The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index; 3 of the 17 sources its claims cite were checked for support.
Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans
Abstract
Insulin resistance plays an important role in the pathophysiology of diabetes and is associated with obesity and other cardiovascular risk factors. The "gold standard" glucose clamp and minimal model analysis are two established methods for determining insulin sensitivity in vivo, but neither is easily implemented in large studies. Thus, it is of interest to develop a simple, accurate method for assessing insulin sensitivity that is useful for clinical investigations. We performed both hyperinsulinemic isoglycemic glucose clamp and insulin-modified frequently sampled iv glucose tolerance tests on 28 nonobese, 13 obese, and 15 type 2 diabetic subjects. We obtained correlations between indexes of insulin sensitivity from glucose clamp studies (SI(Clamp)) and minimal model analysis (SI(MM)) that were comparable to previous reports (r = 0.57). We performed a sensitivity analysis on our data and discovered that physiological steady state values [i.e. fasting insulin (I(0)) and glucose (G(0))] contain critical information about insulin sensitivity. We defined a quantitative insulin sensitivity check index (QUICKI = 1/[log(I(0)) + log(G(0))]) that has substantially better correlation with SI(Clamp) (r = 0.78) than the correlation we observed between SI(MM) and SI(Clamp). Moreover, we observed a comparable overall correlation between QUICKI and SI(Clamp) in a totally independent group of 21 obese and 14 nonobese subjects from another institution. We conclude that QUICKI is an index of insulin sensitivity obtained from a fasting blood sample that may be useful for clinical research.
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3 of 17 cited sources checked · 2 supported · 0 flagged · accuracy not yet measured
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“A well accepted alternative for estimating insulin sensitivity involves minimal model analysis of a frequently sampled iv glucose tolerance test (FSIVGTT) (9 -11).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > I NSULIN IS
What the sources say
- Supportedcites [9] Bergman, 1987, Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp., J Clin Invest source
The Introduction describes minimal-model analysis of a frequently sampled intravenous glucose tolerance test as an alternative to the glucose clamp. The Discussion reports that it yielded an equivalent measure of insulin sensitivity in the study, while noting that wider validation would be needed before recommending general use. (LLM, conf=0.90)
- Not checked — no full text of the sourcecites [10] 1989, Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach., Diabetes source
- Not checked — no full text of the sourcecites [11] Saad, 1997, Differences between the tolbutamide-boosted and the insulin-modified minimal model protocols., Diabetes source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Moreover, we observed a comparable overall correlation between QUICKI and SI Clamp in a totally independent group of 21 obese and 14 nonobese subjects from another institution.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Abstract
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Thus, as expected, the obese and diabetic subjects were significantly more insulin resistant than the nonobese subjects (P Ͻ 2 ϫ 10 Ϫ5 ).”
- Also stated in: § Glucose clamp and minimal model estimates of insulin sensitivity · plain
“As expected, when subjects were evaluated with the gold standard glucose clamp method, obese subjects were more insulin resistant, on the average, than nonobese subjects, and diabetics were the most insulin-resistant group.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Glucose clamp studies
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes- Also stated in: § Glucose clamp and minimal model estimates of insulin sensitivity · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We performed a sensitivity analysis on our data and discovered that physiological steady state values [i.e.fasting insulin (I 0 ) and glucose (G 0 )] contain critical information about insulin sensitivity.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Abstract
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In addition, the linear regression analysis of the subgroups corresponded more closely to the overall regression line when comparing QUICKI and SI Clamp .”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesThe paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“In addition, QUICKI derived from the average results of two fasting blood samples (over 10 min) was similar to QUICKI calculated from a single sample.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Interestingly, we found that the product of fasting insulin and glucose yielded an index of insulin sensitivity that was applicable to both dia-betic and nondiabetic subjects.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The basal glucose levels in the diabetic group were significantly elevated compared with those in the other groups (166 Ϯ 15 mg/dL; P Ͻ 4 ϫ 10 Ϫ5 ).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Insulin-modified FSIVGTT studies
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Note that in contrast to the minimal model-derived SI MM , we were able to calculate meaningful values of QUICKI for all diabetic subjects studied.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Correlations between indexes of insulin sensitivity
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“QUICKI was calculated for all study subjects (mean, 0.382 Ϯ 0.007, 0.331 Ϯ 0.010, and 0.304 Ϯ 0.007 for nonobese, obese, and diabetic subjects, respectively).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes
- Probably not a substantial claim. 6
- It may state two separate claims as one. 15
- The quote only partly states this claim. 2
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Alternatively, periodic oscillations in insulin secretion (both ultradian and 10-to 15-min periods) have been reported in healthy subjects and may also contribute to the weaker correlation in this subgroup (21,22).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
What the sources say
- Not checked — no full text of the sourcecites [21] Polonsky, 1998, Temporal profiles and clinical significance of pulsatile insulin secretion., Horm Res source
- Supportedcites [22] Polonsky, 1988, Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects., J Clin Invest source
The Discussion ('O Normal') describes rapid insulin pulsations in the 10–14-minute range and slower ultradian oscillations of 1–3 hours. It presents the slower oscillations in normal subjects as a finding of this study and reports the rapid pulsations from earlier studies, supporting the claim that both have been reported in healthy subjects. (LLM, conf=0.93)
Strength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Alternatively, periodic oscillations in insulin secretion (both ultradian and 10-to 15-min periods) have been reported in healthy subjects and may also contribute to the weaker correlation in this subgroup (21,22).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
What the sources say
- Not checked — no full text of the sourcecites [21] Polonsky, 1998, Temporal profiles and clinical significance of pulsatile insulin secretion., Horm Res source
- Partly supportedcites [22] Polonsky, 1988, Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects., J Clin Invest sourceExperimental — accuracy not yet measured
The discussion (section “O Normal”; page not provided) reports ultradian insulin-secretion oscillations in normal subjects and describes rapid 10–14-minute pulsations. It does not examine QUICKI, clamp-derived insulin sensitivity, or whether oscillations weaken the correlation between them in a nonobese subgroup. (LLM, conf=0.86)
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We obtained correlations between indexes of insulin sensitivity from glucose clamp studies (SI Clamp ) and minimal model analysis (SI MM ) that were com-parable to previous reports (r ϭ 0.57).”
