Dissociation of letter and picture naming resulting from callosal disconnection
Abstract
BACKGROUND: Detailed mapping of the corpus callosum for functional fractionation in humans remains incomplete. OBJECTIVE: To examine separable interhemispheric transfer of visual information by callosal fibers, especially in the splenium. METHODS: We examined callosal disconnection signs in a 14-year-old boy with a lesion confined to the posterior part of the splenium and reviewed reported cases with callosal lesions. RESULTS AND CONCLUSION: The patient presented with left hemialexia as the only manifestation of callosal disconnection syndrome. The only difficulty demonstrated was in reading aloud or copying letters, which were presented tachistoscopically to the left visual field, with his right hand. He could copy letters presented to his left visual field with his left hand, however. Therefore, left hemialexia was not due to hemiamblyopia or hemineglect. There was no anomia for pictures and colors in the left visual field. MRI revealed that the lesion was limited to the ventroposterior end of the splenium. Review of 40 reported patients with callosal lesions suggests that the anterior to middle part of the splenium is involved in transferring picture information from the language-nondominant hemisphere to the language-dominant hemisphere and that the ventroposterior part is involved in transferring letter information.
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Alexia restricted to the left half of the visual field results from lesions of posterior callosal pathways.
“The clearest example of such a deafferentation is the alexia restricted to the left half of the visual field which results from lesions of posterior callosal pathways (Suzuki et al., 1998).”
From Specialization within the ventral stream: the case for the visual word form area (2004) · cites this paper as Suzuki et al., 1998
Cites
NAESER, M. A., PALUMBO, C. L., HELM-ESTABROOKS, N., STIASSNY-EDER, D., & ALBERT, M. L. (1989) · Brain · doi:10.1093/brain/112.1.1 · Cited by 298 · see citing works
ANALYSIS OF CEREBELLAR MOTOR DISORDERS BY VISUALLY-GUIDED ELBOW TRACKING MOVEMENT
Beppu, H., Nagaoka, M., & Tanaka, R. (1987) · Brain · doi:10.1093/brain/110.1.1 · Cited by 195 · see citing works
Cognitive Interaction After Staged Callosal Section: Evidence for Transfer of Semantic Activation
Sidtis, J. J., Volpe, B. T., Holtzman, J. D., Wilson, D. H., & Gazzaniga, M. S. (1981) · Science · doi:10.1126/science.6782673 · Cited by 176 · see citing works
COLLOID CYST OF THE THIRD VENTRICLE
Trescher, J. H. (1937) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1937.02260160259022 · Cited by 89 · see citing works
Rosa, A., Demiati, M., Cartz, L., & Mizon, J. P. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530210118032 · Cited by 51 · see citing works
Patterns of oral-verbal perseveration in adult aphasics
Pietro, M. J. S., & Rigrodsky, S. (1986) · Brain and Language · doi:10.1016/0093-934x(86)90030-1 · Cited by 44 · see citing works
Overproduction of cerebrospinal fluid in communicating hydrocephalus
Cutler, R. W. P., Murray, J. E., & Moody, R. A. (1973) · Neurology · doi:10.1212/wnl.23.1.1 · Cited by 34 · see citing works
A study of patient who had alexia without agraphia.
Cumming, W. J. K., Hurwitz, L. J., & Perl, N. T. (1970) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.33.1.34 · Cited by 28 · see citing works
Sanson, M. (1996) · PubMed · Cited by 4 · see citing works
Thomas, J. S. (1978) · PubMed · Cited by 4 · see citing works
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Cited by
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Cohen, L., Dehaene, S., Naccache, L., Lehéricy, S., Dehaene-Lambertz, G., Hénaff, M.-A., & Michel, F. (2000) · Brain · doi:10.1093/brain/123.2.291 · Cited by 1,954 · see citing works
Gazzaniga, M. S. (2000) · Brain · doi:10.1093/brain/123.7.1293 · Cited by 1,414 · see citing works
Specialization within the ventral stream: the case for the visual word form area
Cohen, L., & Dehaene, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.12.049 · Cited by 776 · see citing works
Diffusion tensor imaging of the corpus callosum in Autism
Alexander, A. L., Lee, J. E., Lazar, M., Boudos, R., DuBray, M. B., Oakes, T. R., Miller, J. N., Lu, J. K., Jeong, E., McMahon, W. M., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.08.032 · Cited by 593 · see citing works
Cohen, L. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg079 · Cited by 400 · see citing works
Pure alexia as a disconnection syndrome: New diffusion imaging evidence for an old concept
Epelbaum, S., Pinel, P., Raphaël Gaillard, B., Delmaire, C., Perrin, M., Dupont, S., Dehaene, S., & Cohen, L. (2008) · Cortex · doi:10.1016/j.cortex.2008.05.003 · Cited by 283 · see citing works
Zahr, N. M., Torsten Rohlfing, B., Pfefferbaum, A., & Sullivan, E. V. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.09.046 · Cited by 276 · see citing works
The pathophysiology of letter-by-letter reading
Cohen, L., Henry, C., Dehaene, S., Martinaud, O., Lehéricy, S., Lemer, C., & Ferrieux, S. (2004) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.04.018 · Cited by 158 · see citing works
Visualizing the neural bases of a disconnection syndrome with diffusion tensor imaging
Molko, N., Cohen, L., Mangin, J. F., Chochon, F., Lehéricy, S., Bihan, D. L., & Dehaene, S. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/08989290260045864 · Cited by 144 · see citing works
Niogi (2010) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.002.2010 · Cited by 138 · see citing works
Insights into the functional specificity of the human corpus callosum.
