., Rohayem, J., Raidt, J., Kliesch, S., Kumar, N., Sitruk-Ware, R. L., & Nieschlag, E. (2017) · Andrology · doi:10.1111/andr.12328 · Cited by 25
“© 2017 American Society of Andrology and European Academy of Andrology Andrology, 2017, 5, 516–526 519 The QUICKI (Quantitative Insulin Sensitivity Check Index) describes changes in insulin sensitivity and was determined as previously described (Katz et al., 2000).”
MethodRoux-en-Y-Bariatric Surgery Reduces Markers of Metabolic Syndrome in Morbidly Obese Patients
Rega‐Kaun, G., Kaun, C., Jaegersberger, G., Prager, M., Hackl, M., Demyanets, S., Wojta, J., & Hohensinner, P. J. (2019) · Obesity Surgery · doi:10.1007/s11695-019-04190-y · Cited by 25
Fernández-Fígares, I., Lachica, M., Castro, A. M., Nieto, R., González-Valero, L., Rodríguez-López, J. M., & Aguilera, J. F. (2012) · animal · doi:10.1017/s1751731111002308 · Cited by 25
“> Test 1: Quantitative insulin sensitivity check index (QUICKI; Katz et al., 2000) using the following formula:”
MethodNon‐alcoholic fatty liver disease in obese children evaluated by magnetic resonance imaging
Radetti, G., Kleon, W., Stuefer, J., et al. (2006) · Acta Paediatrica · doi:10.1111/j.1651-2227.2006.tb02349.x · Cited by 25
“Insulin sensitivity was evaluated with QUICKI / 1/[log (I0) /log (G0)], where I0 is the fasting insulin and G0 the fasting glucose [11].”
MethodPorto, P. I., García, S. I., Dieuzeide, G., González, C. D., Landa, M. S., & Pirola, C. J. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000119367.21770.d7 · Cited by 24
Effects of Acute Chromium Supplementation on Postprandial Metabolism in Healthy Young Men
Frauchiger, M. T., Wenk, C., & Colombani, P. C. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719378 · Cited by 24
“The quantitative insulin sensitivity check index (QUICKI 1/[log (fasting insulin) log (fasting glucose)]) was used to assess insulin sensitivity [22].”
MethodLuo, Z., Wang, L., Wang, Y., Fan, Y., Jiang, L., Xu, X. P., Du, Y., & Hao, G. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12030818 · Cited by 24
“Our results will be more convincing if similar results were concluded when another validated surrogate marker for IR was used, such as the quantitative insulin sensitivity check index (QUICKI) [51].”
ResultJang, J., Lee, S., Kim, B., Seo, H. S., Kim, W.-S., Ahn, Y., Lee, N.-H., Koh, K. K., Kang, T. S., Jo, S., et al. (2015) · Korean Circulation Journal · doi:10.4070/kcj.2015.45.3.225 · Cited by 24
A novel noninvasive index for nonalcoholic steatohepatitis: a pilot study
Pοlyzos, S. A., Kountouras, J., Slavakis, A., Zafeiriadou, E., Patsiaoura, K., Katsiki, E., Zavos, C., Παπαθεοδώρου, Α., & Terpos, E. (2013) · Biomarkers · doi:10.3109/1354750x.2013.838305 · Cited by 24
“Insulin sensitivity was quantified by the quantitative insulin sensitivity check index (QUICKI) using the formula QUICKI1⁄4 1/[log(glucose) (mg/dL)þ log(insulin) (mU/mL)] (Katz et al., 2000).”
MethodAntidepressant use and glycemic control
Mojtabai, R. (2013) · Psychopharmacology · doi:10.1007/s00213-013-2972-5 · Cited by 24
“Insulin sensitivity was assessed using the Quantitative Insulin Sensitivity Check Index (QUICKI) (Katz et al. 2000) , which is computed as 1/[log(I 0 )+log(G 0 )], where I 0 is the fasting insulin and G 0 is the fasting glucose.”
BackgroundMethodInfluentialGarcés‐Rimón, M., González, C., Vera, G., Uranga, J. A., López‐Fandiño, R., López‐Miranda, V., & Miguel, M. (2018) · Nutrients · doi:10.3390/nu10040441 · Cited by 24
“QUICKI = 1/log fasting insulin (μU/mL) + log fasting glucose (mg/dL) [20].”
