Cited by 539Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchAntioxidant Activity and Oxidative Stress

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Evidence of increased oxidative damage in subjects with mild cognitive impairment

Keller, J. N., Schmitt, F. A., Scheff, S. W., Ding, Q., Chen, Q., Butterfield, D. A., Markesbery, W. R.·2005·Neurology

DOI 10.1212/01.wnl.0000156156.13641.ba

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Abstract

OBJECTIVE: To determine if increased levels of oxidative damage are present in the brains of persons with mild cognitive impairment (MCI), a condition that often precedes Alzheimer disease (AD). METHODS: The authors assessed the amount of protein carbonyls, thiobarbituric acid-reactive substances (TBARS), and malondialdehyde in the superior and middle temporal gyri (SMTG) and cerebellum of short postmortem interval and longitudinally evaluated normal subjects and those with MCI and early AD. RESULTS: Elevated levels of protein carbonyls (approximately 25%), malondialdehyde (approximately 60%), and TBARS (approximately 210%) were observed in the SMTG of individuals with MCI and early AD vs normal control subjects. The elevation in TBARS was associated with the numbers of neuritic but not diffuse plaques. Levels of protein carbonyls increased as delayed verbal memory performance declined. CONCLUSION: Oxidative damage occurs in the brain of subjects with mild cognitive impairment, suggesting that oxidative damage may be one of the earliest events in the onset and progression of Alzheimer disease.

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Authors: Keller, J. N., Schmitt, F. A., Scheff, S. W., Ding, Q., Chen, Q., Butterfield, D. A., & Markesbery, W. R.
Affiliations: University of Kentucky (US)
ORCID: Keller, J. N.
Schmitt, F. A.
Ding, Q.
Butterfield, D. A.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-04-12
Volume: 64
Issue: 7
Pages: 1152-1156
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/01.wnl.0000156156.13641.ba
OpenAlex: W2161844942
Cited by: 539
References: 44
Citations by year: 2026: 3 · 2025: 14 · 2024: 10 · 2023: 17 · 2022: 23 · 2021: 25 · 2020: 16 · 2019: 15 · 2018: 21 · 2017: 26 · 2016: 19 · 2015: 22 · 2014: 30 · 2013: 28 · 2012: 43
FWCI: 21.37
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (5P50AG05114, R01AG018437, P01AG005119, AG0 18437)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: mild cognitive impairment, Alzheimer's disease, oxidative stress, protein carbonyls, malondialdehyde, TBARS, lipid peroxidation, temporal lobe, cerebellum, neuritic plaques, verbal memory, postmortem brain
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cognition Disorders, Female, Free Radicals, Humans, Male, Malondialdehyde, Memory Disorders, Nerve Degeneration, Neuropsychological Tests, Predictive Value of Tests, Up-Regulation, Thiobarbituric Acid Reactive Substances, Oxidative Stress, Disease Progression, Protein Carbonylation, Plaque, Amyloid

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Evidence of increased oxidative damage in subjects with mild cognitive impairment

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