- Also stated in: § Correlations between indexes of insulin sensitivity · plain
“The overall correlation coefficient (r) calculated from a linear least squares regression was 0.57 (P Ͻ 2 ϫ 10 Ϫ5 ).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Abstract
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Correlations between indexes of insulin sensitivity · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, linear regression analysis for the subgroups revealed that the regression line for the diabetic and obese subgroups had a very different slope than that for the nonobese group.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Correlations between indexes of insulin sensitivity
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesThe quote only partly states this claim.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“When correlations between QUICKI and SI Clamp were calculated for each group separately, we found that r ϭ 0.49 for nonobese subjects (P Ͻ 0.01), r ϭ 0.89 for obese subjects (P Ͻ 2 ϫ 10 Ϫ5 ), and r ϭ 0.7 for diabetic subjects (P Ͻ 4 ϫ 10 Ϫ3 ).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Correlations between indexes of insulin sensitivity
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Reassuringly, in these independent studies, we found that the overall correlation between QUICKI and SI Clamp was similar to that in our original analysis (r ϭ 0.77; P Ͻ 2 ϫ 10 Ϫ11 ).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Correlations between indexes of insulin sensitivity
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesThe quote only partly states this claim.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Both obese and diabetic subjects had significantly greater BMIs and fasting insulin levels than the nonobese subjects (P Ͻ 6 ϫ 10 Ϫ6 ), consistent with the presence of obesity and insulin resistance.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Study subjects
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This analysis yielded r ϭ 0.74 for obese subjects (n ϭ 21) and r ϭ 0.91 for nonobese subjects (n ϭ 14), with an overall correlation coefficient of r ϭ 0.90 (n ϭ 35).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Correlations between indexes of insulin sensitivity
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, the correlation coefficient for the nonobese subgroup was 0.49, and the greatest variability in the correlation between QUICKI and SI Clamp was observed among the most insulin-sensitive subjects.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As expected, the fasting glucose levels for both nonobese and obese groups were normal, whereas the diabetic group had elevated levels.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Study subjects
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Similar to our results from glucose clamp studies (and in contrast to minimal model results), insulin sensitivity as assessed by QUICKI was highest in the nonobese group, intermediate in the obese group, and lowest in the diabetic group.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Insulin resistance plays an important role in the pathophysiology of diabetes and is associated with obesity and other cardiovascular risk factors.”
- Also stated in: § I NSULIN IS · plain
“plays an important pathophysiological role in diabetes (1,2).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Abstract
What the sources say
- Not matchedcites [1] 1988, Lilly lecture 1987. The triumvirate: β-cell, muscle, liver. A collusion responsible for NIDDM., Diabetes
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites [2] DeFronzo, 1992, Pathogenesis of NIDDM. A balanced overview., Diabetes Care source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
- Also stated in: § I NSULIN IS · plain
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Steady state conditions were generally achieved about 2 h after the initiation of each study and were maintained for at least 60 min.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Glucose clamp studies
Load-bearingStrength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The overall correlation we obtained between SI Clamp and SI MM was comparable to previous reports whose study subjects included diabetics, suggesting that our studies were technically adequate.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Glucose clamp and minimal model estimates of insulin sensitivity
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Furthermore, QUICKI provides a reproducible and robust estimate of insulin sensitivity, because equally strong correlations with SI Clamp were obtained when fasting data from either the glucose clamp or FSIVGTT studies were used to calculate QUICKI.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, this effect is unlikely to be occurring in our studies, because fasting samples were obtained at the same time in the morning for each subject, and calculating QUICKI from the average of several blood samples (instead of a single sample) did not significantly affect our correlations.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > QUICKI
Strength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, in analyzing an independent dataset, we observed very similar correlations between QUICKI and SI Clamp , strongly suggesting that QUICKI is a robust index of insulin sensitivity.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Relative merits of QUICKI
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“The inability of the minimal model to identify meaningful values for SI MM in a large fraction of our diabetic subjects is consistent with the experience of others and is most likely related to well described difficulties in estimating SI MM under conditions of inadequate insulin secretion (12).”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Glucose clamp and minimal model estimates of insulin sensitivity
What the sources say
- Not checked — no full text of the sourcecites [12] Saad, 1994, A comparison between the minimal model and the glucose clamp in the assessment of insulin sensitivity across the spectrum of glucose tolerance. Insulin Resistance Atherosclerosis Study., Diabetes source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Studies in the same subject were performed at least 1 week apart, and the order of the studies was randomized.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Subjects and Methods
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We conclude that QUICKI is an index of insulin sensitivity obtained from a fasting blood sample that may be useful for clinical research.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Abstract
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“QUICKI is a novel, simple, accurate, and reproducible method for determining insulin sensitivity in humans that may be a useful tool in large epidemiological investigations that study the role of insulin resistance in the pathophysiology of important public health problems such as obesity, cardiovascular diseases, and diabetes.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Relative merits of QUICKI
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Potential limitations to QUICKI include difficulty in applying it to subjects with type 1 diabetes who lack endogenous insulin secretion.”
§ Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans > Relative merits of QUICKI
Strength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
The glucose clamp is the gold standard method for directly measuring insulin sensitivity in vivo.
“Although the glucose clamp is considered to be the gold standard method for directly measuring insulin sensitivity in vivo, it can be implemented in a number of different ways.”
The paper relies on this without support.
The distribution of fasting insulin values is skewed.
“One rational for these transformations is the fact that the distribution of fasting insulin values is skewed.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A recent placebo-controlled trial of ursodiol in NASH found that a proportion of patients receiving placebo had decreases in steatosis, but that improvements in inflammation and cell injury were uncommon.30”
From A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis (2004) · cites this paper as [30]
In the citing paper
“ndirect estimates of insulin resistance, such as HOMA-IR 63 and QUICKI, 64 are derived from fasting S-insulin and glucose concentrations and have been widely used in both nondiabetic and type 2 diabetic subjects as surrogates of insulin sensitivity.65,66”
From Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. (2008) · cites this paper as [64]
Citations
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Pathogenesis of NIDDM. A balanced overview.
