The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface
Open accessAbstract
This review compares the signaling mechanisms of the Wnt and the Hedgehog proteins. Although Wnts and Hedgehogs are unrelated proteins, they are both modified by lipids, possibly through the action of enzymes that are related to each other. At the surface of target cells, the reception of Wnt and Hedgehog signals is regulated by several molecules, some of which, in particular the Frizzled and Smoothened receptors, are related to each other. Several other aspects of Wnt and Hedgehog transport and signaling are discussed, as well as the possible origin of these pathways.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
Self-citationAltered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696
Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling
Mao, B., Wu, W., Davidson, G., Marhold, J., Li, M., Mechler, B. M., Delius, H., Hoppe, D., Stannek, P., Walter, C., et al. (2002) · Nature · doi:10.1038/nature756 · Cited by 1,038
Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
Cooper, M. K., Porter, J. A., Young, K. E., & Beachy, P. A. (1998) · Science · doi:10.1126/science.280.5369.1603 · Cited by 848
Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00224-6 · Cited by 839
Patched acts catalytically to suppress the activity of Smoothened
Taipale, J., Cooper, M. K., Maiti, T., & Beachy, P. A. (2002) · Nature · doi:10.1038/nature00989 · Cited by 794 · cited 2×
“…requires not only a functional Fz, but also the presence of a long, single-pass transmembrane molecule of the Lrp (LDL receptor-related protein) family, which is encoded by arrow in Drosophila (Wehrli et al., 2000) and by Lrp5 or Lrp6 in vertebrates (Pinson et al., 2000; Tamai et al., 2000).”
BackgroundWNT signalling molecules act in axis formation in the diploblastic metazoan Hydra
Hobmayer, B., Rentzsch, F., Kuhn, K., Happel, C. M., von Laue, C. C., Snyder, P., Rothbächer, U., & Holstein, T. W. (2000) · Nature · doi:10.1038/35025063 · Cited by 599
A superfamily of membrane-bound O -acyltransferases with implications for Wnt signaling
Hofmann, K. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01539-x · Cited by 495
Wise, a context-dependent activator and inhibitor of Wnt signalling
Itasaki, N., Jones, C. M., Mercurio, S., Rowe, A., Domingos, P. M., Smith, J. C., & Krumlauf, R. (2003) · Development · doi:10.1242/dev.00674 · Cited by 321
Wg/Wnt Signal Can Be Transmitted through Arrow/LRP5,6 and Axin Independently of Zw3/Gsk3β Activity
Tolwinski, N. S., Wehrli, M., Rives, A., Erdeniz, N., DiNardo, S., & Wieschaus, E. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00063-7 · Cited by 286
Cited by
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
Jamieson, C. H. M., Ailles, L. E., Dylla, S. J., Muijtjens, M., Jones, C., Zehnder, J. L., Gotlib, J., Li, K., Manz, M. G., Keating, A., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040258 · Cited by 1,485
LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
He, X., Semenov, M., Tamai, K., & Zeng, X. (2004) · Development · doi:10.1242/dev.01117 · Cited by 1,044
Bänziger, C., Soldini, D., Schütt, C., Zipperlen, P., Hausmann, G., & Basler, K. (2006) · Cell · doi:10.1016/j.cell.2006.02.049 · Cited by 764
Monounsaturated Fatty Acid Modification of Wnt Protein: Its Role in Wnt Secretion
Takada, R., Satomi, Y., Kurata, T., Ueno, N., Norioka, S., Kondoh, H., Takao, T., & Takada, S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.10.003 · Cited by 788
Functions of heparan sulfate proteoglycans in cell signaling during development
Lin, X. (2004) · Development · doi:10.1242/dev.01522 · Cited by 678
The casein kinase 1 family: participation in multiple cellular processes in eukaryotes
Knippschild, U., Gocht, A., Wolff, S., Huber, N., Löhler, J., & Stöter, M. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2004.12.011 · Cited by 601
A WNT4 Mutation Associated with Müllerian-Duct Regression and Virilization in a 46,XX Woman
Biason-Lauber, A., Konrad, D., Navratil, F., & Schoenle, E. J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040533 · Cited by 438
Cong, F., Schweizer, L., & Varmus, H. (2004) · Development · doi:10.1242/dev.01318 · Cited by 317
The Frizzled family of unconventional G-protein-coupled receptors
Schulte, G., & Bryja, V. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.09.001 · Cited by 253
Helping Wingless take flight: how WNT proteins are secreted
Hausmann, G., Bänziger, C., & Basler, K. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2141 · Cited by 147
Mechanisms and inhibition of Porcupine-mediated Wnt acylation
Liu, Y., Qi, X., Donnelly, L., Elghobashi-Meinhardt, N., Long, T., Zhou, R. W., Sun, Y., Wang, B., & Li, X. (2022) · Nature · doi:10.1038/s41586-022-04952-2 · Cited by 128
Cell non-autonomous regulation of health and longevity
Miller, H. A., Dean, E. S., Pletcher, S. D., & Leiser, S. F. (2020) · eLife · doi:10.7554/elife.62659 · Cited by 102
Li, G., Xu, J., & Li, Z. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.06.015 · Cited by 65
Metadata
- Authors
- Nusse, R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2003-11-15
- Volume
- 130
- Issue
- 22
- Pages
- 5297-5305
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1967949450
- Cited by
- 336
- References
- 12
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