BackgroundKiel, I. A., Lundgren, K., Mørkved, S., Kjøtrød, S., Salvesen, Ø. O., Romundstad, L. B., & Moholdt, T. T. (2018) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2018-000387 · Cited by 25
Kangas, P., Tikkakoski, A., Uitto, M., Viik, J., Bouquin, H., Niemelä, O. J., Mustonen, J. T., & Pörsti, I. H. (2018) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12551 · Cited by 24
“QUICKI could not be calculated from 47 participants.”
MethodInfluentialÍndices para la evaluación de la resistencia a la insulina en individuos mexicanos sin diabetes
Almeda‐Valdés, P., Bello‐Chavolla, O. Y., Caballeros-Barragán, C. R., Gómez‐Velasco, D., Viveros-Ruiz, T., Vargas‐Vázquez, A., & Aguilar-Salinas, C. A. (2018) · Gaceta Médica de México · doi:10.24875/gmm.18004578 · Cited by 25
Dudi, P., Goyal, B., Saxena, V., Rabari, K., Mirza, A. A., Naithani, M., Kumar, T., & Goyal, R. (2019) · Journal of Laboratory Physicians · doi:10.4103/jlp.jlp_163_18 · Cited by 24
“Simpler approaches employing single fasting sample, such as homeostasis model assessment‐insulin resistance (HOMA‐IR) and quantitative insulin sensitivity check index (QUICKI), have been developed, but these indices require insulin estimation, which is a costly parameter and lacks universal availability.[9,10] Triglyc…”
MethodAboulmagd, Y. M., El-Bahy, A. A. Z., Menze, E. T., Azab, S. S., & El‐Demerdash, E. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173224 · Cited by 26
Insulin resistance in the course of acne – literature review
Sadowska‐Przytocka, A., Gruszczyńska, M., Ostałowska, A., Antosik, P., Czarnecka-Operacz, M. M., Adamski, Z., & Łącka, K. (2021) · Advances in Dermatology and Allergology · doi:10.5114/ada.2021.107101 · Cited by 24
“It considers fasting insulin and glucose serum level measurements as well and a significant correlation with glucose clamp has been proven [3].”
BackgroundMethodInfluentialBiomarkers in metabolic syndrome
Cho, Y. H., Lee, Y., Choi, J. I., Lee, S. R., & Lee, S. Y. (2022) · Advances in clinical chemistry · doi:10.1016/bs.acc.2022.07.003 · Cited by 25
A combined continuous and interval aerobic training improves metabolic syndrome risk factors in men
Naderali, E. K., Sari-Sarraf, V., Aliasgarzadeh, A., Naderali, M.-M., & Esmaeili, H. R. (2015) · International Journal of General Medicine · doi:10.2147/ijgm.s81938 · Cited by 25
Hassan, N. E. S., Orabi, H. E., Eid, Y. M., & Mohammed, N. R. (2012) · Middle East Fertility Society Journal · doi:10.1016/j.mefs.2012.04.005 · Cited by 24
Ogawa, S., Matsumae, T., Kataoka, T., YAZAKI, Y., & Yamaguchi, H. (2013) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2013.1029 · Cited by 24
“The OGTT values for plasma levels of glucose and insulin at 0 min (G0 and I0, respectively) were also utilized for measurement of an index of insulin resistance, the homeostasis model assessment of insulin resistance (HOMA-IR), calculated as follows: HOMA-IR = G0 (mg/dl) x I0(μU/ml)/405 (20,22-25).”
Prior Exercise and Postprandial Incretin Responses in Lean and Obese Individuals
Heden, T. D., Liu, Y., Kearney, M. L., Park, Y., Dellsperger, K. C., Thomas, T. R., & Kanaley, J. A. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318294b225 · Cited by 24
“The quantitative insulin sensitivity check index (QUICKI) was used as a surrogate measure of insulin sensitivity (11).”
MethodBreitman, I., Saraf, N., Kakade, M. S., Yellumahanthi, K., White, M., Hackett, J. A., & Clements, R. H. (2011) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2010.12.040 · Cited by 23
“Presently, the homeostasis model assessment (HOMA) index is the most widely used followed by quantitative insulin sensitivity check index (QUICKI), and both have been broadly evaluated (13, 14).”