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Toward Physiological Understanding of Glucose Tolerance: Minimal-Model Approach
Bergman, R. N. (1989) · Diabetes · doi:10.2337/diab.38.12.1512 · Cited by 1,001
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Azab, N. I., Abdel-Aziz, T., Ahmed, A. Y., & El‐Deen, I. M. (2012) · Journal of Saudi Chemical Society · doi:10.1016/j.jscs.2012.07.003 · Cited by 22
“Insulin resistance was measured using the homeostasis model assessment of insulin resistance (HOMA-IR), a reliable marker for insulin resistance, was calculated as fasting insulin · glucose level/22.5 (Katz et al., 2000).”
InfluentialProximal 19q Trisomy: A New Syndrome of Morbid Obesity and Mental Retardation
Zung, A., Rienstein, S., Rosensaft, J., Aviram‐Goldring, A., & Zadik, Z. (2006) · Hormone Research in Paediatrics · doi:10.1159/000096419 · Cited by 22
“using the HOMA calculator v2.2 released by The Oxford center for diabetes, endocrinology and metabolism (http://www.dtu.ox.ac.uk/index), and by the quantitative insulin sensitivity check index (QUICKI) [”
MethodBrufani, C., Manco, M., Nobili, V., Fintini, D., Barbetti, F., & Cappa, M. (2012) · Hormone Research in Paediatrics · doi:10.1159/000341363 · Cited by 22
The effect of obesity and low-dose oral contraceptives on carbohydrate and lipid metabolism
Beasley, A., Estes, C. M., Guerrero, J. M., & Westhoff, C. L. (2011) · Contraception · doi:10.1016/j.contraception.2011.09.014 · Cited by 21
“The natural log HOMA-IR used here has a stronger linear correlation with glucose clamp estimates of insulin sensitivity over wider ranges of insulin sensitivity and resistance and is useful in evaluation of insulin resistance in individuals with glucose intolerance, mild to moderate diabetes and other insulin-resistan…”
BackgroundLancha, A., Moncada, R., Valentí, V., Rodrı́guez, A., Catalán, V., Becerril, S., Ramírez, B., Méndez-Giménez, L., Gil, M. J., Rotellar, F., et al. (2014) · Surgical Endoscopy · doi:10.1007/s00464-014-3490-1 · Cited by 22
“using the quantitative insulin sensitivity check index (QUICKI) [37].”
MethodNumao, S., Sasai, H., Nomata, Y., Matsuo, T., Eto, M., Tsujimoto, T., & Tanaka, K. (2012) · Obesity Facts · doi:10.1159/000346205 · Cited by 22
Fadini, G. P., Bonora, B. M., Marcuzzo, G., Marescotti, M. C., Cappellari, R., Pantano, G., Sanzari, M. C., Durán, X., Vendrell, J. J., Plebani, M., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2867 · Cited by 22
“The quantitative insulin sensitivity check index (QUICKI) was calculated as 1/(log(fasting insulin U/ml) log(fasting glucose mg/dl)) (18).”
MethodReeves, G. M., Keeton, C. P., Correll, C. U., Johnson, J. L., Hamer, R. M., Sikich, L., Hazzard, L. M., Alderman, C., Scheer, A., Mabe, M., et al. (2013) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/1753-2000-7-31 · Cited by 23
“The measurements selected (QUICKI and HOMA-IR) to measure insulin sensitivity in all participants were done based on consultation with our study-wide and site endocrinology experts.”
BackgroundAkın, L., Kurtoğlu, S., Yıkılmaz, A., et al. (2012) · Acta Paediatrica · doi:10.1111/apa.12099 · Cited by 22
“5), quantitative insulin sensitivity check index (QUICKI = 1/[log (fasting insulin) + log (fasting glucose)]) (10) and the Matsuda index defined as [10 000/square root of (fasting glucose 9 fasting insulin) 9 (mean glucose 9 mean insulin during OGTT)] (11).”
MethodNamvaran, F., Rahimi‐Moghaddam, P., Azarpira, N., & Dabbaghmanesh, M. H. (2011) · Molecular Biology Reports · doi:10.1007/s11033-011-1354-5 · Cited by 22
“The insulin/glucose ratio was calculated with the formula: insulin (lU/ml)/glucose (mmol/l) ratio [23].”
MethodCarmina, E., Campagna, A. M., Mansuet, P., Vitale, G., Kort, D. H., & Lobo, R. A. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.06.017 · Cited by 22
“Insulin sensitivity calculated by QUICKI was lower.”
MethodInfluentialKim, W. S., Kim, J. W., Ahn, C. W., & Choi, S. H. (2013) · Journal of the Korean Surgical Society · doi:10.4174/jkss.2013.84.2.88 · Cited by 23
“Insulin resistance was measured by the insulin sensitivity index [14] homeostasis model assessment (HOMA)-insulin resistance [15] and quantitative insulin sensitivity check index (QUICKI) [16] using a web calculator (http://mmatsuda. diabetes-smc.jp/MIndex.html, https://sasl.unibas.ch/ 11calculators-QUICKI.php).”
MethodGeetha, R., Chandrasekaran, S. P., & Anuradha, C. V. (2016) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12671 · Cited by 22
Kolodziejski, P. A., Pruszyńska‐Oszmałek, E., Strowski, M. Z., & Nowak, K. W. (2017) · Endocrine · doi:10.1007/s12020-017-1309-2 · Cited by 22
Repeated Excessive Exercise Attenuates the Anti-Inflammatory Effects of Exercise in Older Men
Sahl, R. E., Andersen, P. R., Grønbæk, K. K., Morville, T. H., Rosenkilde, M., Rasmusen, H. K., Poulsen, S. S., Prats, C., Dela, F., & Helge, J. W. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00407 · Cited by 22
“The Quicki index was calculated as previously described (Katz et al., 2000).”
