The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Dentate gyrus formation requires Emx2
Abstract
Emx 1 and 2 are the murine homologues of the Drosophila empty spiracles gene and based on their expression pattern may be involved in the regional specification of the mammalian forebrain. During early embryogenesis, Emx2 is expressed in the presumptive cerebral cortex and olfactory bulbs and later, in the hippocampus proper and dentate gyrus. The latter are involved in memory processes. To understand the role of Emx2 in vivo, we have mutated the gene in mice. Homozygous embryos die postnatally because of severe urogenital alterations. These mice present cerebral hemispheres with a reduced size and exhibit specific morphological alterations in allocortical structures of the medial wall of the brain. The dentate gyrus is missing and the hippocampus proper is reduced. The medial limbic cortex is also severely shortened. The development of the dentate gyrus is affected at the onset of its formation with defects in the neuroepithelium from which it originates. These findings demonstrate that Emx2 is required for the development of several forebrain structures.
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Cites
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Cited by
Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development
Furuta, Y., Piston, D. W., & Hogan, B. L. M. (1997) · Development · doi:10.1242/dev.124.11.2203 · Cited by 709
Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1
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Early Neocortical Regionalization in the Absence of Thalamic Innervation
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Endocrine Regulation of HOX Genes
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Habituation in rodents: a review of behavior, neurobiology, and genetics
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An Epigenetic Signature for Monoallelic Olfactory Receptor Expression
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Area identity shifts in the early cerebral cortex of Emx2−/− mutant mice
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Self-citationGli3 is required for Emx gene expression during dorsal telencephalon development
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Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2
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Neurogenin 2 has an essential role in development of the dentate gyrus
Galichet, C., Guillemot, F., & Parras, C. M. (2008) · Development · doi:10.1242/dev.015115 · Cited by 108
Metadata
- Authors
- Pellegrini, M., Mansouri, A., Simeone, A., Boncinelli, E., & Gruss, P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1996-12-01
- Volume
- 122
- Issue
- 12
- Pages
- 3893-3898
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2100836659
- Cited by
- 242
- References
- 4
- FWCI
- 4.97
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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