The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure
Open accessAbstract
Planar-cell-polarity (PCP) signalling is necessary for initiation of neural tube closure in higher vertebrates. In mice with PCP gene mutations, a broad embryonic midline prevents the onset of neurulation through wide spacing of the neural folds. In order to evaluate the role of convergent extension in this defect, we vitally labelled the midline of loop-tail(Lp) embryos mutant for the PCP gene Vangl2. Injection of DiI into the node, and electroporation of a GFP expression vector into the midline neural plate, revealed defective convergent extension in both axial mesoderm and neuroepithelium, before the onset of neurulation. Chimeras containing both wild-type and Lp-mutant cells exhibited mainly wild-type cells in the midline neural plate and notochordal plate, consistent with a cell-autonomous disturbance of convergent extension. Inhibitor studies in whole-embryo culture demonstrated a requirement for signalling via RhoA-Rho kinase, but not jun N-terminal kinase, in convergent extension and the onset of neural tube closure. These findings identify a cell-autonomous defect of convergent extension, requiring PCP signalling via RhoA-Rho kinase, during the development of severe neural tube defects in the mouse.
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Cites
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Self-citationGreene, N. D. E., & Copp, A. J. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062012-170354 · Cited by 629
Self-citationPlanar cell polarity in development and disease
Butler, M. T., & Wallingford, J. B. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.11 · Cited by 580
Principles of planar polarity in animal development
Goodrich, L. V., & Strutt, D. (2011) · Development · doi:10.1242/dev.054080 · Cited by 579
Planar Cell Polarity Signaling: From Fly Development to Human Disease
Simons, M., & Mlodzik, M. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091432 · Cited by 578
Ciliary proteins link basal body polarization to planar cell polarity regulation
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Neural tube defects—disorders of neurulation and related embryonic processes
Copp, A. J., & Greene, N. D. E. (2013) · WIREs Developmental Biology · doi:10.1002/wdev.71 · Cited by 268
Self-citationThe amniote primitive streak is defined by epithelial cell intercalation before gastrulation
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Au, K. S., Hebert, L., Hillman, P., Baker, C., Brown, M. R., Kim, D.-K., Soldano, K., Garrett, M., Ashley-Koch, A., Lee, S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-83058-7 · Cited by 20
Cell Signaling: Moving to a Wnt-Rap
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Metadata
- Authors
- Ybot-Gonzalez, P., Savery, D., Gerrelli, D., Signore, M., Mitchell, C. E., Faux, C. H., Greene, N. D. E., & Copp, A. J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2007-02-15
- Volume
- 134
- Issue
- 4
- Pages
- 789-799
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1975456228
- Cited by
- 329
- References
- 8
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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