MethodRole of fatty liver in the association between obesity and reduced hepatic insulin clearance
Matsubayashi, Y., Yoshida, A., Suganami, H., Ishiguro, H., Yamamoto, M., Fujihara, K., Kodama, S., Tanaka, S., Kaku, K., & Sone, H. (2017) · Diabetes & Metabolism · doi:10.1016/j.diabet.2017.12.003 · Cited by 23
Min, S. H., Kim, S., Jeong, I., Cho, H., Jeong, J., Lee, J., Kang, H., Kim, H.-S., Park, K. S., & Lim, S. K. (2017) · Korean Circulation Journal · doi:10.4070/kcj.2017.0200 · Cited by 22
Roshanravan, N., Mahdavi, R., Jafarabadi, M. A., Alizadeh, E., Ghavami, A., Saadat, Y. R., Alamdari, N. M., Dastourı, M., Alipour, S., & Ostadrahimi, A. (2018) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2017.12.011 · Cited by 23
Tripolt, N. J., Stekovic, S., Aberer, F., Url, J., Pferschy, P. N., Schröder, S., Verheyen, N., Schmidt, A. G., Kolesnik, E., Narath, S. H., et al. (2018) · Advances in Therapy · doi:10.1007/s12325-018-0746-5 · Cited by 22
Kalaivanan, K., Priya, C. S., Nanda, D., Vidhya, R., & Anuradha, C. V. (2018) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-018-3432-7 · Cited by 22
Noguchi, R., Kaji, K., Namisaki, T., Moriya, K., Kawaratani, H., Kitade, M., Takaya, H., Aihara, Y., Douhara, A., Asada, K., et al. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11360 · Cited by 22
Gerig, R., Ernst, B., Wilms, B., et al. (2013) · Obesity · doi:10.1002/oby.20098 · Cited by 22
“IR was estimated by calculating the established indices HOMA-IR (10) and quantitative insulin sensitivity check index (QUICKI) (11); the following formulae were used: HOMA-IR ¼ fasting glucose (mmol/L) fasting insulin (lU/mL) / 22.5 QUICKI ¼ 1/(log(fasting insulin lU/mL) þ log(fasting glucose mg/dL)) Note, while highe…”
MethodInfluentialBuyan, N., Bıdecı, A., Özkaya, O., et al. (2006) · Nephrology · doi:10.1111/j.1440-1797.2006.00570.x · Cited by 22
“It was calculated as follows (insulin is expressed in mU/mL and glucose in mg/dL): 1/(log(insulin) + log(glucose)).(10) Glomerular filtration rate was measured by Schwartz’s formula.”
MethodBorai, A., Livingstone, C., ZARIF, H. A., & Ferns, G. A. (2009) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2008.008160 · Cited by 22
The impact of transsphenoidal surgery on glucose homeostasis and insulin resistance in acromegaly
Stelmachowska‐Banaś, M., Zieliński, G., Zdunowski, P., Podgórski, J. K., & Zgliczyński, W. (2011) · Neurologia i Neurochirurgia Polska · doi:10.1016/s0028-3843(14)60103-1 · Cited by 22
“5 [19] and the quantitative in sulin sensitivity check index (QUICKI) = 1/[log (fasting insulin, μIU/mL) + log (fasting glucose, mg/dL)] [20].”
BackgroundAdiponectin in Women with Polycystic Ovary Syndrome
Shin, H., Lee, D., & Lee, J. (2011) · Korean Journal of Family Medicine · doi:10.4082/kjfm.2011.32.4.243 · Cited by 22
Chemotherapy for testicular cancer induces acute alterations in diastolic heart function
van Schinkel, L. D., Willemse, P.-P. M., van der Meer, R. W., Burggraaf, J., van Elderen, S. G. C., Smit, J. W. A., Roos, A., Osanto, S., & Lamb, H. J. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.445 · Cited by 22
“Insulin resistance was assessed with the quantitative insulin sensitivity index (Quicki index), which is calculated using the formula: 1 / (log(fasting insulin μU/mL) + log(fasting glucose mg/dL)) (16).”
Reinehr, T., Scherag, A., Wang, H., Roth, C. L., Kleber, M., Scherag, S., Boes, T., Vogel, C. I. G., Hebebrand, J., & Hinney, A. (2011) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2010.00738.x · Cited by 22
“Additionally, the quantitative insulin sensitivity check index was calculated (22): QUICKI = 1/log [fasting insulin (mU/L)] + log (fasting glucose (mg/dL)].”
MethodBahijri, S., Alissa, E. M., Akbar, D. H., & Ghabrah, T. (2010) · Annals of Saudi Medicine · doi:10.4103/0256-4947.65252 · Cited by 22
Review: Obesity and cardiometabolic syndrome in children
Velasquez‐Mieyer, P., Neira, C. P., Nieto-Martínez, R. E., & Cowan, P. A. (2007) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944707082800 · Cited by 21
Brownley, K. A., Heymen, S., Hinderliter, A. L., Galanko, J. A., & MacIntosh, B. (2012) · Journal of Nutrition · doi:10.3945/jn.111.146365 · Cited by 24
“In addition, insulin sensitivity was calculated using the Quantitative Insulin Sensitivity Check Index (32) on the basis of fasting insulin and glucose concentrations that were obtained at study entry.”
MethodChikani, V., Reding, D. J., Gunderson, P. D., & McCarty, C. A. (2005) · The Journal of Rural Health · doi:10.1111/j.1748-0361.2005.tb00098.x · Cited by 22
Prevalencia del síndrome metabólico y sus componentes en niños y adolescentes con obesidad
Ceballos, L. T., Siguero, J. P. L., & Ortiz, A. J. (2007) · Anales de Pediatría · doi:10.1016/s1695-4033(07)70653-7 · Cited by 22
Hyperreninemia Characterizing Women with Polycystic Ovary Syndrome Improves after Metformin Therapy
Diamanti‐Kandarakis, E., Economou, F., Livadas, S., Tantalaki, E., Piperi, C., Papavassiliou, A. G., & Panidis, D. (2009) · Kidney & Blood Pressure Research · doi:10.1159/000201791 · Cited by 22
Insulin-Like Growth Factor Binding Protein-1 to Screen for Insulin Resistance in Children
Motaghedi, R., Gujral, S., Sinha, S., Sison, C., Ten, S., & Maclaren, N. (2007) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2006.0056 · Cited by 21
What kind of simple fasting index should be used to estimate insulin sensitivity in humans?
