Cited by 625Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment ResearchCancer-related cognitive impairment studies

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Cognitive impairment in incident, untreated Parkinson disease: The Norwegian ParkWest Study

Aarsland, D., Brønnick, K., Larsen, J. P., Tysnes, O. B., Alves, G.·2009·Neurology

DOI 10.1212/01.wnl.0000338632.00552.cb

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Abstract

BACKGROUND: Little is known regarding the cognitive impairment in subjects with early, drug-naïve Parkinson disease (PD). The aim of this study was to explore the proportion with mild cognitive impairment (MCI) and subtypes in an incidence cohort of untreated PD in Southern and Western Norway. METHODS: A total of 196 non-demented, drug-naive patients who were recruited after an extensive search of all new cases of PD in the area and 201 healthy control subjects completed a battery of neuropsychological tests of verbal memory, visuospatial, and attentional-executive functioning. Subjects were classified as MCI if the age- and education-corrected z-score was falling 1.5 standard deviations below the mean for at least one of the cognitive domains. RESULTS: The PD group was more impaired on all neuropsychological tests than controls, but the effect sizes were small. The largest effect size was found for verbal memory. A total of 18.9% of the patients with PD were classified as MCI, with a relative risk of 2.1 (1.2-3.6) in PD compared to the control group. Patients with PD with and without MCI did not differ significantly regarding demographic and motor features. Among PD-MCI patients, nearly two-thirds had a non-amnestic MCI subtype, and one third had an amnestic MCI subtype. CONCLUSIONS: The findings demonstrate a twofold increase in the proportion with cognitive impairment in subjects with early, untreated Parkinson disease (PD) compared to controls. This has implications for diagnosis and management of PD. AD = Alzheimer disease; aMCI-MD = amnestic multiple-domain MCI; aMCI-SD = amnestic single-domain MCI; CVLT-2 = California Verbal Learning Test II; IQCode = Informant Questionnaire on Cognitive decline in the elderly; MADRS = Montgomery and Aasberg Depression Rating Scale; MCI = mild cognitive impairment; MMSE = Mini-Mental State Examination; naMCI-MD = non-amnestic multiple-domain MCI; naMCI-SD = non-amnestic single-domain MCI; PD = Parkinson disease; RR = relative risks; UPDRS = Unified Parkinson's Disease Rating Scale; VOSP = Visual Object and Space Perception Battery.

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Authors: Aarsland, D., Brønnick, K., Larsen, J. P., Tysnes, O. B., & Alves, G.
Affiliations: Stavanger University Hospital (NO)
From The Norwegian Centre for Movement Disorders (D.A., K.B., J.P.L., G.A.), Department of Neurology (J.P.L., G.A.), and Department of Psychiatry (D.A.), Stavanger University Hospital, Stavanger; Department of Neurology (O.B.T.), Haukeland University Hospital, Bergen; and School of Medicine (D.A., J.P.L., O.B.T.), University of Bergen, Norway.
ORCID: Aarsland, D.
Brønnick, K.
Tysnes, O. B.
Alves, G.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-03-31
Volume: 72
Issue: 13
Pages: 1121-1126
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/01.wnl.0000338632.00552.cb
OpenAlex: W2120049868
Cited by: 625
References: 25
Citations by year: 2026: 13 · 2025: 19 · 2024: 24 · 2023: 19 · 2022: 33 · 2021: 34 · 2020: 33 · 2019: 39 · 2018: 34 · 2017: 44 · 2016: 43 · 2015: 40 · 2014: 40 · 2013: 53 · 2012: 48
FWCI: 22.96
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords: Parkinson's disease, mild cognitive impairment, early-stage Parkinson's disease, amnestic MCI, non-amnestic MCI, verbal memory impairment, executive function, visuospatial ability, attention, prevalence of cognitive impairment
MeSH terms: Aged, Cognition Disorders, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Norway, Parkinson Disease, Prospective Studies, Incidence

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Cognitive impairment in incident, untreated Parkinson disease: The Norwegian ParkWest Study

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