Visualizing the neural bases of a disconnection syndrome with diffusion tensor imaging
Abstract
Disconnection syndromes are often conceptualized exclusively within cognitive box-and-arrow diagrams unrelated to brain anatomy. In a patient with alexia in his left visual field resulting from a posterior callosal lesion, we illustrate how diffusion tensor imaging can reveal the anatomical bases of a disconnection syndrome by tracking the degeneration of neural pathways and relating it to impaired fMRI activations and behavior. Compared to controls, an abnormal pattern of brain activity was observed in the patient during word reading, with a lack of activation of the left visual word form area (VWFA) by left hemifield words. Statistical analyses of diffusion images revealed a damaged fiber tract linking the left ventral occipito-temporal region to its right homolog across the lesioned area of corpus callosum and stopping close to the areas found active in fMRI. The behavioral disconnection syndrome could, thus, be related functionally to abnormal fMRI activations and anatomically to the absence of a connection between those activations. The present approach, based on the "negative tracking" of degenerated bundles, provides new perspectives on the understanding of human brain connections and disconnections.
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Callosal lesions of fibers connecting the right-hemispheric visual regions to the VWFA provoke a subtype of pure alexia restricted to words displayed in the left half of the visual field.
“Callosal lesions of fibers connecting the right-hemispheric visual regions to the VWFA provoke a subtype of PA restricted to words displayed in the left half of the visual field [9,50].”
From The visual word form area: expertise for reading in the fusiform gyrus (2003) · cites this paper as [50]
In such cases, reduced activations of the VWFA for words presented in the left hemifield were observed.
“In such cases, we observed reduced activations of the VWFA for words presented in the left hemifield (Cohen et al., 2000; Molko et al., 2002).”
From Specialization within the ventral stream: the case for the visual word form area (2004) · cites this paper as Molko et al., 2002
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Presurgical Tractography Applications
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A correlative measure for processing multiangle diffusion‐weighted images
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Anterior Disconnection Syndrome Revisited using Modern Technologies
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- Authors
- Molko, N., Cohen, L., Mangin, J. F., Chochon, F., Lehéricy, S., Bihan, D. L., & Dehaene, S.
- Affiliations
- Inserm (FR)
- UNAF, Service Hospitalier Frédéric Joliot, Commisariat à l'Energie Atanique
- Pitié-Salpêtrière Hospital (FR)
- Human Brain Research Center, Graduate School of Medicine, Kyoto University (JP)
- Venue
- Journal of Cognitive Neuroscience
- Publisher
- MIT Press - Journals
- Published
- 2002-05
- Volume
- 14
- Issue
- 4
- Pages
- 629-636
- ISSN
- 0898-929X (ISSN-L)
- 1530-8898
- OpenAlex
- W2098520947
- Cited by
- 144
- References
- 34
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2022: 4 · 2021: 3 · 2018: 2 · 2017: 1 · 2016: 5 · 2015: 10 · 2014: 5 · 2013: 10 · 2012: 6
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cognitive Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- disconnection syndrome, alexia, corpus callosum lesions, posterior corpus callosum, visual word form area, interhemispheric connectivity, word reading, fMRI activation, diffusion tensor imaging
- MeSH terms
- Adult, Brain, Brain Mapping, Dominance, Cerebral, Dyslexia, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Reading, Verbal Behavior, Anisotropy
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