Bastard, J., RABASA-LHORET, R. P. R., Maachi, M., Ducluzeau, P., Andréelli, F., Vidal, H., & Laville, M. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70038-1 · Cited by 21
“Some of them, such as homeostasis model assessment (HOMA) [2], the fasting insulin resistance index (FIRI) [3] and the quantitative insulin sensitivity check index (QUICKI) [4], are based on formulae that calculate the product or the addition of fasting plasma insulin and glucose values whereas others measure their ra…”
BackgroundCagnacci, A., Arangino, S., Renzi, A., Cagnacci, P., & Volpe, A. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1450281 · Cited by 22
Simple Fasting Methods to Assess Insulin Sensitivity in Childhood
Cutfield, W. S., & Hofman, P. L. (2005) · Hormone Research in Paediatrics · doi:10.1159/000089314 · Cited by 22
“QUICKI In recent years, Katz and colleagues have developed an alternative formula, based on fasting plasma glucose and insulin values, to assess insulin sensitivity [”
MethodPerseghin, G., Caumo, A., Mazzaferro, V., et al. (2003) · Transplantation · doi:10.1097/01.tp.0000079252.94857.8d · Cited by 22
“QUICKI was calculated as previously described (14):”
BackgroundComparison of intramyocellular lipid metabolism in patients with diabetes and male athletes
Mezincescu, A. M., Rudd, A. E., Cheyne, L., Horgan, G. W., Philip, S., Cameron, D., van Loon, L. J. C., Whitfield, P. D., Gribbin, R., Hu, M. K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47843-y · Cited by 22
de Souza, S. R., de Oliveira, G. M. M., Luiz, R. R., & Rosa, G. (2016) · Nutrición Hospitalaria · doi:10.20960/nh.40 · Cited by 21
“La glucemia, HOMA-IR, y QUICKI fueron significativas en inferiores sólo en el grupo que consumió salvado de avena.”
InfluentialFisher, K. D., Scheffler, T. L., Kasten, S. C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072320 · Cited by 21
“Insulin resistance was estimated using homeostatic model assessment (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) as previously described [21,22].”
MethodPlasma adiponectin—an independent indicator of liver fat accumulation
Pisto, P., Ukkola, O. H., Santaniemi, M., & Kesäniemi, Y. A. (2011) · Metabolism · doi:10.1016/j.metabol.2011.03.009 · Cited by 21
“sensitivity check index {QUICKI = 1/[log (fasting insulin)+log (fasting glucose)]} [26].”
BackgroundThe Relationship Between Metabolic Syndrome and Left Ventricular Mass Index in Obese Children-
Atabek, M. E., Akyüz, E., Eklioğlu, B. S., & Çimen, D. (2011) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.v3i3.26 · Cited by 21
“QUICK-I was calculated as 1/ [(log fasting insulin concentration (μU/mL) + log fasting glucose concentration (mg/dL)] (16,17).”
MethodFreitas, P., Carvalho, D. M., Santos, A. C., Mesquita, J., Matos, M. J., Madureira, A. J., Martínez, E., Sarmento, A., & Medina, J. L. (2012) · BMC Infectious Diseases · doi:10.1186/1471-2334-12-180 · Cited by 21
“QUICKI 1⁄4 1=ðlog fasting insulin in mU=l 1⁄2 þ log fasting plasma glucose inmg=dL 1⁄2 [27].”
Li, X., Kitamura, T., Kawamura, G., Mori, Y., Sato, K., Araki, Y., Sato, R., & Yamada, Y. (2014) · BioScience Trends · doi:10.5582/bst.2014.01060 · Cited by 21
“The quantitative insulin sensitivity check index (QUICKI) was calculated using the following equation: QUICKI = 1/(log [plasma insulin level (μIU/mL)] + log [blood glucose level (mg/dL)]) (15).”
MethodInfluentialCiresi, A., Pizzolanti, G., Leotta, M., Guarnotta, V., Teresi, G., & Giordano, C. S. D. S. (2016) · Journal of Endocrinological Investigation · doi:10.1007/s40618-016-0475-z · Cited by 21
“At univariate analysis, leptin levels at 12 months were found to be directly correlated with BMI (rho 0.683; p < 0.001), WC (rho 0.670; p < 0.001), fasting insulin (rho 0.449; p = 0.013), Homa-IR (rho 0.591; p = 0.001) and inversely correlated with QUICKI (rho −0.432; p = 0.017).”
MethodInfluentialGliemann, L., Rytter, N., Lindskrog, M. S., Slingsby, M. H. L., Akerstrom, T. C. A., Sylow, L., Richter, E. A., & Hellsten, Y. (2017) · The Journal of Physiology · doi:10.1113/jp274623 · Cited by 21
“V̇O2max, maximal oxygen optake; QUICKI, quantitative insulin sensitivity check index (Katz et al. 2000).”
InfluentialDiurnal Variation of Sweet Taste Recognition Thresholds Is Absent in Overweight and Obese Humans
Sanematsu, K., Nakamura, Y., Nomura, M., Shigemura, N., & Ninomiya, Y. (2018) · Nutrients · doi:10.3390/nu10030297 · Cited by 20
“The quantitative insulin sensitivity check index (QUICKI) (=1/(log fasting insulin + log fasting glucose)) and HOMA-IR (=fasting insulin × fasting glucose/405) were calculated for a rough estimation of insulin sensitivity and resistance [14,15].”
You, B. H., Chin, Y., Kim, H., et al. (2018) · Phytotherapy Research · doi:10.1002/ptr.6036 · Cited by 21
“Insulin sensitivity was calculated using the following formula (Katz et al., 2000): insulin sensitivity = 1 / [log (fasting insulin μU/ ml) + log (fasting glucose mg/dl)].”
MethodMetabolic correlates of health-related quality of life among overweight and obese adolescents
Lee, C., Lin, C., Strong, C., Lin, Y.-F., Chou, Y., & Tsai, M. (2018) · BMC Pediatrics · doi:10.1186/s12887-018-1044-8 · Cited by 21
“Compared to normal-weight participants, overweight and obese adolescents had higher BMI z-scores, higher fasting insulin, higher HOMA-IR and QUICKI values, higher TG, lower HDL cholesterol, and lower 25-OHD levels (Table 1).”
