rTMS of the occipital cortex abolishes Braille reading and repetition priming in blind subjects
Abstract
To study the functional involvement of the visual cortex in Braille reading, we applied repetitive transcranial magnetic stimulation (rTMS) over midoccipital (MOC) and primary somatosensory (SI) cortex in blind subjects. After rTMS of MOC, but not SI, subjects made significantly more errors and showed an abolishment of the improvement in reading speed following repetitive presentation of the same word list, suggesting a role of the visual cortex in repetition priming in the blind.
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Neural disruption of visual cortex with TMS interferes with Braille reading.
“Additionally, neural disruption of visual cortex with TMS interferes with Braille reading (Cohen et al., 1997; Kupers et al., 2007).”
From Designing sensory-substitution devices: Principles, pitfalls and potential1 (2016) · cites this paper as Kupers et al., 2007
Cites
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Early ‘visual’ cortex activation correlates with superior verbal memory performance in the blind
Amedi, A., Raz, N., Pianka, P., Malach, R., & Zohary, E. (2003) · Nature Neuroscience · doi:10.1038/nn1072 · Cited by 591 · see citing works
Neural response suppression, haemodynamic repetition effects, and behavioural priming
Henson, R. N., & Rugg, M. D. (2002) · Neuropsychologia · doi:10.1016/s0028-3932(02)00159-8 · Cited by 444 · see citing works
Ptito, M. (2005) · Brain · doi:10.1093/brain/awh380 · Cited by 310 · see citing works
Self-citationAmedi, A., Flöel, A., Knecht, S., Zohary, E., & Cohen, L. (2004) · Nature Neuroscience · doi:10.1038/nn1328 · Cited by 286 · see citing works
What blindness can tell us about seeing again: merging neuroplasticity and neuroprostheses
Merabet, L. B., Rizzo, J. F., Amedi, A., Somers, D. C., & Pascual-Leone, A. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1586 · Cited by 179 · see citing works
Alexia for Braille following bilateral occipital stroke in an early blind woman
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V1 Activation in Congenitally Blind Humans is Associated with Episodic Retrieval
Raz, N., Amedi, A., & Zohary, E. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi026 · Cited by 149 · see citing works
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Neural reorganization following sensory loss: the opportunity of change
Merabet, L. B., & Pascual-Leone, A. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2758 · Cited by 751 · see citing works
Compensatory plasticity and cross-modal reorganization following early visual deprivation
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Designing sensory-substitution devices: Principles, pitfalls and potential1
Kristjánsson, Á., Moldoveanu, A., Jóhannesson, Ó. I., Balan, O., Spagnol, S., Valgeirsdóttir, V. V., & Unnthorsson, R. (2016) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-160647 · Cited by 116 · see citing works
“Additionally, tactile motion discrimination activates dorsal visual stream areas in the congenitally blind (Ptito et al., 2009).”
BackgroundTMS of the occipital cortex induces tactile sensations in the fingers of blind Braille readers
Ptito, M., Fumal, A., de Noordhout, A. M., Schoenen, J., Gjedde, A., & Kupers, R. (2008) · Experimental Brain Research · doi:10.1007/s00221-007-1091-0 · Cited by 113 · see citing works
Self-citationTactile-‘visual’ acuity of the tongue in early blind individuals
Chebat, D.-R., Rainville, C., Kupers, R., & Ptito, M. (2007) · Neuroreport · doi:10.1097/wnr.0b013e3282f2a63 · Cited by 88 · see citing works
Self-citationCortical visual prostheses: From microstimulation to functional percept
Najarpour Foroushani, A., Pack, C. C., & Sawan, M. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aaa904 · Cited by 62 · see citing works
- Authors
- Kupers, R., Pappens, M., de Noordhout, A. M., Schoenen, J., Ptito, M., & Fumal, A.
- Affiliations
- University of Liège (BE)
- From the PET Unit and Department of Surgical Pathophysiology (R.K., M.P.), Rigshospitalet, Copenhagen, Denmark; Department of Neurology and Neuroanatomy (A.M.d.N., J.S., A.F.), University of Liège, Belgium; and Ecole d’Optométrie (M.P.), Université de Montréal, Quebec, Canada.
- Venue
- Neurology
- Published
- 2007-02-27
- Volume
- 68
- Issue
- 9
- Pages
- 691-693
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1968750799
- Cited by
- 74
- References
- 10
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 8 · 2013: 2 · 2012: 11
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- Braille reading, repetition priming, visual cortex, occipital cortex, primary somatosensory cortex, blindness, transcranial magnetic stimulation, reading speed, visual cortex reorganization
- MeSH terms
- Adaptation, Physiological, Adult, Blindness, Cues, Evoked Potentials, Extinction, Psychological, Female, Humans, Male, Neuronal Plasticity, Occipital Lobe, Reading, Sensory Aids, Task Performance and Analysis, Touch, Visual Cortex, Transcranial Magnetic Stimulation
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