MethodSämpi, M., Veneskoski, M., Ukkola, O. H., Kesäniemi, Y. A., & Hörkkö, S. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1858 · Cited by 24
Relationship of pentraxin 3 with insulin sensitivity in gestational diabetes
Todoric, J., Handisurya, A., Knapp, B., Tura, A., Pacini, G., & Kautzky‐Willer, A. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12051 · Cited by 24
Shab‐Bidar, S., Neyestani, T. R., & Djazayery, A. (2011) · BMC Endocrine Disorders · doi:10.1186/1472-6823-11-12 · Cited by 24
“Insulin resistance is evaluated by Quantitative Insulin Check Index (QUICKI) calculated as [39]: QUICKI: 1/[log (insulin) (μU/mL) + log (glucose) (mg/dL)] Serum 25(OH)D concentrations are measured by HPLC method as described elsewhere [40].”
MethodShikany, J. M., Margolis, K. L., Pettinger, M. B., Jackson, R. D., Limacher, M. C., Liu, S., Phillips, L. S., & Tinker, L. F. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.010843 · Cited by 24
“We also conducted analyses using another method of calculating insulin sensitivity—the quantitative insulin sensitivity check index (QUICKI) (13).”
MethodPanidis, D., Τζιόμαλος, Κ., Papadakis, E. P., Chatzis, P., Kandaraki, E., Tsourdi, E. A., Vosnakis, C., & Katsikis, I. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0039 · Cited by 24
Preferential increase in high-molecular weight adiponectin after niacin
Westphal, S., & Luley, C. H. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.09.036 · Cited by 24
“[7] Katz A, Nambi SS, Mather K, et al.”
BackgroundPourhassan, M., Glüer, C.-C., Pick, P., Tigges, W. P., & Müller, M. J. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.189 · Cited by 26
Tsunoda, T., Yamada, M., Akiyama, T., Minami, T., Yoshii, T., Kondo, Y., Satoh, S., & Terauchi, Y. (2016) · Journal of Clinical Medicine Research · doi:10.14740/jocmr2754w · Cited by 24
Comparison of Various Indices of Energy Metabolism in Recumbent and Healthy Dairy Cows
Guyot, H., Detilleux, J., Lebreton, P., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169716 · Cited by 24
Manimmanakorn, N., Manimmanakorn, A., Phuttharak, W., et al. (2017) · Malaysian Journal of Medical Sciences · doi:10.21315/mjms2017.24.4.7 · Cited by 24
“In this study, the quantitative insulin sensitivity check index (QUICKI) was calculated from the inverse of the sum of the logarithm of fasting insulin and fasting glucose [1 / (log (fasting insulin μIU/mL) + log (fasting glucose mg/dL)] (17).”
MethodRobinson, M. D., Mishra, I., Deodhar, S., Patel, V., Gordon, K. V., Vintimilla, R., Brown, K., Johnson, L. A., O’Bryant, S. E., & Cistola, D. P. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1359-5 · Cited by 23
“The correlation coefficients reported here and in Additional file 1: Tables S1 and S2 are for the ln-transformed variables, except the McAuley Index and QUICKI, as these indices are inherently ln-transformed.”
MethodInfluentialChan, D., So, H., Hui, S. C. N., et al. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0010-8 · Cited by 24
Tura, A., Pacini, G., Yamada, Y., Seino, Y., & Åhrén, B. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00288.2018 · Cited by 24
“SI in the fasting state was evaluated by QUICKI (the inverse of the sum of logarithmic values of insulin and glucose) (26).”
MethodNaser, W., Adam, I., Rayis, D. A., Ahmed, M., & Hamdan, H. Z. (2019) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-019-2429-x · Cited by 25
“Insulin secretion was indicated by the HOMA of βcell function (HOMA-β) (%) = 360 × fasting insulin level (μU/ml) / [fasting glucose level (mg/dl) − 63, [22].”