MethodInfluentialInterleukin-38 increases the insulin sensitivity in children with the type 2 diabetes
Liu, Y., Chen, T., Zhou, F., Mu, D., & Liu, S. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106264 · Cited by 21
Fibroscan as a non-invasive predictor of hepatic steatosis in women with polycystic ovary syndrome
Chakraborty, S., Ganie, M. A., Masoodi, I., Jana, M., Shalimar, S., Gupta, N., & Sofi, N. Y. (2020) · The Indian Journal of Medical Research · doi:10.4103/ijmr.ijmr_610_18 · Cited by 21
Wun, C. H., Zhang, M. J., Ho, B. H., McGeough, K., Tan, F. H. Y., & Aziz, A. R. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17134860 · Cited by 24
Filali, Y., Kesäniemi, Y. A., & Ukkola, O. H. (2021) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2021.1904518 · Cited by 21
“A low reading indicated high insulin resistance [10].”
BackgroundCalcaterra, V., Verduci, E., Schneider, L. A., Cena, H., Silvestri, A. D., Vizzuso, S., Vinci, F., Mameli, C., & Zuccotti, G. (2021) · Children · doi:10.3390/children8060449 · Cited by 21
“5) [8]; • Quantitative Insulin sensitivity Check Index (QUICK index) calculated as the inverse of the sum of the logarithms of fasting insulin and fasting glucose: 1/(log(fasting insulin μU/mL) + log(fasting glucose mg/dL)) [38].”
MethodOlaniyi, K. S., Owolabi, M. N., Atuma, C. L., Agunbiade, T. B., & Alabi, B. Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-98605-5 · Cited by 23
de Paiva, P. D. C., Marinho, T. D. S., Mandarim‐de‐Lacerda, C. A., & Águila, M. B. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.108997 · Cited by 21
Nowak, M., & Grzeszczak, W. (2022) · Endokrynologia Polska · doi:10.5603/ep.a2022.0014 · Cited by 24
Hagi, K., Nitta, M., Watada, H., et al. (2023) · Journal of Diabetes Investigation · doi:10.1111/jdi.14070 · Cited by 21
“…ef fi cacy outcomes, including BMI, bodyweight, fasting proinsulin-to-insulin ratio, fasting plasma glucose, glycated albumin, homeostatic model assessment of b -cell function (HOMA-b ), LDL-C and quantitative insulin check index 34 , showed a signi fi cant difference with imeglimin versus placebo.”
BackgroundSayed, A. A., Moteleb, M. M. A., Shafee, E. E., et al. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106052 · Cited by 21
Nunes, E. A., Gonçalves-Neto, L. M., Ferreira, F. B. D., dos Santos, C., Fernandes, L. C., Boschero, A. C., Calder, P. C., & Rafacho, A. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0456 · Cited by 22
Dutta, D., Choudhuri, S., Mondal, S. A., et al. (2013) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.12.007 · Cited by 21
“HOMA2-IR (homeostatic model assessment) and QUICKI (quantitative insulin sensitivity check index) were calculated as measures of IR [7,8].”
BackgroundMethodNelson, T. L., Bessesen, D. H., & Marshall, J. A. (2007) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.747 · Cited by 21
“index [QUICKI = 1/(log(glucose, mg/dL) + log (insulin, uU/mL)] [19].”
Daoussis, D., Panoulas, V. F., John, H., Toms, T. E., Antonopoulos, I., Treharne, G. J., Nightingale, P., Douglas, K., & Kitas, G. D. (2010) · Clinical Rheumatology · doi:10.1007/s10067-010-1446-y · Cited by 21
“Traditional CVD risk factors recorded for each patient included: (1) hypertension (HT) as previously described [17], (2) insulin resistance, which was evaluated using the Homeostasis Model Assessment of Insulin Resistance (HOMA IR) [18] and the Quantitative Insulin sensitivity Check Index (QUICKI) [19]: it was defined…”
MethodThe value of neck circumference (NC) as a predictor of non-alcoholic fatty liver disease (NAFLD)
Hu, Y., Chen, J., Lü, Y., Chen, P., Li, J., Chen, L., Chen, J., Huang, X., Zhang, Y., Bu, S., et al. (2014) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2014.07.001 · Cited by 21
“The quantitative insulin-sensitivity check index (QUICKI) 1⁄4 [1/(log FBG log FINS)] was performed as described earlier [12].”
MethodAmbulatory Blood Pressure and Subclinical Cardiovascular Disease in Children With Turner Syndrome
Akyürek, N., Atabek, M. E., Eklioğlu, B. S., & Alp, H. (2013) · Pediatric Cardiology · doi:10.1007/s00246-013-0740-2 · Cited by 21
“QUICK- I was calculated as 1/[(log fasting insulin concentration (lU/mL) ? log fasting glucose concentration (mg/dL)] [9].”
MethodRen, Z., Zhang, P., Zhang, X., Chen, S.-K., Zhang, H., Lv, D.-T., Zhuang, B.-Q., Wen, Y., Hu, H., Ding, W., et al. (2014) · Nutrition · doi:10.1016/j.nut.2014.10.012 · Cited by 21
Bae, M. J., Lee, S. Y., Kim, Y. J., et al. (2013) · Journal of Women s Health · doi:10.1089/jwh.2012.4148 · Cited by 21
“HOMA-IR (homeostasis assessment of insulin resistance) {fasting insulin ( l IU/mL) · fasting glucose (mg/ dL)/405} 18 and QUICKI (quantitative insulin-sensitivity check index) {1/ [(log fasting insulin ( l IU/mL) · log fasting glucose (mg/dL)]} 19 were used for estimating insulin sensitivity.”
Piatti, P., Setola, E., Galluccio, E., Costa, S., Fontana, B., Stuccillo, M., Crippa, V., Cappelletti, A. M., Margonato, A., Bosi, E., et al. (2014) · Acta Diabetologica · doi:10.1007/s00592-014-0599-6 · Cited by 21
“trations [21] and using OGTT insulin sensitivity (OGIS) method [22–25].”
