The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development
Abstract
The FGF-related proto-oncogene int-2 is implicated in mouse embryogenesis, since it is expressed in specific tissues during gastrulation and neurulation (Wilkinson et al. 1988). Here, we describe the expression of this gene during subsequent fetal development, int-2 transcripts are restricted to Purkinje cells in the cerebellum and to regions of the developing retina containing early-stage differentiating cells. This high level expression is not detected in the mature cerebellum or retina. In addition, int-2 RNA is detected in the mesenchyme of the developing teeth and in sensory regions of the inner ear. This complex and dynamic pattern suggests multiple roles of this proto-oncogene during fetal development of the mouse.
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Cites
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Peptide growth factors are multifunctional
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Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo
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Cited by
Receptor Specificity of the Fibroblast Growth Factor Family
Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., & Goldfarb, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15292 · Cited by 1,871
FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations
Hébert, J. M., Rosenquist, T., Götz, J., & Martin, G. R. (1994) · Cell · doi:10.1016/0092-8674(94)90276-3 · Cited by 589
FGF-4 and BMP-2 have opposite effects on limb growth
Niswander, L., & Martin, G. R. (1993) · Nature · doi:10.1038/361068a0 · Cited by 377
Mcmahon, A. P., Champion, J. E., Mcmahon, J. A., & Sukhatme, V. P. (1990) · Development · doi:10.1242/dev.108.2.281 · Cited by 141
Self-citationUpadhya, D., Ogata, M., & Reneker, L. W. (2013) · Development · doi:10.1242/dev.081042 · Cited by 57
Metadata
- Authors
- Wilkinson, D. G., Bhatt, S., & Mcmahon, A. P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1989-01-01
- Volume
- 105
- Issue
- 1
- Pages
- 131-136
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2183350970
- Cited by
- 308
- References
- 33
- FWCI
- 9.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wilkinson, D. G., Bhatt, S., & Mcmahon, A. P. (1989). Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development. Development. https://doi.org/10.1242/dev.105.1.131
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