BackgroundMethodGhiasi, R., Naderi, R., Sheervalilou, R., & Alipour, M. R. (2019) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2019-0011 · Cited by 24
Pieters, M., Stonehouse, W., Jerling, J. C., Loots, D. T., Mukuddem-Petersen, J., & Hanekom, S. M. (2005) · Blood Coagulation & Fibrinolysis · doi:10.1097/01.mbc.0000174966.86549.27 · Cited by 24
Silveira, P. P., Portella, A. K., Benetti, C. D. S., Zugno, A. I., Scherer, E. B. D. S., de Mattos, C. B., Wyse, Â. T. D. S., Lucion, A. B., & Dalmaz, C. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0531-1 · Cited by 24
“Insulin resistance was evaluated using the Quantitative Insulin Sensitivity Check Index (QUICKI), defined by 1/[log(fasting insulin) ? 1 log(fasting glucose)] [ 30 , 31].”
MethodVrbíková, J., Hill, M., Dvořáková, K., Stanická, S., Vondra, K., & Stárka, L. (2004) · Gynecologic and Obstetric Investigation · doi:10.1159/000077827 · Cited by 24
Tan, M. H., Glazer, N., Johns, D., Widel, M., & Gilmore, K. J. (2004) · Current Medical Research and Opinion · doi:10.1185/030079904125003386 · Cited by 26
Role of Peripheral and Central Insulin Resistance in Neuropsychiatric Disorders
Alagiakrishnan, K., & Halverson, T. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13216607 · Cited by 25
“The validated tests, like QUICKI [78,79] and HOMA-IR, are conducted in a steady-state condition (fasting), whereas in dynamic condition (after an oral glucose load), tests like Matsuda Index and Gutt Index [80,81] are used.”
MethodInsulin resistance markers in term, normoweight neonates. The Mérida cohort
Gesteiro, E., Bastida, S., & Sánchez-Muniz, F. J. (2008) · European Journal of Pediatrics · doi:10.1007/s00431-008-0750-x · Cited by 23
“The quantitative insulin sensitivity check index (QUICKI) is also considered useful for measuring insulin sensitivity [17].”
A Study of Carotid Atherosclerosis in Patients with Non-alcoholic Fatty Liver Disease
Mishra, S., Yadav, D., Gupta, M., Mishra, H. K., & Sharma, P. (2012) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-012-0286-8 · Cited by 23
“Insulin resistance and secretion were calculated by homeostasis model [18, 19] and insulin sensitivity by QUICKI INDEX [20].”
Methodda Rosa, F. T., Osorio, J. S., Trevisi, E., Yanqui-Rivera, F., Estill, C. T., & Bionaz, M. (2017) · PPAR Research · doi:10.1155/2017/7097450 · Cited by 23
“The Quantitative Insulin Sensitivity Check Index (QUICKI; [36]) and the RevisedQUICKI (RQUICKI; [37])were calculated as follows:”
MethodShambrook, P., Kingsley, M., Taylor, N. F., Wundersitz, D. W. T., Wundersitz, C. E., Paton, C. D., & Gordon, B. A. (2020) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2020.02.015 · Cited by 23
Niri, Z. I., Shidfar, F., Jabbari, M., Zarrati, M., Hosseini, A. F., Malek, M., & Dehnad, A. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13193 · Cited by 23
Sundaresan, A., Radhiga, T., & Deivasigamani, B. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1820525 · Cited by 23
Insulin Resistance is Associated with Central Pain in Patients with Fibromyalgia
Pappolla, M. A., Manchikanti, L., Candido, K. D., Grieg, N. H., Seffinger, M. A., Ahmed, F., Fang, X., Andersen, C. R., & Trescot, A. M. (2021) · Pain Physician · doi:10.36076/ppj.2021.24.175-184 · Cited by 24
Sommer, N., Roumane, A., Han, W., Delibegović, M., Rochford, J. J., & Mcilroy, G. D. (2022) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2022.09.014 · Cited by 24
“QUICKI was calculated as previously described.(42) QUICKI = 1/[log(I0) + log(G0)], where I0 is fasting insulin (mU/mL) and G0 is fasting glucose (mg/dL).”
MethodTadiotto, M. C., Corazza, P. R. P., de Menezes-Junior, F. J., de Moraes-Junior, F. B., Tozo, T. A. A., Purim, K. S. M., Mota, J. A. P. S., & Leite, N. (2023) · European Journal of Pediatrics · doi:10.1007/s00431-023-04974-6 · Cited by 25
“CG showed possibly harmful reduction on HDL-c [F(1 23) = 10.046; p = 0.004] and QUICKI [F(1 23) = 2.003; p = 0.167] and harmful increase for HOMA-IR [F(1 23) = 0.167; p = 0.683] and HRrest [F(1 23) = 17.839; p < 0.001].”
