The DOI matches its Crossref record.
The segment polarity gene armadillo interacts with the wingless signaling pathway in both embryonic and adult pattern formation
Abstract
The segment polarity genes of Drosophila were initially defined as genes required for pattern formation within each embryonic segment. Some of these genes also function to establish the pattern of the adult cuticle. We have examined the role of the armadillo (arm) gene in this latter process. We confirmed and extended earlier findings that arm and the segment polarity gene wingless are very similar in their effects on embryonic development. We next discuss the role of arm in pattern formation in the imaginal discs, as determined by using a pupal lethal allele, by analyzing clones of arm mutant tissue in imaginal discs, and by using a transposon carrying arm to produce adults with a reduced level of arm. Together, these experiments established that arm is required for the development of all imaginal discs. The requirement for arm varies along the dorsal-ventral and proximal—distal axes. Cells that require the highest levels of arm are those that express the wingless gene. Further, animals with reduced arm levels have phenotypes that resemble those of weak alleles of wingless. We present a description of the patterns of arm protein accumulation in imaginal discs. Finally, we discuss the implications of these results for the role of arm and wingless in pattern formation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824
van de Wetering, M., Cavallo, R., Dooijes, D., van Beest, M., van Es, J., Loureiro, J., Ypma, A., Hursh, D., Jones, T., Bejsovec, A., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81925-x · Cited by 1,202
Self-citationCompartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein
Basler, K., & Struhl, G. (1994) · Nature · doi:10.1038/368208a0 · Cited by 833
Bänziger, C., Soldini, D., Schütt, C., Zipperlen, P., Hausmann, G., & Basler, K. (2006) · Cell · doi:10.1016/j.cell.2006.02.049 · Cited by 764
Cadherins and cancer: how does cadherin dysfunction promote tumor progression?
Jeanes, A., Gottardi, C. J., & Yap, A. S. (2008) · Oncogene · doi:10.1038/onc.2008.343 · Cited by 772
Direct and Long-Range Action of a Wingless Morphogen Gradient
Zecca, M., Basler, K., & Struhl, G. (1996) · Cell · doi:10.1016/s0092-8674(00)81991-1 · Cited by 731
ILK, PINCH and parvin: the tIPP of integrin signalling
Legate, K. R., Montañez, E., Kudlacek, O., & Füssler, R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1789 · Cited by 676
Axelrod, J. D., Miller, J. R., Shulman, J. M., Moon, R. T., & Perrimon, N. (1998) · Genes & Development · doi:10.1101/gad.12.16.2610 · Cited by 659
Signal transduction through beta-catenin and specification of cell fate during embryogenesis.
Miller, J. R., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.20.2527 · Cited by 656
A Homolog of the armadillo Protein in Drosophila (Plakoglobin) Associated with E-Cadherin
McCrea, P. D., Turck, C. W., & Gumbiner, B. (1991) · Science · doi:10.1126/science.1962194 · Cited by 623
Lee, J. J., von Kessler, D. P., Parks, S., & Beachy, P. A. (1992) · Cell · doi:10.1016/0092-8674(92)90264-d · Cited by 581
Kramps, T., Peter, O., Brunner, E., Nellen, D., Froesch, B., Chatterjee, S., Murone, M., Züllig, S., & Basler, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00679-7 · Cited by 561
Brunner, E., Peter, O., Schweizer, L., & Basler, K. (1997) · Nature · doi:10.1038/385829a0 · Cited by 493
Peifer, M., Sweeton, D., Casey, M., & Wieschaus, E. (1994) · Development · doi:10.1242/dev.120.2.369 · Cited by 426
Self-citationLong-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing
Neumann, C. J., & Cohen, S. M. (1997) · Development · doi:10.1242/dev.124.4.871 · Cited by 417
Loss of Cell Polarity Drives Tumor Growth and Invasion through JNK Activation in Drosophila
Igaki, T., Pagliarini, R. A., & Xu, T. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.042 · Cited by 370
The wingless signalling pathway and the patterning of the wing margin in Drosophila
Couso, J. P., Bishop, S. A., & Arias, A. M. (1994) · Development · doi:10.1242/dev.120.3.621 · Cited by 355
dishevelled is required during wingless signaling to establish both cell polarity and cell identity
Theisen, H., Purcell, J., Bennett, M., Kansagara, D., Syed, A., & Marsh, J. L. (1994) · Development · doi:10.1242/dev.120.2.347 · Cited by 339
Components of wingless signalling in Drosophila
Siegfried, E., Wilder, E. L., & Perrimon, N. (1994) · Nature · doi:10.1038/367076a0 · Cited by 326
Xwnt-11: a maternally expressed Xenopus wnt gene
Ku, M., & Melton, D. A. (1993) · Development · doi:10.1242/dev.119.4.1161 · Cited by 304
Cox, R. T., Kirkpatrick, C., & Peifer, M. (1996) · The Journal of cell biology · doi:10.1083/jcb.134.1.133 · Cited by 300
Self-citationA new nuclear component of the Wnt signalling pathway
Thompson, B., Townsley, F., Rosin-Arbesfeld, R., Musisi, H., & Bienz, M. (2002) · Nature Cell Biology · doi:10.1038/ncb786 · Cited by 288
Negative regulation of Armadillo, a Wingless effector in Drosophila
Pai, L.-M., Orsulic, S., Bejsovec, A., & Peifer, M. (1997) · Development · doi:10.1242/dev.124.11.2255 · Cited by 280
Self-citationMotzny, C. K., & Holmgren, R. (1995) · Mechanisms of Development · doi:10.1016/0925-4773(95)00397-j · Cited by 276
Burke, R., & Basler, K. (1996) · Development · doi:10.1242/dev.122.7.2261 · Cited by 265
Culi, J., & Mann, R. S. (2003) · Cell · doi:10.1016/s0092-8674(02)01279-5 · Cited by 119
Nemo is an inducible antagonist of Wingless signaling during Drosophila wing development
Zeng, Y. A., & Verheyen, E. M. (2004) · Development · doi:10.1242/dev.01177 · Cited by 60
Metadata
- Authors
- Peifer, M., Rauskolb, C., Williams, M., Riggleman, B., & Wieschaus, E.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1991-04-01
- Volume
- 111
- Issue
- 4
- Pages
- 1029-1043
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1819307633
- Cited by
- 251
- References
- 0
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
