The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure
Open accessAbstract
Planar-cell-polarity (PCP) signalling is necessary for initiation of neural tube closure in higher vertebrates. In mice with PCP gene mutations, a broad embryonic midline prevents the onset of neurulation through wide spacing of the neural folds. In order to evaluate the role of convergent extension in this defect, we vitally labelled the midline of loop-tail(Lp) embryos mutant for the PCP gene Vangl2. Injection of DiI into the node, and electroporation of a GFP expression vector into the midline neural plate, revealed defective convergent extension in both axial mesoderm and neuroepithelium, before the onset of neurulation. Chimeras containing both wild-type and Lp-mutant cells exhibited mainly wild-type cells in the midline neural plate and notochordal plate, consistent with a cell-autonomous disturbance of convergent extension. Inhibitor studies in whole-embryo culture demonstrated a requirement for signalling via RhoA-Rho kinase, but not jun N-terminal kinase, in convergent extension and the onset of neural tube closure. These findings identify a cell-autonomous defect of convergent extension, requiring PCP signalling via RhoA-Rho kinase, during the development of severe neural tube defects in the mouse.
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Cites
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
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Identification of Vangl2 and Scrb1 as planar polarity genes in mammals
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Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements
Jessen, J. R., Topczewski, J., Bingham, S., Sepich, D. S., Marlow, F., Chandrasekhar, A., & Solnica-Krezel, L. (2002) · Nature Cell Biology · doi:10.1038/ncb828 · Cited by 504
Kibar, Z., Vogan, K. J., Groulx, N., Justice, M. J., Underhill, D. A., & Gros, P. (2001) · Nature Genetics · doi:10.1038/90081 · Cited by 504
The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos
Park, M., & Moon, R. T. (2002) · Nature Cell Biology · doi:10.1038/ncb716 · Cited by 381
Morphogenesis of the murine node and notochordal plate
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Cited by
Copp, A. J., Adzick, N. S., Chitty, L. S., Fletcher, J. M., Holmbeck, G. N., & Shaw, G. M. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.7 · Cited by 649
Self-citationGreene, N. D. E., & Copp, A. J. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062012-170354 · Cited by 629
Self-citationPlanar cell polarity in development and disease
Butler, M. T., & Wallingford, J. B. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.11 · Cited by 580
Principles of planar polarity in animal development
Goodrich, L. V., & Strutt, D. (2011) · Development · doi:10.1242/dev.054080 · Cited by 579
Planar Cell Polarity Signaling: From Fly Development to Human Disease
Simons, M., & Mlodzik, M. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091432 · Cited by 578
Metadata
- Authors
- Ybot-Gonzalez, P., Savery, D., Gerrelli, D., Signore, M., Mitchell, C. E., Faux, C. H., Greene, N. D. E., & Copp, A. J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2007-02-15
- Volume
- 134
- Issue
- 4
- Pages
- 789-799
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1975456228
- Cited by
- 329
- References
- 8
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ybot-Gonzalez, P., Savery, D., Gerrelli, D., Signore, M., Mitchell, C. E., Faux, C. H., Greene, N. D. E., & Copp, A. J. (2007). Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development. https://doi.org/10.1242/dev.000380
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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