Cited by 158Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsMenopause: Health Impacts and Treatments

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Change in risk of Alzheimer disease over time

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Hebert, L.E., Bienias, J.L., Aggarwal, N.T., Wilson, R.S., Bennett, D.A., Shah, R.C., Evans, D.A.·2010·Neurology

DOI 10.1212/wnl.0b013e3181f0754fPMC PMC2938969

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Abstract

OBJECTIVE: To assess whether the risk of incidence of Alzheimer disease (AD) varies over time. The increase in numbers of people at the oldest ages in the population will bring an increase in the number of people with AD. Projections of the size of the increase assume the risk of AD is constant. METHODS: All persons age 65 or older in a biracial, geographically defined area were invited to participate in a home interview every 3 years. From the approximately 10,000 participants, stratified random samples were selected for detailed clinical evaluation. At each cycle, individuals determined free of AD in a previous cycle, either by examination or by high score on cognitive function tests, were sampled in the subsequent cycle for evaluation for incident AD. The evaluations for disease were structured and uniform across time. These analyses include 1,695 subjects evaluated for incident disease from 1997 through 2008. RESULTS: AD developed in 360 participants. Change over time in risk of incident disease was assessed in logistic regression analyses including evaluation date and controlling for age, gender, education, race, interval from disease-free designation to evaluation for incident disease, and sample design. The time variable (in years) was not significant (odds ratio = 0.970, 95% confidence interval = 0.902 to 1.044). CONCLUSIONS: The null relation of evaluation date to disease incidence suggests no recent change in risk of AD over time, and supports this assumption for projections of AD.

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Authors: Hebert, L. E., Bienias, J. L., Aggarwal, N. T., Wilson, R. S., Bennett, D. A., Shah, R. C., & Evans, D. A.
Affiliations: Rush University Medical Center (US)
Corresponding author: Hebert, L.E.
ORCID: Aggarwal, N.T.
Bennett, D.A.
Shah, R.C.
Evans, D.A.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2010-08-31
Volume: 75
Issue: 9
Pages: 786-791
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.0b013e3181f0754f
PMC: PMC2938969
OpenAlex: W2163324016
Cited by: 158
References: 23
Citations by year: 2026: 6 · 2025: 11 · 2024: 12 · 2023: 8 · 2022: 19 · 2021: 16 · 2020: 10 · 2019: 18 · 2018: 15 · 2017: 14 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 3
FWCI: 2.62
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Neurology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (AG11101)
National Institute on Aging (RC2AG036650, R01AG017917, P30-AG 10161, U01AG012505, R01AG030146, AG 10161, R01 AG15819, AG029652, AG030146, R01AG11101, AG09966, AG-11101, R01AG030142, R01AG032247, U01 AG016979, R01AG011101, R01AG036042, U01AG010483, R01AG015819, P30AG010161, P01AG01449, AG036650, R01AG032755, R01AG030544, RC2AG036547, AG021972, R01AG024480, R01AG021972, P01AG009466, U24AG026395, P30 AG101061, 01AG032984, AG12505, R03AG029652, R01AG009966, R01AG024871, R01AG033678, R01AG034374, R01AG022018)
National Heart, Lung, and Blood Institute (HL 084209, R01HL084209, R01HL096944)
National Institute of Nursing Research (R01NR009543, R01NR010211, NR009543)
National Institute of Environmental Health Sciences (R01ES010902, ES 10902)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: Alzheimer's disease, incidence, oldest old, cognitive function
MeSH terms: Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Black or African American, Chicago, Female, Humans, Longitudinal Studies, Male, Risk Factors, Sex Factors, Socioeconomic Factors, Time Factors, Cohort Studies, Incidence, Black People, White People, Apolipoprotein E4

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