Anxiolytic-like effect of cannabidiol in the rat Vogel conflict test

Moreira, Fabrício A.; Aguiar, Daniele C.; Guimarães, Francisco S.

doi:10.1016/j.pnpbp.2006.06.004

Cited by 207Cannabis and Cannabinoid ResearchMedicinal Plant Extracts EffectsPsychedelics and Drug Studies

Anxiolytic-like effect of cannabidiol in the rat Vogel conflict test

Moreira, Fabrício A., Aguiar, Daniele C., Guimarães, Francisco S.·2006·Progress in Neuro-Psychopharmacology and Biological Psychiatry

DOI 10.1016/j.pnpbp.2006.06.004

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Abstract

Cannabidiol (CBD) is a major constituent of the Cannabis sativa plant. It inhibits the anxiogenic activity of high doses of Delta9-tetrahydrocannabinol and induces anxiolytic-like effects. However, the mechanisms underlying the actions of CBD are unknown. Therefore, the aim of the present study was to test the effects of CBD in the Vogel test, a widely used animal model of anxiety. In addition, it was verified if these effects would depend on benzodiazepine-receptor activation. After 24 h of water deprivation, male Wistar rats were subjected to an initial 3-min non-punished (pre-test) drinking session. This was followed by an additional 24-h period of water deprivation followed by a 3-min punished-licking session (test). Diazepam (3 mg/kg) or CBD (2.5, 5 or 10 mg/kg) were intraperitoneally injected 30 min before the test session. CBD (10 mg/kg) and diazepam had similar anticonflict effects, increasing the number of punished licks. The effect of diazepam, but not of CBD, was prevented by the benzodiazepine-receptor antagonist flumazenil (10 mg/kg). To exclude that the anticonflict effects were reflecting non-specific drug effects, we checked the effects of CBD on water consumption and nociceptive response. The drug did not interfere on the former variable in a non-punished test session. Moreover, contrary to morphine (5 mg/kg), CBD was ineffective in the tail-flick test. In conclusion, CBD induced an anticonflict effect not mediated by benzodiazepine receptors or by non-specific drug interference on nociceptive threshold or water consumption. These results reinforce the hypothesis that this cannabinoid has anxiolytic properties.

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Systemic administration of CBD in rats exerts anxiolytic-like effects in the Vogel conflict test.
“Vogel conflict test (Campos and Guimaraes, 2008; Gomes et al., 2012; Moreira et al., 2006)”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Moreira et al., 2006
CBD induced acute anxiolytic effects when injected into the dPAG and BNST.
“As shown in Figure 2, CBD induced acute anxiolytic effects when injected into the dPAG and BNST (21, 37–41).”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [21]

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“The EPM is a model based on exploratory behavior and its rationale is the natural aversion that rodents have for open Abbreviations: CBD, cannabidiol; Δ9-THC, Δ9-tetrahydrocannabinol; EPM, elevated plus-maze.”
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Authors: Moreira, F. A., Aguiar, D. C., & Guimarães, F. S.
Affiliations: Universidade de São Paulo (BR)
Corresponding author: Moreira, Fabrício A.
ORCID: Moreira, Fabrício A.
Aguiar, Daniele C.
Guimarães, Francisco S.
Venue: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher: Elsevier BV
Published: 2006-12
Volume: 30
Issue: 8
Pages: 1466-1471
ISSN: 0278-5846 (ISSN-L)
DOI: 10.1016/j.pnpbp.2006.06.004
OpenAlex: W2087748457
Cited by: 207
References: 49
Citations by year: 2026: 4 · 2025: 7 · 2024: 11 · 2023: 14 · 2022: 12 · 2021: 15 · 2020: 10 · 2019: 9 · 2018: 13 · 2017: 14 · 2016: 7 · 2015: 9 · 2014: 8 · 2013: 6 · 2012: 18
FWCI: 5.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Topics: Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Keywords: cannabidiol, anxiolytic effects, Vogel conflict test, anxiety, benzodiazepine receptor, flumazenil, diazepam, water deprivation, nociception, tail-flick test, morphine
MeSH terms: Animals, Anxiety, Cannabidiol, Conflict, Psychological, Male, Psychological Tests, Anti-Anxiety Agents, Rats, Wistar, Models, Animal, Rats

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Anxiolytic-like effect of cannabidiol in the rat Vogel conflict test

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