MethodInfluentialHung, A., Leury, B. J., Sabin, M. A., et al. (2014) · Tropical Animal Health and Production · doi:10.1007/s11250-014-0673-7 · Cited by 23
“The homeostatic model assessment (HOMA) was calculated using the formula, HOMA=(fasting insulin×fasting glucose)/ 22.5 (Katz et al. 2000).”
BackgroundMethodInfluentialAssessment of glucose intolerance and insulin sensitivity in polycystic ovary syndrome.
Yıldız, B., & Gedik, O. (2004) · Reproductive Biomedicine Online · doi:10.1016/s1472-6483(10)61645-8 · Cited by 27
“QUICKI is a relatively new method defined as 1/[log(fasting insulin) + log(fasting glucose)] (Katz et al., 2000).”
MethodLee, M., Jang, Y., Kim, K., Cho, H., Jee, S. H., Park, Y., & Kim, M. K. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.07.056 · Cited by 23
An update in prevention and treatment of pediatric obesity
Benavent, M. M. (2008) · World Journal of Pediatrics · doi:10.1007/s12519-008-0033-7 · Cited by 23
Fasting insulin levels as a measure of insulin resistance in American blacks.
Mack, R., Skurnick, B., Sterling-Jean, Y., Pedra‐Nobre, M., & Bigg, D. (2003) · PubMed · Cited by 23
Barsalani, R., Brochu, M., & Dionne, I. J. (2013) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.09.008 · Cited by 23
“[3] Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, et al.”
BackgroundInfluentialSíndrome metabólico: definición, historia, criterios
Pineda, C. A. (2008) · TSpace (University of Toronto) · Cited by 23
Dock‐Nascimento, D. B., de Aguilar‐Nascimento, J. E., & Waitzberg, D. L. (2012) · Revista do Colégio Brasileiro de Cirurgiões · doi:10.1590/s0100-69912012000600002 · Cited by 23
Decreased insulin secretion and glucose clearance in exocrine pancreas‐insufficient pigs
Lozinska, L. M., Weström, B. R., Prykhodko, O., Lindqvist, A., Wierup, N., Åhrén, B., Szwiec, K., & Pierzynowski, S. G. (2015) · Experimental Physiology · doi:10.1113/ep085431 · Cited by 23
“To evaluate insulin sensitivity, the quantitative insulin sensitivity check index (QUICKI) was assessed as 1/[log fasting glucose (in millimoles per litre) + log fasting insulin (in picomoles per litre) (Katz et al. 2000).”
MethodComparison of Surrogate Markers as Measures of Uncomplicated Insulin Resistance in Korean Adults
Kim, T. J., Kim, H. J., Kim, Y. B., Lee, J., Lee, H. J., Hong, J. H., & Lee, J. (2016) · Korean Journal of Family Medicine · doi:10.4082/kjfm.2016.37.3.188 · Cited by 23
Miranda‐Lora, A. L., Cruz, M., Molina‐Díaz, M., et al. (2017) · Pediatric Diabetes · doi:10.1111/pedi.12497 · Cited by 23
“5])(20) was used to evaluate the secretory capacity of the β-cells, and the quantitative insulin sensitivity check index (1/[log fasting insulin μU/mL] + [log fasting glucose mg/dL]) was used to assess insulin sensitivity.(21)”
MethodMaternal dietary free or bound fructose diversely influence developmental programming of lipogenesis
Yürük, A. A., & Nergiz‐Unal, R. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0618-z · Cited by 22
Thomson, E. M., Pilon, S., Guénette, J., Williams, A., & Holloway, A. C. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.01.020 · Cited by 24
Maric, T., Kanu, C., Johnson, M. R., & Savvidou, M. D. (2019) · Metabolism · doi:10.1016/j.metabol.2019.04.005 · Cited by 23
Khodarahmi, M., Kahroba, H., Jafarabadi, M. A., Abbasi, M. M., & Farhangi, M. A. (2020) · BMC Cardiovascular Disorders · doi:10.1186/s12872-020-01366-8 · Cited by 23
Currò, D., Vergani, E., Bruno, C., Comi, S., d’Abate, C., & Mancini, A. (2020) · BioFactors · doi:10.1002/biof.1628 · Cited by 24
Abbie, E., François, M. E., Chang, C. R., Barry, J., & Little, J. P. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.03.008 · Cited by 23
Comparison between HOMA‐IR and ISI‐gly in detecting subjects with the metabolic syndrome
Schianca, G. P. C., Sainaghi, P. P., Castello, L. M., Rapetti, R., Limoncini, A., & Bartoli, E. (2005) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.560 · Cited by 25
“5 [14]; the QUICKI was calculated as follows: 1/[log fasting insulin (μU/mL) + log FG (mg/dL)] [15]; the ISI-gly was calculated as follows: 2/[(insulinp × glycemiap) + 1] [16].”
