Acute resistance exercise induces antinociception by activation of the endocannabinoid system in rats
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BACKGROUND: Resistance exercise (RE) is also known as strength training, and it is performed to increase the strength and mass of muscles, bone strength, and metabolism. RE has been increasingly prescribed for pain relief. However, the endogenous mechanisms underlying this antinociceptive effect are still largely unexplored. Thus, we investigated the involvement of the endocannabinoid system in RE-induced antinociception. METHODS: Male Wistar rats were submitted to acute RE in a weight-lifting model. The nociceptive threshold was measured by a mechanical nociceptive test (paw pressure) before and after exercise. To investigate the involvement of cannabinoid receptors and endocannabinoids in RE-induced antinociception, cannabinoid receptor inverse agonists, endocannabinoid metabolizing enzyme inhibitors, and an anandamide reuptake inhibitor were injected before RE. After RE, CB1 cannabinoid receptors were quantified in rat brain tissue by Western blot and immunofluorescence. In addition, endocannabinoid plasma levels were measured by isotope dilution-liquid chromatography mass spectrometry. RESULTS: RE-induced antinociception was prevented by preinjection with CB1 and CB2 cannabinoid receptor inverse agonists. By contrast, preadministration of metabolizing enzyme inhibitors and the anandamide reuptake inhibitor prolonged and enhanced this effect. RE also produced an increase in the expression and activation of CB1 cannabinoid receptors in rat brain tissue and in the dorsolateral and ventrolateral periaqueductal regions and an increase in endocannabinoid plasma levels. CONCLUSIONS: The present study suggests that a single session of RE activates the endocannabinoid system to induce antinociception.
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Exercise-induced elevations of endocannabinoid levels have been proposed to account partially for anxiolytic, anti-nociceptive and neuroprotective properties of exercise.
“Exerciseinduced elevations of endocannabinoid levels have been proposed to account partially for anxiolytic (Tantimonaco et al., 2014;Fuss et al., 2015), anti-nociceptive (Galdino et al., 2014) and neuroprotective (Hill et al., 2010a) properties of exercise, which are all responses that instead are affected in a negative direction by sleep loss (e.g.Roy-Byrne et al., 1986;Schuh-Hofer et al., 2013;”
From Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans (2016) · cites this paper as Galdino et al., 2014
The increase of circulating endocannabinoids following exercise has been proposed to partially account for anxiolytic, anti-nociceptive, and neuroprotective properties of physical exercise.
“The increase of circulating levels of endocannabinoids following exercise has been proposed to partially account for the anxiolytic (Tantimonaco et al., 2014), anti-nociceptive (Galdino et al., 2014) and neuroprotective (Hill et al., 2010a) properties of physical exercise.”
From Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans (2016) · cites this paper as Galdino et al., 2014
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- Authors
- Galdino, G., Romero, T., Pinho da Silva, J. F., Aguiar, D., de Paula, A. M., Cruz, J., Parrella, C., Piscitelli, F., Duarte, I., Di Marzo, V., & Perez, A.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- Istituto di Chimica Biomolecolare (IT)
- Corresponding author
- Galdino, Giovane
- Romero, Thiago
- Aguiar, Daniele
- Duarte, Igor
- Venue
- Anesthesia & Analgesia
- Published
- 2014-09
- Volume
- 119
- Issue
- 3
- Pages
- 702-715
- ISSN
- 0003-2999 (ISSN-L)
- PMC
- PMC4139418
- OpenAlex
- W2328951891
- Cited by
- 72
- References
- 68
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 5 · 2018: 4 · 2017: 10 · 2016: 5 · 2015: 2 · 2014: 1
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Anesthesia & Analgesia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (P01DA009789, DA 009789)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Keywords
- resistance training, antinociception, endocannabinoid system, CB1 receptor, CB2 receptor, anandamide, periaqueductal gray, analgesia, exercise-induced analgesia
- MeSH terms
- Animals, Chromatography, High Pressure Liquid, Fluorescent Antibody Technique, Injections, Intraventricular, Injections, Spinal, Injections, Subcutaneous, Male, Microinjections, Pain Measurement, Periaqueductal Gray, Physical Conditioning, Animal, Mass Spectrometry, Blotting, Western, Proto-Oncogene Proteins c-fos, Rats, Wistar, Receptor, Cannabinoid, CB1, Rats, Resistance Training, Nociception, Cannabinoid Receptor Agonists, Cannabinoid Receptor Antagonists, Endocannabinoids
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