Funnell, M. G., Corballis, P., & Gazzaniga, M. (2000) · Brain : a journal of neurology · doi:10.1093/brain/123.5.920 · Cited by 77 · see citing works
Ivanovic, D. M., Leiva, B. P., Pérez, H. T., Inzunza, N. B., Almagià, A. F., Toro, T. D., Urrutia, M. S. C., Cervilla, J. O., & Bosch, E. O. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00431-7 · Cited by 106 · see citing works
Lin, S. E., Chen, H., Zhao, J., Li, S., He, S., & Weng, X. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.071 · Cited by 88 · see citing works
Le, T. H., Mukherjee, P., Henry, R. G., Berman, J., Ware, M. L., & Manley, G. T. (2005) · Neurosurgery · doi:10.1227/01.neu.0000144846.00569.3a · Cited by 84 · see citing works
Baird, A. A., Colvin, M. K., Horn, J. D. V., Inati, S., & Gazzaniga, M. S. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/0898929053467569 · Cited by 75 · see citing works
Visual interhemispheric communication and callosal connections of the occipital lobes
Berlucchi, G. (2013) · Cortex · doi:10.1016/j.cortex.2013.02.001 · Cited by 66 · see citing works
Beyond the visual word form area: The orthography–semantics interface in spelling and reading
Purcell, J. J., Shea, J., & Rapp, B. C. (2014) · Cognitive Neuropsychology · doi:10.1080/02643294.2014.909399 · Cited by 51 · see citing works
Gainotti, G. (2003) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2003.08.006 · Cited by 50 · see citing works
Treatment of reading impairment after stroke
Leff, A. P., & Behrmann, M. (2008) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3283168dc7 · Cited by 44 · see citing works
Cognitive impairments associated with corpus callosum infarction: a ten cases study.
Huang, X., Du, X., Song, H., Zhang, Q., Jia, J., Xiao, T., & Wu, J. (2015) · PubMed Central · Cited by 41 · see citing works
Brain mechanisms of recovery from pure alexia: A single case study with multiple longitudinal scans.
Cohen, L., Dehaene, S., McCormick, S. F., Durant, S., & Zanker, J. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.07.009 · Cited by 28 · see citing works
Regional Callosal Morphology in Autism and Macrocephaly
Kilian, S., Brown, W. S., Hallam, B. J., McMahon, W., Lu, J. K., Johnson, M., Bigler, E. D., & Lainhart, J. E. (2007) · Developmental Neuropsychology · doi:10.1080/87565640701729821 · Cited by 33 · see citing works
Jang, S., Lee, J., Yeo, S., & Chang, M. (2013) · Journal of Stroke & Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2012.10.015 · Cited by 26 · see citing works
(2010) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195300369.001.0001 · Cited by 25 · see citing works
Four-dimensional tractography animates neural propagations via distinct interhemispheric pathways
Mitsuhashi, T., Sonoda, M., Jeong, J., Silverstein, B. H., Iwaki, H., Luat, A. F., Sood, S., & Asano, E. (2020) · Clinical Neurophysiology · doi:10.1016/j.clinph.2020.11.030 · Cited by 23 · see citing works
Visual agnosia and focal brain injury
Martinaud, O. (2017) · Revue Neurologique · doi:10.1016/j.neurol.2017.07.009 · Cited by 21 · see citing works
Implicit reading in Chinese pure alexia
Shan, C., Zhu, R., Xu, M., Luo, B., & Weng, X. (2010) · Brain and Language · doi:10.1016/j.bandl.2010.05.006 · Cited by 14 · see citing works
Two Cases of Japanese CADASIL with Corpus Callosum Lesion.
