The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The CARD-carrying caspase Dronc is essential for most, but not all,developmental cell death in Drosophila
Open accessAbstract
The initiator caspase Dronc is the only Drosophila caspase that contains a caspase activation and recruitment domain (CARD). Although Dronc has been implicated as an important effector of apoptosis, the genetic function of dronc in normal development is unclear because dronc mutants have not been available. In an EMS mutagenesis screen,we isolated four point mutations in dronc that recessively suppress the eye ablation phenotype caused by eye-specific overexpression of hid. Homozygous mutant dronc animals die during pupal stages; however, at a low frequency we obtained homozygous adult escapers. These escapers have additional cells in the eye and wings that are less transparent and slightly curved down. We determined that this is due to lack of apoptosis. Our analyses of dronc mutant embryos suggest that dronc is essential for most apoptotic cell death during Drosophila development, but they also imply the existence of a dronc-independent cell death pathway. We also constructed double mutant flies for dronc and the apoptosis inhibitor diap1. dronc mutants can rescue the ovarian degeneration phenotype caused by diap1 mutations, confirming that dronc acts genetically downstream of diap1.
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Cites
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651
Joazeiro, C. A. P., & Weissman, A. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00077-5 · Cited by 1,249
Daish, T. J., Mills, K., & Kumar, S. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.09.018 · Cited by 171
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Programmed Cell Death in Animal Development and Disease
Fuchs, Y., & Steller, H. (2011) · Cell · doi:10.1016/j.cell.2011.10.033 · Cited by 1,915
The mitochondrial pathways of apoptosis
Estaquier, J., Vallette, F., Vayssiere, J.-L., & Mignotte, B. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2869-1_7 · Cited by 637
Autophagy, Not Apoptosis, Is Essential for Midgut Cell Death in Drosophila
Denton, D., Shravage, B., Simin, R., Mills, K., Berry, D. L., Baehrecke, E. H., & Kumar, S. (2009) · Current Biology · doi:10.1016/j.cub.2009.08.042 · Cited by 385
Hou, Y.-C. C., Chittaranjan, S., Barbosa, S. G., McCall, K., & Gorski, S. M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200712091 · Cited by 180
Ajuba Family Proteins Link JNK to Hippo Signaling
Sun, G., & Irvine, K. D. (2013) · Science Signaling · doi:10.1126/scisignal.2004324 · Cited by 153
Yacobi-Sharon, K., Namdar, Y., & Arama, E. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.02.002 · Cited by 119
Developmentally programmed cell death in Drosophila
Denton, D., Aung-Htut, M. T., & Kumar, S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.014 · Cited by 75
Mills, K., Daish, T., Harvey, K. F., Pfleger, C. M., Hariharan, I. K., & Kumar, S. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200512126 · Cited by 70
Non-apoptotic cell death in animal development
Kutscher, L. M., & Shaham, S. (2017) · Cell Death & Differentiation · doi:10.1038/cdd.2017.20 · Cited by 67
Interactions of DNR1 with the apoptotic machinery of Drosophila melanogaster
Primrose, D. A., Chaudhry, S., Johnson, A. G. D., Hrdlicka, A., Schindler, A., Tran, D., & Foley, E. (2007) · Journal of Cell Science · doi:10.1242/jcs.03417 · Cited by 15
Retromer deficiency in Tauopathy models enhances the truncation and toxicity of Tau
Asadzadeh, J., Ruchti, E., Jiao, W., Limoni, G., MacLachlan, C., Small, S. A., Knott, G., Santa-Maria, I., & McCabe, B. D. (2022) · Nature Communications · doi:10.1038/s41467-022-32683-5 · Cited by 14
Metadata
- Authors
- Xu, D., Li, Y., Arcaro, M., Lackey, M., & Bergmann, A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2005-05-01
- Volume
- 132
- Issue
- 9
- Pages
- 2125-2134
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2027986342
- Cited by
- 182
- References
- 4
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- green
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