The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2

Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes

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Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2

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TREM-1 amplifies inflammation and is a crucial mediator of septic shock

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Mutations in Two Genes Encoding Different Subunits of a Receptor Signaling Complex Result in an Identical Disease Phenotype

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Association of DAP12 with Activating CD94/NKG2C NK Cell Receptors

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Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts

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DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features

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TREM‐1 (Triggering Receptor Expressed on Myeloid Cells): A New Player in Acute Inflammatory Responses

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DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming.

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Impaired Differentiation of Osteoclasts in TREM-2–deficient Individuals

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How neuroinflammation contributes to neurodegeneration

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Microglia in Alzheimer’s disease

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Microglial physiology: unique stimuli, specialized responses

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The myeloid cells of the central nervous system parenchyma

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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

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Myelin in the Central Nervous System: Structure, Function, and Pathology

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TREM2 — a key player in microglial biology and Alzheimer disease

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Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

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Microglia: Dynamic Mediators of Synapse Development and Plasticity

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The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

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Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids

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TREM2, microglia, and neurodegenerative diseases

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TREM2 in Neurodegenerative Diseases

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TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

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TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

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Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia–like Syndrome Without Bone Involvement

Guerreiro, R. J., Lohmann, E., Brás, J. M., Gibbs, J. R., Rohrer, J. D., Gurunlian, N., Dursun, B., Bilgic, B., Hanagasi, H., Gurvit, H., et al. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.579 · Cited by 374

Soluble TREM2 induces inflammatory responses and enhances microglial survival

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Factors regulating microglia activation

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TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury

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Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status

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Immune Signaling in Neurodegeneration

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TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

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Coding variants in TREM2 increase risk for Alzheimer's disease

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Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation

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Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease

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Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo

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TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

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TREM2 regulates microglial cell activation in response to demyelination in vivo

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Blockade of TREM‐2 exacerbates experimental autoimmune encephalomyelitis

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TREM2-Ligand Interactions in Health and Disease

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An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function

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The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration

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Microglia in the developing brain: a potential target with lifetime effects

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The FTD‐like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism

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Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia

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The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders

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Microglia in Brain Development, Homeostasis, and Neurodegeneration

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OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

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TREM2 shedding by cleavage at the H157‐S158 bond is accelerated for the Alzheimer's disease‐associated H157Y variant

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From expression to signaling: Roles of TREM-1 and TREM-2 in innate immunity and bacterial infection

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The Role of APOE and TREM2 in Alzheimer′s Disease—Current Understanding and Perspectives

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Microglia as modulators of cognition and neuropsychiatric disorders

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Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia

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TREM2 is associated with the risk of Alzheimer's disease in Spanish population

Benitez, B. A., Cooper, B., Pastor, P., Jin, S.-C., Lorenzo, E., Cervantes, S., & Cruchaga, C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.12.018 · Cited by 163

A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family

Guerreiro, R., Bilgic, B., Guven, G., Brás, J., Rohrer, J., Lohmann, E., Hanagasi, H., Gurvit, H., & Emre, M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.06.005 · Cited by 158

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

Lessard, C. B., Malnik, S. L., Zhou, Y., Ladd, T. B., Cruz, P. E., Ran, Y., Chakrabaty, P., Mahan, T. E., Holtzman, D. M., Ulrich, J. D., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201809027 · Cited by 156

TREM 2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post‐Mortem Temporal Cortices

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TREM2 is associated with increased risk for Alzheimer’s disease in African Americans

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The surface‐exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor

Stefano, L., Racchetti, G., Bianco, F., Passini, N., Gupta, R. S., Panina‐Bordignon, P., & Meldolesi, J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06130.x · Cited by 150

Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease

Giraldo, M., Lopera, F., Siniard, A. L., Corneveaux, J. J., Schrauwen, I., Carvajal, J., Muñoz, C., Ramirez-Restrepo, M., Gaiteri, C., Myers, A. J., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.016 · Cited by 147

Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition

Price, B. R., Sudduth, T. L., Weekman, E. M., Johnson, S. N., Hawthorne, D., Woolums, A. E., & Wilcock, D. M. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01915-0 · Cited by 146

Dual Induction of TREM2 and Tolerance-Related Transcript, Tmem176b, in Amyloid Transgenic Mice: Implications for Vaccine-Based Therapies for Alzheimer’s Disease

Melchior, B., Garcia, A., Hsiung, B., Lo, K. M., Doose, J. M., Thrash, J. C., Stalder, A. K., Staufenbiel, M., Neumann, H., & Carson, M. J. (2010) · ASN NEURO · doi:10.1042/an20100010 · Cited by 134

Soluble TREM2: Innocent bystander or active player in neurological diseases?

Filipello, F., Goldsbury, C., You, S. F., Locca, A., Karch, C. M., & Piccio, L. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105630 · Cited by 134

Microglia-Mediated Neuroprotection, TREM2, and Alzheimer’s Disease: Evidence From Optical Imaging

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Microglia: unique and common features with other tissue macrophages

Prinz, M., Tay, T. L., Wolf, Y., & Jung, S. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1267-1 · Cited by 126

Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment

Nadeem, M. S., Kazmi, I. A., Ullah, I., Muhammad, K., & Anwar, F. (2021) · Antioxidants · doi:10.3390/antiox11010087 · Cited by 129

Mutations inTREM2lead to pure early-onset dementia without bone cysts

Chouery, É., Delague, V., Bergougnoux, A., Koussa, S., Serre, J., & Mégarbané, A. (2008) · Human Mutation · doi:10.1002/humu.20836 · Cited by 121

R47H TREM2 variant increases risk of typical early‐onset Alzheimer's disease but not of prion or frontotemporal dementia

Slattery, C. F., Beck, J. A., Harper, L., Adamson, G., Abdi, Z., Uphill, J., Campbell, T., Druyeh, R., Mahoney, C. J., Rohrer, J. D., et al. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.05.1751 · Cited by 119

TREM2 in Alzheimer’s disease

Jiang, T., Yu, J., Zhu, X., & Tan, L. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8424-8 · Cited by 122

Stimulation of TREM2 with agonistic antibodies—an emerging therapeutic option for Alzheimer's disease

Schlepckow, K., Morenas‐Rodríguez, E., Hong, S. Y., & Haass, C. (2023) · The Lancet Neurology · doi:10.1016/s1474-4422(23)00247-8 · Cited by 122

TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

Del‐Aguila, J. L., Benítez, B. A., Li, Z., Dube, U., Mihindukulasuriya, K. A., Budde, J., Farias, F., Fernández, M. V., Ibáñez, L., Jiang, S., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0319-3 · Cited by 106

Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders

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Developmental Regulation of TREM2 and DAP12 Expression in the Murine CNS: Implications for Nasu-Hakola Disease

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Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice

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TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism

Zheng, H., Cheng, B., Li, Y., Li, X., Chen, X., & Zhang, Y.-W. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00395 · Cited by 94

A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature

Dardiotis, E., Siokas, V., Pantazi, E., Dardioti, M., Rikos, D., Xiromerisiou, G., Markou, A., Papadimitriou, D. A., Speletas, M. G., & Hadjigeorgiou, G. M. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.01.015 · Cited by 88

Role of microglia-neuron interactions in diabetic encephalopathy

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Epigenomic profiling of preterm infants reveals DNA methylation differences at sites associated with neural function

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TREM2‐dependent effects on microglia in Alzheimer's disease

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Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation

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The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases

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The TREM2-DAP12 signaling pathway in Nasu–Hakola disease: a molecular genetics perspective

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RNA-Seq analysis implicates dysregulation of the immune system in schizophrenia

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A comprehensive profile of ChIP-Seq-based PU.1/Spi1 target genes in microglia.

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Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice

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TREM2 and sTREM2 in Alzheimer’s disease: from mechanisms to therapies

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TREM2 Variants and Neurodegenerative Diseases: A Systematic Review and Meta-Analysis

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Nasu–Hakola disease and primary microglial dysfunction

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