MethodHung, A., Leury, B. J., Sabin, M. A., Lien, T. F., & Dunshea, F. R. (2014) · Animal Production Science · doi:10.1071/an12255 · Cited by 24
Abo–Elmatty, D. M., & Zaitone, S. A. (2011) · PubMed · Cited by 22
Does bicarbonated mineral water rich in sodium change insulin sensitivity of postmenopausal women?
Schoppen, S., Sánchez-Muniz, F. J., Pérez-Granados, M., Gómez-Gerique, J. A., Sarriá, B., Navas‐Carretero, S., & Vaquero, M. P. (2007) · PubMed · Cited by 23
Behavioral, metabolic, and molecular correlates of lower insulin sensitivity in Mexican-Americans
Ho, R. C., Davy, K. P., Hickey, M. S., Summers, S. A., & Melby, C. L. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00105.2002 · Cited by 23
“Four estimates of insulin sensitivity were used: fasting plasma insulin, the homeostatic model assessment of insulin resistance (HOMA-IR) (28), the quantitative insulin sensitivity check index (QUICKI) (38), and the revised QUICKI (54) by use of the following formulas”
BackgroundMethodResultInfluentialAn inadequate glycaemic response to glucagon is linked to insulin resistance in preterm infants?
Jackson, L., Burchell, A., McGeechan, A., & Hume, R. (2002) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.88.1.f62 · Cited by 23
de Souza, A. L., Batista, G. A., & Alegre, S. M. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.10.018 · Cited by 25
Sambanis, C., Τζιόμαλος, Κ., Kountana, E., Kakavas, N., Zografou, I., Balaska, A., Koulas, G., Karagiannis, A. I., & Zamboulis, C. (2007) · Acta Diabetologica · doi:10.1007/s00592-007-0014-7 · Cited by 23
“homeostasis model assessment (HOMA) of insulin resistance (HOMA-IR) and by the Quantitative Insulin Sensitivity Check Index (QUICKI); insulin secretion was assessed by HOMA of b-cell function (HOMA-b) [12, 13].”
MethodRoden, M., Laakso, M., Johns, D., Widel, M., Urquhart, R., Richardson, C., Mariz, S., & Tan, M. H. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01610.x · Cited by 23
Radonjić, M., Wielinga, P. Y., Wopereis, S., Kelder, T., Goelela, V. S., Verschuren, L., Toet, K. H., van Duyvenvoorde, W., der Vat, B. J. C. V. D. W.-V., Stroeve, J. H. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056122 · Cited by 22
“Plasma glucose was quantified by glucose hexokinase method (Instruchemie, Delfzijl, The Netherlands) and plasma insulin by ELISA (Ultrasensitive mouse insulin ELISA, Mercodia, Uppsala, Sweden) to calculate QUICKI insulin sensitive index as reported [12].”
MethodAdaptive Expression of MicroRNA-125a in Adipose Tissue in Response to Obesity in Mice and Men
Diawara, M. R., Hue, C., Wilder, S. P., Venteclef, N., Aron‐Wisnewsky, J., Scott, J., Clément, K., Gauguier, D., & Caldérari, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091375 · Cited by 25
“[17].”
Tastesen, H. S., Rønnevik, A. K., Borkowski, K., Madsen, L., Kristiansen, K., & Liaset, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112859 · Cited by 22
“5 [35] and Quantitative Insulin Sensitivity Check Index (QUICKI) was calculated as follows: 1/(log(insulin [mU/l])+log(glucose [mg/dl])) [36].”