Iwatsuki, K., Murakami, T., Manabe, Y., Narai, H., Warita, H., Hayashi, T., & Abe, K. (2001) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.195.135 · Cited by 14 · see citing works
Corpus callosum has different channels for transmission of spatial frequency information
Kalaycıoğlu, C., Nalçacı, E., Schmiedt‐Fehr, C., & Başar‐Eroğlu, C. (2009) · Brain Research · doi:10.1016/j.brainres.2009.08.018 · Cited by 13 · see citing works
Alexia and agraphia in Japanese
Suzuki, K. (2022) · Neurology and Clinical Neuroscience · doi:10.1111/ncn3.12610 · Cited by 11 · see citing works
Starrfelt, R., & Woodhead, Z. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-821377-3.00010-6 · Cited by 11 · see citing works
Rofes, A., & Mahon, B. (2021) · Intraoperative Mapping of Cognitive Networks · doi:10.1007/978-3-030-75071-8_11 · Cited by 5 · see citing works
Yi, W., Wu, T., Chen, W., Yuan, T., Luo, B., Shan, C., Li, J., He, S., & Weng, X. (2013) · Brain Structure and Function · doi:10.1007/s00429-012-0499-x · Cited by 7 · see citing works
Frak, V., Paulignan, Y., Jeannerod, M., Michel, F., & Cohen, H. (2005) · Brain and Cognition · doi:10.1016/j.bandc.2005.09.010 · Cited by 7 · see citing works
Improvement in callosal disconnection syndrome with recovery of callosal connectivity
Morihara, K., Kakinuma, K., Kobayashi, E., Kawakami, N., Narita, W., Kanno, S., Tanaka, F., & Suzuki, K. (2021) · Neurocase · doi:10.1080/13554794.2021.1959935 · Cited by 5 · see citing works
Examination of the split fovea theory in a case of pure left hemialexia
Siéroff, É., & Michal Lavidor, B. (2007) · Cognitive Neuropsychology · doi:10.1080/02643290601161926 · Cited by 5 · see citing works
Description of interhemispheric disconnection syndrome in a patient with Marchiafava-Bignami disease
Politis, D. G., Tirigay, R., Gómez, P., & Tabernero, M. E. (2013) · World Journal of Neuroscience · doi:10.4236/wjns.2013.33024 · Cited by 4 · see citing works
Acquired dyslexias following temporal lesions
Cohen, L. (2022) · Handbook of clinical neurology · doi:10.1016/b978-0-12-823493-8.00003-1 · Cited by 3 · see citing works
Barton, J. J. S., Rubino, C., Albonico, A., Jackson, M., & Davies-Thompson, J. (2022) · Cortex · doi:10.1016/j.cortex.2022.09.015 · Cited by 3 · see citing works
Sakurai, Y. (2025) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2025.1664803 · Cited by 2 · see citing works
Chen, Z., Luo, B., Xu, M., Shang, D., & Liang, H. (2013) · Aphasiology · doi:10.1080/02687038.2013.805727 · Cited by 2 · see citing works
Extensive Callosal Infarction Showing Difficulty in Knitting as an Initial Symptom
Suzuki, K., Takiguchi, Y., Miyamoto, T., Miyamoto, M., Hirata, K., Hara, K., Suzuki, S., Takebayashi, K., Aso, Y., & Inukai, T. (2008) · Internal Medicine · doi:10.2169/internalmedicine.47.1095 · Cited by 1 · see citing works
Vanishing splenial lesion presenting as alexia with dysgraphia
Jain, R. S., Kumar, S., Paul, M., & Agrawal, R. (2015) · Journal of Neurology · doi:10.1007/s00415-015-7675-x · Cited by 1 · see citing works
Wan, S., Sun, Y., Ye, Q., Gu, Y., Sommer, W., & Cao, X. (2023) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2023.108568 · Cited by 1 · see citing works
Barton, J. J. S., Albonico, A., & Starrfelt, R. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-15646-5.00012-9 · Cited by 1 · see citing works
Cohen, L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00068-2 · Cited by 1 · see citing works
Original Article Cognitive impairments associated with corpus callosum infarction: a ten cases study
Huang, X., Du, X., Song, H., Zhang, Q., Jia, J., Xiao, T., & Wu, J. (2015)
Segregated and integrated hemispheric processes in vision and movement
Chiang, T.-C. (2006) · Doctoral thesis, University of London.
Ohta, M., & Takeshita, I. (2000) · Japanese Journal of Neurosurgery · doi:10.7887/jcns.9.812
From Right to Left: Interhemispheric Interactions while Seeing Words and Hearing Sentences
Chu, R. (2018) · TSpace (University of Toronto)
- Authors
- Suzuki, K., Yamadori, A., Endo, K., Fujii, T., Ezura, M., & Takahashi, A.
- Affiliations
- Tohoku University (JP)
- ORCID
- Venue
- Neurology
- Published
- 1998-11
- Volume
- 51
- Issue
- 5
- Pages
- 1390-1394
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2146318512
- Cited by
- 51
- References
- 10
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 1
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Life Sciences › Neuroscience › Cognitive Neuroscience › Spatial Neglect and Hemispheric Dysfunction
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Keywords
- corpus callosum, splenium, letter naming, picture naming, interhemispheric transfer, visual information transfer, language-dominant hemisphere, callosal lesions, reading aloud, letter copying
- MeSH terms
- Adolescent, Intracranial Arteriovenous Malformations, Cerebral Hemorrhage, Cognition, Corpus Callosum, Embolization, Therapeutic, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Pattern Recognition, Visual, Reading, Visual Fields
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