The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
NF-κB activity in transgenic mice: developmental regulation and tissue specificity
Abstract
The transcription factor family NF-κB/Rel is responsible for the regulation of a large number of cellular genes and some viruses. Since there is a strong similarity between the NF-κB/Rel family members and the Drosophila melanogaster protein DORSAL, which is activated early during embryogenesis, we were interested in determining the pattern of NF-κB activity during mouse development. Two lacZ reporter constructs, each driven by promoter elements that are dependent on the presence of nuclear NF-κB/Rel activity, were used to produce transgenic mice. The analysis of these mice did not identify nuclear NF-κB/Rel activity in early development prior to implantation or during the gastrulation processes. Earliest expression of the lacZ transgene was detected on day E12.5. Before birth lacZ expression was seen in discrete regions of the rhombencephalon of the developing brain, in the spinal medulla, in some of the blood vessels and in the thymus. After birth, the NF-κB/Rel activity in the thymus remained but nuclear activity was also found in the bone marrow, in the spleen and in the capsule of the lymph nodes. In the central nervous system, drastic changes in NF-κB/Rel activity could be observed in the first 3 weeks after birth, when the cortex and the cerebellum reach functional and morphological maturity. Considering the results of the p50, p65, relB and c-rel knock-out mice and our present findings, we believe that the NF-κB/Rel proteins known so far are probably not implicated in processes of early development and differentiation of the different tissues, but rather in maintaining their function once matured.
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Cites
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745
Cressman, D. E., Greenbaum, L. E., Haber, B. A., & Taub, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43831-8 · Cited by 224
Cited by
NF-kB: a crucial transcription factor for glial and neuronal cell function
O'Neill, L. A. J., & Kaltschmidt, C. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01035-1 · Cited by 1,013
NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review
Shih, R.-H., Wang, C.-Y., & Yang, C.-M. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00077 · Cited by 910
NF-κB in neuronal plasticity and neurodegenerative disorders
Mattson, M. P., & Camandola, S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11916 · Cited by 877
Inhibition of osteoblastic bone formation by nuclear factor-κB
Chang, J., Wang, Z., Tang, E., Fan, Z., McCauley, L., Franceschi, R., Guan, K., Krebsbach, P. H., & Wang, C.-Y. (2009) · Nature Medicine · doi:10.1038/nm.1954 · Cited by 481
GFAP promoter elements required for region‐specific and astrocyte‐specific expression
Lee, Y., Messing, A., Su, M., & Brenner, M. (2008) · Glia · doi:10.1002/glia.20622 · Cited by 424
Kaltschmidt, B., & Kaltschmidt, C. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001271 · Cited by 392
Xu, W., Chi, L., Row, B. W., Xu, R., Ke, Y., Xu, B., Luo, C., Kheirandish, L., Gozal, D., & Liu, R. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.03.055 · Cited by 377
Cellular Specificity of NF-κB Function in the Nervous System
Dresselhaus, E. C., & Meffert, M. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01043 · Cited by 345
Constitutive Nuclear Factor-κB Activity Is Required for Central Neuron Survival
Bhakar, A. L., Tannis, L.-L., Zeindler, C., Russo, M. P., Jobin, C., Park, D. S., MacPherson, S., & Barker, P. A. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08466.2002 · Cited by 310
Inhibition of NF-κB potentiates amyloid β-mediated neuronal apoptosis
Kaltschmidt, B., Uherek, M., Wellmann, H., Volk, B., & Kaltschmidt, C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9409 · Cited by 279
Requirement of NF-κB/Rel for the development of hair follicles and other epidermal appendices
Schmidt-Ullrich, R., Aebischer, T., Hülsken, J., Birchmeier, W., Klemm, U., & Scheidereit, C. (2001) · Development · doi:10.1242/dev.128.19.3843 · Cited by 216
Self-citationSchmidt-Ullrich, R., Tobin, D. J., Lenhard, D., Schneider, P., Paus, R., & Scheidereit, C. (2006) · Development · doi:10.1242/dev.02278 · Cited by 171
Self-citationFridmacher, V., Kaltschmidt, B., Goudeau, B., Ndiaye, D., Rossi, F. M., Pfeiffer, J., Kaltschmidt, C., Israël, A., & Mémet, S. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09403.2003 · Cited by 167
Self-citationSkeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity
Latil, M., Rocheteau, P., Châtre, L., Sanulli, S., Mémet, S., Ricchetti, M., Tajbakhsh, S., & Chrétien, F. (2012) · Nature Communications · doi:10.1038/ncomms1890 · Cited by 165
Self-citationRaasch, J., Zeller, N., van Loo, G., Merkler, D., Mildner, A., Erny, D., Knobeloch, K.-P., Bethea, J. R., Waisman, A., Knust, M., et al. (2011) · Brain · doi:10.1093/brain/awq359 · Cited by 106
Nuclear factor-κB-like activity increases in murine cerebral cortex after sleep deprivation
Chen, Z., Gardi, J., Kushikata, T., Fang, J., & Krueger, J. M. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.6.r1812 · Cited by 78
NF-κB, IκB, and IRAK Control Glutamate Receptor Density at the Drosophila NMJ
Heckscher, E. S., Fetter, R. D., Marek, K. W., Albin, S. D., & Davis, G. W. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.005 · Cited by 72
β-Catenin Regulates Wound Healing and IL-6 Expression in Activated Human Astrocytes
Edara, V. V., Nooka, S., Proulx, J., Stacy, S., Ghorpade, A., & Borgmann, K. (2020) · Biomedicines · doi:10.3390/biomedicines8110479 · Cited by 25
Overactivation of the NF‐κB pathway impairs molar enamel formation
Yamada, A., Kawasaki, M., Miake, Y., Yamada, Y., Blackburn, J., Kawasaki, K., Trakanant, S., Nagai, T., Nihara, J., Kudo, T., et al. (2020) · Oral Diseases · doi:10.1111/odi.13384 · Cited by 9
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Metadata
- Authors
- Schmidt-Ullrich, R., Mémet, S., Lilienbaum, A., Feuillard, J., Raphaël, M., & Israël, A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1996-07-01
- Volume
- 122
- Issue
- 7
- Pages
- 2117-2128
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2102353091
- Cited by
- 226
- References
- 2
- FWCI
- 4.53
- Type
- journal article
- Language
- en
- Open access
- closed
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