Kusunoki, Y., Katsuno, T., Nakae, R., Watanabe, K., Ochi, F., Tokuda, M., Akagami, T., Miuchi, M., Miyagawa, J., & Namba, M. (2015) · Gynecological Endocrinology · doi:10.3109/09513590.2015.1075498 · Cited by 22
“01) and negatively correlated with QUICKI (rs¼ 0.62, p50.”
MethodInfluentialKoh, K. K., Oh, P. C., Sakuma, I., Lee, Y., Han, S. H., & Shin, E. K. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.08.051 · Cited by 22
Hong, S., Sung, Y., Hong, Y. S., Jeong, K., Chung, H., & Lee, H. (2017) · Clinical Endocrinology · doi:10.1111/cen.13380 · Cited by 22
Sanad, E. F., Hamdy, N. Μ., Eletriby, A., Sebak, S. A., & EL-Mesallamy, H. O. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.07.013 · Cited by 22
Jung, S., Han, J., Park, H.-S., et al. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2460-5 · Cited by 22
“Improvements in insulin resistance [50] and insulin sensitivity [51] are the most important therapeutic parameter in patients with type 2 diabetes.”
BackgroundAbbaszadeh, F., Azizi, S., Mobasseri, M., & Ebrahimi‐Mameghani, M. (2021) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-021-00669-w · Cited by 23
“Finally, insulin sensitivity estimates were calculated using QUICKI [31] and HOMA-B [32] index for estimating β-cell function as follows: QUICKI score = 1/ (log(fasting insulin [μU/mL]) + log(fasting glucose [mg/ dL])) HOMA-B = (360 × fasting insulin [µIU/mL])/(fasting glucose [mg/dL] − 63).”
MethodInfluentialAnvarifard, P., Ostadrahimi, A., Ardalan, M., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-37033-z · Cited by 22
Insulin Resistance in Patients with Acne Vulgaris
Gruszczyńska, M., Sadowska‐Przytocka, A., Szybiak, W., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11082294 · Cited by 22
“Similar indexes include the quantitative insulin sensitivity check index (QUICKI) or the Matsuda index, which requires three measurements of glucose and insulin serum levels to be taken during an oral glucose tolerance test (OGTT) [27,28].”
MethodGüven, A., Özgen, İ. T., Güngör, O., Aydın, M., & Baysal, K. (2010) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.v2i1.21 · Cited by 23
“Quantitative insulin sensitivity check index (QUICKI) was determined by the formula (29).”
MethodKim, Y. A., Ku, E. J., Khang, A. R., Hong, E. S., Kim, K. M., Moon, J. H., Choi, S. H., Park, K. S., Jang, H. C., & Lim, S. K. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.08.014 · Cited by 20
“[25] Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, et al.”
BackgroundMethodThe Classification of Diabetes Mellitus: A Conceptual Framework
Ize-Ludlow, D., & Sperling, M. A. (2005) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2005.07.001 · Cited by 22
“The quantitative insulin sensitivity check index [36] is similar to the simple equation form of the HOMA model in all comparative respects, except that QUICKI uses a log transform of the insulin x glucose product.”
MethodCheng, C., Daskalakis, C., & Falkner, B. E. (2009) · Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2009.00231.x · Cited by 22
Metadata
- Authors
- Katz, A., Nambi, S. S., Mather, K., Baron, A. D., Follmann, D. A., Sullivan, G., & Quon, M. J.
- Affiliations
- National Institutes of Health (US)
- Indiana University Indianapolis (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2000-07-01
- Volume
- 85
- Issue
- 7
- Pages
- 2402-2410
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2126327417
- Cited by
- 3,931
- References
- 48
- Citations by year
- 2026: 97 · 2025: 129 · 2024: 142 · 2023: 174 · 2022: 188 · 2021: 173 · 2020: 184 · 2019: 145 · 2018: 153 · 2017: 174 · 2016: 170 · 2015: 164 · 2014: 184 · 2013: 219 · 2012: 169
- FWCI
- 33.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- QUICKI, insulin sensitivity, insulin resistance, fasting insulin, fasting blood glucose, glucose clamp, minimal model analysis, type 2 diabetes, obesity, insulin resistance index
- MeSH terms
- Adult, Blood Glucose, Diabetes Mellitus, Female, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Models, Biological, Obesity, Glucose Clamp Technique
About these checks
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