MethodLipid, adipokine and ghrelin levels in myocardial infarction patients with insulin resistance
Gruzdeva, O. V., Учасова, Е. Г., Belik, E. V., et al. (2014) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-14-7 · Cited by 21
“, serum insulin and glucose levels as well as the IR index [3].”
BackgroundInfluentialVos, R. C., Wit, J. M., Pijl, H., Kruyff, C. C., & Houdijk, E. C. A. M. (2011) · Trials · doi:10.1186/1745-6215-12-110 · Cited by 22
“Insulin sensitivity is calculated using the quantitative insulin-sensitivity check index (QUICKI) formula: 1/(log fasting insulin (mU/L)+log fasting glucose (mg/dl)) [89].”
MethodEspinós, J. J., Corcoy, R., & Calaf, J. (2009) · Gynecological Endocrinology · doi:10.1080/09513590802585597 · Cited by 21
Markopoulos, M. C., Valsamakis, G., Kouskouni, E. E., Boutsiadis, A., Papassotiriou, I., Creatsas, G. K., & Mastorakos, G. P. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0550 · Cited by 20
Pastucha, D., Filipčíková, R., Horáková, D., Radová, L., Marinov, Z., Malinčíková, J., Kocvrlich, M., Horák, S., Bezdičková, M., & Dobiáš, M. (2013) · Physiological Research · doi:10.33549/physiolres.932438 · Cited by 26
Al‐Hakeim, H. K., & Abdulzahra, M. S. (2014) · Journal of Medical Biochemistry · doi:10.2478/jomb-2014-0033 · Cited by 21
“Klju~ne re~i: Benetov indeks, HbA1c, insulinska rezistencija, QUICKI, dijabetes melitus tip 2 Methods Venous blood samples (5 mL) were drawn from each patient and control subject.”
BackgroundMethodInfluentialEstrogen deprivation in primate pregnancy leads to insulin resistance in offspring
Maniu, A., Aberdeen, G. W., Lynch, T. J., Nadler, J. L., Kim, S. O. K., Quon, M. J., Pepe, G. J., & Albrecht, E. D. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0530 · Cited by 21
“The value for the QUICKI, an index highly correlated with assessment of insulin sensitivity using the euglycemic glucose clamp method (Katz et al. 2000, Chen et al. 2005, Lee et al. 2011), was lower (P<0.01) in offspring from letrozoletreated baboons (0.337 ± 0.012) than untreated animals (0.429 ±…”
MethodInfluentialSelf-citationGraus‐Nunes, F., Rachid, T. L., Santos, F. D. O. D. S., Barbosa‐da‐Silva, S., & Souza‐Mello, V. (2016) · Endocrine · doi:10.1007/s12020-016-1213-1 · Cited by 21
Variable reliability of surrogate measures of insulin sensitivity after Roux-en-Y gastric bypass
Bojsen-Møller, K. N., Dirksen, C., Svane, M. S., Jørgensen, N. B., Holst, J. J., Richter, E. A., & Madsbad, S. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00291.2016 · Cited by 22
“Based on fasting concentrations (mean of three samples) of glucose (G0), insulin (I0), and fatty acids (FA0), we evaluated the following surrogate indices of insulin sensitivity: HOMA-IR (24) (expressed as inverse-HOMA-IR 1/HOMA-IR to estimate insulin sensitivity rather than resistance), the computer-generated HOMA of…”
BackgroundMethodShitole, S. G., Biggs, M. L., Reiner, A. P., Mukamal, K. J., Djoussé, L., Ix, J. H., Barzilay, J. I., Tracy, R. P., Siscovick, D. S., & Kizer, J. R. (2019) · Diabetes Care · doi:10.2337/dc19-0723 · Cited by 22
“resistance were selected: 1) quantitative insulin-sensitivity check index (QUICKI), which is derived from a formula using fasting insulin and fasting glucose and correlates well with glucose clamp studies (24,25), and 2) HOMA 2 index of”
MethodMcilroy, G. D., Mitchell, S. E., Han, W., et al. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.042655 · Cited by 21
Ibrahim, F., Samarawickrama, A., Hamzah, L., Vincent, R., Gilleece, Y. C., Waters, L. J., Kegg, S., Barbini, B., Campbell, L. J., Post, F. A., et al. (2020) · HIV Medicine · doi:10.1111/hiv.12961 · Cited by 21
Chin, S. O., Hwang, Y., Cho, I.-J., Jeong, I., Ahn, K. J., & Chung, H. Y. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3425 · Cited by 23
Obesity and insulin resistance in women with polycystic ovary syndrome
Hsu, C.-S., Wu, C., Wan-Chun, C., Ching-Tzu, L., Chang, C.-J., & Ming-I, H. (2010) · Gynecological Endocrinology · doi:10.3109/09513590.2010.488776 · Cited by 21
“Table II shows that the ISI (GIR, HOMA-IR, QUICKI) and the percentage of insulin resistance did not differ significantly among the women with PCOS and the normal control group whether they were nonobese or obese.”
MethodInfluentialGastaldelli, A., Perego, L., Paganelli, M., Sesti, G., Hribal, M. L., Chávez, A. O., DeFronzo, R. A., Pontiroli, A. E., & Folli, F. B. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9690-9 · Cited by 21
“We also calculated the QUICKI index [21] which can be considered an index of hepatic insulin sensitivity [22] although it also correlates with the euglycemic insulin clamp [21].”
MethodGreyling, A., Pieters, M., Hoekstra, T., Oosthuizen, W., & Schutte, A. E. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.04.006 · Cited by 21
The impact of sleep apnea treatment on carbohydrate metabolism in patients with acromegaly
Duarte, F. H. G., Jallad, R. S., Amaro, A. C. S., Drager, L. F., Lorenzi‐Filho, G., & Bronstein, M. D. (2012) · Pituitary · doi:10.1007/s11102-012-0430-8 · Cited by 21
“uk [21] and QUICKI, calculated from the following formula: QUICKI = 1/[log (Basal insulin mU/L) ? log (Basal glucose mg/dL)] [22].”
