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Cited by 420

The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.

Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes

Mullins, Mary C., Hammerschmidt, Matthias, Kane, Donald A., Odenthal, Jörg, Brand, Michael, Eeden, Fredericus J. M. van, Furutani-Seiki, Makoto, Granato, Michael, Haffter, Pascal, Heisenberg, Carl-Philipp, Jiang, Yun-Jin, Kelsh, Robert N., Nüsslein-Volhard, Christiane·1996·Development
DOI 10.1242/dev.123.1.81
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Abstract

We identified 6 genes that are essential for specifying ventral regions of the early zebrafish embryo. Mutations in these genes cause an expansion of structures normally derived from dorsal-lateral regions of the blastula at the expense of ventrally derived structures. A series of phenotypes of varied strengths is observed with different alleles of these mutants. The weakest phenotype is a reduction in the ventral tail fin, observed as a dominant phenotype of swirl, piggytail, and somitabun and a recessive phenotype of mini fin, lost-a-fin and some piggytail alleles. With increasing phenotypic strength, the blood and pronephric anlagen are also reduced or absent, while the paraxial mesoderm and anterior neuroectoderm is progressively expanded. In the strong phenotypes, displayed by homozygous embryos of snailhouse, swirl and somitabun, the somites circle around the embryo and the midbrain region is expanded laterally. Several mutations in this group of genes are semidominant as well as recessive indicating a strong dosage sensitivity of the processes involved. Mutations in the piggytail gene display an unusual dominance that depends on both a maternal and zygotic heterozygous genotype, while somitabun is a fully penetrant dominant maternal-effect mutation. The similar and overlapping phenotypes of mutants of the 6 genes identified suggest that they function in a common pathway, which begins in oogenesis, but also depends on factors provided after the onset of zygotic transcription, presumably during blastula stages. This pathway provides ventral positional information, counteracting the dorsalizing instructions of the organizer, which is localized in the dorsal shield.

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Metadata

Authors
Mullins, M. C., Hammerschmidt, M., Kane, D. A., Odenthal, J., Brand, M., Eeden, F. J. M. V., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.-P., Jiang, Y.-J., Kelsh, R. N., & Nüsslein-Volhard, C.
Venue
Development
Publisher
The Company of Biologists
Published
1996-12-01
Volume
123
Issue
1
Pages
81-93
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.123.1.81
OpenAlex
W2124357826
Cited by
420
References
81
FWCI
8.29
Type
journal article
Language
en
Open access
closed

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