The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis
Abstract
To contribute to an understanding of the roles and mechanisms of action of Wnts in early vertebrate development, we have characterized the normal expression of Xenopus laevis Wnt-5A, and investigated the consequences of misexpression of this putative signalling factor. Xwnt-5A transcripts are expressed throughout development, and are enriched in both the anterior and posterior regions of embryos at late stages of development, where they are found primarily in ectoderm, with lower levels of expression in mesoderm. Overexpression of Xwnt-5A in Xenopus embryos leads to complex mal-formations distinct from those achieved by ectopic expression of Xwnts -1, -3A, or -8. This phenotype is unlikely to result from Xwnt-5A acting as an inducing agent, as overexpression of Xwnt-5A does not rescue dorsal structures in UV-irradiated embryos, does not induce mesoderm in blastula caps, and Xwnt-5A does not alter the endogenous patterns of expression of goosecoid, Xbra, or Xwnt-8. To pursue whether Xwnt-5A has the capacity to affect morphogenetic movements, we investigated whether overexpression of Xwnt-5A alters the normal elongation of blastula cap explants induced by activin. Intriguingly, Xwnt-5A blocks the elongation of blastula caps in response to activin, without blocking the differentiation of either dorsal or ventral mesoderm within these explants. The data are consistent with Xwnt-5A having the potential activity of modifying the morphogenetic movements of tissues.
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Cited by
Veeman, M. T., Axelrod, J. D., & Moon, R. T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00266-1 · Cited by 1,359
Self-citationSilberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
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Analysis of Dishevelled signalling pathways during Xenopus development
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Modulation of Embryonic Intracellular Ca2+Signaling byWnt-5A
Slusarski, D. C., Yang-Snyder, J., Busa, W. B., & Moon, R. T. (1997) · Developmental Biology · doi:10.1006/dbio.1996.8463 · Cited by 404
Self-citationThe planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos
Park, M., & Moon, R. T. (2002) · Nature Cell Biology · doi:10.1038/ncb716 · Cited by 381
Self-citationMlodzik, M. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02770-1 · Cited by 341
Marlow, F., Topczewski, J., Sepich, D., & Solnica-Krezel, L. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00864-3 · Cited by 337
The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos
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Wnt-5A/Ror2 Regulate Expression of XPAPC through an Alternative Noncanonical Signaling Pathway
Schambony, A., & Wedlich, D. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.02.016 · Cited by 310
Heads or tails: Wnts and anterior–posterior patterning
Yamaguchi, T. P. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00417-1 · Cited by 276
Dishevelled: at the crossroads of divergent intracellular signaling pathways
Boutros, M., & Mlodzik, M. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00046-5 · Cited by 275
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Wnt signaling in development and disease
Freese, J. L., Pino, D., & Pleasure, S. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.09.003 · Cited by 180
Calcium signaling in vertebrate embryonic patterning and morphogenesis
Slusarski, D. C., & Pelegri, F. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.04.043 · Cited by 178
Origin of the Precerebellar System
Rodriguez, C. I., & Dymecki, S. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00059-3 · Cited by 149
WNT/β-catenin pathway activation in hepatocellular carcinoma: a clinical perspective
Chua, M.-S., Ma, L., Wei, W., & So, S. (2014) · Gastrointestinal Cancer: Targets and Therapy · doi:10.2147/gictt.s44256 · Cited by 12
Metadata
- Authors
- Moon, R. T., Campbell, R. M., Christian, J. L., McGrew, L. L., Shih, J., & Fraser, S.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1993-09-01
- Volume
- 119
- Issue
- 1
- Pages
- 97-111
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2125008623
- Cited by
- 329
- References
- 1
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
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