MethodRelaxin-3 is associated with metabolic syndrome and its component traits in women
Ghattas, M. H., Mehanna, E. T., Mesbah, N. M., et al. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.09.018 · Cited by 21
Panoulas, V. F., Douglas, K., Smith, J., Metsios, G. S., Elisaf, M., Nightingale, P., & Kitas, G. D. (2009) · Clinical and Experimental Hypertension · doi:10.1080/10641960802621267 · Cited by 21
“Insulin resistance was evaluated using the Homeostasis Model Assessment of Insulin Resistance (HOMA IR) (22) and the Quantitative Insulin sensitivity Check Index (QUICKI) (23): it was defined as presence of diabetes or, in its absence, HOMA IR of ≥ 2.5 and/or QUICKI of ≤ 0.333.”
MethodInfluentialSzabo, T. S., von Haehling, S., Habedank, D., Rauchhaus, M., Lainščak, M., Sandek, A., Schefold, J. C., Anker, S. D., & Doehner, W. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.07.030 · Cited by 21
Shin, Y., Park, S., & Choue, R. (2009) · Nutrition Research and Practice · doi:10.4162/nrp.2009.3.2.128 · Cited by 23
“We used the modified quantitative insulin sensitivity check index [QUICKI; 1 / (log(fasting insulin µU/mL) + log(fasting glucose mg/dL)] (Katz et al., 2000; Laaksonen et al., 2005) which was measured from the fasting blood samples that were taken at the beginning of the blood kinetics.”
MethodHOMA, QUICKI and MFfm to Measure Insulin Resistance in Morbid Obesity
Ruano, M. M., Silvestre, V. D. B., Castro, R., et al. (2006) · Obesity Surgery · doi:10.1381/096089206776945048 · Cited by 22
Protective Role of Oryeongsan Against Renal Inflammation and Glomerulosclerosis in db/db Mice
Yoon, J. J., Lee, Y. J., Kang, D. G., et al. (2014) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x14500906 · Cited by 21
“The blood glucose concentration was measured in whole blood obtained from the tail vein using an Onetouchr UltraTM Blood glucose Meter and Test Strip (Life Scan, CA, USA), and the HOMA-IR and QUICKI were calculated biweekly using the following formula (Katz et al., 2000):”
MethodRizza, S., Clementi, F., Porzio, O., Cardellini, M., Savo, A., Sérino, M., Chiricolo, G., Romeo, F., Lauro, R., & Federici, M. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.12.001 · Cited by 21
“Insulin sensitivity was assessed using Quicki (1/log10 fasting insulin mU/ml þ log10 fasting glucose mg/dl) [17].”
MethodPharmacogenomics of Metabolic Effects of Rosiglitazone
Šeda, O., Šedová, L., Oliyarnyk, O., Kazdová, L., K⊘enová, D., Corbeil, G., Hamet, P., Tremblay, J., & K⊘en, V. (2008) · Pharmacogenomics · doi:10.2217/14622416.9.2.141 · Cited by 21
“QUICKI was calculated from fasting plasma glucose (G)0 in mg/dl and insulin (I)0 in μIU/ml as follows: [33].”
MethodSamra, R. A., Hwalla, N. C., Torbay, N., Dib, L. H., & Fuleihan, G. E. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2049 · Cited by 21
Glucose Metabolism in Overweight Hispanic Adolescents With and Without Polycystic Ovary Syndrome
Nur, M. M., Newman, I. M., & Siqueira, L. (2009) · Pediatrics · doi:10.1542/peds.2008-2050 · Cited by 21
Insulin sensitivity and pancreatic β-cell function in patients with primary aldosteronism
Grewal, S., Fosam, A., Chalk, L., Deven, A., Suzuki, M., Correa, R. R., Blau, J. E., Demidowich, A. P., Stratakis, C. A., & Muniyappa, R. (2021) · Endocrine · doi:10.1007/s12020-020-02576-y · Cited by 20
“QUICKI is a fasting-based surrogate measure of insulin sensitivity, calculated from fasting blood glucose and plasma insulin concentrations: QUICKI= 1/((log(Insulinfasting)+log(Glucosefasting))) [30].”
MethodMonod, C., Kotzaeridi, G., Linder, T., Yerlikaya‐Schatten, G., Wegener, S., Mosimann, B., Henrich, W., Tura, A., & Göbl, C. S. (2023) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.14688 · Cited by 21
“…estimated from fasting parameters using the quantitative insulin sensitivity check index (QUICKI), multiplied by 10 2 for clearer presentation, 16 as well as by the improved triglyceride-glucose index (TyGIS), which was recently developed and validated in pregnant women by our study group.”
MethodThe Relationship between Vitamin D, Inflammatory Markers, and Insulin Resistance in Children
Okuyan, Ö., Dümür, Ş., Elgörmüş, N., & Uzun, H. (2024) · Nutrients · doi:10.3390/nu16173005 · Cited by 20
“The status of IR in participants was also evaluated by using fasting glucose-to-insulin ratio (FGIR), quantitative insulin sensitivity check index (QUICKI), and HOMA-β [18,19].”
Method
Metadata
- Authors
- Katz, A., Nambi, S. S., Mather, K., Baron, A. D., Follmann, D. A., Sullivan, G., & Quon, M. J.
- Affiliations
- National Institutes of Health (US)
- Indiana University Indianapolis (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2000-07-01
- Volume
- 85
- Issue
- 7
- Pages
- 2402-2410
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2126327417
- Cited by
- 3,931
- References
- 48
- Citations by year
- 2026: 97 · 2025: 129 · 2024: 142 · 2023: 174 · 2022: 188 · 2021: 173 · 2020: 184 · 2019: 145 · 2018: 153 · 2017: 174 · 2016: 170 · 2015: 164 · 2014: 184 · 2013: 219 · 2012: 169
- FWCI
- 33.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- QUICKI, insulin sensitivity, insulin resistance, fasting insulin, fasting blood glucose, glucose clamp, minimal model analysis, type 2 diabetes, obesity, insulin resistance index
- MeSH terms
- Adult, Blood Glucose, Diabetes Mellitus, Female, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Models, Biological, Obesity, Glucose Clamp Technique
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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